Review
Hematology
John-Paul Tung, Sara Chiaretti, Melinda M. Dean, Annette J. Sultana, Michael C. Reade, Yoke Lin Fung
Summary: Transfusion-related acute lung injury (TRALI) is a common complication of blood transfusion, caused by antibodies or biological response modifiers (BRMs). Multiple possible pathways for TRALI have been identified, including neutrophil activation, monocyte and neutrophil dependence, and endothelial cell and complement dependence. These pathways ultimately lead to the symptoms of TRALI. In addition to the known pathways, other pathways are likely to contribute to the pathogenesis of TRALI.
Article
Physiology
Liqin Ling, Jie Zhang, Yansong Li, Chaonan Liu, Lei Du, Jing Zhou
Summary: Platelets may play a dual role in TRALI, with the activation of platelets by thrombin being a key factor. Anti-thrombin may be a better approach than anti-activated platelets in potential therapies for TRALI.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Da-Wei Chen, Tian Kang, Xiu-Zhang Xu, Wen-Jie Xia, Xin Ye, Yong-Bin Wu, Yao-Ri Xu, Jing Liu, Hui Ren, Jing Deng, Yang-Kai Chen, Hao-Qiang Ding, Muhammad Aslam, Wioleta M. Zelek, B. Paul Morgan, Rick Kapur, Sentot Santoso, Yong-Shui Fu
Summary: Anti-CD36 antibodies can cause transfusion-related acute lung injury (TRALI), especially in Asian populations. However, the pathological mechanism of anti-CD36 Ab-mediated TRALI and potential therapies are not well understood. In this study, a mouse model of anti-CD36 Ab-mediated TRALI was developed, and it was found that TRALI could be prevented and treated by targeting Fc and complement C5 activation. These findings suggest the potential for anti-C5 drugs in the treatment of TRALI caused by anti-CD36 antibodies.
Article
Immunology
Shujing Zou, Hongyu Jie, Xinai Han, Jinghong Wang
Summary: Neutrophil extracellular traps (NETs) play a critical role in the inflammatory response and bacterial clearance, but their excessive activation can cause an inflammatory storm and organ dysfunction. Acute lung injury caused by sepsis is the main cause of organ damage. NET formation can accelerate the development of acute lung injury through the release of cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Respiratory System
Pearl Toy, Mark R. Looney, Mark Popovsky, Miodrag Palfi, Gosta Berlin, Catherine E. Chapman, Paula Bolton-Maggs, Michael A. Matthay
Summary: Transfusion-related acute lung injury (TRALI) is a condition characterized by acute respiratory distress syndrome (ARDS) after blood transfusion, often associated with donor leukocyte antibodies or plasma from multiparous donors. While there have been successful measures to reduce TRALI, there are still unanswered questions regarding non-antibody TRALI mechanisms, the impact of blood products on ARDS in massive transfusion patients, and accurate diagnosis of TRALI.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Review
Physiology
Wolfgang M. Kuebler, Nishaka William, Martin Post, Jason P. Acker, Mark J. Mcvey
Summary: Respiratory transfusion reactions, especially transfusion-related acute lung injury (TRALI), have significant morbidity and mortality. Current methods of diagnosing and treating TRALI are limited. EVs play a role in mediating TRALI by acting as triggers for the first and/ or second hit. Further research is needed to explore EVs as therapeutic targets and biomarkers for TRALI diagnosis.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aiping Le, Wei Liu, Chenggao Wu, Piaoping Hu, Juan Zou, Yize Wu, Linju Kuang
Summary: This study found that HLA-A2 antibody activates Src phosphorylation, NF-kappa B, and NLRP3 inflammasome, leading to the activation of PMNs and exacerbation of TRALI. This discovery provides a promising target for the treatment of antibody-mediated TRALI.
