期刊
CURRENT ORGANIC CHEMISTRY
卷 17, 期 11, 页码 1225-1234出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272811317110008
关键词
Racemization; Amines; Enzymes; Dynamic kinetic resolution
This paper gives an overview of the available methods for racemization of amines and related derivatives, and the racemization catalysts can be coupled with enzymes to achieve the dynamic kinetic resolution, which provides enantiopure products with approximate 100% yields. Transition metal-catalyzed racemization, free radical-based racemization, racemase leading to automatic racemization and alkali-catalyzed racemization have been summarized, and their advantages and disadvantages have been discussed and compared. A purely enzymatic method would enable efficient and environmentally benign processes as a green and sustainable technique.
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