Article
Plant Sciences
Adolfo Andrade-Cetto, Fernanda Espinoza-Hernandez, Gerardo Mata-Torres, Sonia Escandon-Rivera
Summary: This study confirmed the traditional use of E. longifolium and A. firma as hypoglycemic agents in a hyperglycemic animal model for the first time. Both plants exhibited a significant hypoglycemic effect and inhibited enzymes involved in glucose metabolism in vitro.
Review
Chemistry, Multidisciplinary
Chuan Li, Wei-wei Jia, Jun-ling Yang, Chen Cheng, Olajide E. Olaleye
Summary: Chinese herbal medicines have complex chemical compositions, posing challenges for studying their therapeutic effects. They are often used in combination with other drugs, raising concerns about drug interactions. However, evidence suggests that combining Chinese herbal medicines with synthetic drugs can be beneficial for treating multifactorial diseases. Multi-compound and drug-combination pharmacokinetic approaches have been established to study these issues.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Horticulture
Aida Araceli Rodriguez-Hernandez, Fernanda Guadalupe Flores-Soria, Omar Patino-Rodriguez, Abraham Escobedo-Moratilla
Summary: Mexico, a megadiverse country, has a significant amount of biodiversity and traditional medicinal plants. This study analyzed national sanitary registries of herbal products from 2001 to 2020 in Mexico and identified the native plants commonly used in these products. The findings highlight the importance of these medicinal plants as a valuable source of information and resources for potential therapeutic applications.
Review
Plant Sciences
Maryam Mirahmad, Shahrzad Mohseni, Ozra Tabatabaei-Malazy, Fataneh Esmaeili, Sudabeh Alatab, Roodabeh Bahramsoltani, Hanieh-Sadat Ejtahed, Husseyn Qulami, Zahra Bitarafan, Babak Arjmand, Elahe Nazeri
Summary: This study systematically reviewed the literature to evaluate the effects of various herbal medicines with anti-oxidative and anti-inflammatory properties on CRP levels in animal models of T2DM. The results showed that many herbal medicines were effective in treating diabetes and its complications by reducing CRP concentrations and oxidative stress levels.
Article
Biodiversity Conservation
Durga H. Kutal, Ripu M. Kunwar, Yadav Uprety, Yagya P. Adhikari, Shandesh Bhattarai, Binaya Adhikari, Laxmi M. Kunwar, Man D. Bhatt, Rainer W. Bussmann
Summary: This study tested the non-random medicinal plant selection hypothesis using national- and community-level datasets through different regression analyses, finding that negative binomial regression was the most useful method. The results identified over-utilized and underutilized plant families, with implications for sustainable conservation and pharmacological research in community-level studies.
JOURNAL OF ETHNOBIOLOGY AND ETHNOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Hei Ming Kenneth Ho, Zhaoan Xiong, Hui Ying Wong, Asma Buanz
Summary: The global increase in sales of substandard and falsified medical products poses a threat to global health systems, with the need for stronger detection technologies. A study on herbal supplements claiming to be natural alternatives to Viagra found that most of the products actually contained the active ingredient of Viagra, highlighting the importance of stringent regulation for e-commerce platforms.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Agricultural Engineering
Minghuan Wang, Ying Liu, Shanqi Wang, Kui Wang, Ying Zhang
Summary: This study successfully developed a compound microbial agent to improve the composting process of Chinese medicinal herbal residues. The results showed that the inoculated groups had higher nutrient contents, organic carbon degradation rate, germination index, and microbial community diversity compared to the control group. The compound microbial agent (K1 + P1 + N4) was recommended for the composting of CMHRs, offering a new solution for reducing waste in this area.
