Article
Immunology
Stuart Astbury, Catherine J. Reynolds, David K. Butler, Diana C. Munoz-Sandoval, Kai-Min Lin, Franziska P. Pieper, Ashley Otter, Afroditi Kouraki, Lola Cusin, Jessica Nightingale, Amrita Vijay, Simon Craxford, Guruprasad P. Aithal, Patrick J. Tighe, Joseph M. Gibbons, Corinna Pade, George Joy, Mala Maini, Benny Chain, Amanda Semper, Timothy Brooks, Benjamin J. Ollivere, Aine McKnight, Mahdad Noursadeghi, Thomas A. Treibel, Charlotte Manisty, James C. Moon, Ana M. Valdes, Rosemary J. Boyton, Daniel M. Altmann
Summary: SARS-CoV-2 infection can lead to a range of outcomes, influenced by factors such as challenge dose, age, gender, comorbidity, and host genomic variation. Human leukocyte antigen (HLA) polymorphisms may affect immune response and disease outcomes. This study investigated the association between HLA-II alleles and symptomatic COVID-19, virus-specific antibody, and T-cell immunity in UK healthcare workers (HCWs). The results showed that certain HLA-II alleles were associated with an increased risk of symptomatic COVID-19 and altered immune responsiveness to viral proteins.
Article
Immunology
Cassandra Ballou, Franca Barton, Elizabeth H. Payne, Thierry Berney, Jean Villard, Raphael P. H. Meier, David Baidal, Rodolfo Alejandro, Mark Robien, Thomas L. Eggerman, Malek Kamoun, Yannick D. Muller
Summary: The exact contribution of HLA matching to graft survival in pancreatic islet transplantation remains unclear. This study evaluated the impact of HLA-DR matching, including the presence of diabetogenic HLA-DR3 or HLA-DR4 matches, on long-term islet survival.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Hiroki Yamada, Takanori Sasaki, Kotaro Matsumoto, Katsuya Suzuki, Masaru Takeshita, Shuhei Tanemura, Noriyasu Seki, Hideto Tsujimoto, Tsutomu Takeuchi
Summary: The study found that HLA-DR+ Tph cells were correlated with DAS28-ESR, while HLA-DR- Tph cells accurately reflected disease activity during treatment. MTX treatment independently reduced the proportion of HLA-DR+ Tph cells.
Article
Immunology
Hamza Arshad Dar, Fahad Nasser Almajhdi, Shahkaar Aziz, Yasir Waheed
Summary: This study designed and evaluated a potential multi-epitope vaccine against RSV using immunoinformatics. The vaccine was found to be stable, non-allergenic, flexible, and antigenic. Computational immune simulation results indicated that the vaccine could generate a high titer of antibodies and effector T-cells, making it a promising candidate for stimulating humoral and cellular responses against RSV infection.
Article
Biochemistry & Molecular Biology
Suresh Kumar, Johannes Koenig, Andreas Schneider, Fredrik Wermeling, Sanjaykumar Boddul, Sebastian J. Theobald, Miriam Vollmer, Doreen Kloos, Nico Lachmann, Frank Klawonn, Stefan Lienenklaus, Steven R. Talbot, Andre Bleich, Nadine Wenzel, Constantin von Kaisenberg, James Keck, Renata Stripecke
Summary: This study demonstrates that a modular lentiviral system can enhance cellular immune responses in HIS-mice, promoting increased lymph node cellularity, maturation of terminal effector CD4(+) T cells, and significantly higher development of IgG(+) and IgA(+) B cells. This approach opens up new possibilities for basic human immunology research and preclinical use of lentiviral vectors to deliver HLAs into HIS-mice.
Article
Biochemistry & Molecular Biology
Pallavi M. Shanthappa, Renuka Suravajhala, Prashanth Suravajhala, Geetha Kumar, Nidheesh Melethadathil
Summary: This study focuses on identifying new epitopes from databases and constructing a multi-epitope based vaccine against Norovirus. The developed vaccine candidate shows good solubility and stability, providing a potential solution for further experimental investigations.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Virology
A. K. M. Muraduzzaman, Patricia T. Illing, Nicole A. Mifsud, Anthony W. Purcell
Summary: Influenza A virus is a respiratory pathogen that causes significant damage to life and the economy. Current vaccines do not provide sufficient cross-protection, while vaccines that induce CD8(+) T cells have shown promise in providing cross-protection against different strains of the virus.
