Review
Clinical Neurology
Martijn de Neeling, Dirk Liessens, Bart Depreitere
Summary: Mild traumatic brain injury (mTBI) has a high incidence worldwide, and long-term persistent postconcussion symptoms (PPCS) are predicted by psychological and psychiatric factors. Anxiety, depressive symptoms, and emotional distress early after injury can predict PPCS burden and functional outcome. Coping styles, preinjury psychiatric disorders and mental health also correlate with PPCS burden and functional outcome.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Paul G. Harch
Summary: This systematic review examines the evidence for hyperbaric oxygen therapy in Persistent Postconcussion Syndrome using a dose-analysis based on the scientific definition of hyperbaric oxygen therapy. The results suggest that hyperbaric oxygen therapy at 1.5 ATA can significantly improve symptoms and cognitive function in patients with mild traumatic brain injury Persistent Postconcussion Syndrome, with positive and negative results found at different doses of oxygen and pressure.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Christina Devoto, Rany Vorn, Sara Mithani, Timothy B. Meier, Chen Lai, Steven P. Broglio, Thomas Mcallister, Christopher C. Giza, Daniel Huber, Jaroslaw Harezlak, Kenneth L. Cameron, Gerald Mcginty, Jonathan Jackson, Kevin Guskiewicz, Jason P. Mihalik, Alison Brooks, Stefan Duma, Steven Rowson, Lindsay D. Nelson, Paul Pasquina, Christine Turtzo, Lawrence Latour, Michael A. Mccrea, Jessica M. Gill, CARE Consortium Investigators
Summary: This study aimed to investigate plasma phosphorylated tau (p-tau181) protein in mild traumatic brain injury (mTBI) patients and concussed athletes. The study found that plasma p-tau181 concentrations were significantly elevated within 48 hours of injury in both groups, with the highest levels observed in patients with neuroimaging evidence of injury. These findings suggest that plasma p-tau181 concentrations may be related to brain injury and could potentially serve as an early diagnostic biomarker for mTBI/concussions.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Sophia Wagberg, Britt-Marie Stalnacke, Beatrice M. M. Magnusson
Summary: This study evaluates post-TBI symptoms and disabilities seven to eight years after mild TBI (mTBI), showing that women and individuals with repeated TBI experience more severe symptoms and functional decline. These findings have implications for clinical practice and research, and should be considered in rehabilitation and follow-up plans.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rehabilitation
Toril Skandsen, Jonas Stenberg, Turid Follestad, Migle Karaliute, Simen B. Saksvik, Cathrine E. Einarsen, Hanna Lillehaug, Asta K. Haberg, Anne Vik, Alexander Olsen, Grant L. Iverson
Summary: Personal factors play an important role in predicting postconcussion symptoms in patients with mild traumatic brain injury (MTBI). Factors such as work status, preinjury health problems, and gender were found to be predictors of postconcussion symptoms. Intracranial abnormalities on CT scans were also identified as a risk factor for postconcussion symptoms.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Rehabilitation
Noah D. Silverberg, Grant L. Iverson, Alison Cogan, Kristen Dams-O-Connor, Richard Delmonico, Min Jeong P. Graf, Mary Alexis Iaccarino, Maria Kajankova, Joshua Kamins, Karen L. McCulloch, Gary McKinney, Drew Nagele, William J. Panenka, Amanda R. Rabinowitz, Nick Reed, Jennifer Wethe, Victoria Whitehair, Vicki Anderson, David B. Arciniegas, Mark T. Bayley, Jeffery J. Bazarian, Kathleen R. Bell, Steven P. Broglio, David Cifu, Gavin A. Davis, Jiri Dvorak, Ruben J. Echemendia, Gerard A. Gioia, Christopher C. Giza, Sidney R. Hinds II, Douglas I. Katz, Brad G. Kurowski, John J. Leddy, Natalie Le Sage, Angela Lumba-Brown, Andrew I. R. Maas, Geoffrey T. Manley, Michael McCrea, David K. Menon, Jennie Ponsford, Margot Putukian, Stacy J. Suskauer, Joukje van der Naalt, William C. Walker, Keith Owen Yeates, Ross Zafonte, Nathan D. Zasler, Roger Zemek
Summary: This study aims to develop new diagnostic criteria for mild traumatic brain injury (TBI) that are appropriate for use across the lifespan and in sports, civilian trauma, and military settings. Through a rapid evidence review and Delphi method, a 90.7% agreement on the diagnostic criteria was reached, which will improve the quality and consistency of mild TBI research and clinical care.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Multidisciplinary Sciences
Mohammed M. Alnawmasi, Sieu K. Khuu
Summary: This study investigated the impact of TBI on the allocation and maintenance of visual attention to multiple moving targets using a multiple object tracking task. The results showed that patients with mild TBI had greater deficits in maintaining visual attention and detecting targets, particularly when the tracking load and distraction increased.
