Article
Clinical Neurology
Uzma Samadani, Robert J. Spinner, Gerard Dynkowski, Susan Kirelik, Tory Schaaf, Stephen P. Wall, Paul Huang
Summary: This study conducted an eye tracking study for the diagnosis of concussion and validated the sensitivity and specificity of the eye tracking algorithm. The results showed that eye tracking has high sensitivity but low specificity.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Mary C. Whitman
Summary: The review focuses on the current understanding of axon guidance mechanisms in cranial motor nerves, and how disease-causing mutations disrupt axon targeting. Abnormalities of axon growth and guidance are often limited to a single nerve or subdivision, even when the causative gene is ubiquitously expressed.
ANNUAL REVIEW OF VISION SCIENCE, VOL 7, 2021
(2021)
Article
Ophthalmology
Sweksha Priya, Sujata Guha, Shruti Mittal, Satish Sharma, Md. Shahid Alam
Summary: This study aimed to describe the epidemiological and clinical characteristics of pediatric ocular motor cranial nerve palsy, finding that the third cranial nerve was the most commonly affected in children and was the most amblyogenic. Neuroimaging yield was highest for combined cranial nerve palsy, and the most frequently managed conservatively was the fourth nerve palsy in this group.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Clinical Neurology
Joonhyoung Kim, Kyungdo Han, Juhwan Yoo, Kyung-Ah Park, Sei Yeul Oh
Summary: This study found a significant association between serum GGT level and the incidence of ocular motor cranial nerve palsy (CNP) through analyzing data from the National Sample Cohort database in Korea. Elevated GGT levels were linked to an increased risk of ocular motor CNP, while the association with ALT levels was not as strong.
NEUROLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Dong-Wan Kang, Sue Young Ha, Jung-Joon Sung, Hyunwoo Nam
Summary: Ocular cranial nerve palsy of presumed ischemic origin (OCNPi) is a common type of ocular cranial nerve palsy in patients aged >= 50 years, but there is currently no definite diagnostic test. This study found an association between cerebral small vessel disease and OCNPi, with white matter hyperintensities being an independent predictor of ischemic origin in patients with unilateral OCNP.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Soolienah Rhiu, Kyungdo Han, Juhwan Yoo, Kyung-Ah Park, Sei Yeul Oh
Summary: There is a significant association between migraines and the development of ocular motor cranial nerve palsy (CNP). Specifically, younger age, male gender, smokers, and diabetes patients with migraines have a higher risk of developing ocular motor CNP.
SCIENTIFIC REPORTS
(2022)
Review
Clinical Neurology
Christa Einspieler, Daniela Prayer, Peter B. Marschik
Summary: Research on the onset and ontogeny of human behavior shows that fetal movement patterns are spontaneously generated, with the embryo starting to move by 7.5 weeks of gestation. Different movement patterns such as general movements, isolated limb movements, and breathing movements appear later, indicating a close association between activity and the development of peripheral and central structures. In cases of developmental brain dysfunction, fetal general movements may change in sequence and form, suggesting a dysfunction in the developing nervous system.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Article
Immunology
Giovanni Zanotelli, Lorenzo Bresciani, Mariagiulia Anglani, Alessandro Miscioscia, Francesca Rinaldi, Marco Puthenparampil
Summary: This case report describes a 27-year-old woman who presented with fever, headache, and other symptoms, and was diagnosed with bacterial meningitis caused by Neisseria meningitidis. While the symptoms improved with antibiotic therapy, the facial nerve palsy worsened. However, treatment with oral steroids led to complete regression of the symptoms.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Clinical Neurology
William Shew, Michael T. M. Wang, Helen Danesh-Meyer
Summary: Isolated ischemic ocular cranial nerve palsies (OCNP) increase the risk of subsequent stroke in patients, particularly within the first year. The risk is highest for the 3rd cranial nerve palsies.
JOURNAL OF CLINICAL NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Haitao Liu, Fei Liao, Pedro de la Villa
Summary: The study revealed that the EOG response amplitude was significantly greater in the left eye compared to the right eye for light bars moving from right to left, but similar for light bars moving vertically. Horizontal stimuli were found to generate significant interocular differences in EOG response amplitude.
Article
Multidisciplinary Sciences
Susanne Hopf, Julia B. Hennermann, Alexander K. Schuster, Norbert Pfeiffer, Susanne Pitz
Summary: NPC patients exhibit oculomotor dysfunction, including slowed peak velocity in saccadometry, which correlates negatively with SARA score. Macular OCT reveals significant foveal thinning in NPC patients, specifically in the outer nuclear layer and outer retinal layer.
