Review
Biochemistry & Molecular Biology
Agnieszka Dettlaff-Pokora, Julian Swierczynski
Summary: SARS-CoV-2 impairs the renin-angiotensin-aldosterone system by binding the ACE2 enzyme, leading to an increase in angiotensin 2 and a decrease in angiotensin (1-7), potentially worsening damage to the lungs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Persoulla A. Nicolaou
Summary: Sex-related differences in clinical manifestations, risk factors, and treatment drug use in patients with heart failure are significant, particularly in the regulation of the renin-angiotensin-aldosterone system (RAAS). While current evidence suggests potential differences in the efficacy of RAAS drugs between men and women, further research is needed to determine the optimal treatment strategies for both genders.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Nikoo Saeedi, Saeide Mansoori, Fereshteh Asgharzadeh, Atena Soleimani, Samaneh Mollazadeh, Seyed Mahdi Hassanian
Summary: This study examined the potential clinical impact of ACEI/ARB on metastatic renal cell carcinoma (mRCC). The results found that patients undergoing treatment with ACEI/ARB had higher overall survival and progression-free survival compared to non-users.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Medicine, General & Internal
Ruxin Wang, Haowen Ye, Yongting Zhao, Jinjing Wei, Ying Wang, Xiaofang Zhang, Lihong Wang
Summary: This meta-analysis found that sacubitril/valsartan has a positive effect on glycemic control and the prevention of new-onset diabetes mellitus, especially in patients with heart failure.
Article
Biochemistry & Molecular Biology
Filippo Confalonieri, Xhevat Lumi, Goran Petrovski
Summary: Epiretinal membrane (ERM) is a common condition affecting the macula. The current treatment approach is surgery, but this case report suggests that angiotensin receptor blockers (ARBs) may have antifibrotic activity on ERM formation and resolution. Further clinical studies are needed to explore this phenomenon.
Article
Medicine, General & Internal
Seok Hui Kang, Bo Yeon Kim, Eun Jung Son, Gui Ok Kim, Jun Young Do
Summary: This study aimed to evaluate patient survival with the use of renin-angiotensin system blockers (RASBs) in maintenance hemodialysis (HD) patients, and found that the use of RASBs was associated with higher patient survival rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Kengo Azushima, Jean -Paul Kovalik, Takahiro Yamaji, Jianhong Ching, Tze Wei Chng, Jing Guo, Jian-Jun Liu, Mien Nguyen, Rashidah Binte Sakban, Simi E. George, Puay Hoon Tan, Su Chi Lim, Susan B. Gurley, Thomas M. Coffman
Summary: This study found that in a mouse model of diabetic nephropathy, there were elevated lactate levels and impaired energy metabolism in the kidneys. Treatment with an angiotensin-receptor blocker (ARB) improved these abnormalities. Increased expression of lactate dehydrogenase isoforms, specifically LdhA in the proximal tubule, was also observed. Urinary lactate levels were found to be predictive of clinical outcomes in diabetic patients with kidney disease.
KIDNEY INTERNATIONAL
(2023)
Article
Infectious Diseases
Hee-Sung Kim, Minseok Kang, Gilwon Kang
Summary: This study found that in hypertensive patients with COVID-19, older age, male sex, a diagnosis of diabetes mellitus, and renal replacement therapy were risk factors for a severe clinical course. Additionally, the use of ARBs and ACEIs before or after COVID-19 infection did not affect a patient's risk of contracting COVID-19 or contribute to a worse prognosis for the disease.
BMC INFECTIOUS DISEASES
(2021)
Article
Oncology
Marcin Zeman, Wladyslaw Skalba, Agata Malgorzata Wilk, Alexander Jorge Cortez, Adam Maciejewski, Agnieszka Czarniecka
Summary: The use of ARBs instead of ACEIs may improve the outcome of the combined therapy for rectal cancer patients with associated hypertension.
