Article
Geriatrics & Gerontology
Hiromi Sano, Atsushi Nambu
Summary: ZNS is an anticonvulsant drug that has beneficial effects on Parkinson's disease and its side effect, L-DOPA-induced dyskinesia, but can also have adverse effects.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Jinyoung Youn, Mansu Kim, Suyeon Park, Ji Sun Kim, Hyunjin Park, Jin Whan Cho
Summary: This study investigates the structural changes in the basal ganglia related to levodopa-induced dyskinesia (LID) in Parkinson's disease (PD). The results demonstrate distinct shape alterations, especially in the globus pallidus interna (GPi), in the LID group compared to the non-LID group. These findings suggest the crucial role of the basal ganglia pathway in the development of LID.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Maria Saez, Ettel Keifman, Samuel Alberquilla, Camila Coll, Ramon Reig, Mario Gustavo Murer, Rosario Moratalla
Summary: This study found that D2-type dopamine receptors and the striatopallidal pathway play important roles in modulating dyskinesia, and suggest that targeting striatopallidal axon terminals at the GPe may have therapeutic potential in the management of LID.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Abdeslam Chagraoui, Giuseppe Di Giovanni, Philippe De Deurwaerdere
Summary: The discovery of the D3 receptor has sparked interest in the field of neurological diseases, particularly Parkinson's disease. This article discusses the role of D3 receptors in Parkinson's disease and their relationship with current treatments, highlighting the potential interactions between D1 and D3 receptors that may contribute to motor side effects.
Article
Biochemistry & Molecular Biology
Mitchell J. Bartlett, Omar S. Mabrouk, Lajos Szabo, Andrew J. Flores, Kate L. Parent, Jean M. Bidlack, Michael L. Heien, Robert T. Kennedy, Robin Polt, Scott J. Sherman, Torsten Falk
Summary: The study examined a glycopeptide BBI-11008 with selective delta-opioid receptor agonism, showing good central penetration and effects on levodopa-induced dyskinesia in rats. The results suggest a balance of mu- and delta-opioid agonism is required for modulation in this model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Rayanne Poletti Guimaraes, Danilo Leandro Ribeiro, Keila Bariotto dos Santos, Livea Dornela Godoy, Mirella Rosine Correa, Fernando Eduardo Padovan-Neto
Summary: The motor symptoms of Parkinson's disease are primarily caused by neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta and dopaminergic striatal deficit. Animal models are widely used to simulate PD pathology in the laboratory, with rodents being the most commonly used due to their ease of handling and maintenance.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Neurosciences
Alexandra B. Nelson, Allison E. Girasole, Hsien-Yang Lee, Louis J. Ptacek, Anatol C. Kreitzer
Summary: Abnormal involuntary movements, or dyskinesias, are observed in various neurologic disorders, and may be caused by alterations in neural activity or connectivity. This study shows that dysfunction in the indirect pathway of the striatum contributes to the development of dyskinesia in a mouse model, suggesting that hypoactivity in the indirect pathway may be a key mechanism for involuntary movements in other disorders.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Mariangela Scarduzio, Ellen J. Hess, David G. Standaert, Karen L. Eskow Jaunarajs
Summary: This review provides an overview of synaptic dysfunctions and neurochemical alterations in hyperkinetic movement disorders, including changes in synaptic plasticity and neuromodulation.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Multidisciplinary Sciences
Clara Rodriguez-Sabate, Manuel Rodriguez, Ingrid Morales
Summary: Two new recurrence plot methods were introduced to study the long-term dynamics and interactions between different brain regions. These methods were applied to compare interactions between patients with Parkinson's disease and healthy controls, revealing disruptions in interactions that may contribute to motor disorders and side effects of dopaminergic drugs.
Article
Neurosciences
Zhihua Liu, Aijuan Yan, Jiahao Zhao, Shuyuan Yang, Lu Song, Zhenguo Liu
Summary: The study revealed the important role of p75NTR in patients with Parkinson's disease and suggested it as a new target for managing L-dopa-induced dyskinesia.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Weitang Liu, Wenwen Lao, Renxing Zhang, Hongyan Zhu
Summary: Parkinson's disease is characterized by the degeneration of dopaminergic neurons in the substantia nigra (SN), leading to motor deficits. This study found alterations in the expression of Nav1.1 sodium channels in the basal ganglia (BG) of a PD animal model, with reduced levels in dopaminergic neurons of the SN and increased levels in parvalbumin-positive neurons of the globus pallidus (GP). Blocking these channels with phenytoin improved motor disabilities and reduced synchronous oscillations in the BG.
