☆ 4.5 Article

Enantioselective Organocatalytic Friedel-Crafts Alkylations

CURRENT ORGANIC CHEMISTRY (2011)

期刊

CURRENT ORGANIC CHEMISTRY

卷 15, 期 24, 页码 4022-4045

出版社

BENTHAM SCIENCE PUBL LTD

DOI: 10.2174/138527211798109196

关键词

Organocatalysis; friedel-crafts alkylation; iminium catalysis; SOMO catalysis; hydrogen-bonding catalysis

类别

Chemistry, Organic

资金

National Science Foundation of China [20872043]
Wuhan Municipality [200851430486]

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Protocol

Reagent

摘要

Over the last few decades, the catalytic asymmetric Friedel-Crafts alkylation has become a powerful strategy that provides enantioenriched structural motifs of established value in medicinal chemistry or complex target synthesis. While the traditionally chiral Lewis-acid catalyzed Friedel-Crafts alkylation has been extensively reviewed in the literature, we focused this review on the recent advances on organocatalytic Friedel-Crafts alkylations. According to activation modes, this review is divided into three main sections, including 1) alkylations via iminium catalysis, 2) alkylations via SOMO catalysis, and 3) alkylations by chiral hydrogen-bond donors.

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