Article
Engineering, Environmental
Yuandong Shen, Jie Yang, Xi Chen, Yan Chen, Xu Xu, Mingxiu Zhan, Yue He, Wentao Jiao, Yongguang Yin
Summary: Disposal of organic-contaminated soil through ceramsite production can generate ceramsite with acceptable properties and completely remediate the soil. High-temperature decomposition, thermal desorption, and degradation are the main mechanisms for pollutant removal.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Computer Science, Artificial Intelligence
Zenghao Bao, Zichang Tan, Jun Li, Jun Wan, Xibo Ma, Zhen Lei
Summary: Facial age estimation has diverse application scenarios and has been extensively studied. Existing studies focus on general age estimation or long-tailed age estimation, but there is often a trade-off between performance in head classes and tail classes. In this paper, a unified framework named GLAE is proposed, which achieves good performance in both tasks through feature rearrangement, auxiliary learning, and adaptive routing.
IEEE TRANSACTIONS ON IMAGE PROCESSING
(2023)
Review
Nutrition & Dietetics
Alessia Alunno, Francesco Carubbi, Elena Bartoloni, Davide Grassi, Claudio Ferri, Roberto Gerli
Summary: In recent years, there has been increasing interest in the influence of diet on rheumatic and musculoskeletal diseases (RMDs). Diet may play a role in the development and progression of these conditions through pro-inflammatory properties and effects on insulin resistance, obesity, and other co-morbidities. Research has been more extensive in rheumatoid arthritis (RA) compared to systemic lupus erythematosus (SLE), with most SLE studies conducted on experimental models.
Article
Nutrition & Dietetics
Wojciech Tanski, Natalia Swiatoniowska-Lonc, Mateusz Tabin, Beata Jankowska-Polanska
Summary: This systematic review analyzed 71 studies and found that increased consumption of omega-3 fatty acids may have a beneficial effect on reducing pain and disease activity in patients with rheumatoid arthritis (RA). The studies demonstrated the positive influence of unsaturated fatty acids on the clinical parameters of RA. The content of omega-3 fatty acids in the diet, mainly derived from fish, may contribute to a lower incidence of RA. The review suggests that a diet rich in long-chain unsaturated fatty acids should be the standard of care, along with pharmacotherapy, in the treatment of RA.
Review
Immunology
Nuria Barbarroja, Miriam Ruiz-Ponce, Laura Cuesta-Lopez, Carlos Perez-Sanchez, Chary Lopez-Pedrera, Ivan Arias-de La Rosa, Eduardo Collantes-Estevez
Summary: Liver disease is a significant cause of increased morbidity and mortality worldwide. Inflammation and the accumulation of fat in the liver can lead to hepatic damage, progressing to fibrosis and eventually cirrhosis, which are closely associated with cardiovascular disease. Patients with inflammatory conditions like rheumatoid arthritis and psoriatic arthritis have a higher risk of liver disease compared to the general population, possibly due to chronic inflammation, autoimmunity, treatments, and metabolic deregulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Yamin Nie, Xiuli Tao, Ying Zhou, Xiaoding Yuan, Ying Zhuo, Ya-Qin Chai, Ruo Yuan
Summary: This study introduces PEDOT as a functional ligand for NCs, which plays a role in stabilization, electrical conductivity, and electrocatalytic activity, leading to the preparation of high ECL efficiency NCs. The PEDOT-hosted Ag NCs show unprecedented ECL intensity, paving the way for potential applications in light-emitting devices and clinical biosensing, as demonstrated by sensitive detection of dopamine.
