期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 21, 期 1, 页码 101-108出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2010.11.004
关键词
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资金
- Korea Healthcare Technology RD Project [A092006]
- Medical Research Center [2010-0029480]
- Chungbuk BIT Research-Oriented University Consortium
- Ministry of Education, Culture, Sports, Sciences and Technology of Japan [22370041, 22121006, 21227003, A-041]
- Grants-in-Aid for Scientific Research [21227003, 22370041, 22121006] Funding Source: KAKEN
The timely nuclear-cytoplasmic translocation of proteins and RNAs by importins and exportins is important for controlling biological processes. Since the 2004 publication of the first exportin structure, Cse1p, the X-ray structures of exportin-5 complexed with pre-microRNA, exportin-t complexed with tRNA, and three CRM1-related structures have revealed the binding mechanism involved in specific cargo recognition. Pre-microRNA and tRNA have conserved 3' 2-4-nucleotide overhang motifs and similar short double-stranded regions. Exportin-5 and exportin-t bind a conserved 3' overhang strongly, and they weakly enclose the short double-stranded stems, each in a different manner. The structures of the nuclear export complexes of small double-stranded RNAs, pre-microRNAs, and tRNAs provide information about the specificities of the two exportins in the context of transcription and translation control.
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