Review
Nutrition & Dietetics
Theoharris Frangos, Wolfgang Maret
Summary: Zinc and cadmium play crucial roles in osteoarthritis and rheumatoid arthritis, affecting the immune system, inflammation, and metabolism. The mutations in proteins involved in zinc homeostasis and cadmium exposure through inhalation may contribute to joint destruction.
Article
Chemistry, Medicinal
Xiangyu Zhao, Dahye Kim, Godagama Gamaarachchige Dinesh Suminda, Yunhui Min, Jiwon Yang, Mangeun Kim, Yaping Zhao, Mrinmoy Ghosh, Young-Ok Son
Summary: AJNR, extracted from Achyranthes japonica Nakai root, demonstrated inhibitory effects against arthritis by attenuating IL-6-mediated catabolic or anabolic alterations, reducing cartilage erosion, inflammation, and pannus formation in arthritis models.
Article
Biochemistry & Molecular Biology
Doretta Cuffaro, Aleix Gimeno, Bianca Laura Bernardoni, Riccardo Di Leo, Gerard Pujadas, Santiago Garcia-Vallve, Susanna Nencetti, Armando Rossello, Elisa Nuti
Summary: Scientists developed a virtual screening workflow to identify selective non-zinc-binding MMP-13 inhibitors by targeting its specific structural features. Three ligands that could inhibit MMP-13 in the micromolar range were discovered, and one of them showed selectivity over other MMPs. Structure-based analysis guided the chemical optimization, resulting in a new N-acyl hydrazone-based derivative with improved inhibitory activity and selectivity for the target enzyme.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
J. Zhou, C. Liu, Y. Sun, M. Francis, M. S. Ryu, A. Grider, K. Ye
Summary: Genetically determined copper and zinc status were positively associated with osteoarthritis, particularly increasing the risk of localized OA, while an increase in calcium levels decreased the risk of localized OA.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Biochemistry & Molecular Biology
Shahid Parwez, Lalita Panigrahi, Shakil Ahmed, Mohammad Imran Siddiqi
Summary: This study utilizes machine learning-based virtual screening and structure-based rational drug design to identify potential inhibitors of MMP-13 with diverse chemical scaffolds. Two compounds showed potent dose-dependent inhibitory activity and could be further optimized for the design and development of more effective MMP-13 inhibitors.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Orthopedics
Qingxi Lin, Bingxiang Zhou, Xiaoxiao Song, Wei Ye, Qinglong Li, Tong Shi, Chen Cheng, Yetian Li, Xing Wei
Summary: This study validated a common genetic risk factor in ACPA-positive patients with RA, which is associated with the tissue production of MMP-3 and disease progression. Further functional analysis into the role of rs7607479 in MMP-3 expression can shed new light on the genetic architecture of ACPA-positive RA.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Chemistry, Medicinal
Alison M. Bendele, Madhavi Neelagiri, Venugopal Neelagiri, Irving Sucholeiki
Summary: Osteoarthritis (OA) is a chronic disorder causing damage to cartilage and surrounding tissues, with current treatments providing symptom relief but not affecting disease progression. A new MMP-13 inhibitor, AQU-019, shows potential disease-modifying properties in OA treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Tiina Lehtola, Elina Nummenmaa, Lauri Tuure, Mari Hamalainen, Riina M. Nieminen, Teemu Moilanen, Antti Pemmari, Eeva Moilanen
Summary: Dexamethasone attenuates MMP-13 expression in chondrocytes through MKP-1 and p38 MAP kinase-dependent mechanisms, suggesting MKP-1 as a protective factor and a potential drug target for treating OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Rama Hussein, Imad Aboukhamis
Summary: This study aimed to compare serum MMP-3 levels with predictors of response to therapy in Syrian rheumatoid arthritis patients and explore its worth as a valuable biomarker for therapy outcomes. The results showed a significant decrease in serum MMP-3 levels after therapy and it can be used as a biomarker for estimating therapeutic response in RA patients, though not better than DAS28-ESR.
Article
Rheumatology
Mingyue Cheng, Yan Zhao, Yazhou Cui, Chaofang Zhong, Yuguo Zha, Shufeng Li, Guangxiang Cao, Mian Li, Lei Zhang, Kang Ning, Jinxiang Han
Summary: This study investigated the role of microbial dysbiosis and metabolic disorders in different stages of rheumatoid arthritis (RA). The findings suggest that microbial dysbiosis and metabolic disorders exhibit distinct patterns and play stage-specific roles in RA. This provides new insights for prognosis and therapy of RA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Iona J. MacDonald, Chien-Chung Huang, Shan-Chi Liu, Yen-You Lin, Chih-Hsin Tang
Summary: The CCN family of matricellular proteins play essential roles in processes like angiogenesis, wound healing, and inflammation, particularly in the inflammatory pathologies of rheumatoid arthritis and osteoarthritis. Several proteins within the CCN family are thought to be potential therapeutic targets for these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Zhi Zhao, Zhiyan Wang, Lijia Pei, Xinshe Zhou, Yang Liu
Summary: Research has shown that overexpression of AFAP1-AS1 promotes chondrocyte proliferation, inhibits miR-512-3p expression, and regulates matrix synthesis in osteoarthritis.
Article
Public, Environmental & Occupational Health
Desheng Zhao, Jian Cheng, Ping Bao, Yanwu Zhang, Fengjuan Liang, Hao Wang, Xu Wang, Shiyuan Fang, Hong Su
Summary: This study found a significant association between temperature decrease and RA admission, with females and patients aged 41-65 years being more vulnerable to the effect. However, no significant association between temperature and OA admission was observed.
Article
Engineering, Electrical & Electronic
Ahmad Mobed, Sanam Dolati, Seyed Kazem Shakouri, Bina Eftekharsadat, Behzad Izadseresht
Summary: OA and RA are two most frequent types of degenerative joint diseases in adults, with common symptoms but differences in pathological manifestations. Biomarker detection can identify disease development at early stages, benefiting patients with prompt diagnosis.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Review
Rheumatology
Christopher McMaster, Alix Bird, David F. L. Liew, Russell R. Buchanan, Claire E. Owen, Wendy W. Chapman, Douglas E. Pires
Summary: Deep learning has become the leading method in machine learning and has great potential for applications in rheumatology, particularly for handling unstructured data such as images and text. It is important for rheumatologists to understand the methods and limitations of deep learning algorithms and contribute to the development of relevant clinical applications.
ARTHRITIS & RHEUMATOLOGY
(2022)
