期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 18, 期 5, 页码 601-608出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2008.08.002
关键词
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资金
- National Institutes of Health
- National Center for Research Resources, Biomedical Technology Program [P41 RR001209, RR08630]
- SSRL Structural Molecular Biology Program
- SSRL SMB Program
- US Department of Energy
- Office of Biological and Environmental Research
- DOE
X-ray scattering and diffraction from non-crystalline systems have gained renewed interest in recent years, as focus shifts from the structural chemistry information gained by high-resolution studies to the context of structural physiology at larger length scales. Such techniques permit the study of isolated macromolecules as well as highly organized macromolecular assemblies as a whole under near-physiological conditions. Time-resolved approaches, made possible by advanced synchrotron instrumentation, add a crucial dimension to many of these investigations. This article reviews experimental approaches in non-crystalline X-ray scattering and diffraction that may be used to illuminate important scientific questions such as protein/nucleic acid folding and structure-function relationships in large macromolecular assemblies.
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