Article
Multidisciplinary Sciences
Fatima Regina Nunes de Sousa, Vanessa Costa de Sousa Ferreira, Conceicao da Silva Martins, Hugo Victor Dantas, Frederico Barbosa de Sousa, Virginia Claudia Carneiro Girao-Carmona, Paula Goes, Gerly Anne de Castro Brito, Renata Ferreira de Carvalho Leitao
Summary: The study evaluated the effect of Zoledronic acid on orthodontic tooth movement and root and bone resorption, finding that it can reduce tooth movement and exhibit anti-resorptive effects.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Frank H. Ebetino, Shuting Sun, Philip Cherian, Sahar Roshandel, Jeffrey D. Neighbors, Eric Hu, James E. Dunford, Parish P. Sedghizadeh, Charles E. McKenna, Venkat Srinivasan, Robert K. Boeckman, R. Graham G. Russell
Summary: Bisphosphonates are a class of drugs that were first shown to inhibit bone resorption in the 1960s. After several decades of research, the detailed molecular understanding of their mechanisms of action and effects in the body has been elucidated. Bisphosphonates primarily work by inhibiting the enzyme FDPS in bone cells, resulting in reduced bone resorption. They also have a high affinity for bone mineral. Furthermore, chemical modifications of bisphosphonates can be made to customize their properties for different uses.
Article
Multidisciplinary Sciences
Joao Cardeira-da-Silva, Anabela Bensimon-Brito, Marco Tarasco, Ana S. Brandao, Joana T. Rosa, Jorge Borbinha, Paulo J. Almeida, Antonio Jacinto, M. Leonor Cancela, Paulo J. Gavaia, Didier Y. R. Stainier, Vincent Laize
Summary: By studying the bone patterning during zebrafish fin ray regeneration, it was discovered that the fin rays form through two mineralization fronts and bifurcation is not a simple splitting process. Osteolytic tubules play a key role in defining the position of the branchpoint.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Endocrinology & Metabolism
Wacili Da, Lin Tao, Yue Zhu
Summary: In recent years, research on the mechanism underlying bone metabolic disorders based on energy metabolism has made significant progress, focusing on the impact of osteoclast energy metabolism disorder on bone homeostasis and proposing a compensatory recovery mechanism as a new approach for the treatment of osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jesus Delgado-Calle, Kevin McAndrews, Gerald Wu, Ashley L. Orr, Adam Ferrari, Xiaolin Tu, Venkatesan Srinivasan, G. David Roodman, Frank H. Ebetino, Robert K. Boeckman, Teresita Bellido
Summary: This study reveals that PTH signaling upregulates Notch pathway components, and Notch activation contributes to the catabolic actions of PTH in bone. Deleting the PTH receptor or overexpressing sclerostin in osteocytes abolishes the increase in Notch components caused by PTH. Moreover, bone-targeted Notch inhibition enhances the bone anabolic effects of intermittent PTH.
Article
Cell Biology
Tao Huang, Congyun Zhao, Yi Zhao, Yuan Zhou, Lei Wang, Donghua Hang
Summary: RO4929097 can effectively inhibit RANKL-induced osteoclastogenesis, reduce NFATc1 protein expression, and decrease bone resorption. In vivo experiments demonstrate that RO4929097 has an inhibitory effect on LPS-induced bone resorption.
Article
Biochemistry & Molecular Biology
Fujun Jin, Yexuan Zhu, Meijing Liu, Rongze Wang, Yi Cui, Yanting Wu, Gang Liu, Yifei Wang, Xiaogang Wang, Zhe Ren
Summary: In this study, Babam2 was identified as an essential negative regulator of osteoclast formation and bone resorption. It interacts with Hey1 to inhibit Nfatc1 transcription, thus negatively regulating osteoclastogenesis. Targeting Babam2 may be a novel therapeutic approach for osteoclast-related bone diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Nutrition & Dietetics
So Young Eun, Yoon-Hee Cheon, Gyeong Do Park, Chong Hyuk Chung, Chang Hoon Lee, Ju-Young Kim, Myeung Su Lee
Summary: Vigeo, a mixture of fermented extracts, showed protective effects against inflammatory bone loss and osteoclastogenesis induced by LPS and RANKL, respectively, by inhibiting various signaling pathways and gene expressions.
