Review
Cell Biology
Boquan Wu, Shilong You, Hao Qian, Shaojun Wu, Saien Lu, Ying Zhang, Yingxian Sun, Naijin Zhang
Summary: SIRT2 protein is closely related to cardiovascular diseases, playing a role in cardiac hypertrophy and diabetic cardiomyopathy, affecting heart failure. In vascular diseases, the role of SIRT2 depends on the degree of oxidative stress stimulation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Chennian Xu, Jian Wang, Zhenge Fan, Shuang Zhang, Rui Qiao, Yu Liu, Jian Yang, Lifang Yang, Huishan Wang
Summary: This study found that melatonin alleviates myocardial I/R injury by inhibiting oxidative stress via the AMPK/Nrf2 signaling pathway.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Lei-Lei Ma, Zhi-Wen Ding, Pei-Pei Yin, Jian Wu, Kai Hu, Ai-Jun Sun, Yun-Zeng Zou, Jun-Bo Ge
Summary: The study shows that preconditioning with hypertrophic stress protects the heart from I/R injury by improving mitochondrial metabolism, reducing oxidative/nitrative stress and inhibiting apoptosis. ALDH2 is obligatorily required for the development of cardiac hypertrophic preconditioning and acts as the mediator of this process.
Article
Cardiac & Cardiovascular Systems
Jiayi Liu, Wei Li, Ke-Qiong Deng, Song Tian, Hui Liu, Hongjie Shi, Qian Fang, Zhen Liu, Ze Chen, Tian Tian, Shanyu Gan, Fengjiao Hu, Manli Hu, Xu Cheng, Yan-Xiao Ji, Peng Zhang, Zhi-Gang She, Xiao-Jing Zhang, Shaoze Chen, Jingjing Cai, Hongliang Li
Summary: The study found a close correlation between Trim16 expression and hypertrophy-related heart failure in both humans and mice. Trim16 deficiency exacerbated cardiomyocyte enlargement, while Trim16 overexpression attenuated cardiac hypertrophy and remodeling. Mechanistically, Prdx1 is an essential target of Trim16 in cardiac hypertrophy, and the Trim16-Prdx1 axis represents a promising therapeutic strategy for hypertrophy-related heart failure.
CIRCULATION RESEARCH
(2022)
Article
Chemistry, Medicinal
Shi-Meng Liu, Ya-Rong Zhang, Yao Chen, Deng-Ren Ji, Jie Zhao, Su Fu, Mo-Zhi Jia, Yan-Rong Yu, Chao-Shu Tang, Wei Huang, Ye-Bo Zhou, Yong-Fen Qi
Summary: This study found that intermedin (IMD) can attenuate vascular calcification (VC) caused by chronic kidney disease (CKD) by improving mitochondrial function and inhibiting mitochondrial oxidative stress. IMD acts by upregulating the protein Sirt3 in mitochondria, which restores the decreased mitochondrial membrane potential and inhibits mitochondrial oxidative stress in calcified vascular smooth muscle cells.
