期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 19, 期 2, 页码 197-202出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2009.02.003
关键词
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资金
- British Biotechnology and Biological Sciences Research Council
- BBSRC [BB/E021042/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/E021042/1] Funding Source: researchfish
The p53 tumour suppressor protein has presented a challenge for structural biology for more than two decades. The complete p53 molecule has eluded numerous attempts to determine its structure, presumably owing to the intrinsic conformational flexibility that is essential to the protein's function. Recent data obtained by X-ray crystallography, NMR spectroscopy and electron microscopy provide new insight into the quaternary architecture of the whole molecule and new strategies for examining how these structures correlate with the cell and molecular biology of the 'Guardian of the Genome'.
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