Review
Immunology
Ewa Oleszycka, Kamila Kwiecien, Patrycja Kwiecinska, Agnieszka Morytko, Natalia Pocalun, Michelle Camacho, Piotr Brzoza, Brian A. A. Zabel, Joanna Cichy
Summary: The skin, as the largest organ exposed to the environment, plays a critical role in integrating signals and defending against external threats. The interactions between the epidermis, immune system, and nervous system are now recognized for their importance in regulating and maintaining the skin barrier function in relation to skin pathophysiology. Dysregulation of these connections can lead to chronic inflammatory diseases and conditions associated with chronic pain or itch.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Fabrice Cognasse, Anne Claire Duchez, Estelle Audoux, Theo Ebermeyer, Charles Antoine Arthaud, Amelie Prier, Marie Ange Eyraud, Patrick Mismetti, Olivier Garraud, Laurent Bertoletti, Hind Hamzeh-Cognasse
Summary: Platelets are anucleate cytoplasmic fragments derived from medullary megakaryocytes. They form platelet plugs by adhering to damaged endothelium and secrete growth factors that contribute to platelet aggregation and vascular repair. Platelets also play a major role in inflammation and immune defense through receptors and lectins. Additionally, platelet activation leads to the release of inflammatory mediators and direct activation of immune cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
P. Chieosilapatham, C. Kiatsurayanon, Y. Umehara, J. V. Trujillo-Paez, G. Peng, H. Yue, L. T. H. Nguyen, F. Niyonsaba
Summary: The skin serves as a complex immune organ, with keratinocytes playing a crucial role in the pathogenesis of atopic dermatitis. Activation of keratinocytes contributes to immune dysregulation and biological processes that drive the development of atopic dermatitis. Understanding the innate immune functions of keratinocytes can provide insights into the pathophysiological processes of atopic dermatitis and aid in the development of new therapeutic approaches.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Immunology
Ekramy E. Sayedahmed, Nelly O. Elshafie, Guangjun Zhang, Sulma I. Mohammed, Suryaprakash Sambhara, Suresh K. Mittal
Summary: The bovine adenovirus vector platform induces enhanced innate and adaptive immunity compared to the human adenovirus vector platform in mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Annette Ives, Didier Le Roy, Charlotte Theroude, Juergen Bernhagen, Thierry Roger, Thierry Calandra
Summary: The cytokine MIF plays a chemokine-like role in promoting the migration of dendritic cells (DCs) by activating the Src/PI3K signaling pathway and myosin II complexes. MIF contributes to the recruitment of DCs to draining lymph nodes through autocrine and paracrine activities acting via CD74. These findings indicate that MIF is crucial for DC motility and trafficking.
Review
Biochemistry & Molecular Biology
Hanjiang Gu, Yufei Zhang, Weihui Zeng, Yumin Xia
Summary: Interferons play a crucial role in the pathogenesis of psoriasis by directly affecting skin resident cells, recruiting and modulating inflammatory cells, and exacerbating inflammation response.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Article
Medicine, Research & Experimental
Gabsik Yang, Hye Eun Lee, Magdalena Trzeciak, Tadeusz Pawelczyk, Osamu Takeuchi, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee
Summary: Regnase-1 downregulation is observed in both atopic dermatitis patients and mice. Regnase-1 deficiency leads to global changes in gene expression related to innate immune and inflammatory responses, particularly chemokines. The levels of Regnase-1 in the skin are inversely related to chemokine expression in both atopic dermatitis patients and Regnase-1-deficient mice, indicating that enhanced chemokine production contributes to increased inflammation at lesion sites. Subcutaneous administration of recombinant Regnase-1 significantly improves atopic dermatitis-like skin inflammation with reduced chemokine production in a mouse model. These findings suggest that Regnase-1 plays a crucial role in maintaining skin immune homeostasis and regulating chemokine expression, making it a potential therapeutic target for chronic inflammatory diseases like atopic dermatitis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Mohamed L. Sobah, Aimee C. Scott, Miranda Laird, Cassandra Koole, Clifford Liongue, Alister C. Ward
Summary: By investigating the zebrafish socs3b gene, it was found that socs3b gene plays a critical role in regulating neutrophil production and macrophage activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Zhi-Hong Wang, Yu Feng, Qingfang Hu, Xue-Long Wang, Li Zhang, Teng-Teng Liu, Jiang-Tao Zhang, Xiaohua Yang, Qing-Yue Fu, Dan-Ni Fu, Ji Hu, Tong Liu
Summary: The roles of keratinocyte TLR2 and TLR7 signaling pathways in the pathogenesis of chronic itch are distinct.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nuri Choi, Gabsik Yang, Joo Hyeon Jang, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee
Summary: The study found that loganin can prevent gout inflammation by inhibiting the NLRP3 inflammasome and reducing neutrophil recruitment. Additionally, loganin blocks mitochondrial DNA synthesis and inhibits mitochondrial damage, thus preventing the occurrence of gout inflammation.
Review
Immunology
Edries Yousaf Hajam, Patricia Panikulam, Chung-Ching Chu, Haarshadri Jayaprakash, Amitabha Majumdar, Colin Jamora
Summary: As the interface between the body and the environment, the skin not only acts as a physical barrier, but also as an immunologically active organ. Regulatory T cells (T-regs) play a crucial role in maintaining homeostasis, clearing pathogens, and promoting wound healing. Recent studies have uncovered non-lymphoid functions of cutaneous T-regs, suggesting that they have executive control over various biological activities in the skin. These findings highlight the importance of T-regs and their potential role in future discoveries in the field of regenerative medicine.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Daniel Prantner, Shreeram Nallar, Katharina Richard, David Spiegel, Kim D. Collins, Stefanie N. Vogel
Summary: MG, a highly reactive compound, may be produced by M1 macrophages during sepsis, contributing to over-exuberant inflammation.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Immunology
John T. Schroeder, Anja P. Bieneman
Summary: COVID-19, caused by SARS-CoV-2, has become a global pandemic with significant health and socioeconomic consequences. Infection with SARS-CoV-2 can lead to lung injury and acute respiratory distress syndrome (ARDS), possibly due to a dysregulated innate immune response or cytokine release syndrome (CRS). The spike protein of SARS-CoV-2 plays a crucial role in the infection process, and recent research has shown that the S1 subunit can activate monocytes to produce cytokines associated with CRS in COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Lige Wu, Weiqing Zhao, Shuxian Tang, Rui Chen, Mei Ji, Xin Yang
Summary: This review examines the role of ILC2s in solid tumors and highlights their crucial regulatory role in tumor immunity. ILC2s may serve as an important predictor for tumor prognosis and a new therapeutic target after immunotherapy resistance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Yudai Matsui, Naoki Takemura, Yoshitaka Shirasaki, Michihiro Takahama, Yoshihiko Noguchi, Kenta Ikoma, Yixi Pan, Shuhei Nishida, Manabu Taura, Akiyoshi Nakayama, Takashi Funatsu, Takuma Misawa, Yoshie Harada, Toshiaki Sunazuka, Tatsuya Saitoh
Summary: In this study, the compound NNM-E derived from Streptomyces was found to effectively inhibit the inflammatory response mediated by NLRP3 inflammasome, with low toxicity.
INTERNATIONAL IMMUNOLOGY
(2022)