Article
Endocrinology & Metabolism
Hui Zhang, Yuxuan Li, Lin Yuan, Lutian Yao, Jie Yang, Liping Xia, Hui Shen, Jing Lu
Summary: The study demonstrated the immunosuppressive function of IL-35 on RANKL and M-CSF-induced osteoclastogenesis and angiogenesis through Th17/IL-17 axis. Utilizing IL-35 as a therapeutic approach may serve as a novel treatment option for osteoporosis by suppressing bone resorption and angiogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Jinjin Cao, Shaoming Wang, Congmin Wei, Hongru Lin, Chen Zhang, Yehui Gao, Zixian Xu, Zhou Cheng, Wan-chun Sun, Hong-bing Wang
Summary: In this study, Agrimophol (AGR) was found to inhibit RANKL-induced osteoclastogenesis through various mechanisms, suggesting its potential as a therapeutic agent against bone lysis diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Vinicius de Paiva Goncalves, Marta Liliana Musskopf, Angeliz Rivera-Concepcion, Christina Yu, Sing Wai Wong, Stephen A. Tuin, Yizu Jiao, Cristiano Susin, Luis Carlos Spolidorio, Patricia Almeida Miguez
Summary: This study showed that hesperidin impaired osteoclastogenesis in vitro, but high-dose dietary hesperidin increased osteoclast numbers and promoted inflammation-induced alveolar bone loss in vivo. However, hesperidin at a dose of 500 mg/kg exhibited a bone-sparing effect on skeletal bones under physiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
H. S. Zhang, C. X. Jiang, Y. T. Ji, Y. F. Zhang, Z. Chen, Z. G. Cao, H. Liu
Summary: The Mir338 cluster is significantly enriched in gingival tissues with periodontitis and plays a role in both inflammation and alveolar bone loss. Knockout of the Mir338 cluster in mice attenuates alveolar bone loss and affects macrophage polarization and osteoclast formation. The Mir338 cluster could be a potential therapeutic target for periodontitis-related bone loss.
JOURNAL OF DENTAL RESEARCH
(2023)
Review
Geriatrics & Gerontology
Bridget Boston, Deepak Ipe, Bogdan Capitanescu, Andrei Gresita, Stephen Hamlet, Robert Love, Michael Hadjiargyrou, Chien-Ling Huang, Iulian Nusem, Rodica Ileana Miroiu, Aurel Popa-Wagner, Patrick Hans-Heinrich Warnke, Eugen Bogdan Petcu
Summary: Medication-related osteonecrosis of the jaw (MRONJ) refers to the non-healing jawbone ulcerative-necrotic lesion appearing after dental therapy or minor trauma in patients treated previously with certain medications. Studies have been conducted to explore MRONJ's classification, clinical features, and pathophysiology, as well as its management and new trends in treatment. Conservative therapy may not be effective for severe cases of MRONJ, but new methods that promote local angiogenesis and vascularization show promise in limited trials.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Review
Biochemistry & Molecular Biology
Xin Zhao, Suryaji Patil, Fang Xu, Xiao Lin, Airong Qian
Summary: The article focuses on the importance of osteoclasts in bone metabolism and their relationship with osteoporosis, while also introducing some drug therapies targeting these molecules.
