期刊
CURRENT TREATMENT OPTIONS IN NEUROLOGY
卷 15, 期 4, 页码 519-528出版社
CURRENT MEDICINE GROUP
DOI: 10.1007/s11940-013-0223-z
关键词
Lennox-Gastaut syndrome; LGS; Epilepsy; Treatment; Clobazam; Rufinamide; Topiramate; Lamotrigine; Levetiracetam; Valproic acid; Zonisamide; Felbamate; Ketogenic diet; Vagus nerve stimulator; Corpus callostomy
Lennox-Gastaut syndrome (LGS) is one of the most difficult epilepsy syndromes to treat, and many children are refractory to standard treatment regimens. Valproic acid, topiramate, and lamotrigine are considered first-line therapies. Newer agents, including clobazam and rufinamide, are promising additions to the current treatment options. The ketogenic diet and vagus nerve stimulation are important adjuncts, with increasing evidence to support their use. Corpus callosotomy should be considered in refractory cases. Finally, focal resective surgery should be considered in patients with lesional disease, although for most patients with LGS this is unlikely to be the case.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据