Article
Cell Biology
Jose A. Godoy-Lugo, Dora A. Mendez, Ruben Rodriguez, Akira Nishiyama, Daisuke Nakano, Jose G. Sonanez-Organis, Rudy M. Ortiz
Summary: Increased Ang II signaling leads to insulin resistance and liver steatosis. Angiotensin receptor blockers (ARBs) not only ameliorate hypertension, but also improve lipid metabolism and hepatic steatosis. Chronic AT1 blockade increases plasma Ang 1-7, reduces liver lipids, and decreases expression of fatty acid transporter 5 and fatty acid synthase.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Chu-Lin Chou, Ching-Hao Li, Te-Chao Fang
Summary: High fructose intake is associated with obesity and metabolic syndrome, but the blockers of renin-angiotensin system and calcium channel can reduce triacylglycerol storage in fructose-induced adiposity by inhibiting PU.1 activation.
Review
Oncology
Brendan Sieber, Julius Strauss, Zihai Li, Margaret E. Gatti-Mays
Summary: Polypharmacy is common among cancer patients, but its impact on the efficacy and side effects of immune checkpoint inhibitors (ICI) remains unclear. This systematic review analyzed clinical studies on the impact of concomitant medications on ICI outcomes and toxicity in patients with advanced solid tumors. The studies did not find a significant impact on ICI efficacy or immune related adverse events (irAEs) with the use of these medications.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Thays Calista Santiago, Larissa Parra, Joao V. Nani, Thiago M. Fidalgo, Nicholas J. Bradshaw, Mirian A. F. Hayashi
Summary: The renin-angiotensin system (RAS) has recently been recognized for its potential roles in the brain, with angiotensin-converting enzyme (ACE) and other RAS components implicated in brain disorders. This review identifies the functions of the RAS and ACEs in the brain, and their association with neurodegenerative and psychiatric illnesses. The findings suggest that ACE inhibitors and angiotensin receptor blockers could be valuable as a novel integrated treatment approach for various brain disorders, particularly psychiatric illnesses.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Oncology
Zsofia D. Drobni, Olivier Michielin, Thiago Quinaglia, Daniel A. Zlotoff, Leyre Zubiri, Hannah K. Gilman, Sama Supraja, Bela Merkely, Veronika Muller, Ryan J. Sullivan, Kerry L. Reynolds, Michael J. Pittet, Rakesh K. Jain, Tomas G. Neilan
Summary: This retrospective study investigated the association between the use of renin-angiotensin-aldosterone system (RAAS) inhibitors and outcomes in patients treated with immune checkpoint inhibitors (ICIs). The results showed that hypertension patients who concomitantly took a RAAS inhibitor during ICI therapy had better overall survival. This benefit was particularly significant among patients with gastrointestinal and genitourinary cancers.
EUROPEAN JOURNAL OF CANCER
(2022)
Review
Cardiac & Cardiovascular Systems
Sarah M. Nwia, Ana Paula O. Leite, Xiao Chun Li, Jia Long Zhuo
Summary: Cardiovascular disease demonstrates significant biological sex differences, allowing for tailored approaches to prevention and treatment. Hypertension, a major risk factor for various diseases, affects a significant percentage of the American population. Women have lower rates of hypertension during reproductive years, but this protection diminishes after menopause. Treatment-resistant hypertension remains a challenge, suggesting unknown mechanisms in blood pressure regulation. Understanding the genetic and hormonal differences in hypertension can lead to sex-specific treatments and improved outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Roberto Ferrari, Rita Pavasini, Stefano Censi, Angelo Squeri, Giuseppe Rosano
Summary: The new guidelines for the diagnosis and management of chronic coronary syndromes released by the European Society of Cardiology during the annual meeting in Paris introduce positive innovations, but show inconsistencies and limitations in the section on medical therapy that need further attention.