BIORESOURCE TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Caroline de Aragao Tannus, Fernanda de Souza Dias, Filipe Barbosa Santana, Daniele Cristina Muniz Batista dos Santos, Hemerson Iury Ferreira Magalhaes, Fabio de Souza Dias, Anibal de Freitas Santos Junior
Summary: This study aimed to analyze the element content in medicinal plants and herbal medicines from Brazil, identifying them as sources of various essential and trace elements for human consumption. Low levels of arsenic, cadmium, cobalt, molybdenum, lead, and antimony were detected, while all samples showed considerable levels of aluminum. Principal component analysis and hierarchical cluster analysis revealed that the samples could be separated into two large groups.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Zimo Zhao, Xinyi He, Yan Sun
Summary: A meta-analysis found that the use of sulfonylureas and insulin in diabetic patients may increase the incidence of pancreatic cancer, while metformin and TZDs were not significantly associated with pancreatic cancer incidence. Due to significant heterogeneity across studies, further well-adjusted data and better-organized clinical trials are needed to interpret the relationship between hypoglycemic agents and pancreatic cancer incidence in diabetic patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Microbiology
Meimei Zhang, Wenyu Han, Jingmin Gu, Cao Qiu, Qiujie Jiang, Jianbao Dong, Liancheng Lei, Fengyang Li
Summary: This review discusses the research progress and application value of Chinese herbal medicines (CHMs) in regulating bacterial biofilm formation. CHMs have the ability to inhibit, impair, or decrease bacterial biofilm formation by modulating the bacterial quorum sensing system or nucleotide-based second messengers. These findings contribute to the development of effective biofilm inhibitors and provide a novel treatment strategy to control biofilm-related infections.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Plant Sciences
Han Yu, Ting-na Li, Qian Ran, Qin-wan Huang, Jin Wang
Summary: SCK, a traditional Chinese medicinal plant, has been used for detoxification, defervescence, detumescence, and antiphlogosis historically. Research shows that SCK and its herbal medicines contain multiple active components that may have potential therapeutic effects on various diseases, highlighting the need for further studies on pharmacology, pharmacokinetics, and quality control.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Clement G. G. Yedjou, Jameka Grigsby, Ariane Mbemi, Daryllynn Nelson, Bryan Mildort, Lekan Latinwo, Paul B. B. Tchounwou
Summary: Diabetes mellitus (DM) is a chronic metabolic disease associated with high blood sugar levels and various complications. Medicinal plants and vitamins have shown potential in the prevention and treatment of DM. This review article aims to study DM and explore the therapeutic modalities based on medicinal plants and vitamins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Abraham Madariaga-Mazon, Jose J. Naveja, Jose L. Medina-Franco, Karla O. Noriega-Colima, Karina Martinez-Mayorga
Summary: Natural products, especially from medicinal plants, are important sources of bioactive compounds, including those with potential antidiabetic properties. Despite the abundance of research articles on antidiabetic compounds, the lack of a chemical database hampers their application in drug development.
Article
Biodiversity Conservation
Sizhao Liu, Beixi Zhang, Jiangju Zhou, Qiyi Lei, Qiong Fang, Edward J. Kennelly, Chunlin Long
Summary: The study documented 237 medicinal plant species traded in the Kaili traditional market, classified into 20 medical conditions. The Miao people comprised 53.4% of informants. The inflammation category showed the highest FIC value of 0.95, indicating good agreement among vendors. The FL index identified 15 culturally important medicinal plant species.
JOURNAL OF ETHNOBIOLOGY AND ETHNOMEDICINE
(2021)
Article
Pharmacology & Pharmacy
Marisa Milena Scherrer, Stefan Zerbe, Joshua Petelka, Ina Saeumel
Summary: The use of traditional medicinal plants is important in remote rural areas. Environmental education is crucial for preserving local knowledge. Stakeholders in the Autonomous Province of Bozen-South Tyrol in Italy reveal the role of traditional medicinal plants in healthcare, cultural identity, and environmental education.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Li Zhang, Sheng-Ye Yang, Feng-Rong Qi-Li, Xiao-Xiao Liu, Wei-Tao Zhang, Chao Peng, Ping Wu, Ping Li, Pingping Li, Xiaojun Xu
Summary: Isoliquiritigenin (ISO) is a lipid-lowering compound that improves nonalcoholic fatty liver disease and nonalcoholic steatohepatitis by regulating SIRT1 expression. IQGAP2 was identified as the direct target of ISO in lipid homeostasis regulation, and a novel IQGAP2-CREB-SIRT1 axis was demonstrated for the first time in treating NAFLD/NASH.
