Review
Pharmacology & Pharmacy
Hao-Yun Luo, Hai-Ying Shen, R. Serene Perkins, Ya-Xu Wang
Summary: Methylation is an important mechanism in cancer pathology, and the adenosine metabolic clearance enzyme ADK plays a role in regulating tumor suppressor gene methylation and tumor development. Targeting DNA methylation of cancer-related genes is a promising therapeutic strategy, but current drugs have side effects, highlighting the need for safer and more specific inhibitors.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Galina Zhulai, Eugenia Oleinik, Mikhail Shibaev, Kirill Ignatev
Summary: This review discusses two enzymes, ADK and ADA, that are involved in the reduction of adenosine levels. ADK eliminates adenosine by phosphorylation, while ADA regulates adenosine levels by converting it to inosine. These enzymes play important roles in cancer development and may serve as potential therapeutic targets.
Article
Biochemistry & Molecular Biology
Peng Wang, Rifeng Gao, Tingting Wu, Jinyan Zhang, Xiaolei Sun, Fan Fan, Cong Wang, Sanli Qian, Bingyu Li, Yunzeng Zou, Yuqing Huo, John Fassett, Yingjie Chen, Junbo Ge, Aijun Sun
Summary: This study demonstrates that cardiomyocyte ADK deletion improves myocardial I/R injury through epigenetic upregulation of IGF-1 expression.
Article
Engineering, Biomedical
Jiaul Hoque, Yu-Ru V. Shih, Yuze Zeng, Hunter Newman, Nivedita Sangaj, Neha Arjunji, Shyni Varghese
Summary: Extracellular adenosine plays a key role in maintaining bone health and could be used to treat bone loss, but challenges remain in systemic administration due to short half-life and ubiquitous receptors. Bone-targeting nanocarriers demonstrated higher accumulation in vertebrae and attenuated bone loss in mice, suggesting potential for treating bone degenerative diseases like osteoporosis.
Article
Medicine, General & Internal
Rachael Cherie Cvejic, Tim R. Watkins, Adrian R. Walker, Simone Reppermund, Preeyaporn Srasuebkul, Brian Draper, Adrienne Withall, Di Winkler, Ingrid Honan, Deidre Mackechnie, Julian Trollor
Summary: A study in New South Wales, Australia, found that younger people (aged 15-64 years) with neuropsychiatric disorders who were discharged from hospitals to residential aged care (RAC) were mainly associated with progressive neurological and cognitive disorders. Other influencing factors included acute precipitants such as a range of conditions and injuries, as well as older age, being unmarried or not having a partner, living in lower socioeconomic areas, functional issues, and the need for palliative care.
Editorial Material
Education, Scientific Disciplines
Sarah Levitt, Alex Henri-Bhargava, David B. Hogan, Kenneth Shulman, Sara B. Mitchell
Summary: The article introduces the development and practices of the Brain Medicine Fellowship, a training program that aims to cultivate interdisciplinary expertise in the assessment and treatment of complex brain disorders. It highlights the innovative educational design and the impact of the program through the Brain Medicine Clinic, benefiting patients and caregivers.
Article
Medicine, General & Internal
Rachael Cherie Cvejic, Tim R. Watkins, Adrian R. Walker, Simone Reppermund, Preeyaporn Srasuebkul, Brian Draper, Adrienne Withall, Di Winkler, Ingrid Honan, Deidre Mackechnie, Julian Trollor
Summary: This study examined the sociodemographic and diagnostic factors associated with discharge from hospital to residential aged care for younger people with neuropsychiatric disorders. The study found that progressive neurological and cognitive disorders were most strongly associated with discharge to aged care. Other factors included older age, not being partnered, living in areas of lower socioeconomic status, functional issues, and the need for palliative care.
Article
Medicine, General & Internal
Valdemar Landgren, Elisabeth Fernell, Christopher Gillberg, Magnus Landgren, Mats Johnson
Summary: This study investigates predictors of adverse outcomes in children with attention-deficit/hyperactivity disorder (ADHD) combined with developmental coordination disorder (DCD) compared to children without these disorders at the age of six. The findings highlight the importance of considering neurodevelopmental symptoms, such as ADHD severity, in predicting adverse outcomes in adulthood. The study suggests that a comprehensive neurodevelopmental profiling should inform research and clinical practice in order to better understand and address the associated comorbidities and problems in ADHD.
Article
Medicine, General & Internal
Annet Heijerman-Holtgrefe, Chaim Huyser, Cara Verdellen, Jolande van de Griendt, Laura Beljaars, Kees-Jan Kan, Ramon Lindauer, Danielle Cath, Pieter Hoekstra, Lisbeth Utens
Summary: This paper outlines the study protocol for the Dutch Tackle Your Tics study, which aims to provide effective treatment for children and adolescents with tic disorders. The program is a 4-day intensive and comprehensive group-based intervention that includes exposure and response prevention treatment and additional supporting components. The effectiveness of Tackle Your Tics is being studied through a single-blinded randomized controlled trial to identify predictors/moderators. If proven effective, this intervention can expand evidence-based treatment possibilities for children and adolescents with tic disorders.
