4.5 Article

The Meyers Reaction (1994-2010)

期刊

CURRENT ORGANIC CHEMISTRY
卷 15, 期 14, 页码 2413-2437

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BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138527211796150561

关键词

Nucleophilic aromatic substitution; Meyers reaction; oxazolines; Grignard reagents; organolithium reagents

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The Meyers reaction, i.e. the nucleophilic aromatic substitution reaction between aryloxazolines with organolithium and organomagnesium reagents is a very efficient and reliable method for the formation of new carbon-carbon and carbon-heteroatom bonds. The aim of this review is to present a general overview of this reaction in chiral and racemic form, emphasizing its scope and limitations. The literature is covered since 1994.

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