Article
Biochemistry & Molecular Biology
Dandan Huang, Qihan Ding, Shenbao Chen, Shouqin Lu, Yan Zhang, Mian Long
Summary: E-selectins negatively regulate neutrophil transmigration by altering endothelial plasticity, downregulating cortactin and Arp2/3 activation, and enhancing VE-cadherin adhesive function. The findings also highlight the overlapping functions of redundant P-selectins in neutrophil adhesion and transmigration, contributing to better understanding of actin remodeling and junctional integrity in endothelial cells mediating leukocyte TEM.
Review
Biochemistry & Molecular Biology
Angelo Zinellu, Arduino A. Mangoni
Summary: Statins can effectively decrease circulating levels of cell adhesion molecules, including P-selectin, L-selectin, and E-selectin, which are involved in the pathogenesis of atherosclerosis. Research indicates that statins have a significant impact on reducing these selectins independently of baseline lipid profiles and other patient characteristics, potentially contributing to cardiovascular risk reduction.
Article
Biochemistry & Molecular Biology
Ka Zhang, Hao Kan, Aiqin Mao, Li Geng, Xin Ma
Summary: Research reveals that excessive salt intake leading to high blood pressure results in significant changes in cell composition and communication in the aorta, including an increase in the proportion of smooth muscle cells, cells lining blood vessels, and T cells, as well as activation of multiple signaling pathways. The study identifies 21 associated genes, such as Nox4, and provides potential targets for the prevention and treatment of hypertension.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Alessandra Oliva, Emanuele Rando, Dania Al Ismail, Massimiliano De Angelis, Francesca Cancelli, Maria Claudia Miele, Raissa Aronica, Vera Mauro, Federica Di Timoteo, Lorenzo Loffredo, Claudio M. Mastroianni
Summary: This study compared sE-selectin levels in COVID-19 patients and found that higher levels were associated with increased risk of ICU admission, potentially serving as a predictor for disease severity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Afeez Adekunle Ishola, Chian-Shiu Chien, Yi-Ping Yang, Yueh Chien, Aliaksandr A. Yarmishyn, Ping-Hsing Tsai, Jerry Chieh-Yu Chen, Po-Kuei Hsu, Yung-Hung Luo, Yuh-Min Chen, Kung-Hou Liang, Yuan-Tzu Lan, Teh-Ia Huo, Hsin- Ma, Ming-Teh Chen, Mong-Lien Wang, Shih-Hwa Chiou
Summary: Lung cancers, particularly non-small cell lung cancers, have a poor prognosis. A circular noncoding RNA called C190 has been identified as a negative prognostic biomarker for lung cancer, and this study explores its mechanistic function and potential as a therapeutic target for NSCLC.
Article
Biochemistry & Molecular Biology
Yaqian Wang, Fangfang Chen, Yuan Zhang, Xiangyu Zheng, Shiyan Liu, Meijuan Tang, Ziling Wang, Pan Wang, Yongping Bao, Dan Li
Summary: Sulforaphane (SFN) was found to promote migration and tube formation of HUVECs under hypoxic conditions, while alleviating hypoxia-induced proliferation retardation. Additionally, SFN protected against hypoxia-induced mitochondrial injury and regulated angiogenesis via modulation of Nrf2 and mitochondrial dynamics.
Article
Oncology
Sandra Genduso, Vera Freytag, Daniela Schetler, Lennart Kirchner, Alina Schiecke, Hanna Maar, Daniel Wicklein, Florian Gebauer, Katharina Broeker, Christine Stuerken, Karin Milde-Langosch, Leticia Oliveira-Ferrer, Franz L. Ricklefs, Florian Ewald, Gerrit Wolters-Eisfeld, Kristoffer Riecken, Ludmilla Unrau, Linda Krause, Hanibal Bohnenberger, Anne Offermann, Sven Perner, Susanne Sebens, Katrin Lamszus, Linda Diehl, Stefan Linder, Manfred Juecker, Udo Schumacher, Tobias Lange
Summary: This study analyzed the cooperative effects of ITGB4 and E-/P-selectin in the tumor microenvironment. The results showed that the interaction between ITGB4 and E-/P-selectin promotes tumor growth and attracts MDSCs into the tumor tissue. These findings have important clinical implications for tumor therapy.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Retraction
Biochemistry & Molecular Biology
Zu-Dong Meng, Xiao-Lan Wang, Tian-Ping Du, Yu Wang, Gui-Fang Qin, Hong-Bo Zhao, Yu-Jie Chen, Bo Tian
Summary: The study on the effects of RNA interference-mediated E-selectin gene silencing on vascular endothelial cells of mice with immunologic contact urticaria was retracted due to image elements of the experimental data being published elsewhere in a different scientific context.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Elliott J. Hagedorn, Julie R. Perlin, Rebecca J. Freeman, Samuel J. Wattrus, Tianxiao Han, Clara Mao, Ji Wook Kim, Ines Fernandez-Maestre, Madeleine L. Daily, Christopher D'Amato, Michael J. Fairchild, Raquel Riquelme, Brian Li, Dana A. V. E. Ragoonanan, Khaliun Enkhbayar, Emily L. Henault, Helen G. Wang, Shelby E. Redfield, Samantha H. Collins, Asher Lichtig, Song Yang, Yi Zhou, Balvir Kunar, Jesus Maria Gomez-Salinero, Thanh T. Dinh, Junliang Pan, Karoline Holler, Henry A. Feldman, Eugene C. Butcher, Alexander van Oudenaarden, Shahin Rafii, J. Philipp Junker, Leonard I. Zon
Summary: This study identifies a unique gene expression signature and regulatory landscape in sinusoidal endothelial cells within the hematopoietic stem and progenitor cell (HSPC) niche. By manipulating enhancers and transcription factors, the researchers reveal a transcriptional code that induces ectopic niche endothelial cells that support the recruitment, maintenance, and division of HSPCs. These findings provide insights for generating synthetic HSPC niches and developing therapies to modulate the endogenous niche.