CURRENT PROBLEMS IN CARDIOLOGY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Massimiliano Caprio, Cristiana Vitale, Giuseppe M. C. Rosano
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Giuseppe M. C. Rosano, Cristiana Vitale, Gianluigi Savarese
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Petar M. Seferovic, Hiroyuki Tsutsui, Dennis M. McNamara, Arsen D. Ristic, Cristina Basso, Biykem Bozkurt, Leslie T. Cooper, Gerasimos Filippatos, Tomomi Ide, Takayuki Inomata, Karin Klingel, Ales Linhart, Alexander R. Lyon, Mandeep R. Mehra, Marija Polovina, Ivan Milinkovic, Kazufumi Nakamura, Stefan D. Anker, Ivana Veljic, Tomohito Ohtani, Takahiro Okumura, Thomas Thum, Carsten Tschope, Giuseppe Rosano, Andrew J. S. Coats, Randall C. Starling
Summary: Endomyocardial biopsy (EMB) is an invasive procedure commonly used for monitoring heart transplant rejection and diagnosing various cardiac disorders. Advances in EMB equipment and techniques have improved diagnostic precision. An expert consensus document provides a comprehensive overview on EMB, covering practical approaches, updated indications, revised surveillance plans, the impact of multimodality imaging, and current global clinical practices.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Giuseppe M. C. Rosano, Brenda Moura, Marco Metra, Michael Boehm, Johann Bauersachs, Tuvia Ben Gal, Stamatis Adamopoulos, Magdy Abdelhamid, Vasiliki Bistola, Jelena Celutkiene, Ovidiu Chioncel, Dimitrios Farmakis, Roberto Ferrari, Gerasimos Filippatos, Loreena Hill, Ewa A. Jankowska, Tiny Jaarsma, Pardeep Jhund, Mitja Lainscak, Yuri Lopatin, Lars H. Lund, Davor Milicic, Wilfried Mullens, Fausto Pinto, Piotr Ponikowski, Gianluigi Savarese, Thomas Thum, Maurizio Volterrani, Stefan D. Anker, Petar M. Seferovic, Andrew J. S. Coats
Summary: Implementation of treatment in heart failure is hindered by poor tolerability and renal function issues, leading to difficulty in reaching target drug doses. A personalized approach to therapy based on patient profiles may be more effective than traditional forced titration of each drug class.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
D. Rodolico, D. D'amario, G. Rosano, U. Dahlstrom, F. Crea, L. Lund, G. Savarese
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Correction
Cardiac & Cardiovascular Systems
J. Celutkiene, R. Pudil, T. Lopez-Fernandez, J. Grapsa, P. Nihoyannopoulos, J. Bergler-Klein, A. Cohen-Solal, D. Farmakis, C. G. Tocchetti, S. von Haehling, V Barberis, F. A. Flachskampf, J. Ceponlene, E. Haegler-Laube, T. Suter, T. Lapinskas, S. Prasad, R. A. de Boer, K. Wechalekar, M. S. Anker, Z. Iakobishvili, C. Bucciarelli-Ducci, J. Schulz-Menger, B. Cosyns, O. Gaemperli, Y. Belenkov, J-S Hulot, M. Galderisi, P. Lancellotti, J. Bax, T. H. Marwick, O. Chioncel, T. Jaarsma, W. Mullens, M. Piepoli, T. Thum, S. Heymans, C. Mueller, B. Moura, F. Ruschitzka, J. L. Zamorano, G. Rosano, A. J. S. Coats, R. Asteggiano, P. Seferovic, T. Edvardsen, A. R. Lyon
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Correction
Cardiac & Cardiovascular Systems
O. Chioncel, J. Parissis, A. Mebazaa, H. Thiele, S. Desch, J. Bauersachs, V-P Harjola, E-L Antohi, M. Arrigo, T. B. Gal, J. Celutkiene, S. P. Collins, D. DeBacker, V. A. Iliescu, E. Jankowska, T. Jaarsma, K. Keramida, M. Lainscak, L. H. Lund, A. R. Lyon, J. Masip, M. Metra, O. Miro, A. Mortara, C. Mueller, W. Mullens, M. Nikolaou, M. Piepoli, S. Price, G. Rosano, A. Vieillard-Baron, J. M. Weinstein, S. D. Anker, G. Filippatos, F. Ruschitzka, A. J. S. Coats, P. Seferovic
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Biykem Bozkurt, Andrew J. S. Coats, Hiroyuki Tsutsui, Magdy Abdelhamid, Stamatis Adamopoulos, Nancy Albert, Stefan D. Anker, John Atherton, Michael Bohm, Javed Butler, Mark H. Drazner, G. Michael Felker, Gerasimos Filippatos, Gregg C. Fonarow, Mona Fiuzat, Juan-Esteban Gomez-Mesa, Paul Heidenreich, Teruhiko Imamura, James Januzzi, Ewa A. Jankowska, Prateeti Khazanie, Koichiro Kinugawa, Carolyn S. P. Lam, Yuya Matsue, Marco Metra, Tomohito Ohtani, Massimo Francesco Piepoli, Piotr Ponikowski, Giuseppe M. C. Rosano, Yasushi Sakata, Randall C. Starling, John R. Teerlink, Orly Vardeny, Kazuhiro Yamamoto, Clyde Yancy, Jian Zhang, Shelley Zieroth
Summary: This document proposes a universal definition of heart failure and revised stages of HF, as well as a new classification based on left ventricular ejection fraction (LVEF). The stages of HF are categorized into HF at-risk, pre-HF, HF, and advanced HF, while the classification includes HFrEF, HFmrEF, HFpEF, and HFimpEF based on LVEF levels.
