Article
Medicine, Research & Experimental
Xiufeng Ju, Haiyan Chen, Tongtong Miao, Jiang Ni, Liang Han
Summary: Brain metastases from breast cancer are difficult to surgically remove and have limited drug treatment options due to their growth patterns and the blood-brain barrier. By assembling prodrug-loaded nanoparticles that target both the BBB and metastatic breast cancer, researchers were able to significantly extend the survival time of mice with intracranial metastatic breast cancer, suggesting a potential important direction for drug therapy against brain metastases.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Haoan Wu, Xingchun Gao, Yuanyuan Luo, Jiang Yu, Gretchen Long, Zhaozhong Jiang, Jiangbing Zhou
Summary: The development of multifunctional polymeric nanoparticles for effective treatment of GBM is reported. The nanoparticles are designed to penetrate brain tumors through neutrophil elastase-triggered shrinkability, iRGD-mediated targeted delivery, and lexiscan-induced autocatalysis.
Article
Multidisciplinary Sciences
Jianglong Kong, Rui Zou, Ga-Lai Law, Yi Wang
Summary: In this study, a NIR PL nanoparticle TRZD was synthesized, which exhibited excellent rechargeable NIR PL in vivo and could be used for long-term autofluorescence-free imaging. TRZD could inhibit the tumor growth of glioma models and provide a promising multifunctional nanoparticle for theranostics of brain diseases.
Review
Pharmacology & Pharmacy
Sabina Quader, Kazunori Kataoka, Horacio Cabral
Summary: CNS tumors are highly lethal and treatment-resistant, mainly due to the difficulty of delivering drugs to the brain tumor site. Supramolecular nanomedicines show promise in addressing this challenge and improving brain tumor targeting.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Meng Tian, Rui Xing, Juan Guan, Bingxue Yang, Xin Zhao, Juanjuan Yang, Changyou Zhan, Shiyi Zhang
Summary: A newly designed nanoantidote can neutralize chemotherapy agents in normal cells without entering tumors, demonstrating an effective way to reduce chemotoxicity while maintaining therapeutic efficacy.
Article
Chemistry, Multidisciplinary
Giulia Birolini, Marta Valenza, Ilaria Ottonelli, Alice Passoni, Monica Favagrossa, Jason T. Duskey, Mauro Bombaci, Maria Angela Vandelli, Laura Colombo, Renzo Bagnati, Claudio Caccia, Valerio Leoni, Franco Taroni, Flavio Forni, Barbara Ruozi, Mario Salmona, Giovanni Tosi, Elena Cattaneo
Summary: This study demonstrates the potential benefits of using hybrid-g7-NPs-chol for delivering cholesterol to the brain in Huntington's disease (HD) treatment. The nanoparticles can efficiently target neural cells and release cholesterol in a controlled manner within the brain, leading to improved cognitive function and motor defects in HD animals without inflammatory reactions. The findings suggest that this novel approach could be a promising strategy for treating HD by enhancing endogenous cholesterol biosynthesis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Melgious Jin Yan Ang, Jeehyun Yoon, Mingzhu Zhou, Han-Lin Wei, Yi Yiing Goh, Zhenglin Li, Jia Feng, Haifang Wang, Qianqian Su, Derrick Sek Tong Ong, Xiaogang Liu
Summary: Nanoparticles modified with ligands can cross the blood-brain barrier, endocytose into the lysosomes of glioblastoma cells, and undergo endolysosomal escape under photochemical ionization. Metronomic chemotherapy using dual-drug-loaded nanocarriers can induce an enhanced antitumor effect 3.5 times greater than standard chemotherapy.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yan Zou, Yibin Wang, Sen Xu, Yanjie Liu, Jinlong Yin, David B. Lovejoy, Meng Zheng, Xing-Jie Liang, Jong Bae Park, Yuri M. Efremov, Ilya Ulasovand, Bingyang Shi
Summary: A new type of GBM-cell membrane camouflaged and pH-sensitive biomimetic nanoparticles have been developed for combined TMZ and CDDP therapy for GBM. The results show that these nanoparticles can efficiently transport drugs across the blood-brain barrier and specifically target GBM, allowing for controlled release at GBM sites and demonstrating potent anti-GBM effects without obvious side effects.
