Article
Chemistry, Physical
Sana Saffour, Amal A. AL-Sharabi, Asaf Evrim Evren, Meral Yilmaz Cankilic, Leyla Yurttas
Summary: In this study, thirteen new compounds were synthesized and evaluated for their antifungal and antimicrobial activities. One compound exhibited the best activity and selectivity against Yersinia enterocolitica. Additionally, all compounds showed good activity against filamentous fungi.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Agriculture, Multidisciplinary
Dongguo Xia, Xiang Cheng, Xiaohang Liu, Chengqi Zhang, Yunxiao Wang, Qiaoyun Liu, Qi Zeng, Niqian Huang, Yao Cheng, Xianhai Lv
Summary: Novel pyrazole carboxylate derivatives containing a flexible thiazole backbone were successfully synthesized and evaluated for their antifungal bioactivities. Compound 24 showed excellent bioactivities against Botrytis cinerea and Sclerotinia sclerotiorum, while compound 15 exhibited remarkable antifungal activity against Valsa mali. Compounds 3, 15, and 24 are promising antifungal candidates worthy of further fungicide development.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Yan-Yan Ding, Han Zhou, Bao-Qi Peng-Deng, Bao-Qi Zhang, Zhi-Jun Zhang, Guang-Han Wang, Shao-Yong Zhang, Zheng-Rong Wu, Yi-Rong Wang, Ying-Qian Liu
Summary: Since the isolation of the first natural carbazole alkaloid, murrayanine, from Mwraya Spreng, carbazole alkaloid derivatives have attracted wide attention for their anti-tumor, anti-viral, and anti-bacterial activities. Recent research has shown that carbazole alkaloids and their derivatives exhibit diverse biological activities. This study provides the first comprehensive description of the antifungal and antibacterial activities of carbazole alkaloids in the past decade (2012-2022), including both natural and partially synthesized compounds. The challenges and problems faced by this class of alkaloids are also summarized. This paper will facilitate further exploration of carbazole alkaloids.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ahlam Oulous, Tarik Harit, Meryem Idrissi Yahyaoui, Abdeslam Asehraou, Fouad Malek
Summary: New pyrazole-tetrazole hybrid molecules were synthesized via two pathways and showed moderate antimicrobial activity against bacteria and fungi.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Siddappa A. Patil, Shivaputra A. Patil, Ever A. Ble-Gonzalez, Stephen R. Isbel, Sydney M. Hampton, Alejandro Bugarin
Summary: This review discusses various carbazole derivatives and their antimicrobial activity, providing valuable references for medicinal chemists in their search for new approaches to combat microbial infections, which are a leading cause of death worldwide.
Article
Biochemistry & Molecular Biology
Zesheng Hao, Bin Yu, Wei Gao, Haoyin Chen, Dongyan Yang, You Lv, Yue Zhang, Lei Chen, Zhijin Fan
Summary: Twenty-one novel pyrazole-thiazole carboxamide derivatives were synthesized and evaluated for their fungicidal activities, with compounds 6d and 6j showing promising results both in vitro and in vivo, particularly compound 6j demonstrating good protective activity against Rhizoctonia solani and Puccinia sorghi Schw.
MOLECULAR DIVERSITY
(2022)
Article
Chemistry, Physical
Vineetha Telma D'Souza, Janardhana Nayak, Desmond Edward D'Mello, P. Dayananda
Summary: Triazoles and quinoline compounds have been well studied for their biological activities. In this study, a novel series of compounds were synthesized and screened for antimicrobial activities, with some showing significantly higher bioactivities compared to normal drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Biochemistry & Molecular Biology
Min He, Yuan-Jing Li, Jiang Shao, Chen Fu, Ya-Sheng Li, Zi-Ning Cui
Summary: alpha-Glucosidase inhibitors (AGIs) were synthesized and screened for inhibitory activity against alpha-glucosidase. Compounds III-11, III-16, and III-39 showed promising inhibitory activity and could be considered as potential candidates for the development of novel antidiabetic drugs.
BIOORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Cui Deng, Heng Yan, Jun Wang, Bao-shan Liu, Kai Liu, Yu-min Shi
Summary: This review summarizes the research progress made regarding the anti-HIV potential of imidazole, oxazole, and thiazole hybrids, and discusses the structure-activity relationships (SARs) to facilitate the further rational design of more effective candidates.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Niedzialkowska, Aleksandra Felczak, Iwona E. Glowacka, Dorota G. Piotrowska, Katarzyna Lisowska
Summary: One of the main challenges in medicinal chemistry is the search for new substances with antimicrobial potential. Carbazole-containing compounds have shown promise as antibacterial, antifungal, and antiviral agents. This study examined the antimicrobial potential and toxicity of newly synthesized isomeric fluorinated 4-[4-(benzylamino)butoxy]-9H-carbazole derivatives. The derivatives showed effectiveness in inhibiting the growth of Gram-positive bacteria, particularly Staphylococcus aureus strains. However, Gram-negative strains and human fibroblast cells showed higher resistance and toxicity to these compounds. The results suggest the need for further modification of these structures to enhance their activity against pathogenic microorganisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Suman Punia, Vikas Verma, Devinder Kumar, Ashwani Kumar, Laxmi Deswal
Summary: A series of pyrazole-imidazole-triazole hybrids were synthesized and evaluated for antimicrobial activity, with one compound demonstrating excellent potency against A. niger. Molecular docking studies were used to determine the binding conformation of the most active compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Pharmacology & Pharmacy
Mazen M. Almehmadi, Ahad M. Alsaiari, Mustafa Halawi, Osama Abdulaziz, Mohammad Asif
Summary: A series of novel ether compounds were synthesized and screened for antibacterial and antifungal activities. The compounds showed certain activity, but were less potent than standard drugs.
LATIN AMERICAN JOURNAL OF PHARMACY
(2022)
Article
Agriculture, Multidisciplinary
Meng Li, Weiwei Wang, Xiang Cheng, Yunxiao Wang, Yao Chen, Jiexiu Gong, Xihao Chang, Xianhai Lv
Summary: In this study, a series of pyrazole carboxamide thiazole derivatives were designed, synthesized, and evaluated for their antifungal activities against plant pathogens. The bioassay results showed that several compounds exhibited good antifungal activities, with compounds 6i and 19i showing better efficacy than the control drug. Compound 23i also displayed significant inhibitory activity against a potato pathogen. Scanning electron microscopy analyses revealed that compound 6i could disrupt the surface morphology of the target fungus.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Infectious Diseases
Victor Kartsev, Athina Geronikaki, Alexander Zubenko, Anthi Petrou, Marija Ivanov, Jasmina Glamoclija, Marina Sokovic, Lyudmila Divaeva, Anatolii Morkovnik, Alexander Klimenko
Summary: In this study, the design, synthesis, and antimicrobial activity of new heteroaryl (aryl) thiazole derivatives were reported. The compounds demonstrated moderate antibacterial activity and better antifungal activity. Compound 3 showed the highest activity among the tested compounds.
Article
Chemistry, Medicinal
Jun-Da Qi, Yu-Qing Meng, Jingxin Sun, Wan-Xin Li, Hou-Xiang Zhai, Changhao Zhang, Jishan Quan, Cheng-Hua Jin
Summary: Four novel pyrazole derivatives were synthesized and their antibacterial and antifungal activities were evaluated. Some of these compounds exhibited strong antifungal activity and high selectivity without cytotoxicity against human cells.
ARCHIV DER PHARMAZIE
(2023)