JOURNAL OF CARDIAC FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Davor Milicic, Binyamin Ben Avraham, Ovidiu Chioncel, Yaron D. Barac, Eva Goncalvesova, Avishai Grupper, Johann Altenberger, Maria Frigeiro, Arsen Ristic, Nicolaas De Jonge, Steven Tsui, Jacob Lavee, Giuseppe Rosano, Marisa Generosa Crespo-Leiro, Andrew J. S. Coats, Petar Seferovic, Frank Ruschitzka, Marco Metra, Stefan Anker, Gerasimos Filippatos, Stamatis Adamopoulos, Miriam Abuhazira, Jeremy Elliston, Israel Gotsman, Righab Hamdan, Yoav Hammer, Tal Hasin, Lorrena Hill, Osnat Itzhaki Ben Zadok, Wilfried Mullens, Sanemn Nalbantgil, Massimo Francesco Piepoli, Piotr Ponikowski, Luciano Potena, Arjang Ruhparwar, Aviv Shaul, Laurens F. Tops, Stephan Winnik, Tiny Jaarsma, Finn Gustafsson, Tuvia Ben Gal
Summary: The advancements in LVAD technology and the shortage of donor hearts have led to an increase in LVAD-supported patients, especially older patients undergoing destination therapy, who are at higher risk for other comorbidities. This article provides definitions and a structured approach for managing LVAD-supported patients presenting with various complications in the emergency department, as well as discussing the challenging issue of declaring death in these patients.
Article
Cardiac & Cardiovascular Systems
Mateusz Sokolski, Sander Trenson, Justyna M. Sokolska, Domenico D'Amario, Philippe Meyer, Nana K. Poku, Tor Biering-Sorensen, Mats C. Hojbjerg Lassen, Kristoffer G. Skaarup, Eduardo Barge-Caballero, Anne-Catherine Pouleur, Davide Stolfo, Gianfranco Sinagra, Klemens Ablasser, Viktoria Muster, Peter P. Rainer, Markus Wallner, Alessandra Chiodini, Pascal S. Heiniger, Fran Mikulicic, Judith Schwaiger, Stephan Winnik, Huseyin A. Cakmak, Margherita Gaudenzi, Massimo Mapelli, Irene Mattavelli, Matthias Paul, Irina Cabac-Pogorevici, Claire Bouleti, Marzia Lilliu, Chiara Minoia, Jeroen Dauw, Jerome Costa, Ahmet Celik, Nathan Mewton, Carlos E. L. Montenegro, Yuya Matsue, Goran Loncar, Michal Marchel, Aris Bechlioulis, Lampros Michalis, Marcus Dorr, Edgard Prihadi, Felix Schoenrath, Daniel R. Messroghli, Wilfried Mullens, Lars H. Lund, Giuseppe M. C. Rosano, Piotr Ponikowski, Frank Ruschitzka, Andreas J. Flammer
Summary: The study assessed the outcome of hospitalized COVID-19 patients with heart failure (HF) compared to those with other cardiovascular diseases and risk factors. It found that patients with HF had a higher in-hospital mortality rate, and acute HF events during hospitalization were associated with further increased mortality.