BRAIN RESEARCH BULLETIN
(2021)
Article
Computer Science, Artificial Intelligence
Arooj Nawaz, Osman Hasan, Shaista Jabeen
Summary: Deep brain stimulation (DBS) is a widely accepted treatment for Parkinson's disease (PD). Traditional DBS is always ON and can cause side effects. Closed-loop DBS allows adjusting stimulation according to patient needs, addressing this problem.
NEURAL COMPUTATION
(2023)
Article
Biochemistry & Molecular Biology
Tung-Tai Kuo, Yuan-Hao Chen, Vicki Wang, Eagle Yi-Kung Huang, Kuo-Hsing Ma, Nigel H. H. Greig, Jin Jung, Ho- Choi, Lars Olson, Barry J. J. Hoffer, Kuan-Yin Tseng
Summary: This study evaluated the efficacy of PT320 on L-DOPA-induced dyskinetic behaviors and neurochemistry in a progressive Parkinson's disease MitoPark mouse model. The results showed that early administration of PT320 significantly reduced the severity of L-DOPA-induced abnormal involuntary movements, particularly in excessive standing and abnormal paw movements. However, late administration of PT320 did not improve any L-DOPA-induced dyskinesia measurements. Furthermore, early treatment with PT320 increased both tonic and phasic release of dopamine in striatal slices, indicating its potential role in alleviating L-DOPA-induced dyskinesia in Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Vaibhav Jain, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Hafiz A. Makeen, Mohammed Albratty, Abdulkarim M. Meraya, Asim Najmi
Summary: Parkinson's disease is a neurodegenerative disorder characterized by loss of dopaminergic nerve cells due to oxidative stress. Symptoms include muscle stiffness, disturbed sleep, fatigue, and voice impairment. Recent studies have shown that certain cannabinoids act as antioxidants and may protect nerve cells from degeneration. Combining cannabinoids with existing drugs could potentially revolutionize the treatment of Parkinson's disease, offering new hope for patients suffering from this debilitating illness.
NEUROTOXICITY RESEARCH
(2023)
Article
Neurosciences
M. Angela Cenci, Katrine Skovgard, Per Odin
Summary: Dopamine replacement therapy is the most effective treatment for Parkinson's disease, but it is limited by its side effects. Recent evidence suggests that altered dopamine transmission affects non-dopaminergic neurotransmitter systems in the brain. Researchers are exploring drugs that target non-dopaminergic receptors to improve the side effects of dopamine replacement therapy. This review discusses the different non-dopaminergic targets that have been studied, with a particular focus on modulators of glutamatergic and serotonergic transmission.
Article
Geriatrics & Gerontology
Giulia Costa, Maria Jose Sisalli, Nicola Simola, Salvatore Della Notte, Maria Antonietta Casu, Marcello Serra, Annalisa Pinna, Antonio Feliciello, Lucio Annunziato, Antonella Scorziello, Micaela Morelli
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Article
Neurosciences
Aurora Musa, Nicola Simola, Gessica Piras, Francesca Caria, Emmanuel Shan Onaivi, Maria Antonietta De Luca
Article
Neurosciences
Giulia Costa, Stefan Spulber, Elena Paci, Maria Antonietta Casu, Sandra Ceccatelli, Nicola Simola, Micaela Morelli
Summary: The study suggests that prenatal exposure to glucocorticoids may increase the susceptibility to central toxicity of amphetamine-related drugs used later in life in an age-dependent manner. Prenatal exposure to high levels of glucocorticoids induced dopaminergic damage and glia activation when the offspring were later treated with the psychoactive drug MDMA.
