Article
Medicine, Research & Experimental
Sebastian Garcia Menendez, Virna Margarita Martin Gimenez, Michael F. Holick, Francisco J. Barrantes, Walter Manucha
Summary: SARS-CoV-2 infection can harm the central nervous system, and vitamin D may act as a neuroprotective and neuroreparative agent by regulating neuroinflammatory responses.
Review
Endocrinology & Metabolism
Dapinder Kaur, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Vishnu Nayak Badavath, Syed Shams ul Hassan, Mohammad Mehedi Hasan, Saurabh Bhatia, Ahmed Al-Harassi, Haroon Khan, Simona Bungau
Summary: Recombinant DNA technology has produced erythropoietin (EPO), which has shown neuroprotective effects in the treatment of neurodegenerative diseases, particularly Alzheimer's disease (AD). AD is characterized by the accumulation of plaques and tangles, and currently lacks a successful treatment strategy. Various clinical studies have demonstrated the potential therapeutic benefits of EPO as a neuroprotective agent in the treatment of AD.
METABOLIC BRAIN DISEASE
(2022)
Review
Geriatrics & Gerontology
Majid Tozihi, Behrouz Shademan, Hadi Yousefi, Cigir Biray Avci, Alireza Nourazarian, Gholamreza Dehghan
Summary: Cerebral ischemia-reperfusion (CIR) injury is caused by the generation of reactive oxygen species (ROS), which leads to cellular oxidation. The reperfusion process impairs crucial cell survival cascades, such as mitochondrial biogenesis and antioxidant enzyme activity. Melatonin, a hormone naturally produced in the body, has high concentrations in the cerebrospinal fluid and brain. Age-related decline in melatonin production may contribute to the development of neurological disorders. Understanding the intracellular and molecular mechanisms is crucial before investigating melatonin's neuroprotective effects in CIR injury.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Neurosciences
Xueling Ma, Yuan Shi
Summary: This review investigates the role of erythropoietin (Epo) in the prevention of brain injury in preterm infants. Various animal models have shown that Epo has multiple protective effects. However, it is still too early to recommend Epo as the standard treatment for preterm brain injury.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Clinical Neurology
Ji Man Hong, Mun Hee Choi, Geun Hwa Park, Hee Sun Shin, Seong-Joon Lee, Jin Soo Lee, Yong Cheol Lim
Summary: The efficacy and safety of cranial MBH procedures under local anesthesia for augmenting transdural revascularization after EPO treatment in stroke patients were investigated. Results showed that the combination of MBH and EPO significantly improved revascularization success and perfusion parameters.
Review
Plant Sciences
Yu-Ying Chen, Qiu-Ping Liu, Pei An, Min Jia, Xin Luan, Jian-Yuan Tang, Hong Zhang
Summary: Ginsenoside Rd is an active compound with broad pharmacological effects that can reduce neurological damage and provide neuroprotection. It exerts its effects through anti-inflammatory, antioxidant, anti-apoptotic, inhibition of Ca2+ influx, and protection of mitochondria pathways, inhibiting excitatory toxicity, regulating nerve growth factors, and promoting nerve regeneration.
Article
Radiology, Nuclear Medicine & Medical Imaging
Julien Poublanc, Olivia Sobczyk, Reema Shafi, Ece Su Sayin, Jacob Schulman, James Duffin, Kamil Uludag, John C. Wood, Chau Vu, Rohan Dharmakumar, Joseph A. Fisher, David J. Mikulis
Summary: This study demonstrates the feasibility of mapping cerebral perfusion metrics using BOLD MRI during modulation of pulmonary venous oxygen saturation. Results show that induced changes in deoxyhemoglobin can be used as a noninvasive vascular contrast agent for cerebral perfusion imaging.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jialan Lyu, Yuchen Chen, Weiwei Yang, Ting Guo, Xiao Xu, Yongmei Xi, Xiaohang Yang, Wanzhong Ge
Summary: The microRNA miR-210 plays a crucial role in regulating lipid metabolism and preventing neurodegeneration in the Drosophila retina. Its specific expression in photoreceptor neurons affects the functioning of neurons by targeting ACS transcription.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Plant Sciences
Na Wang, Xianlei Wang, Mengjiao He, Wenxiu Zheng, Dongmei Qi, Yongqing Zhang, Chun-chao Han
Summary: The treatment of nervous system diseases has long been a challenging issue for researchers due to their complexity, but with the aging society, there is a growing interest in finding effective treatments. Ginseng polysaccharides have shown potential in immune regulation, antioxidant properties, and anti-inflammatory effects. Studies have revealed that ginseng polysaccharides may play a role in ameliorating nervous system diseases through immune system regulation, inflammatory response, and oxidative damage.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Zhiyong Liu, Manish Kumar, Sushma Devi, Atul Kabra
Summary: This study investigated the neuroprotective effects of cucurbitacin E (CuE) on neurobehavioral impairments caused by cerebral hypoperfusion. CuE alleviated brain cell death induced by cerebral hypoperfusion and improved memory, sensory, and motor functions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Amanda Larissa Dias Pacheco, Igor Santana de Melo, Maisa de Araujo Costa, Mariah Morais Celestino Amaral, Nivea Karla de Gusmao Taveiros Silva, Yngrid Mickaelli Oliveira Santos, Daniel Leite Goes Gitai, Marcelo Duzzioni, Alexandre Urban Borbely, Robinson Sabino Silva, Ana Luiza Ferreira Donatti, Luisa Mestriner, Carlos Alessandro Fuzo, Richard D. Cummings, Norberto Garcia-Cairasco, Marcelo Dias-Baruffi, Olagide Wagner de Castro
Summary: Administration of GAL-1 reduces the severity of seizures, inflammation, and neurodegeneration, suggesting a neuroprotective effect in the early stage of epileptogenesis.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Nutrition & Dietetics
Zeinab Rafiee, Alba M. Garcia-Serrano, Joao M. N. Duarte
Summary: Obesity, type 2 diabetes, and their associated comorbidities can impact brain metabolism and function, potentially leading to cognitive impairment. Alterations in taurine homeostasis may play a role in metabolic and neurodegenerative disorders. Accumulation of taurine in the brain could serve as a compensatory mechanism to prevent neurodegeneration.
Review
Biochemistry & Molecular Biology
Matteo Haupt, Stefan T. Gerner, Mathias Baehr, Thorsten R. Doeppner
Summary: Despite significant progress in stroke therapy, ischemic stroke still imposes a high socioeconomic burden on industrialized countries. Current treatment paradigms focus on thrombolysis or thrombectomy, which are only suitable for a fraction of patients. Therefore, there is an urgent need for adjuvant therapeutic approaches like neuroprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Gagandeep Jaiswal, Puneet Kumar
Summary: This study investigated the neuroprotective effect of the NADPH oxidase inhibitor apocynin in pentylenetetrazole-induced epilepsy and related comorbidities. The results demonstrated that apocynin significantly reduced seizure severity, oxidative stress, neurotransmitter alterations, and comorbid conditions in mice.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Nutrition & Dietetics
Alexey Sokolov, Nadezhda M. Dubrovskaya, Valeria A. Kostevich, Dmitrii S. Vasilev, Irina V. Voynova, Elena T. Zakharova, Olga L. Runova, Igor Semak, Alexander Budevich, Natalia N. Nalivaeva, Vadim B. Vasilyev
Summary: The protective effects of apo-rhLF on the cognitive functions of rat offspring subjected to prenatal hypoxia have been analyzed. The results showed that apo-rhLF can rescue cognitive deficits caused by prenatal hypoxia and improve memory.
