Article
Psychiatry
Brian P. Brennan, Jiana Schnabel, Harrison G. Pope, James I. Hudson
Summary: The use of serotonergic antidepressants in hospitalized COVID-19 patients did not show a significant difference in outcomes compared to those not using antidepressants, based on the results of a study that aimed to replicate previous findings.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Cardiac & Cardiovascular Systems
Anna Calvi, Ilaria Fischetti, Ignazio Verzicco, Martino Belvederi Murri, Stamatula Zanetidou, Riccardo Volpi, Pietro Coghi, Stefano Tedeschi, Mario Amore, Aderville Cabassi
Summary: Patients with depression who take antidepressant medication may have an increased risk of developing hypertension. Different types of antidepressants have varying effects on blood pressure, with selective serotonin reuptake inhibitors being the safest class, while dopamine-norepinephrine reuptake inhibitors may lead to blood pressure increases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Obstetrics & Gynecology
Yu-Shian Cheng, Cheuk-Kwan Sun, Pin-Yang Yeh, Ming-Kung Wu, Kuo-Chuan Hung, Hsien-Jane Chiu
Summary: The study found that serotonergic antidepressants are effective in treating sleep disturbances in perimenopausal and postmenopausal women, especially in those without major depressive disorder. The dropout rates were comparable between the antidepressant and placebo groups.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2021)
Article
Psychiatry
Marjan Shokrani, Sanaz Askari, Negin Eissazade, Seyed Vahid Shariat, Behnam Shariati, Masoomeh Yarahmadi, Mohammadreza Shalbafan
Summary: This study aimed to evaluate the efficacy and safety of agomelatine augmentation of sertraline in the treatment of patients with moderate to severe OCD. The results showed that while agomelatine did not improve OCD symptoms, the combination treatment was safe and effective compared to placebo.
Article
Pediatrics
Lourdes M. DelRosso, Oliviero Bruni, Maria P. Mogavero, Amy Fickensher, Carlos H. Schenck, Raffaele Ferri
Summary: This study aimed to investigate the frequency of antidepressant use in children undergoing polysomnography (PSG). It was found that among the 3,371 patients who underwent PSG, 367 children were taking antidepressants. Girls had a decreased sleep stage N3 compared to boys, and children with insomnia had longer sleep latency. Antidepressants were found to affect REM latency and percentage, and certain antidepressants were associated with periodic leg movements during sleep.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2023)
Article
Psychiatry
Abel Thamby, Srinivas Balachander, Syed Farooq Ali, Shyam Sundar Arumugham, T. S. Jaisoorya, Janardhanan C. Narayanaswamy, Y. C. Janardhan Reddy
Summary: The study found that medication-naive OCD patients tend to remit faster than those who were previously treated, although the overall remission rate was the same in both groups. Future prospective naturalistic studies can compare the outcomes of medication-naive OCD patients treated with medications and CBT.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Psychiatry
Kirupamani Viswasam, David Berle, Denise Milicevic, Vladan Starcevic
Summary: This study investigated the prevalence of anxiety and related disorders during pregnancy, with OCD showing a steady increase in prevalence from the first to the third trimester. A significant proportion of women developed these disorders during pregnancy, indicating a potential risk factor. The findings have important implications for the recognition, prevention, and treatment of anxiety disorders during pregnancy.
PSYCHIATRY RESEARCH
(2021)
Review
Psychiatry
Yang Du, Biao Du, Yun Diao, Zubin Yin, Jin Li, Yunfeng Shu, Zizhen Zhang, Lizhi Chen
Summary: This systematic review examined the efficacy and acceptability of different types of antidepressants and benzodiazepines for the treatment of panic disorder in adult patients. Results suggest that medications like escitalopram, venlafaxine, and benzodiazepines may be effective options, but further high-quality RCTs are needed for confirmation.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Clinical Neurology
Ya-Mei Tzeng, I-Hsun Li, Hui-Han Kao, Jui-Hu Shih, Chin-Bin Yeh, Yi-Hsien Chen, Li-Ting Kao
Summary: This study found that antidepressants can reduce the subsequent risk of psoriasis in patients with major depressive disorder, particularly selective serotonin reuptake inhibitors and low-dose antidepressants have significant protective effects.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Clinical Neurology
Daniela Caldirola, Domenico De Donatis, Alessandra Alciati, Silvia Dacco, Giampaolo Perna
Summary: This article systematically reviews the recommended medications and optimal doses for treating panic disorder in older patients. The findings suggest that research in this area is scarce, outdated, and affected by methodological flaws, lacking significant advances.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Soon H. Yang, Charles F. Seifert
Summary: The use of serotonergic antidepressants (SADs) during the perioperative period is associated with an increased risk of bleeding in patients undergoing orthopedic surgery. Patients on SADs had a higher percentage of requiring transfusion and a longer hospital stay compared to those not on SADs.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Nam-Ju Ji, Seung-Yeon Jeon, Kyung-Joon Min, Myung Ki, Weon-Young Lee
Summary: This study investigated the relationship between the type of initial antidepressants and treatment adherence in outpatients with new onset depression. The results showed a significant association between initial antidepressant type and treatment adherence during the first three- and six-month treatment periods for employed and self-employed patients newly diagnosed with major depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Ivo H. Cerda, Paul J. Fitzgerald
Summary: The article presents a neurochemical model of unipolar major depressive disorder and predicts optimal pharmacological treatment based on different subtypes of depression. It suggests using different medications for high and low NE/5HT depression, and predicts the effects of rapidly acting antidepressants on different subtypes.