PHYTOTHERAPY RESEARCH
(2021)
Article
Spectroscopy
Teng Liu, Qiyao Peng, Junyi Wang, Chao Yu, Xuekuan Huang, Quan Luo, Yajun Zeng, Yi Hou, Yuan Zhang, Aiming Luo, Zhaoxia Zou, Meizi Chen, Yongbo Peng
Summary: A new ratiometric fluorescent probe NPNA-H2Sn was developed with high sensitivity and advantage of colorimetric imaging for rapid and accurate detection of H2Sn. The probe can be used for evaluating the physiological and pathological functions of H2Sn, providing a powerful molecular tool for research in living biosystems.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Nanoscience & Nanotechnology
Liping Deng, Mengqing Xiao, Anshan Wu, Dong He, Sanqian Huang, Tanggang Deng, Jiawei Xiao, Xinyu Chen, Yongbo Peng, Ke Cao
Summary: This study investigates the role of selenium nanoparticles in alleviating cisplatin-induced acute kidney injury. The results suggest that selenium nanoparticles can reduce renal damage by inhibiting ferroptosis, and our self-developed Se/Albumin nanoparticles show superior therapeutic effects compared to regular selenium nanoparticles.
ACS APPLIED NANO MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Qiyao Peng, Dan Wan, Rongrong Zhou, Hongyu Luo, Junyi Wang, Lingyan Ren, Yajun Zeng, Chao Yu, Shuihan Zhang, Xuekuan Huang, Yongbo Peng
Summary: The INO80 chromatin remodeling complex and NFRKB play important roles in gene transcription regulation. NFRKB has attracted wide attention in DNA repair, cell pluripotency, telomere protection, and protein activity regulation. This review provides an important reference for further research.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Tanggang Deng, Qianling Zhu, Lin Xie, Youhong Liu, Yuchong Peng, Linglong Yin, Yingxue Gao, Tuoyu Cao, Yuxin Fu, Xuli Qi, Songwei Zhang, Yongbo Peng, Youxiang Hou, Xiong Li
Summary: The cell division cycle (CDC6) has been identified as a critical molecule contributing to radioresistance in cancer cells. The demethylated form of cantharidin, Norcantharidin (NCTD), has been found to re-sensitize radioresistant cancer cells by inducing CDC6 protein degradation, leading to enhanced cell killing and apoptosis. NCTD promotes CDC6 protein degradation through a Cullin1 neddylation-mediated ubiquitin-proteasome pathway.
MOLECULAR CARCINOGENESIS
(2022)
Article
Spectroscopy
Quan Luo, Ziyi Luo, Hui Zeng, Yu Xiao, Yongbo Peng, Gang Liu
Summary: Hypochlorous acid (HClO) is an important biomarker in inflammation, and this study presents a new mitochondria-targetable NIR fluorescent probe, NIR-ClO, for specific analysis and imaging of HClO levels in osteoarthritis. NIR-ClO exhibits high sensitivity and selectivity towards HClO, with a low limit of detection and fast response time, making it a promising tool for future osteoarthritis diagnosis research.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Pharmacology & Pharmacy
Hongyu Luo, Munan Wang, Ke Xu, Qiyao Peng, Bo Zou, Shi Yin, Chao Yu, Lingyan Ren, Ping Li, Li Tang, Yongbo Peng, Xuekuan Huang
Summary: This study successfully predicted the possible molecular mechanism of the Fushengong decoction (FSGD) in chronic renal failure (CRF) through a dual-dimension network pharmacology analysis. The results were verified through in vivo experiments, demonstrating the potential of FSGD to protect renal function and reduce fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemical Research Methods
Zhengze Shen, Dan Wang, Chaoqun Yu, Yongbo Peng, Lifang Cheng, Yuan Zhang
Summary: In this study, the oxylipin profiles of adipose-derived mesenchymal stem cells (ADSCs) under cytokine stimulation were comprehensively analyzed using a UPLC-MS/MS method. The results showed that ADSCs activated by the combination of IFN-gamma and TNF-alpha up-regulated LOX-15 products 7-HDHA and 15-HEPE, which are involved in the pro-resolution phase of inflammation. These findings provide a fundamental understanding of MSC-derived oxylipins and may contribute to optimizing MSC-based therapies.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Biochemistry & Molecular Biology
Hui-Min Cheng, Mingming Xing, Ya-Ping Zhou, Weitao Zhang, Zeyu Liu, Lan Li, Zuguo Zheng, Yuanchen Ma, Pingping Li, Xiaoxuan Liu, Ping Li, Xiaojun Xu
Summary: Heat shock protein 90 beta (Hsp90 beta) plays a specific role in osteoclasts by binding to Ikk beta, reducing its degradation, and promoting NF-kappa B signaling. It also increases cholesterol biosynthesis, leading to the expression of osteoclastogenic genes. Inhibiting or deleting Hsp90 beta can alleviate bone loss in osteoporosis.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Engineering, Biomedical
Wei Xiang, Yongbo Peng, Hongliang Zeng, Chunping Yu, Qun Zhang, Biao Liu, Jiahao Liu, Xing Hu, Wensu Wei, Minhua Deng, Ning Wang, Xuewen Liu, Jianfei Xie, Weibin Hou, Jin Tang, Zhi Long, Long Wang, Jianye Liu
Summary: In this study, a novel targeting system called protein tyrosine kinase 7 aptamer-Gemcitabine conjugate (PTK7-GEMs) was designed and synthesized to deliver Gemcitabine (GEM) to bladder cancer cells. PTK7-GEMs exhibited specific binding to cancer cells and induced cytotoxicity. In vivo experiments demonstrated that PTK7-GEMs had strong anti-tumor efficacy and excellent biosafety.