Article
Biochemical Research Methods
Bayo Lau, Prashant S. Emani, Jackson Chapman, Lijing Yao, Tarsus Lam, Paul Merrill, Jonathan Warrell, Mark B. Gerstein, Hugo Y. K. Lam
Summary: This paper presents a hybrid classical-quantum workflow for computer-aided drug design, specifically targeting ligand-protein binding in the presence of genetic mutations. By using quantum machine learning to infer mutation impact, the study identifies the mutation-impact predictor as the best candidate for quantum replacement. The results show that the quantum machine learning models can perform as well as, if not better than, classical baselines.
Article
Biochemistry & Molecular Biology
Kenji Tanimura, Shigeru Saito, Sayaka Tsuda, Yosuke Ono, Hajime Ota, Shinichiro Wada, Masashi Deguchi, Mikiya Nakatsuka, Takeshi Nagamatsu, Tomoyuki Fujii, Gen Kobashi, Hisashi Arase, Hideto Yamada
Summary: The anti-beta 2-glycoprotein I/HLA-DR antibody is associated with antiphospholipid syndrome and recurrent pregnancy loss. This study demonstrates that the antibody is significantly associated with adverse obstetric outcomes and recurrent pregnancy loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Guilhem Richard, Anne S. De Groot, Gary D. Steinberg, Tzintzuni Garcia, Alec Kacew, Matthew Ardito, William D. Martin, Gad Berdugo, Michael F. Princiotta, Arjun Balar, Randy F. Sweis
Summary: Utilizing the immunoinformatic system Ancer for neoantigen analysis can enhance risk stratification and survival prediction accuracy, demonstrating superior performance in bladder cancer research.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Hamid Reza Jahantigh, Behzad Shahbazi, Hamed Gouklai, Hans van der Weken, Zahra Gharibi, Zahra Rezaei, Mehri Habibi, Khadijeh Ahmadi
Summary: Monkeypox, a zoonotic virus, has become a public health emergency of international concern. Previous research suggests that smallpox vaccines may offer some protection against Monkeypox. This study used bioinformatics techniques to develop a multi-epitope vaccine candidate that can induce a strong immune response.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Bibiana Quirant-Sanchez, Oriol Plans-Galvan, Ester Lucas, Eduard Argudo, Eva Maria Martinez-Caceres, Fernando Armestar
Summary: The early identification and treatment of at-risk patients with sepsis is crucial for reducing mortality. This study assessed the correlation between HLA-DR expression on monocytes ((M)HLA-DR ratio), sepsis index (CD64 expression on neutrophils/(M)HLA-DR ratio), C-reactive protein (CRP), and sepsis development. Biomarkers were tested in 77 critically ill patients over a period of 15 days. Most patients (71%) developed sepsis within 4.2±1.3 days after admission. On day 3, patients who subsequently developed sepsis had lower (M)HLA-DR+ levels and higher sepsis indexes compared to those who did not develop sepsis. The (M)HLA-DR ratio recovered slowly before day 6, while the sepsis index remained elevated up to day 9 in septic patients. Optimal cut-offs for predicting sepsis development were CRP levels > 106.90 mg/mL and (M)HLA-DR expression rate < 72.80%. Periodic monitoring of (M)HLA-DR expression, CRP, and sepsis index may help identify high-risk sepsis patients in the ICU.
Article
Biochemistry & Molecular Biology
Md Chayan Ali, Mst Shanzeda Khatun, Sultana Israt Jahan, Raju Das, Yeasmin Akter Munni, Md Mafizur Rahman, Raju Dash
Summary: This study aimed to design an effective epitope-based peptide vaccine against NTS species, utilizing immunoinformatics and molecular modeling approaches, to identify promising T and B cell epitopes and construct a multiepitope vaccine with good affinity and stability. In silico immune simulation showed a strong immune response, suggesting the potential of the predicted vaccine constructs as candidates against common NTS species.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Immunology
Mingkai Yu, Yuejie Zhu, Yujiao Li, Zhiqiang Chen, Tong Sha, Zhiwei Li, Fengbo Zhang, Jianbing Ding
Summary: This study developed a multi-epitope vaccine against Echinococcus granulosus using immunoinformatics tools and molecular docking methods. The vaccine was able to activate B lymphocytes to produce specific antibodies for protection against infection, as well as activate T lymphocytes to clear the parasites in the body. In vivo and in vitro experiments confirmed the vaccine's good antigenicity and immunogenicity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mahour Farzan, Mahan Farzan, Yousef Mirzaei, Sara Aiman, Fatemeh Azadegan-Dehkordi, Nader Bagheri
Summary: This study aims to develop a multi-epitope vaccine for monkeypox virus (MPXV) by analyzing protein sequences and selecting effective epitopes. The vaccine showed good safety and immunogenicity. However, further experiments are needed to validate these results.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)