ADVANCED MATERIALS
(2022)
Review
Polymer Science
Camelia-Elena Tincu (Iurciuc), Calin Vasile Andritoiu, Marcel Popa, Lacramioara Ochiuz
Summary: This paper reviews the characteristics and treatment of glioblastoma, as well as the structure and function of the blood-brain barrier. It also emphasizes the role of albumin in treating glioblastoma and highlights the progress in albumin nanoparticle technology.
Article
Polymer Science
Bijuli Rabha, Kaushik Kumar Bharadwaj, Siddhartha Pati, Bhabesh Kumar Choudhury, Tanmay Sarkar, Zulhisyam Abdul Kari, Hisham Atan Edinur, Debabrat Baishya, Leonard Ionut Atanase
Summary: Brain cancers, particularly high-grade gliomas/glioblastoma, have poor prognosis despite conventional treatments due to issues like the blood-brain barrier. Nanotheranostics, combining imaging and therapies, can improve treatment efficacy, while polymer nanoparticles are gaining attention for their precise targeting and minimal adverse effects in drug delivery.
Article
Pharmacology & Pharmacy
Yu-Chen Lo, Wen-Jen Lin
Summary: The study utilized a peptide-conjugated nano-delivery system to enhance penetration into tumor cells by overcoming the blood brain barrier. NPs conjugated with T7 peptide showed higher accumulation in the brain and lower biodistribution in nontarget tissues. The benefit of T7 peptide as a targeting ligand for NPs across the BBB was elucidated in this study.
Review
Chemistry, Multidisciplinary
Jianglong Kong, Runxuan Chu, Yi Wang
Summary: Stroke is a major cause of death and disability worldwide. Neuroprotective therapy, combined with thrombolytic therapy, is an important treatment for stroke.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Polymer Science
Jisan Ahamed, B. H. Jaswanth Gowda, Waleed H. Almalki, Neelima Gupta, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Malignant brain tumors have a poor prognosis and low survival rate due to the challenges in drug delivery, including crossing the blood-brain barrier, achieving optimal drug distribution within the tumor, and minimizing damage to healthy cells. Nanotechnology has emerged as a promising approach for brain tumor treatment by using nanoparticles to overcome these obstacles.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Engineering, Environmental
Zengjin Wang, Congcong Zhang, Fengyan Huang, Xiaojing Liu, Zhiping Wang, Bing Yan
Summary: Ingestion of nanoparticles during pregnancy can be dangerous to fetal brain development, especially in early pregnancy. Experimental results show that nanoparticles can cross multiple biological barriers, and the toxicity to the fetus depends on the stages of pregnancy and fetal development.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Nanoscience & Nanotechnology
SeongHoon Jo, In-Cheol Sun, Cheol-Hee Ahn, Sangmin Lee, Kwangmeyung Kim
Summary: The blood-brain barrier poses a challenge to the delivery of imaging probes and therapeutic agents to the brain. Methods like ultrasound-mediated nano-particle delivery and photoacoustic brain imaging have emerged as potential solutions. Focused ultrasound is a popular means of enhancing drug delivery through temporary opening of the blood-brain barrier, while photoacoustic brain imaging uses light-to-heat conversion and ultrasound detection to visualize brain morphologies or diseases. The versatility of nanoparticles allows for successful brain imaging and treatment through the combined action of ultrasound and nanoparticulate agents.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Biomedical
Johnson V. John, Alec McCarthy, Yajuan Su, Daniel N. Ackerman, S. M. Shatil Shahriar, Mark A. Carlson, St. Patrick Reid, Joshua L. Santarpia, Wuqiang Zhu, Jingwei Xie
Summary: This study presents a novel nanofiber capsule that can be used for minimally invasive collection of biological samples, facilitating early diagnosis and screening of various diseases.
ACTA BIOMATERIALIA
(2022)
Article
Materials Science, Multidisciplinary
Xiping Jiang, Yunfan Kong, Mitchell Kuss, Joel Weisenburger, Hani Haider, Robert Harms, Wen Shi, Bo Liu, Wen Xue, Jianghu Dong, Jingwei Xie, Philipp Streubel, Bin Duan
Summary: This study presents a novel therapeutic method that combines three-dimensional (3D) bioprinting and melt electrospinning writing techniques to regenerate the tendon-to-bone interface. The use of 3D-bioprinted pre-differentiated autologous adipose-derived mesenchymal stem cells (ADMSC) generated biomimetic multilayered scaffolds that recapitulated the compositional and cellular structures of the interface. In vivo studies demonstrated the superior histological score and improved collagen organization of the scaffold with spatially differentiated autologous ADMSCs.