MOLECULAR IMMUNOLOGY
(2022)
Article
Immunology
Katharina Jandl, Johannes Lorenz Berg, Anna Birnhuber, Elisabeth Fliesser, Izabela Borek, Benjamin Seeliger, Sascha David, Julius J. Schmidt, Gregor Gorkiewicz, Martin Zacharias, Tobias Welte, Horst Olschewski, Akos Heinemann, Malgorzata Wygrecka, Grazyna Kwapiszewska
Summary: Immune cell recruitment, endothelial cell barrier disruption, and platelet activation are common in lung injuries like COVID-19-induced ARDS. In this study, we investigated the role of endostatin, a bioactive fragment of the basement membrane protein collagen XVIII alpha 1, on cellular functions associated with ARDS. Our results showed that endostatin enhanced neutrophil and platelet activity, as well as induced microvascular barrier disruption.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yunhong Yu, Zhengqiu Lian
Summary: Transfusion-related acute lung injury (TRALI) is a severe adverse event and a leading cause of transfusion-associated death. Effective management strategies for the prevention and treatment of associated lung edema are urgently needed. Recent studies have advanced our understanding of TRALI pathogenesis and led to a decrease in TRALI-associated morbidity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Mickael Vourc'h, Antoine Roquilly, Adrien Foucher, Christelle Retiere, Fanny Feuillet, Sapna Devi, Hamish E. G. McWilliam, Cecile Braudeau, Geraldine Bourreille, Abderrahman Hachani, Dermot O'Kane, Scott N. Mueller, Joseph Ischia, Jean-Christian Roussel, Jean-Christophe Rigal, Regis Josien, Bertrand Rozec, Jose A. Villadangos, Karim Asehnoune
Summary: This study found that transfusion of packed red blood cells with high levels of MRP_14 may increase the incidence of AKI after cardiac surgery. Higher concentrations of MRP_14 were found in packed red blood cells from female donors or prepared by whole blood filtration.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Paulette A. Krishack, Maile K. Hollinger, Timothy G. Kuzel, Trevor S. Decker, Tyler J. Louviere, Cara L. Hrusch, Anne Sperling, Philip A. Verhoef
Summary: Recent studies suggest that patients with allergies/asthma have a higher survival rate against pulmonary infections, and there is a correlation between survival from acute respiratory distress syndrome and higher eosinophil counts. Research indicates that eosinophils play a key role in protecting against lung injury, and modulation of pulmonary type 2 immunity may represent a novel therapeutic strategy.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kai Guo, Shuxuan Ma
Summary: TRALI, as a rare complication associated with transfusion medicine, has unclear pathogenesis and lacks specific therapies. Understanding the mechanisms of TRALI is crucial for the design of preventive and therapeutic strategies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Immunology
Yi Liu, Rong Wang, Congkuan Song, Song Ding, Yifan Zuo, Ke Yi, Ning Li, Bo Wang, Qing Geng
Summary: Transfusion-related acute lung injury (TRALI) is a leading cause of death associated with blood transfusion. TRALI can be categorized into antibody-mediated and non-antibody-mediated types. Neutrophil extracellular traps (NETs) formed by activated neutrophils play a significant role in TRALI. Platelets, macrophages, endothelial cells, and complements also promote NET formation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Critical Care Medicine
Shuangchun Liu, Ronghai Lin, Xianchao Zhang, Yinyi Lv, Jie Zhu, Guang Chen, Yunting Du
Summary: This study investigated the pathophysiological mechanisms of TRALI using a rat model. The findings indicated that TRALI increased inflammatory cytokines and activated toll-like receptor 4/nuclear factor kappa B and mitogen-activated protein kinase signaling pathways. HMGB1 and RIP3 may serve as diagnostic markers for TRALI and promote inflammation through these signaling pathways.
Article
Critical Care Medicine
Xin Yuan, Peng Jiang, CongChao Qiao, Na Su, Pan Sun, Fangzhao Lin, Changqing Li
Summary: This study aimed to explore the effects of the platelet surface glycoprotein IIb/IIIa receptor antagonist tirofiban on coagulation and fibrinolytic abnormalities in a mouse model of antibody-mediated transfusion-associated acute lung injury (ALI). The results showed that tirofiban decreased lung injury indices and improved survival rates in the mouse model. Furthermore, tirofiban significantly reduced coagulation and fibrinolytic abnormalities compared to the model group.