Review
Medicine, Research & Experimental
Indiara Brusco, Maria Fernanda Pessano Fialho, Gabriela Becker, Evelyne Silva Brum, Amanda Favarin, Lara Panazzolo Marquezin, Patrick Tuzi Serafini, Sara Marchesan Oliveira
Summary: Kinins are endogenous peptides that play an essential role in physiological and pathological processes by activating two transmembrane receptors. This review summarizes the current understanding of the involvement of kinin receptors and their potential therapeutic applications in various painful conditions. The pharmacological actions and clinical potential of kinin receptor antagonists and other targeting molecules are also discussed.
Review
Medicine, Research & Experimental
Catherine R. Healy, Georgina Gethin, Abhay Pandit, David P. Finn
Summary: Chronic wounds impose a significant burden on individuals and the healthcare system, with pain being the most challenging aspect of living with these wounds. The cutaneous endocannabinoid system shows potential in addressing wound-related pain and inflammation, as well as promoting wound healing. However, more research, including preclinical studies and randomized control trials, is needed to fully explore the therapeutic applications of the endocannabinoid system in chronic wound management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Federica Armeli, Alessio Bonucci, Elisa Maggi, Alessandro Pinto, Rita Businaro
Summary: The Mediterranean diet has broad-spectrum neuroprotective activity, potentially counteracting neurodegeneration by modulating the endocannabinoid system. The co-evolution of the human endocannabinoid system and dietary habits in the Mediterranean lifestyle may play a key role in pro-homeostatic activity.
Review
Biochemistry & Molecular Biology
Vasty Osei-Amponsa, Kylie J. Walters
Summary: The ubiquitin-proteasome system (UPS) plays a critical role in protein quality control and regulation of protein lifespans. This article provides an overview of UPS, focusing on its receptors and deubiquitinating enzymes (DUBs). The importance of dynamics and the presence of functional domains in substrate receptors for binding and processing ubiquitin chains are highlighted. The UPS offers therapeutic opportunities, including the use of proteasome inhibitors and the development of PROTACs for degrading disease-associated proteins. The therapeutic potential of proteasome receptors, such as hRpn13, is discussed.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Shuai Wang, Xin Qi
Summary: Astaxanthin, a natural xanthophyll carotenoid, shows neuroprotective effects by alleviating oxidative stress, reducing the production of neuroinflammatory factors, and maintaining the integrity of the blood-brain barrier. It modulates neuroinflammation through mechanisms such as scavenging radicals, activating antioxidant systems, and suppressing inflammatory pathways. Further research is needed to fully understand its potential in treating neurological diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Vishweshwara Bhat, Emmanuel Shan Onaivi, Venkatanarayanan Sharma
Summary: Research on tinnitus has significantly increased in the past decade, with the aim of finding a cure for this auditory disorder. Although hyperacusis can coexist with tinnitus, the mechanisms behind them are different. Tinnitus is believed to be a result of sensory epilepsy, originating from the auditory brainstem region. The use of cannabis and the endocannabinoid system (ECS) has gained renewed interest, particularly in relation to tinnitus associated with COVID-19. The involvement of cannabinoid receptors (CBRs) in the auditory system and the ECS signaling in hearing and tinnitus are being explored, highlighting the potential therapeutic target of cannabinoid CB2R ligands for tinnitus.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Ti-Yen Yeh, Ming-Fong Chang, Yu-Yu Kan, Hao Chiang, Sung-Tsang Hsieh
Summary: The expression of heat shock protein 27 (HSP27) in sensory neurons of the dorsal root ganglia (DRG) mediates neuropathic pain after nerve injury. Silencing HSP27 alleviated neuropathic pain behaviors, while overexpression of HSP27 induced neuropathic pain. HSP27 interacts with the purinergic receptor P2X3, affecting the degradation rate of P2X3 and providing a new mechanism for injury-induced neuropathic pain.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Kenneth B. Walsh, Amanda E. McKinney, Andrea E. Holmes
Summary: The medicinal use of cannabis has a long history, with recent breakthroughs in understanding the pharmacology of minor cannabinoids showing potential therapeutic benefits in the treatment of various conditions. Although studies demonstrate their agonist and antagonist activities at multiple targets, further research is needed to fully understand their pharmacological mechanisms.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xin Zhao, Suryaji Patil, Fang Xu, Xiao Lin, Airong Qian
Summary: The article focuses on the importance of osteoclasts in bone metabolism and their relationship with osteoporosis, while also introducing some drug therapies targeting these molecules.
Review
Pharmacology & Pharmacy
Enis Kostallari, Shantha Valainathan, Louise Biquard, Vijay H. Shah, Pierre-Emmanuel Rautou
Summary: Chronic liver disease affects over 800 million people worldwide with a high mortality rate. Understanding the role of extracellular vesicles in liver diseases can lead to the development of more effective therapies.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Shin-ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Haru Yamamoto, Yoshiyasu Takefuji, Fumitake Satoh
Summary: Mitochondria are a major source of reactive oxygen species (ROS) and center dot OH; inflammation can lead to serious diseases; molecular hydrogen (H-2) may inhibit ROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Mladjan Golubovic, Tomislav Kostic, Miodrag Djordjevic, Velimir Peric, Milan Lazarevic, Dragan J. Milic, Vesna Marjanovic, Aleksandar M. Veselinovic
Summary: This study developed a conformation-independent and 3D field-based QSAR modeling approach for designing Nav1.7 inhibitors for pain treatment, and verified the model quality and predictability through various statistical methods. The results showed a strong correlation between 3D QSAR and conformation-independent models, facilitating computer-aided design of new compounds as potential analgesics.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Review
Behavioral Sciences
Hao-Jun You, Jing Lei, Antti Pertovaara
Summary: The thalamic mediodorsal (MD) and ventromedial (VM) nuclei play crucial roles in discriminating noxious and innocuous peripheral afferents, promoting and inhibiting nociception. Enhancing thalamic VM nucleus activity or reducing thalamic MD nucleus-induced facilitation may be a promising approach for controlling pathological pain effectively.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Neurosciences
Nynke J. van den Hoogen, Erika K. Harding, Chloe E. D. Davidson, Tuan Trang
Summary: Chronic pain is a significant burden that affects many people worldwide. The cannabinoid system, specifically CB1 and CB2 receptors, plays a key role in pain modulation. Targeting these receptors has shown promise in improving pain outcomes in preclinical models. This review focuses on understanding how cannabinoids modulate microglia function and its implications for pain relief.
FRONTIERS IN NEURAL CIRCUITS
(2022)
Review
Neurosciences
Wenjing Shen, Li Jiang, Jingyi Zhao, Haili Wang, Meng Hu, Lanlan Chen, Yingzhu Chen
Summary: Parkinson's disease is a neurological disorder characterized by motor dysfunction. Recent research has suggested that lipids, particularly bioactive lipids, play a significant role in the pathophysiology of PD. This study aims to explore the molecular metabolism and physiological functions of bioactive lipids in PD to improve our understanding of the disease.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)