APPLIED MATERIALS TODAY
(2022)
Article
Multidisciplinary Sciences
Bing Xu, Fan Li, Wenjing Zhang, Yajuan Su, Ling Tang, Pengsheng Li, Jyotsna Joshi, Aaron Yang, Dong Li, Zhao Wang, Shu Wang, Jingwei Xie, Haiwei Gu, Wuqiang Zhu
Summary: The research findings suggest that FGF1 and CHIR99021 protect the heart against ischemic injury by improving myocardial metabolism, which may have important implications for the treatment of acute myocardial infarction in humans.
Article
Engineering, Biomedical
Yajuan Su, Navatha Shree Sharma, Johnson V. John, Gitali Ganguli-Indra, Arup K. Indra, Adrian F. Gombart, Jingwei Xie
Summary: Engineered exosomes treated with immunomodulating compounds exhibit multiple biological functions and contain more cathelicidin. They have great potential in therapeutic applications for infection management, wound healing, and tissue regeneration.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Multidisciplinary Sciences
Ganggang Zhao, Yun Ling, Yajuan Su, Zanyu Chen, Cherian J. Mathai, Ogheneobarome Emeje, Alexander Brown, Dinesh Reddy Alla, Jie Huang, Chansong Kim, Qian Chen, Xiaoqing He, David Stalla, Yadong Xu, Zehua Chen, Pai-Yen Chen, Shubhra Gangopadhyay, Jingwei Xie, Zheng Yan
Summary: Laser scribing of metallic conductive transition metal oxides on soft elastomers has been achieved, with high electrical conductivity, biocompatibility, chemical stability, and compatibility with magnetic resonance imaging. This method shows potential for constructing bioelectronics and soft actuators.
Article
Chemistry, Multidisciplinary
Johnson John, Navatha Shree Sharma, Guosheng Tang, Zeyu Luo, Yajuan Su, Shelbie Weihs, S. M. Shatil Shahriar, Guangshun Wang, Alec McCarthy, Justin Dyke, Yu Shrike Zhang, Ali Khademhosseini, Jingwei Xie
Summary: This study introduces a strategy to use nanofiber aerogels combined with the LL-37-mimic peptide W379 for accelerated healing of diabetic wounds, showing great potential for clinical applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Yajuan Su, Jaime T. Yrastorza, Mitchell Matis, Jenna Cusick, Siwei Zhao, Guangshun Wang, Jingwei Xie
Summary: This review article discusses the threat of biofilms to human health, explores the mechanisms of biofilm formation and treatment strategies, and summarizes established biofilm models used in research. Furthermore, it discusses potential targets for the development of new strategies to combat biofilms and presents the latest technologies for the prevention and treatment of biofilms. The article concludes by pointing out directions for future studies.
Article
Dermatology
Huy Quang Tran, S. M. Shatil Shahriar, Zheng Yan, Jingwei Xie
Summary: Nowadays, wound dressings have evolved to incorporate various functional components that not only protect wounds but also accelerate healing and monitor wound-healing status. The advances in nanotechnologies and materials science have paved the way for the development of functional wound dressings. However, understanding the structure and composition of wound dressings is crucial for their successful application.