Article
Pharmacology & Pharmacy
Kubra Koc, Fatime Geyikoglu, Ozge Cakmak, Aynur Koca, Zerrin Kutlu, Ferhunde Aysin, Asli Yilmaz, Hakan Askin
Summary: This study found that pretreatment with beta-sitosterol has a protective effect in renal ischemia/reperfusion injury, potentially mitigating inflammatory response and tissue damage by regulating oxidative stress.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rachid Akki, Rosalba Siracusa, Marika Cordaro, Alessia Remigante, Rossana Morabito, Mohammed Errami, Angela Marino
Summary: Studies have shown that cells and tissues may enhance their resistance to more severe ischaemic injuries by undergoing ischemic preconditioning under low oxidative stress conditions. This review summarizes the latest knowledge on adaptive mechanisms, signaling transduction pathways, antioxidant systems, and in vivo adaptation strategies in response to ischemia/reperfusion and brain trauma events.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Sunshan Lu, Xingtong Chen, Qian Chen, Zhen Cahilog, Lili Hu, Yan Chen, Jian Cao, Jiaolin Ning, Bin Yi, Kaizhi Lu, Jianteng Gu
Summary: Intraoperative administration of dexmedetomidine in elderly patients undergoing iatrogenic lower limb ischemia-reperfusion injury can mitigate respiratory function deterioration and suppress oxidative stress response.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Wenyan Liu, Yang Fan, Hongfan Ding, Dan Han, Yang Yan, Rongqian Wu, Yi Lv, Xinglong Zheng
Summary: NMP attenuates IRI of DCD liver by inhibiting CIRP-mediated oxidative stress and mitochondrial fission.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Ruikang Feng, Yufeng Xiong, Yourong Lei, Qin Huang, Hao Liu, Xiaojie Zhao, Zhiyuan Chen, Hui Chen, Xiuheng Liu, Lei Wang, Xiaodong Weng
Summary: AKI is mainly caused by renal IRI, and LSD1 has been shown to be positively related to renal IRI. Inhibition of LSD1 can alleviate tissue damage, ferroptosis, and oxidative stress caused by IRI through the TLR4/NOX4 pathway. LSD1 may be a potential therapeutic target for renal IRI.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Patrick M. Pilz, Jennifer E. Ward, Wei-Ting Chang, Attila Kiss, Edward Bateh, Alokkumar Jha, Sudeshna Fisch, Bruno K. Podesser, Ronglih Liao
Summary: This article outlines the strengths, limitations, and outcomes of small and large animal models of heart failure with reduced ejection fraction currently used in basic and translational research. Animal models play a critical role in understanding the molecular mechanisms of heart failure, although no model completely recapitulates the full human disease.
CIRCULATION RESEARCH
(2022)
Article
Andrology
Recep B. Degirmentepe, Fatih Altunrende, Muammer Bozkurt, Erkan Merder, Alper Otunctemur, Kivilcim Sonmez, Funda Yildirim, Saniye Ada, Ferruh K. Isman, Mustafa B. Cekmen
Summary: In this study, the effect of liraglutide on experimental testicular ischaemia reperfusion in rats was evaluated in terms of biochemistry, histopathology, and immunohistochemistry. The results showed that liraglutide treatment has a moderate preventive effect against I/R injury in testicular torsion by demonstrating anti-inflammatory, antioxidant, and antiapoptotic properties.
Article
Cardiac & Cardiovascular Systems
Muding Li, Yingyun Hu, Hao Zhou, Yundai Chen
Summary: Mitochondrial fusion is inhibited in myocardial IR, and the upstream mechanism is unclear. NR4A1 aggravates myocardial IR and increases oxidative stress, affecting mitochondrial function and morphology. Inhibiting NR4A1 improves oxidative stress levels and mitochondrial function, reducing IR.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Cell Biology
Mel S. Lee, Hon-Kan Yip, Chih-Chao Yang, John Y. Chiang, Tien-Hung Huang, Yi-Chen Li, Kuan-Hung Chen, Pei-Hsun Sung
Summary: This study showed that therapy with double overexpression of miR-19a-3p and miR-20a-5p to human inducible pluripotent stem cell-derived mesenchymal stem cells was more effective than using mesenchymal stem cells alone for preserving renal function in rats with pre-existing chronic kidney disease and subsequent ischaemia-reperfusion injury. The in vitro study demonstrated that the double overexpression of miR-19a-3p reversed the increased oxidative stress, inflammatory signaling, and cell apoptosis/death signaling induced by p-Cresol in NRK-52E cells. Additionally, animal experiments indicated that the double overexpression of miR-19a-3p and miR-20a-5p was superior to mesenchymal stem cells alone in preserving residual kidney function and architecture in chronic kidney disease with ischaemia-reperfusion injury rat models.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yungang Shan, Deqing Chen, Bo Hu, Guangtao Xu, Wanlu Li, Ye Jin, Xiuhui Jin, Xin Jin, Limin Jin
Summary: The study demonstrated that allicin exerts a protective effect against renal ischemia/reperfusion injury in rats by regulating apoptosis, oxidative stress, and inflammatory response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)