PSYCHIATRY RESEARCH
(2021)
Editorial Material
Pharmacology & Pharmacy
Armando Silva Almodovar, Dung Nguyen, Milap C. Nahata
Summary: Antidepressants may have a role in treating patients with RA and associated conditions, but further research is needed to assess their efficacy and safety.
ANNALS OF PHARMACOTHERAPY
(2022)
Review
Psychology, Clinical
Natan Pereira Gosmann, Marianna de Abreu Costa, Marianna de Barros Jaeger, Julia Frozi, Lucas Spanemberg, Gisele Gus Manfro, Samuele Cortese, Pim Cuijpers, Daniel Samuel Pine, Giovanni Abrahao Salum
Summary: Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) have similar efficacy in treating anxiety, obsessive-compulsive, and stress-related disorders. A network meta-analysis compared adverse event patterns between SSRIs and SNRIs in children and adults with these disorders. The analysis found that medication groups had higher adverse event rates, with nausea being the most common adverse event. Results also showed differences in overall tolerability and specific symptoms between medications.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Clinical Neurology
Laura Palagini, Pierre A. Geoffroy, Mario Miniati, Giulio Perugi, Giovanni Biggio, Donatella Marazziti, Dieter Riemann
Summary: This paper reviews the relationships between sleep, circadian phasing alterations, and neurodegenerative/neuroprogressive processes in mood disorders. Studies suggest that insomnia and altered circadian sleep may contribute to neurodegeneration and neuroprogression, increasing risks such as accumulation of neurotoxic proteins and oxidative stress. Targeting sleep disturbances may have neuroprotective benefits for mood disorders.
Article
Clinical Neurology
James McLauchlan, Emma M. Thompson, Ygor A. Ferrao, Euripedes C. Miguel, Lucy Albertella, Donatella Marazziti, Leonardo F. Fontenelle
Summary: The study found that love-precipitated OCD is associated with greater severity of sensory phenomena and later age at onset, but not with other characteristics and comorbid disorders. It suggests further exploration to determine the clinical significance of romantic love in shaping the expression of OCD.
Editorial Material
Clinical Neurology
Donatella Marazziti, Alessandro Arone, Tea Ivaldi, Konstantin Kuts, Konstantin Loganovsky
Summary: While space exploration is an attractive goal, there are psychological and psychopathological risks that should be considered, such as disturbances in sleep-wake cycle, personality changes, and depression. These risks could lead to central nervous system alterations and potential impairments in mission success and individual health. More studies are needed to prevent and address these risks in space exploration.
Letter
Clinical Neurology
Donatella Marazziti, Stephen M. Stahl
Article
Clinical Neurology
Laura Musetti, Antonio Tundo, Erika Cambiali, Claudia Del Grande, Rocco De Filippis, Caterina Franceschini, Luca Proietti, Sophia Betro, Donatella Marazziti, Liliana Dell'Osso
Summary: The study found that the combination of antidepressants with mood stabilizers/second-generation antipsychotics is effective and safe in the short and long term for a specific subgroup of bipolar depressed patients.
Article
Clinical Neurology
Donatella Marazziti, Filippo M. Barberi, Leonardo Fontenelle, Beatrice Buccianelli, Manuel G. Carbone, Elisabetta Parra, Stefania Palermo, Lucia Massa, Claudia Tagliarini, Alessandra Della Vecchia, Federico Mucci, Alessandro Arone, Liliana Dell'Osso
Summary: This study compared vitamin D levels in adult patients with obsessive-compulsive disorder (OCD) and explored possible correlations with patients' characteristics. The results showed a negative correlation between vitamin D levels and the severity of OCD and specific symptoms, with some differences based on gender. Further research is needed to confirm these findings and evaluate the effectiveness of vitamin D supplementation in OCD patients.
Review
Clinical Neurology
Mario Miniati, Francesca Marzetti, Laura Palagini, Ciro Conversano, Beatrice Buccianelli, Donatella Marazziti, Angelo Gemignani
Summary: This paper reviews the efficacy of Interpersonal Psychotherapy (IPT) administered via telephone (IPT-T). Thirteen studies were selected for analysis, with results showing that IPT-T had response rates similar to traditional IPT. However, the results are limited by small sample sizes, selection bias, and heterogeneity of rating scales.