ANALYTICAL CHEMISTRY
(2021)
Article
Rheumatology
Anthony James Ocon, George Reed, Dimitrios A. Pappas, Jeffrey R. Curtis, Joel M. Kremer
Summary: The study found that initiating glucocorticoids in steroid-naive RA patients is associated with an increased risk of cardiovascular events, especially at daily doses of >= 5mg, cumulative doses exceeding 1100mg, and durations longer than 81 days. No increased risk was found at lower doses or shorter durations.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Nutrition & Dietetics
Lingling Sun, Jiahao Zhu, Shuai Mi, Yasong Li, Tianle Wang, Yingjun Li
Summary: The study found a causal relationship between genetically predicted levels of palmitoleic acid and oleic acid and a lower risk of RA. However, causality between MUFAs and OA could not be inferred from this research. Further investigation is needed to understand the role of MUFA supplementation in arthritis prevention.
Review
Medicine, General & Internal
Bas Dijkshoorn, Reinder Raadsen, Michael T. Nurmohamed
Summary: RA patients have a 1.5 times higher risk of developing cardiovascular diseases compared to the general population. This is partly due to systemic inflammation causing increased atherogenesis, and an increased prevalence of traditional cardiovascular risk factors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Anne-Mari Mustonen, Sylvain Tollis, Reijo Kaekelae, Sanna P. Sihvo, Sanna Palosaari, Vesa-Matti Pohjanen, Aaron Yli-Hallila, Petri Lehenkari, Petteri Nieminen
Summary: Emerging evidence suggests that fatty acids and their derivatives can have both beneficial and detrimental effects on inflammatory processes and joint degradation in osteoarthritis and rheumatoid arthritis. This study characterized the specific fatty acid signatures in synovial membranes of OA and RA patients, and identified differences in fatty acid composition that could potentially predict inflammatory states.
Article
Environmental Sciences
Kailee E. Hopkins, Melissa A. McKinney, Robert J. Letcher, Kim J. Fernie
Summary: The tissues of tree swallows in two sites in southern Ontario, Canada, were analyzed for various PFAAs. PFOS was the dominant PFAA, followed by other PFAAs including long-chain PFCAs. Short-chain PFSAs and PFCAs had lower concentrations compared to the long-chain ones. The presence of a wastewater treatment plant (WWTP) may contribute to higher levels of certain PFAAs in tree swallow tissues.
ENVIRONMENTAL POLLUTION
(2023)
Review
Biochemistry & Molecular Biology
Camille Jacques, Ilaria Floris, Beatrice Lejeune
Summary: The article discusses the role of TNF-α and IL-1β in rheumatoid arthritis (RA) and how the micro-immunotherapy medicine 2LARTH (R) utilizes ultra-low doses of these two cytokines to restore the body's homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Xiao Liu, Zhengcong Cao, Nannan Liu, Guangxun Gao, Mingrui Du, Yingwen Wang, Boyang Cheng, Maorong Zhu, Bo Jia, Luxiang Pan, Wangqian Zhang, Yuran Jiang, Wei He, Linlin Xu, Wei Zhang, Qunxing An, Qingdong Guo, Jintao Gu
Summary: This study used engineering technology to generate T7 peptide-decorated exosomes, which efficiently deliver chemotherapy drugs to GBM cells, enhance chemosensitivity, and reverse therapeutic resistance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Seonyoung Kang, Kyungdo Han, Jin-Hyung Jung, Yeonghee Eun, In Young Kim, Jiwon Hwang, Eun-Mi Koh, Seulkee Lee, Hoon-Suk Cha, Hyungjin Kim, Jaejoon Lee
Summary: This large-scale nationwide cohort study investigated the association between cardiovascular disease (CVD) risk and rheumatoid arthritis (RA) and factors that may increase CVD risk. The study found that RA patients had a 50% higher risk of myocardial infarction (MI) and a 20% higher risk of stroke. The association between RA and CVD was more prominent in females, and the association between RA and MI risk was significant in individuals without diabetes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Bohan Ma, Hui Feng, Chao Feng, Yi Liu, Hailing Zhang, Jincheng Wang, Wenjuan Wang, Pengcheng He, Fan Niu
Summary: The study designed a dual-targeting proteolysis-targeting chimera (PROTAC) type drug that can induce Bcr/Abl degradation and activate the p53 pathway simultaneously, potentially overcoming drug resistance in Ph+ leukemias.