SCIENTIFIC REPORTS
(2022)
Review
Critical Care Medicine
Carol Cancelliere, Leslie Verville, Jacob L. Stubbs, Hainan Yu, Cesar A. Hincapie, J. David Cassidy, Jessica J. Wong, Heather M. Shearer, Gaelan Connell, Danielle Southerst, Scott Howitt, Brett Guist, Noah D. Silverberg
Summary: This systematic review and meta-analysis found that nearly one in three adults with mild traumatic brain injury experience mild severity post-concussion symptoms 3-6 months later. However, controlling for attrition bias, the true prevalence may be one in six. This highlights the need for studies with representative samples and high retention rates.
JOURNAL OF NEUROTRAUMA
(2023)
Review
Critical Care Medicine
Carol Cancelliere, Leslie Verville, Jacob L. Stubbs, Hainan Yu, Cesar A. Hincapie, J. David Cassidy, Jessica J. Wong, Heather M. Shearer, Gaelan Connell, Danielle Southerst, Scott Howitt, Brett Guist, Noah D. Silverberg
Summary: Studies on the long-term symptoms and disability after mild traumatic brain injury (mTBI) have produced mixed results. This systematic review and meta-analysis aimed to determine the prevalence of self-reported post-concussion symptoms (PCS) and disability following mTBI. The findings suggest that approximately one in three adults with mTBI experience at least mild severity PCS 3-6 months after the injury, but controlling for attrition bias, the true prevalence may be one in six. Well-designed studies with representative samples and high retention rates are needed to further investigate this issue.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
Ido Ben Zvi, Oren Shaia Harel, Amos Douvdevani, Penina Weiss, Chen Cohen, Eynat Ben Ari, Gal Gross, Yehonatan Menndel, David Felzensztein, Noa Schwartz, Shani Berkowitz, Michael Drescher, Sagi Harnof
Summary: This study suggests that circulating cell-free DNA (cfDNA) can be used as a potential biomarker for screening postconcussion syndrome (PCS) in the emergency room. The results show a correlation between cfDNA levels and cognitive performance status, indicating the potential of cfDNA as an early predictor of PCS.
JOURNAL OF NEUROSURGERY
(2022)
Article
Immunology
Emer Ryan, Lynne Kelly, Catherine Stacey, Dean Huggard, Eimear Duff, Danielle McCollum, Ann Leonard, Gerard Boran, Dermot R. Doherty, Turlough Bolger, Eleanor J. Molloy
Summary: This study demonstrates altered cytokine profiles and endotoxin responses in children with traumatic brain injury (TBI), including mild TBI. Children with mild TBI showed decreased levels of IL-8, IL-10, IL-17A, and TNF-alpha compared to controls, along with increased levels of IFN-gamma. In severe TBI, there was no significant IL-6 response to endotoxin, but an increase in IL-17A. These findings suggest immune dysfunction following TBI, especially in mild cases.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Anesthesiology
Cayden Peixoto, Derrick Matthew Buchanan, Richard Nahas
Summary: Missed diagnosis of mTBI is common in patients presenting to the ED after MVC, and these patients are at risk of developing chronic pain syndromes. Better screening for mTBI is needed, especially in patients with loss of consciousness, altered mental state, posttraumatic amnesia, or postinjury headache, who are at increased risk of PCS.
Article
Medicine, General & Internal
Sung Ho Jang, Eun Bi Choi, Young Seo Lee
Summary: This study examined the incidence and characteristics of physical disabilities in patients with postconcussion syndrome (PCS) after a mild traumatic brain injury (mTBI). It found that approximately 5% of patients with PCS after mTBI had definite physical disabilities, with most of them showing mild quadriparesis.
Article
Multidisciplinary Sciences
Marissa Sgro, Giulia Iacono, Glenn R. Yamakawa, Zoe N. Kodila, Benjamin J. Marsland, Richelle Mychasiuk
Summary: Dysregulation of the gut microbiome can perpetuate neuroinflammation and alter intestinal permeability, affecting the deficits caused by mild traumatic brain injury. This study found that adolescents are more susceptible to microbiome depletion caused by antibiotic administration, and may compensate for the injury by increasing "beneficial bacteria". Furthermore, microbiome depletion prior to the injury may exacerbate secondary inflammatory cascades.