Letter
Clinical Neurology
Donatella Marazziti
Article
Biology
Donatella Marazziti, Paola Mangiapane, Manuel Glauco Carbone, Florinda Morana, Alessandro Arone, Lucia Massa, Stefania Palermo, Miriam Violi, Giovanni Bertini, Leonardo Massoni, Sara Fantasia, Andrea Pozza, Federico Mucci, Benedetto Morana
Summary: Recently, there has been renewed interest in the role of vitamin D in neuropsychiatry, especially in mood disorders such as major depression and bipolar disorders. This study evaluated vitamin D levels in a sample of inpatients with bipolar disorders and found that their vitamin D levels were significantly lower than the normative values. The findings support the role of vitamin D in bipolar disorders and suggest that further studies should be conducted to investigate the potential benefits of vitamin D supplementation in treating mood disorders.
Article
Biology
Mario Miniati, Sara Busia, Ciro Conversano, Graziella Orru, Rebecca Ciacchini, Viarda Cosentino, Donatella Marazziti, Angelo Gemignani, Laura Palagini
Summary: This study aimed to investigate whether university students were more prone to cognitive fusion, rumination, and depressive symptoms compared to non-university students of the same age. The results showed that university students scored significantly higher in cognitive fusion, rumination, and depressive symptoms. Therefore, it is important to target these issues and provide psychoeducational and psychotherapeutic interventions for university students.
Article
Neurosciences
Beatrice Buccianelli, Donatella Marazziti, Alessandro Arone, Stefania Palermo, Marly Simoncini, Manuel Glauco Carbone, Leonardo Massoni, Miriam Violi, Liliana Dell'Osso
Summary: Despite uncertainties in its diagnostic framework, pseudodementia can be characterized as a condition with depressive symptoms and cognitive impairment in the absence of dementia. This study aimed to assess neurological and cognitive dysfunctions in elderly depressed subjects and explore the relationship between cognitive impairment and depressive symptoms. The findings suggest that pseudodementia represents a borderline condition between depression and cognitive decline that should be identified and treated promptly.
Review
Biology
Donatella Marazziti, Claudia Carmassi, Gabriele Cappellato, Ilaria Chiarantini, Leonardo Massoni, Federico Mucci, Alessandro Arone, Miriam Violi, Stefania Palermo, Giovanni De Iorio, Liliana Dell'Osso
Summary: Post-traumatic stress disorder (PTSD) is a complex and challenging psychopathological condition with a heterogeneous clinical picture. The current pharmacological treatments for PTSD are mainly empirical and based on the serotonergic system, but they show only partial benefits due to limited knowledge of its neurobiology. New pathogenetic hypotheses, including different mediators and pathways, are urgently needed for the development of novel and more efficient drugs.
Article
Biology
Valentina Falaschi, Lionella Palego, Donatella Marazziti, Laura Betti, Laura Musetti, Alessandra Maglio, Valerio Dell'Oste, Simona Sagona, Antonio Felicioli, Barbara Carpita, Alberto Brogi, Federico Mucci, Enrico Massimetti, Liliana Dell'Osso, Gino Giannaccini
Summary: This study aims to contribute to the method of subtyping major depressed patients by exploring the relationships between circulating BDNF, inflammatory/metabolic markers in the blood, and clinical characteristics. The findings reveal that inflammatory parameters are positively correlated with depression scores, and different forms of BDNF are associated with specific patient characteristics. The study suggests that BDNF may differentiate depression conditions and provide a deeper understanding of the peripheral biomarker profiles in major depressive episodes.
Article
Endocrinology & Metabolism
Donatella Marazziti
Summary: The present paper is a personal narration of the author's scientific pathway in studying oxytocin. The author's interest in the neurobiology of human emotions was sparked by a pioneering study on romantic lovers and eventually led to a shift in research focus from diseases to physiological states related to love. The author suggests that future studies should further explore the role of oxytocin in human nature and its potential therapeutic applications in various physiological and pathological conditions, which could potentially improve the lives of individuals and societies.
COMPREHENSIVE PSYCHONEUROENDOCRINOLOGY
(2023)
Review
Health Care Sciences & Services
Helene Kane, Jade Gourret Baumgart, Wissam El-Hage, Jocelyn Deloyer, Christine Maes, Marie-Clotilde Lebas, Donatella Marazziti, Johannes Thome, Laurence Fond-Harmant, Frederic Denis
Summary: This systematic literature review explores the development of using digital technologies for remote monitoring and assessment in the context of the COVID-19 pandemic. The analysis reveals variations in the integration of digital technologies, depending on countries, contexts, local regulations, and modalities of care. The use of videoconferencing has significantly increased, impacting working conditions and therapeutic relationships. This crisis has provided professionals an opportunity to gain experience in remote care and better understand the possibilities and limitations of these digital technologies.
JMIR HUMAN FACTORS
(2022)