Review
Education & Educational Research
Yeliz Tunga, Kursat Cagiltay
Summary: Eye movement modeling examples (EMME) are video modeling examples that include eye-movement recordings of the model, providing attentional guidance. This study reviews empirical studies employing EMME to synthesize existing literature and identify gaps for further research. Thirty-one peer-reviewed studies published between 2009 and 2022 were included. Results indicate an increase in EMME studies, with a focus on teaching cognitive skills rather than perceptual skills. Design features of EMME are still inconclusive, calling for more research on its effects and different design characteristics.
EDUCATION AND INFORMATION TECHNOLOGIES
(2023)
Article
Green & Sustainable Science & Technology
Yu-Ling Hsieh, Ming-Feng Lee, Guey-Shya Chen, Wei-Jie Wang
Summary: This study aims to understand the visual cognition of visitors and investigates how exhibition planning and design influence the cognitive process through eye movement analysis. The results show that individuals interested in the displayed content exhibit better cognitive performance, while those uninterested tend to be distracted. Eye movement and fixation can be used as reference indicators to improve the effectiveness of presenting information.
Article
Medicine, General & Internal
Shin Yeop Oh
Summary: This study investigated the clinical features and factors affecting recovery in patients with acquired sixth cranial nerve (CN6) palsy. The findings revealed that age and etiology significantly influenced the outcomes, with microvascular and brain vascular lesions being the most common causes. The overall recovery rate was approximately 82%, and there were variations in recovery rates and durations based on different etiologies.
Article
Neurosciences
Limin Zhang, Hong Cui
Summary: The study found that EEG measurements collected by MUSE 2 are not very useful indicators of cognitive workload changes in our setting, while eye movement measurements collected by Tobii Pro Nano are effective for monitoring workload fluctuations and identifying interface design issues in a smartphone setting, with maximum pupil diameter being the main indicator of workload surges.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jose M. Soto, Dongxia Feng, Huaiyu Sun, Yilu Zhang, Kristopher A. Lyon, Buqing Liang, Laura K. Reed, Jason H. Huang
Summary: The novel technique described in the article aims to preserve the vascular supply of scalp flap by modifying the incision site, potentially reducing wound complications and operative times. Hospital chart review of 7 cases showed successful preservation of superficial temporal and postauricular arteries, with rapid healing of the scalp flap and reduced complications.
WORLD NEUROSURGERY
(2021)
Letter
Surgery
Thomas M. Egan, Stephen Wall, Lewis Goldfrank, John J. Requard
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Letter
Clinical Neurology
Dongxia Feng, Jason H. Huang
WORLD NEUROSURGERY
(2021)
Article
Public, Environmental & Occupational Health
Azizi A. Seixas, Iredia M. Olaye, Stephen P. Wall, Pat Dunn
Summary: The COVID-19 pandemic has brought to light inefficiencies and deficiencies in chronic disease management in the US, with digital health and telemedicine solutions offering potential solutions but facing limitations. It is suggested to gamify these solutions through a pantheoretical framework for optimal results.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Stephen P. Wall, Patricio Castillo, Francine Shuchat Shaw, Elizabeth Norman, Natalia Martinez-Lopez, Mairyn Lopez-Rios, Hehidy Paulino, Bruce Homer, Jan L. Plass, Joseph E. Ravenell
Summary: This study aimed to investigate the impact of medical videos and storylines on deceased organ donor registration among clients in Latinx-owned barbershops and beauty salons. Results demonstrated that medical footage, sad, or unresolved storylines did not significantly affect registration and changes in organ donation willingness.
HEALTH EDUCATION & BEHAVIOR
(2022)
Article
Communication
Stephen P. Wall, Patricio Castillo, Francine Shuchat-Shaw, Elizabeth Norman, David Brown, Natalia Martinez-Lopez, Mairyn Lopez-Rios, Azizi A. Seixas, Jan L. Plass, Joseph E. Ravenell
Summary: This study evaluated the impact of different types of videos on organ donor registration among black men and found that targeted or tailored videos can increase the willingness stage of change for organ donation. However, they were not effective in encouraging registration.
JOURNAL OF HEALTH COMMUNICATION
(2022)
Review
Neurosciences
Jie Dong, Tingwei Xiao, Qiuyue Xu, Fei Liang, Simeng Gu, Fushun Wang, Jason H. Huang
Summary: This study provides a review of the development of personality theories and emotional dimensional theory, exploring the relationship between them and the neural mechanisms involved. The results suggest a correlation between personality traits and emotions, both of which are influenced by monoamine neurotransmitters.
