Review
Chemistry, Inorganic & Nuclear
Thimma Subramanian Prathima, Badruzzaman Choudhury, Md. Gulzar Ahmad, Kaushik Chanda, M. M. Balamurali
Summary: Numerous biologically active metal complexes have been reported for their unique features and enhanced functions in inhibiting cancer progression. However, many of these drugs have failed at various levels of clinical trials despite performing well in the laboratory.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Inorganic & Nuclear
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Cintia C. Vequi-Suplicy, Ana M. Pizarro
Summary: The passage describes the rapid hydrolysis and high basicity of complexes [Os(eta 6-arene)(C,N-phenylpyridine)Z] with chlorido or tethered oxygen as the ligand. It also reveals the structure-activity relationship between Os-CN and Os-NN complexes.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Lukas Masaryk, Darina Muthna, Petr Halas, Pavel Zoufaly, Eva Peterova, Radim Havelek, Bohuslav Drahos, David Milde, Alena Mrkvicova, Pavel Starha
Summary: In the presence of carboxypeptidase, the hydrolytically stable complex partially released the bioactive substituent indomethacin, which was bound through the amide bond to the chelating moiety. The stability in the presence of other relevant biomolecules and cancer cell viability were also investigated in this study.
DALTON TRANSACTIONS
(2022)
Review
Biochemistry & Molecular Biology
Kacper Poblocki, Joanna Drzezdzon, Tomasz Kostrzewa, Dagmara Jacewicz
Summary: Photodynamic therapy (PDT) is an alternative cancer treatment method that utilizes photosensitizers to convert light emission into radical oxygen-derived species (ROS), and can interact with compounds such as metal organic frameworks (MOFs). The interaction between DNA and metal-based complexes plays a key role in the development of new anti-cancer drugs, affecting the amount of ROS generated, quantum emission efficiency, and phototoxic index.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Applied
Rais Ahmad Khan, Amal AlFawaz, Nida N. Farshori, Anup Paul, Mohammed H. Jaafar, Ali Alsalme
Summary: Two organometallic ruthenium (II) complexes containing analogs of aminobenzimidazole were synthesized and characterized. Their binding affinity with human serum albumin and cytotoxic potential against cancer cells were evaluated. One of the complexes showed promising cytotoxic properties, indicating its potential as an anticancer therapeutic.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Michele De Franco, Marina Saab, Marina Porchia, Cristina Marzano, Steven P. Nolan, Fady Nahra, Kristof Van Hecke, Valentina Gandin
Summary: A series of NHC-based selenourea Ag(I) and Au(I) complexes were found to possess outstanding anticancer potential, overcoming drug resistance through selective inhibition of TrxR.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Qi-Yuan Yang, Rui Ma, Yun-Qiong Gu, Xiao-Fang Xu, Zhen-Feng Chen, Hong Liang
Summary: Targeting metabolic reprogramming to treat cancer, by using arene-ruthenium(II)/osmium(II) complexes to potentiate the anticancer effect of metformin (Met.) via glucose metabolism reprogramming, could increase overall survival and reduce side effects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Inorganic & Nuclear
Saumyaranjan Mishra, Suman Kumar Tripathy, Debasish Paul, Paltan Laha, Manas Kumar Santra, Srikanta Patra
Summary: In this study, a heterodinuclear complex was synthesized using terpyridyl/phenylpyridine and asymmetric phpy as ligands. The asymmetric binding mode of phpy in the complex was confirmed through various spectroscopy and crystallography techniques. The complex exhibited a broad low energy charge transfer band and showed anticancer activity and selectivity towards human breast cancer cells.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Dawid Zych
Summary: This study focuses on the theoretical investigations of mono- and dinuclear complexes, utilizing density functional theory calculations to understand their optical properties and physical parameters. The results have significant implications for the field of chemistry and materials science.
Article
Chemistry, Multidisciplinary
Tuan-Anh Nguyen, E. Daiann Sosa Carrizo, Helene Cattey, Paul Fleurat-Lessard, Julien Roger, Jean-Cyrille Hierso
Summary: In comparison to mononuclear gold Lewis acid catalysts, digold complexes and dual-gold catalysis have shown distinct and powerful potential for activating carbon-carbon multiple bonds. This study designs novel tetranuclear gold(I) dicationic complexes supported by stabilizing constraint diphosphinoferrocenyl ligands and attractive closed-shell Au...Au aurophilic interactions, and demonstrates their effectiveness in producing strained azabicyclo[4.1.0]hept-4-enes with high selectivity in the cycloisomerization of low-substituted 1,6-enynes.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Stefan Latis, Christoph Marschner, Judith Baumgartner, Sharon Prince, Supratim Biswas, Suparna Chakraborty, Kimberly G. Garcia, Ron M. A. Heeren, Sebastiaan Van Nuffel, Burgert Blom
Summary: This study reports the synthesis and characterisation of piano-stool triphenylstibine and triphenylarsine arene complexes, and their in vitro cytotoxic evaluation on breast cancer cell lines. The tin containing complexes demonstrate remarkable activity and selectivity.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Li Wei, Rajesh Kushwaha, Anyi Dao, Zhongxian Fan, Samya Banerjee, Huaiyi Huang
Summary: A novel axisymmetric bis-tridentate Ir(iii) photocatalyst (Ir3) with synergetic type I/II photosensitization and photocatalytic activity was reported. Ir3 exhibited high photocytotoxicity against drug-resistant cancer cells under normoxia and hypoxia. The photoactivated anticancer mechanism of Ir3 was investigated in detail. Overall, this new photo-redox catalyst can overcome hypoxia and drug resistance-related problems in clinical anticancer therapy.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Tasha R. Steel, Kelvin K. H. Tong, Tilo Sohnel, Stephen M. F. Jamieson, L. James Wright, James D. Crowley, Muhammad Hanif, Christian G. Hartinger
Summary: Multimetallic complexes have been synthesized and characterized, with studies conducted on their binding properties with DNA and protein models. The anticancer activity of the complexes was evaluated against cancer cell lines, showing moderate antiproliferative effects.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Brondwyn S. McGhie, Janice R. Aldrich-Wright
Summary: Cancer is responsible for over 9 million deaths worldwide each year. Current treatment options have low success rates, especially for late-stage cancers. Researchers globally are continuously searching for alternative treatment options. This study focuses on innovations in inorganic anticancer therapies with photoactive and luminescent properties. Transition metals offer advantages in both chemotherapeutics and luminescence. The study explores the effects of structural changes on the properties and the use of inherent luminescent properties for monitoring cellular localization in photodynamic therapy.