Article
Dentistry, Oral Surgery & Medicine
T. Ding, J. Zou, J. Qi, H. Dan, F. Tang, H. Zhao, Q. Chen
Summary: This study successfully fabricated an isoguanosine-tannic acid (isoG-TA) supramolecular hydrogel with ideal adhesion and anti-OLK effect. Both isoG and TA showed inhibition of dysplastic oral keratinocytes (DOKs) in vitro. Both isoG-TA and G-TA hydrogels possessed potential in delaying the malignant transformation of OLK, with the G-TA hydrogel showing a better statistical effect, providing an effective strategy for controlling OLK.
JOURNAL OF DENTAL RESEARCH
(2022)
Review
Neurosciences
Daniel Hunter, Zoe Jamet, Laurent Groc
Summary: This text discusses the discovery of autoimmune encephalitis, especially the presence of autoantibodies against the glutamatergic NMDA receptor. It explores the diversity of NMDAR-Abs and their mechanisms leading to receptor dysfunction, as well as the need for further research in this area and its potential implications.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Chemistry, Multidisciplinary
Yu-Ru V. Shih, David Kingsley, Hunter Newman, Jiaul Hoque, Ankita Gupta, B. Duncan X. Lascelles, Shyni Varghese
Summary: This study demonstrates the feasibility of using adenosine and its material-assisted local delivery as a therapeutic approach to treat bone trauma and associated pain. Adenosine provides pain relief and promotes bone healing simultaneously, offering an improved method compared to current therapeutics.
Article
Medicine, General & Internal
Masatoshi Yamashita, Kuriko Kagitani-Shimono, Yoshiyuki Hirano, Sayo Hamatani, Shota Nishitani, Akiko Yao, Sawa Kurata, Hirotaka Kosaka, Minyoung Jung, Tokiko Yoshida, Tsuyoshi Sasaki, Koji Matsumoto, Yoko Kato, Mariko Nakanishi, Masaya Tachibana, Ikuko Mohri, Kenji J. Tsuchiya, Tetsuya Tsujikawa, Hidehiko Okazawa, Eiji Shimizu, Masako Taniike, Akemi Tomoda, Yoshifumi Mizuno
Summary: This study aims to correct site differences in MRI scanners and clarify brain structure and network characteristics of children with ADHD and ASD using large samples collected in a multi-centre collaboration. Additionally, the relationship between these characteristics and genetic, epigenetic, biochemical markers, and behavioral and psychological measures will be investigated.
Article
Medicine, General & Internal
Hilde M. Geurts, Joost A. Agelink van Rentergem, Tulsi Radhoe, Carolien Torenvliet, Wikke J. van der Putten, Annabeth P. Groenman
Summary: This study aims to fill the knowledge gaps in the field of autism spectrum conditions in adults by assessing cognitive aging in ASC through a multi-stage design. Participants include ASC patients, ADHD patients, and a control group without ASC/ADHD. The research will provide valuable data for understanding the concept of ASC and providing support for autistic adults.
Article
Medicine, General & Internal
Norman Poole, Sarah Cope, Serena Vanzan, Aimee Duffus, Nadia Mantovani, Jared Smith, Barbara M. Barrett, Melanie Tokley, Martin Scicluna, Sarah Beardmore, Kati Turner, Mark Edwards, Robert Howard
Summary: Functional cognitive disorder (FCD) is increasingly seen in clinics assessing cognitive disorders. A brief psychological intervention using acceptance and commitment therapy principles has been developed for FCD patients. This feasibility study aims to assess recruitment feasibility, adherence to the intervention, and acceptability of treatment through a randomized controlled trial.
Article
Clinical Neurology
Xinghui He, Fan Chen, Yifan Zhang, Qing Gao, Yuguang Guan, Jing Wang, Jian Zhou, Feng Zhai, Detlev Boison, Guoming Luan, Tianfu Li
Review
Neurosciences
Detlev Boison, Jong M. Rho
Article
Cardiac & Cardiovascular Systems
Yong Wang, Yiming Xu, Siyuan Yan, Kaixiang Cao, Xianqiu Zeng, Yaqi Zhou, Zhiping Liu, Qiuhua Yang, Yue Pan, Xiaoling Wang, Detlev Boison, Yunchao Su, Xuejun Jiang, Vijay S. Patel, David Fulton, Neal L. Weintraub, Yuqing Huo
Summary: The study reveals a novel mechanism by which ADK promotes VSMC proliferation via inducing aberrant DNA hypermethylation, down-regulating KLF4 expression and promoting neointima formation. The findings suggest the possibility of targeting ADK as an epigenetic modulator to combat vascular injury.