ADVANCES IN WOUND CARE
(2023)
Article
Chemistry, Multidisciplinary
Fan Zhao, Yajuan Su, Junying Wang, Svetlana Romanova, Dominick J. DiMaio, Jingwei Xie, Siwei Zhao
Summary: Biofilm infection in chronic wounds is common and delays wound healing. This paper describes a highly effective electrical antibiofilm treatment system that uses high-intensity current to debride biofilm and enhance antibiotic delivery. The system reduces bacterial count of MRSA biofilm-infected ex vivo skin wounds and demonstrates in vivo antibiofilm efficacy in a diabetic mouse-based wound infection model. This novel technology provides a quick, safe, and highly efficacious treatment for chronic wound biofilm infections.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Alec McCarthy, Navatha Shree Sharma, Phil A. Holubeck, Demi Brown, Rajesh Shah, Daniel McGoldrick, Johnson V. John, S. M. Shatil Shahriar, Jingwei Xie
Summary: Drawing inspiration from biological systems, researchers have developed a biomaterial interface that can reversibly interlock using electrostatic flocking. This technology has potential applications in tissue engineering and biomedical devices, as it improves cell survivability and enhances compression and shearing resistance. By introducing extracellular matrix reinforcement, the interlocking interface can serve as a binder for modular tissue engineering, a scaffold for tissue interfaces, or a friction-based coupler.
ADVANCED MATERIALS
(2023)
Article
Medicine, Research & Experimental
Aaron P. Decker, Yajuan Su, Biswajit Mishra, Atul Verma, Tamara Lushnikova, Jingwei Xie, Guangshun Wang
Summary: This study investigates the effects of peptide stability on antimicrobial and antibiofilm activity and finds that peptide antimicrobial activity is critical for in vivo efficacy. Using a nanofiber/microneedle delivery device can protect peptides from degradation and provide a new approach for direct use of natural peptides or their cocktails for antimicrobial treatment.
MOLECULAR PHARMACEUTICS
(2023)
Article
Multidisciplinary Sciences
Yadong Xu, Yajuan Su, Xianchen Xu, Brian Arends, Ganggang Zhao, Daniel N. Ackerman, Henry Huang, St. Patrick Reid, Joshua L. Santarpia, Chansong Kim, Zehua Chen, Sana Mahmoud, Yun Ling, Alexander Brown, Qian Chen, Guoliang Huang, Jingwei Xie, Zheng Yan
Summary: We report a phase separation-based synthesis of porous liquid metal-elastomer composites with high leakage resistance and antimicrobial property, along with large stretchability, tissue-like compliance, high and stable electrical conductivity over deformation, high breathability, and magnetic resonance imaging compatibility. The enabled skin-interfaced bioe-lectronics can monitor cardiac electrical and mechanical activities and offer electrical stimulations in a mechanically imperceptible and electrically stable manner even during motions.
Review
Materials Science, Biomaterials
Donghee Lee, Kai Yang, Jingwei Xie
Summary: Regeneration and functional recovery of damaged nerves are challenging. Microfluidic devices in combination with injury techniques have been applied to test biological hypotheses in nerve injury and regeneration. In this article, current in vitro nerve injury models on a chip that mimic in vivo axonal injuries and the regeneration process of axons are summarized.
Article
Chemistry, Multidisciplinary
Yun Ling, Ganggang Zhao, Yajuan Su, Qian Wu, Yadong Xu, Zehua Chen, Brian Arends, Ogheneobarome Emeje, Guoliang Huang, Jingwei Xie, Zheng Yan
Summary: This study reports the design, fabrication, and biomedical application of porous mesh bioelectronics that exhibit skin-inspired nonlinear mechanics and other desired features. By combining porous serpentine meshes of polyimide (PI) with ultrasoft, sticky, and antibacterial polydimethylsiloxane (PDMS), the porous hybrid meshes not only retain skin-like nonlinear mechanical properties but also enable the integration of both soft and hard bioelectronic components. This study exemplifies the integration of electrophysiological sensors and commercial accelerometers on multifunctional porous meshes for monitoring heart electrical and mechanical functions.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yajuan Su, Syed Muntazir Andrabi, S. M. Shatil Shahriar, Shannon L. Wong, Guangshun Wang, Jingwei Xie
Summary: This study presents a near-infrared (NIR) light-responsive microneedle patch that can release antimicrobial peptide for the treatment of wound biofilms. The patch contains IR780 iodide as a photothermal conversion agent and molecularly engineered peptide W379 as an antimicrobial agent, loaded in dissolvable PVP microneedles and coated with a phase change material TD. When exposed to NIR light, the patch releases the antimicrobial peptide, showing high antibacterial efficacy in vitro. This microneedle system also demonstrates excellent antibiofilm activities in ex vivo and in vivo experiments and has the potential to deliver other antimicrobial agents.
JOURNAL OF CONTROLLED RELEASE
(2023)