Review
Chemistry, Medicinal
Yao Jiang, Di Zou, Yumeng Li, Simeng Gu, Jie Dong, Xianjun Ma, Shijun Xu, Fushun Wang, Jason H. Huang
Summary: This study reviews the advancements in monoamine neurotransmitters in the field of Major Depressive Disorder (MDD) and their impact on new pathways such as inflammation, oxidative stress, neurotrophins, and neurogenesis. The monoamine hypothesis is extended to basic emotions, with dopamine, norepinephrine, and serotonin playing different roles. The paper also briefly discusses the potential of monoamine neurotransmitters as a therapeutic approach for MDD, along with their limited clinical efficacy, side effects, and delayed onset of action.
Article
Ophthalmology
Wei Wei, Marco Mazzola, Oscar Otero-Marquez, Yuehong Tong, Eric Souied, Giuseppe Querques, K. Bailey Freund, R. Theodore Smith
Summary: This study demonstrated that geographic atrophy (GA) can originate from soft drusen/pigment epithelial detachments (PEDs) and subretinal drusenoid deposits (SDDs), and the final quantitative autofluorescence (qAF) levels differ between the two pathways. This finding can simplify and facilitate research on GA by studying the disease as two separate components.
Article
Genetics & Heredity
Dan Qi, Yiqun Geng, Jacob Cardenas, Jinghua Gu, S. Stephen Yi, Jason H. H. Huang, Ekokobe Fonkem, Erxi Wu
Summary: Peripheral blood is being explored as a noninvasive alternative to tissue biopsy for developing biomarkers for glioblastoma (GBM), but the lack of a robust detection approach has hindered the identification of widely utilized blood-based biomarkers in clinical settings. This study introduces WBGR, a globin reduction technique for RNA sequencing of whole blood, and demonstrates its ability to detect GBM-associated transcriptomic changes. Through transcriptomic analysis of tumor tissues, a 10-gene panel (GBM-Dx panel) consisting of mRNA, long noncoding RNA, and microRNA was identified as a potential tool for early detection and clinical management of GBM. The integrated approach of WBGR offers comprehensive analytic capacity for blood-based marker identification.
NPJ GENOMIC MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Simeng Gu, Yumeng Li, Yao Jiang, Jason H. Huang, Fushun Wang
Summary: This paper reviews the role of trauma-induced glymphatic system impairment and ROS-mediated inflammation in Major Depressive Disorder (MDD).
Review
Biochemistry & Molecular Biology
Matthew Su, Damir Nizamutdinov, Hanli Liu, Jason H. H. Huang
Summary: Alzheimer's disease is a neurodegenerative disease and the leading cause of dementia worldwide, characterized by progressive memory and intellectual decline. There is currently no known cure or treatment to stop its irreversible progression. Photobiomodulation using light in the red to near-infrared spectrum has shown promise in improving brain function. This review discusses recent advancements and mechanisms in Alzheimer's disease pathogenesis, as well as the potential therapeutic benefits of transcranial near-infrared light treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anthony V. Nguyen, Jose M. Soto, Sarah-Marie Gonzalez, Jennifer Murillo, Eric R. Trumble, Frank Y. Shan, Jason H. Huang
Summary: The 2021 World Health Organization Classification of Tumors of the Central Nervous System introduced the H3.3-G34R/V mutant glioma alongside the already recognized H3-K27M altered glioma, reflecting advances in understanding the roles of oncohistones in gliomagenesis. However, the prognosis remains poor for patients with these disease entities and the H3.3-G34R/V mutant gliomas are particularly understudied. Further research is needed to explore the molecular mechanisms underlying gliomagenesis and develop effective diagnosis, treatment, and future therapeutics.
Letter
Ophthalmology
Alauddin Bhuiyan, Eric Souied, Rando L. Allikmets, R. Theodore Smith
Article
Clinical Neurology
Teresa Gerhalter, Anna M. Chen, Seena Dehkharghani, Rosemary Peralta, Fatemeh Adlparvar, James S. Babb, Tamara Bushnik, Jonathan M. Silver, Brian S. Im, Stephen P. Wall, Ryan Brown, Steven H. Baete, Ivan I. Kirov, Guillaume Madelin
Summary: The study found that while there were significant differences in sodium concentration and anisotropy in specific regions, overall patients had lower sodium concentrations compared to controls. Linear regression analysis showed significantly lower global sodium concentrations in patients, with the strongest correlation found between global grey matter sodium concentration and patient outcomes. This suggests that sodium imaging may be a non-invasive and sensitive method for assessing outcomes in mild traumatic brain injury.
BRAIN COMMUNICATIONS
(2021)