期刊
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
卷 11, 期 7, 页码 757-763出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920110792927775
关键词
beta-Arrestin; desensitization; G protein-coupled receptor; selectivity; G protein; high throughput screening; receptor subtype; species
G protein-coupled receptors represent one of the largest families of drug targets. Time and cost may be saved if GPCR modulators are assessed in terms of signaling pathway selectivity, species selectivity, and selectivity against closely-related family members early in the drug discovery process, perhaps even at the stage of high-throughput screening. Examples are given of how these kinds of selectivity have been addressed during screening.
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