Review
Cardiac & Cardiovascular Systems
Amr Abdin, Stefan D. Anker, Javed Butler, Andrew J. Stewart Coats, Ingrid Kindermann, Mitja Lainscak, Lars H. Lund, Marco Metra, Wilfried Mullens, Giuseppe Rosano, Jonathan Slawik, Jan Wintrich, Michael Boehm
Summary: Timely diagnosis and treatment are crucial for the prognosis of patients with acute HF, and early and intensive treatment in the post-worsening HF period may reduce rates of early readmission and mortality.
Article
Cardiac & Cardiovascular Systems
Binyamin Ben Avraham, Marisa Generosa Crespo-Leiro, Gerasimos Filippatos, Israel Gotsman, Petar Seferovic, Tal Hasin, Luciano Potena, Davor Milicic, Andrew J. S. Coats, Giuseppe Rosano, Frank Ruschitzka, Marco Metra, Stefan Anker, Johann Altenberger, Stamatis Adamopoulos, Yaron D. Barac, Ovidiu Chioncel, Nicolaas De Jonge, Jeremy Elliston, Maria Frigeiro, Eva Goncalvesova, Avishay Grupper, Righab Hamdan, Yoav Hammer, Loreena Hill, Osnat Itzhaki Ben Zadok, Miriam Abuhazira, Jacob Lavee, Wilfried Mullens, Sanemn Nalbantgil, Massimo F. Piepoli, Piotr Ponikowski, Arsen Ristic, Arjang Ruhparwar, Aviv Shaul, Laurens F. Tops, Steven Tsui, Stephan Winnik, Tiny Jaarsma, Finn Gustafsson, Tuvia Ben Gal
Summary: LVAD technology is widely accepted as a good alternative for the treatment of patients with advanced heart failure, providing increased survival rates for LVAD-supported patients. However, complications related to the device and patient-device interaction pose a significant burden on the medical system. This article aims to provide tools and guidance for non-LVAD specialized physicians to meet the medical needs of the fast-growing population of LVAD-supported patients.
Article
Cardiac & Cardiovascular Systems
Reza Goharani, Amir Vahedian-Azimi, Mohamad Amin Pourhoseingholi, Farzaneh Amanpour, Giuseppe M. C. Rosano, Amirhossein Sahebkar
Summary: This study analyzed the survival rate of patients with in-hospital cardiac arrest after discharge from the intensive care unit, finding that the implementation of feedback devices improved survival and length of stay.
Article
Cardiac & Cardiovascular Systems
Finn Gustafsson, Binyamin Ben Avraham, Ovidiu Chioncel, Tal Hasin, Avishai Grupper, Aviv Shaul, Sanemn Nalbantgil, Yoav Hammer, Wilfried Mullens, Laurens F. Tops, Jeremy Elliston, Steven Tsui, Davor Milicic, Johann Altenberger, Miriam Abuhazira, Stephan Winnik, Jacob Lavee, Massimo Francesco Piepoli, Lorrena Hill, Righab Hamdan, Arjang Ruhparwar, Stefan Anker, Marisa Generosa Crespo-Leiro, Andrew J. S. Coats, Gerasimos Filippatos, Marco Metra, Giuseppe Rosano, Petar Seferovic, Frank Ruschitzka, Stamatis Adamopoulos, Yaron Barac, Nicolaas De Jonge, Maria Frigerio, Eva Goncalvesova, Israel Gotsman, Osnat Itzhaki Ben Zadok, Piotr Ponikowski, Luciano Potena, Arsen Ristic, Tiny Jaarsma, Tuvia Ben Gal
Summary: This article provides details on the management of hospitalized LVAD-supported patients, including blood pressure assessment, medical therapy, challenges related to anesthesia and non-cardiac surgical interventions, as well as discharge and palliative care considerations.