Article
Pharmacology & Pharmacy
Nicholas Pintori, Maria Paola Castelli, Cristina Miliano, Nicola Simola, Paola Fadda, Liana Fattore, Maria Scherma, Maria Grazia Ennas, Rafaela Mostallino, Giovanna Flore, Marta De Felice, Claudia Sagheddu, Marco Pistis, Gaetano Di Chiara, Maria Antonietta De Luca
Summary: Repeated exposure to JWH-018 induced anxious and aversive behaviors, decreased dopamine neurons in the VTA, and altered dopaminergic transmission. The drug also affected dopamine sensitivity in the NAc shell and core, while causing neuroinflammatory responses in specific brain areas. This study suggests that recurring use of Spice/K2 drugs may have detrimental effects on behavior and dopamine regulation.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marcello Serra, Annalisa Pinna, Giulia Costa, Alessandro Usiello, Massimo Pasqualetti, Luigi Avallone, Micaela Morelli, Francesco Napolitano
Summary: Rhes is a gene regulated by thyroid hormones that modulates dopamine neurotransmission through inhibition of the striatal cAMP/PKA pathway. It is expressed at high levels in the dorsal striatum and is involved in the survival of midbrain dopaminergic neurons, pointing towards a modulation of autophagy and mitophagy processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Rafael Franco, Rafael Rivas-Santisteban, Gemma Navarro, Annalisa Pinna, Irene Reyes-Resina
Summary: This paper explores the potential mechanisms of dopaminergic denervation in Parkinson's disease by studying genes related to familial cases. It proposes that gene mutations can alter the processing of alpha-synuclein or disrupt vesicular trafficking and protein processing mechanisms. Mitochondria play a central role in both pathways, suggesting that targeting G protein-coupled receptors in neurons' mitochondria may lead to new therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Marcello Serra, Jacopo Marongiu, Nicola Simola
Summary: The study evaluated the emission of ultrasonic vocalizations in C57BL/6J mice after repeated treatment with amphetamine and dopamine receptor agonist. The results showed that mice emitted USVs during social contacts, but did not significantly vocalize after drug administration or drug-paired environmental cues.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Annalisa Pinna, Giulia Costa, Marcello Serra, Liliana Contu, Micaela Morelli
Summary: The study found that the combination of L-dopa, eltoprazine, and preladenant could potentially delay the onset of dyskinesia, maintain the efficacy of L-dopa, and reduce neuroinflammation markers in the nigrostriatal system of 6-OHDA-lesioned rats.
Article
Neurosciences
Giulia Costa, Marcello Serra, Nicola Simola
Summary: The study found that rats emitted different frequencies of USVs during tickling, novel object recognition test (NOR), and single trial continuous spontaneous alternation behavior (SAB) test, but this calling behavior was not linked with behavioral readouts indicative of memory function. However, rats that predominantly emitted 22-kHz USVs during tickling displayed impaired performance in the NOR test.
Article
Behavioral Sciences
Silvia Corongiu, Christian Dessi, Elena Espa, Augusta Pisanu, Annalisa Pinna, Daniele Lecca, Sandro Fenu, Cristina Cadoni
Summary: Genetic background and age at first exposure are critical variables in individual vulnerability to drug addiction. The study shows that alcohol consumption, especially binge-drinking, by young people predicts future drinking problems. This study highlights the importance of understanding the influence of age and genetic background on the development of alcohol dependence.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Pathik Parekh, Marcello Serra, Mohamad Allaw, Matteo Perra, Jacopo Marongiu, Giulia Tolle, Annalisa Pinna, Maria Antonietta Casu, Maria Manconi, Pierluigi Caboni, Olivier J. J. Manzoni, Micaela Morelli
Summary: It has been found that incorporating Nasco grape pomace extract into the Nutriosomes nanovesicle system can enhance its brain bioavailability after oral administration and exhibit neuroprotective effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Neurosciences
Andrea Grignolio, Micaela Morelli, Marco Tamietto
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Maria Francesca Palmas, Michela Etzi, Augusta Pisanu, Chiara Camoglio, Claudia Sagheddu, Michele Santoni, Maria Francesca Manchinu, Mauro Pala, Giuliana Fusco, Alfonso De Simone, Luca Picci, Giovanna Mulas, Saturnino Spiga, Maria Scherma, Paola Fadda, Marco Pistis, Nicola Simola, Ezio Carboni, Anna R. Carta
Summary: The study demonstrates that intracerebral infusion of pre-formed human alpha synuclein oligomers (H-alpha SynOs) provides a valid model for studying cognitive symptoms in Parkinson's disease, accompanied by neuroinflammation, shedding light on the mechanisms underlying cognitive impairment.
Article
Neurosciences
Annalisa Pinna, Pathik Parekh, Micaela Morelli
Summary: This review discusses the role of serotonin 5-HT1A receptors and adenosine A2A receptors in dyskinetic movements induced by chronic levodopa in Parkinson's Disease (PD) patients. Preclinical and clinical studies have shown the interaction between serotonin 5-HT1A receptors and other receptors, such as 5-HT1B receptors and adenosine A2A receptors. The combination of 5-HT1A/1B receptor agonists and A2A receptor antagonists effectively counteracts dyskinetic movements induced by chronic levodopa without impairing motor behavior, suggesting a potential therapeutic approach for PD motor deficits and levodopa-induced dyskinesia.
Article
Clinical Neurology
Annalisa Pinna, Marcello Serra, Jacopo Marongiu, Micaela Morelli
PARKINSONISM & RELATED DISORDERS
(2020)