CARDIOVASCULAR RESEARCH
(2021)
Review
Clinical Neurology
Devin K. Binder, Detlev Boison, Tore Eid, Wayne N. Frankel, Ana Mingorance, Bret N. Smith, Penny A. Dacks, Vicky Whittemore, Annapurna Poduri
Editorial Material
Dentistry, Oral Surgery & Medicine
Manvitha Kuchukulla, Detlev Boison
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2021)
Article
Neurosciences
Omar Ashraf, Trong Huynh, Benton S. Purnell, Madhuvika Murugan, Denise E. Fedele, Vineet Chitravanshi, Detlev Boison
Summary: SUDEP, a leading cause of death in patients with refractory epilepsy, is believed to be caused by centrally-mediated respiratory dysfunction. Research shows that seizures can trigger a surge in adenosine release, which suppresses breathing. Suppressing phrenic nerve activity may serve as a predictive biomarker for imminent SUDEP, allowing for timely intervention to potentially prevent SUDEP.
Review
Pharmacology & Pharmacy
Detlev Boison, Michael F. Jarvis
Summary: Adenosine kinase (ADK) is a widely expressed enzyme that regulates the concentration of adenosine and plays a crucial role in the endogenous protective effects of adenosine. Recent research has identified a potential role for the nuclear ADK isoform in epigenetic modulation, offering the possibility of developing novel ADK-isoform selective inhibitors.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Aarti Jagannath, Norbert Varga, Robert Dallmann, Gianpaolo Rando, Pauline Gosselin, Farid Ebrahimjee, Lewis Taylor, Dragos Mosneagu, Jakub Stefaniak, Steven Walsh, Teele Palumaa, Simona Di Pretoro, Harshmeena Sanghani, Zeinab Wakaf, Grant C. Churchill, Antony Galione, Stuart N. Peirson, Detlev Boison, Steven A. Brown, Russell G. Foster, Sridhar R. Vasudevan
Summary: Adenosine plays a crucial role in regulating circadian rhythms through multiple signaling pathways, influenced by sleep history and light exposure. These findings contribute to understanding the interaction between sleep and circadian timing.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Neurosciences
Detlev Boison
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Hoda Gebril, Amir Wahba, Xiaofeng Zhou, Tho Lai, Enmar Alharfoush, Emanuel DiCicco Bloom, Detlev Boison
Summary: The study found high levels of ADK-L expression during cerebellar development, which was maintained into adulthood. In the developing cerebellum, ADK-L was expressed in immature Purkinje cells and granular neuron precursors, while in adulthood, it was absent from Purkinje cells but widely expressed in mature granule neurons and their molecular layer processes. These findings suggest a functional role of ADK-L in the plasticity of the cerebellum.
Article
Biochemistry & Molecular Biology
Madhuvika Murugan, Denise Fedele, David Millner, Enmar Alharfoush, Geetasravya Vegunta, Detlev Boison
Summary: Adenosine kinase plays a crucial role in regulating adenosine metabolism and DNA methylation status through interactions with transmethylation reactions. The two isoforms of ADK have distinct subcellular localizations and may have different roles in epigenetic regulation. This review summarizes recent progress in understanding the biochemical interactions between ADK metabolism and epigenetic modifications.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Review
Neurosciences
Edward Beamer, Manvitha Kuchukulla, Detlev Boison, Tobias Engel
Summary: Despite progress in understanding the pathogenesis of hyperexcitable networks and lowered seizure thresholds, treating epilepsy remains challenging. Many patients are resistant to current medications, which only provide symptomatic relief. Efforts are focused on finding new treatments with novel mechanisms of action to modify disease progression. Purines like ATP and adenosine play key roles in the epileptogenic process, with potential as targets for therapeutic strategies.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Amir E. Wahba, Denise Fedele, Hoda Gebril, Enmar AlHarfoush, Kiran S. Toti, Kenneth A. Jacobson, Detlev Boison
Summary: The study revealed that the adenosine kinase isoform ADK-L determines global DNA methylation levels in cancer cells, with the highest expression in HeLa cells. Inhibitors targeting ADK were found to significantly reduce global DNA methylation in HeLa cells, suggesting a potential therapeutic strategy for cancer treatment.
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2021)
Review
Clinical Neurology
Madhuvika Murugan, Detlev Boison
Article
Psychiatry
Cassidy L. Moody, Adam J. Funk, Emily Devine, Ryan C. Devore Homan, Detlev Boison, Robert E. Mccullumsmith, Sinead M. O'Donovan
SCHIZOPHRENIA BULLETIN
(2020)