DEVELOPMENTAL CELL
(2023)
Article
Cell Biology
Marc Scherlinger, Vivien Guillotin, Isabelle Douchet, Pierre Vacher, Andrea Boizard-Moracchini, Jean-Philippe Guegan, Anne Garreau, Nathalie Merillon, Agathe Vermorel, Emmanuel Ribeiro, Irene Machelart, Estibaliz Lazaro, Lionel Couzi, Pierre Duffau, Thomas Barnetche, Jean-Luc Pellegrin, Jean-Francois Viallard, Maya Saleh, Thierry Schaeverbeke, Patrick Legembre, Marie-Elise Truchetet, Helene Dumortier, Cecile Contin-Bordes, Vanja Sisirak, Christophe Richez, Patrick Blanco
Summary: This study identified a P-selectin-dependent pathway in patients with systemic lupus erythematosus (SLE) and validated it as a potential therapeutic avenue. Platelets from SLE patients interacted with Treg cells via the P-selectin/PSGL-1 axis, affecting Treg cell function and suppressing immune responses. Blocking P-selectin in a mouse model of SLE improved disease features, indicating its potential as a therapeutic target.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Kay K. Myo Min, Darling Rojas-Canales, Daniella Penko, Mark DeNichilo, Michaelia P. Cockshell, Charlie B. Ffrench, Emma J. Thompson, Olof Asplund, Christopher J. Drogemuller, Rashmi B. Prasad, Leif Groop, Shane T. Grey, Helen E. Thomas, Thomas Loudovaris, Thomas W. Kay, My G. Mahoney, Claire F. Jessup, P. Toby Coates, Claudine S. Bonder
Summary: This study identifies DSG2 as an important adhesion molecule in supporting pancreatic beta-cells. DSG2 is widely expressed in human pancreatic islets and lack of DSG2 leads to reduced islet size and number, decreased insulin content, increased susceptibility to hyperglycemia-inducing models, and increased sensitivity to cytokine-induced beta-cell apoptosis. This study provides new insights for exploring the treatment of type 1 diabetes.
CELL DEATH & DISEASE
(2022)
Article
Chemistry, Analytical
Lixin Zhao, Ningning Zhang, Mengting He, Peng Luo, Liang Tan
Summary: A nanozyme-based competitive electrochemical immunosensor was developed for the quantitative determination of E-selectin. The immobilized nanocomposites on the modified electrode acted as nanozymes and participated in the electrocatalytic process, resulting in a high cathodic peak current. The assembly of nanocomposites on the electrode was inhibited by E-selectin due to the competitive immunoreaction, leading to a decrease in the current signal.
Article
Biophysics
Yuncheng Man, Erdem Kucukal, Shichen Liu, Ran An, Utku Goreke, William J. Wulftange, Zoe Sekyonda, Allison Bode, Jane A. Little, Deepa Manwani, Evi X. Stavrou, Umut A. Gurkan
Summary: Neutrophil recruitment to the inflamed endothelium is crucial in the development of vaso-occlusive crisis in sickle cell disease (SCD). However, there is no standardized approach for assessing neutrophil recruitment to the inflamed endothelium for personalized risk stratification and therapeutic response prediction in SCD. This study presents a microfluidic device functionalized with E-selectin as a strategy to assess neutrophil binding under physiologic flow in normoxia and hypoxia in SCD. The findings provide mechanistic insight into neutrophil-endothelial interactions under hypoxia and offer a clinically feasible means for assessing neutrophil binding to E-selectin using clinical whole blood samples, which can guide therapeutic decisions for SCD patients.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Medicine, Research & Experimental
Xiangyu Zhang, Hui Liu, Jennifer Q. Zhou, Stefanie Krick, Jarrod W. Barnes, Victor J. Thannickal, Yan Y. Sanders
Summary: H4K16Ac plays a critical role in regulating chromatin structure and gene expression related to fibrosis, suggesting potential therapeutic strategies for age-related diseases like IPF.
Article
Cardiac & Cardiovascular Systems
JaeKyoung Ahn, Hankyeol Jeong, Bo-Gyeong Seo, Ki-Soo Park, Cheol Hwangbo, Han-Gyul Kim, Jin-Sin Koh, Jaemin Kim
Summary: This study conducted a genome-wide association study (GWAS) in a Korean population to identify germline genetic variants associated with vascular aging. The study revealed 60 genes related to angiogenesis, inflammatory response in blood vessels, and cardiovascular diseases, and found an enrichment of putative protective alleles in an independent population with decelerated vascular aging phenotypes. Additionally, the study showed differential mRNA expression levels of putative causal genes in aging human primary endothelial cells. These findings shed light on the contribution of genetic variants to the etiology of vascular aging and the potential link between vascular aging and cardiovascular traits.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)