Article
Pharmacology & Pharmacy
Hao Tian, Tao Jiang, Kai Yang, Ruonan Ning, Tianqi Wang, Qi Zhou, Niandong Qian, Ping Huang, Lei Guo, Min Jiang, Xiaobing Xi, Xing Xu, Lianfu Deng
Summary: This study found that alpha-asarone (ASA), a compound derived from the traditional Chinese medicinal herb Acorus tatarinowii, can inhibit the activity of overactivated osteoclasts and reduce bone resorption. ASA's effects on osteoclastogenesis are dose-dependent and mediated through multiple signaling pathways. In an estrogen-deficiency-induced osteoporosis model, ASA also improved bone microstructure.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pathology
Suruchi Mittal, Nicola J. Brown, Ingunn Holen
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2018)
Article
Oncology
Jessalyn M. Ubellacker, Ninib Baryawno, Nicolas Severe, Molly J. DeCristo, Jaclyn Sceneay, John N. Hutchinson, Marie-Therese Haider, Catherine S. Rhee, Yuanbo Qin, Walter M. Gregory, Ana C. Garrido-Castro, Ingunn Holen, Janet E. Brown, Robert E. Coleman, David T. Scadden, Sandra S. McAllister
Article
Biochemistry & Molecular Biology
Hannah K. Brown, Gloria Allocca, Penelope D. Ottewell, Ning Wang, Nicola J. Brown, Peter I. Croucher, Colby L. Eaton, Ingunn Holen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Oncology
Lewis A. Quayle, Penelope D. Ottewell, Ingunn Holen
CLINICAL & EXPERIMENTAL METASTASIS
(2018)
Article
Oncology
Claudia Tulotta, Diane Lefley, Katy Freeman, Walter M. Gregory, Andrew M. Hanby, Paul R. Heath, Faith Nutter, J. Mark Wilkinson, Amy R. Spicer-Hadlington, Xinming Liu, Steven M. J. Bradbury, Lisa Hambley, Victoria Cookson, Gloria Allocca, Marianna Kruithof de Julio, Robert E. Coleman, Janet E. Brown, Ingunn Holen, Penelope D. Ottewell
CLINICAL CANCER RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Russell Hughes, Xinyue Chen, Keith D. Hunter, Jamie K. Hobbs, Ingunn Holen, Nicola J. Brown
Article
Oncology
Gloria Allocca, Russell Hughes, Ning Wang, Hannah K. Brown, Penelope D. Ottewell, Nicola J. Brown, Ingunn Holen
JOURNAL OF BONE ONCOLOGY
(2019)
Review
Oncology
Lubaid Saleh, Caroline Wilson, Ingunn Holen
Article
Biochemistry & Molecular Biology
Ran Ran, Hannah Harrison, Nur Syamimi Ariffin, Rahna Ayubi, Henry J. Pegg, Wensheng Deng, Andrea Mastro, Penny D. Ottewell, Susan M. Mason, Karen Blyth, Ingunn Holen, Paul Shore
Review
Physiology
Philippe Clezardin, Rob Coleman, Margherita Puppo, Penelope Ottewell, Edith Bonnelye, Frederic Paycha, Cyrille B. Confavreux, Ingunn Holen
Summary: Skeletal metastases are common complications of many cancers, significantly impacting patients' quality of life. The multistage process of bone metastasis involves various cellular and molecular mechanisms. While existing bone-targeted agents have made progress, further research and more effective treatment options are still needed.
PHYSIOLOGICAL REVIEWS
(2021)
Article
Oncology
Russell Hughes, Xinyue Chen, Natasha Cowley, Penelope D. Ottewell, Rhoda J. Hawkins, Keith D. Hunter, Jamie K. Hobbs, Nicola J. Brown, Ingunn Holen
Summary: Bone metastasis in breast cancer patients is a debilitating and incurable complication that requires further research into cellular and molecular mechanisms, as well as the development of new therapeutic strategies to improve survival rates.
Article
Oncology
Lewis A. Quayle, Amy Spicer, Penelope D. Ottewell, Ingunn Holen
Summary: Breast cancer cells can enter a dormant state and potentially recur many years later. The mechanisms of how cancer cells enter dormancy are poorly understood, but a study has identified genes that may underpin breast cancer cell dormancy. These genes could potentially inform the development of new treatments to prevent breast cancer recurrence.
Article
Oncology
Lubaid Saleh, Penelope D. Ottewell, Janet E. Brown, Steve L. Wood, Nichola J. Brown, Caroline Wilson, Catherine Park, Simak Ali, Ingunn Holen
Summary: CDK4/6 inhibitor palbociclib significantly impedes tumour growth in murine models of both estrogen receptor positive and triple negative bone metastatic breast cancer when given daily. However, tumour cells become insensitive to palbociclib after a treatment break, and the levels of key proteins may play a role in this.
Article
Oncology
Diane Lefley, Faith Howard, Fawaz Arshad, Steven Bradbury, Hannah Brown, Claudia Tulotta, Rachel Eyre, Denis Alferez, J. Mark Wilkinson, Ingunn Holen, Robert B. Clarke, Penelope Ottewell
BREAST CANCER RESEARCH
(2019)
Review
Cell Biology
Ingunn Holen, Valerie Speirs, Bethny Morrissey, Karen Blyth
DISEASE MODELS & MECHANISMS
(2017)