Article
Clinical Neurology
Randall J. Hlubek, Michael A. Bohl, Tyler S. Cole, Clinton D. Morgan, David S. Xu, Steve W. Chang, Jay D. Turner, U. Kumar Kakarla
Article
Neurosciences
Joshua S. Catapano, Alistair J. Chapman, S. Harrison Farber, Lance P. Horner, Clinton Morgan, Scott Brigeman, Benjamin K. Hendricks, Minggen Lu, Douglas R. Fraser
Review
Clinical Neurology
Jean-Nicolas Gallant, Clinton D. Morgan, Joseph B. Stoklosa, Stephen R. Gannon, Chevis N. Shannon, Christopher M. Bonfield
WORLD NEUROSURGERY
(2018)
Article
Clinical Neurology
Joshua S. Catapano, Joseph M. Zabramski, Jacob F. Baranoski, Scott Brigeman, Clinton D. Morgan, Benjamin K. Hendricks, Michael A. Mooney, Felipe C. Albuquerque, Peter Nakaji, Robert F. Spetzler
Article
Endocrinology & Metabolism
Tyler S. Cole, Heidi Jahnke, Jakub Godzik, Clinton D. Morgan, Peter Nakaji, Andrew S. Little
Article
Clinical Neurology
Jakub Godzik, Corey T. Walker, Cory Hartman, Bernardo de Andrada, Clinton D. Morgan, George Mastorakos, Steven Chang, Jay Turner, Randall W. Porter, Laura Snyder, Juan Uribe
OPERATIVE NEUROSURGERY
(2019)
Review
Clinical Neurology
Joshua S. Catapano, Michaela Lee, Damjan Veljanoski, Alexander C. Whiting, Scott Brigeman, Clinton D. Morgan, Mohamed A. Labib, Andrew F. Ducruet, Peter Nakaji
ACTA NEUROCHIRURGICA
(2019)
Article
Clinical Neurology
Faiz U. Ahmad, Erica F. Bisson, Stephen Shelby Burks, Jason J. Chang, A. Jessey Chugh, Ian Cote, Jason M. Frerich, Zachary C. Gersey, Benjamin K. Hendricks, Michael Karsy, Manish Kasliwal, Katie L. Krause, Glen R. Manzano, Clinton D. Morgan, Laura A. Snyder, Christian C. Swinney, Khoi D. Than, Christian B. Theodotou, Anand Veeravagu, Jacqueline Ventura
OPERATIVE NEUROSURGERY
(2019)
Article
Neuroimaging
Joshua S. Catapano, Alexander C. Whiting, Derrick J. Wang, Randall J. Hlubek, Mohamed A. Labib, Clinton D. Morgan, Scott Brigeman, Vance L. Fredrickson, Daniel D. Cavalcanti, Kris A. Smith, Andrew F. Ducruet, Felipe C. Albuquerque
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2020)
Article
Critical Care Medicine
Joshua S. Catapano, Alistair J. Chapman, Matthew Dull, Joseph M. Abbatematteo, Lance P. Horner, Jakub Godzik, Scott Brigeman, Clinton D. Morgan, Alexander C. Whiting, Minggen Lu, Joseph M. Zabramski, Douglas R. Fraser
NEUROCRITICAL CARE
(2019)
Article
Clinical Neurology
Joshua S. Catapano, Nicolas C. Rubel, Damjan Veljanoski, S. Harrison Farber, Alexander C. Whiting, Clinton D. Morgan, Scott Brigeman, Michael T. Lawton, Joseph M. Zabramski
WORLD NEUROSURGERY
(2019)
Article
Chemistry, Multidisciplinary
Woo Seok Kim, Sungcheol Hong, Clinton Morgan, Peter Nakaji, Michael T. Lawton, Sung Il Park
APPLIED SCIENCES-BASEL
(2020)
Editorial Material
Clinical Neurology
Zach Pennington, Clinton D. Morgan, Juan S. Uribe
OPERATIVE NEUROSURGERY
(2021)
Article
Medicine, General & Internal
Michael A. Bohl, Clinton D. Morgan, Michael A. Mooney, Garrett J. Repp, Jennifer N. Lehrman, Brian P. Kelly, Steve W. Chang, Jay D. Turner, U. Kumar Kakarla
CUREUS JOURNAL OF MEDICAL SCIENCE
(2019)
Article
Clinical Neurology
Clinton D. Morgan, Travis R. Ladner, George L. Yang, Marjorie N. Moore, Russell D. Parks, William F. Walsh, John C. Wellons, Chevis N. Shannon
CHILDS NERVOUS SYSTEM
(2018)