BIOMATERIALS RESEARCH
(2022)
Article
Engineering, Environmental
Biao Liu, Jinrong Wang, Yongbo Peng, Hongliang Zeng, Qun Zhang, Minhua Deng, Wei Xiang, Jiahao Liu, Xing Hu, Xuewen Liu, Jianfei Xie, Weibin Hou, Jin Tang, Zhi Long, Long Wang, Jianye Liu
Summary: Conventional chemotherapy cannot specifically target cancer cells, leading to damage to normal tissues and organs. In addition, cancer stem cells (CSCs)-induced tumor regrowth and drug resistance limit the effectiveness of certain chemotherapy drugs. This study developed a CD71/CD44 dual-aptamer-gemcitabine (CD71-CD44-GEMs) conjugate for treating bladder cancer by targeting bladder cancer cells and bladder CSCs. The results showed that CD71-CD44-GEMs had selective binding and high inhibitory effects on bladder cancer both in vitro and in vivo. It also exhibited stronger binding affinity and inhibitory efficacy compared to CD71-GEMs or CD44-GEMs in bladder cancer. Therefore, CD71-CD44-GEMs represents a promising approach for bladder cancer treatment as it can effectively target both bladder cancer cells and CSCs and deliver drugs efficiently.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Kai Xu, Peng Huang, Yixuan Wu, Teng Liu, Ningyi Shao, Lulu Zhao, Xiaoyan Hu, Junlei Chang, Yongbo Peng, Shaogang Qu
Summary: This study describes a tailor-made human serum albumin-based selenium nanosystem for the treatment of PD that can overcome the intestinal epithelial barrier and blood-brain barrier. The system has lower toxicity and higher efficacy compared to other selenium species and is able to protect dopamine neurons and improve PD symptoms.
Article
Chemistry, Multidisciplinary
Liling Deng, Yan Li, Geng Zhong, Wen Lei, Yongbo Peng, Zhaojing Zhu
Summary: This study investigated the effects of different types of starch on the texture and flavor of konjac tofu. It was found that adding a certain proportion of corn starch, Canna edulis Ker starch, or potato starch can improve the texture and flavor of konjac tofu, resulting in a better structure and mouthfeel.
Article
Engineering, Chemical
Liling Deng, Yongbo Peng, Yan Li, Geng Zhong, Dan Liu, Zhaojing Zhu
Summary: The chemically modified konjac glucomannan phosphate ester (KGMP) has been developed to overcome the limitations of low solubility, instability, and poor fluidity of konjac glucomannan (KGM). The study investigated the physical, chemical, and rheological properties of KGMP with different degrees of substitution (DS). The results show that KGMP has potential applications in temperature-sensitive matrix materials, gelling food, and water-retaining agents.
JOURNAL OF FOOD ENGINEERING
(2023)
Article
Oncology
Lili Deng, Yan Zhao, Wen Liu
Summary: This study found that overexpression of PFKP can enhance resistance of colorectal cancer to 5-FU by promoting glycolysis. Silencing PFKP, on the other hand, can make colorectal cancer cells more sensitive to 5-FU and increase apoptosis. Therefore, PFKP could be a novel candidate for targeted therapy for 5-FU-resistant colorectal cancer.
JOURNAL OF CHEMOTHERAPY
(2023)
