Article
Biochemistry & Molecular Biology
Luz Herrero-Manley, Ana Alabajos-Cea, Luis Suso-Marti, Enrique Viosca-Herrero, Isabel Vazquez-Arce
Summary: The study aimed to test the practicality of the existing diagnostic criteria for early knee osteoarthritis (EKOA) and evaluate the clinical progression of both healthy subjects at risk and patients diagnosed with EKOA. The participants were classified into EKOA and healthy subjects based on disability, pain, and self-reported variables. Most participants remained in their original classification, although some were reclassified during the follow-ups. The current diagnostic criteria could lead to misdiagnosis due to fluctuations in patients' conditions.
Article
Nursing
Staja Q. Booker, Angela Starkweather, Todd M. Manini, Roland Staud, Roger B. Fillingim
Summary: African American older adults with knee osteoarthritis experience more severe chronic pain and physical disability compared to White individuals. This study aims to characterize the biopsychosocial-behavioral mechanisms that predict movement-evoked pain (MEP) in this population and develop a targeted self-management intervention to reduce pain and enhance movement.
Article
Rehabilitation
Kaitlin G. Rabe, Tyler J. Stockman, Andrew M. Kern, Wolfgang Wirth, Felix Eckstein, Leena Sharma, John A. Lynch, Michael C. Nevitt, Donald D. Anderson, Neil A. Segal
Summary: The aim of this study was to determine whether tibiofemoral contact stress can predict the risk of worsening knee pain. The findings suggest that elevated contact stress is associated with the development of worsening knee pain over an 84-month period.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2022)
Article
Rheumatology
Daniel L. Riddle, Levent Dumenci
Summary: This study examined the effectiveness of PASS in differentiating pain and function outcome satisfaction after knee arthroplasty. Using data from a randomized clinical trial and prior research, latent class analyses were performed on two outcome measures and compared with PASS scores. The results showed that latent class analyses outperformed PASS in differentiating growth trajectories of self-rated health and pain outcomes.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Holly T. Philpott, Trevor B. Birmingham, Ryan Pinto, Codie A. Primeau, Dominique Arsenault, Brent A. Lanting, Yayuan Zhu, C. Thomas Appleton
Summary: This study found that moderate-to-severe synovitis is strongly associated with constant pain in patients with knee OA. Inflammation may play a specific role in pain experiences, especially in the early stages of knee OA.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Orthopedics
W. Wu, A. L. Bryant, R. S. Hinman, K. L. Bennell, B. R. Metcalf, M. Hall, P. K. Campbell, K. L. Paterson
Summary: Medial and lateral knee contact forces (KCFs) differ across grades of radiographic knee osteoarthritis (OA) severity, but are not associated with knee pain severity. Medial KCFs during early and middle stance are higher in participants with moderate and severe OA compared to mild OA. In contrast, lateral KCFs are higher in mild OA during middle to late stance. The external loading component (KAM) of medial KCF during middle to late stance is greater in participants with moderate and severe OA, while the internal (muscle) component is greater in participants with moderate and severe OA during early stance. There are no associations between medial KCF and knee pain in any radiographic OA grade.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Orthopedics
J. E. Collins, Y. H. Yang, M. B. Opare-Addo, E. Losina
Summary: Recent work aimed to describe the frequency and duration of episodes of pain worsening in persons with knee osteoarthritis (OA). The study found that most participants experienced at least one clinically relevant increase in pain, but less than half had sustained pain worsening episodes. These findings provide a more nuanced understanding of the fluctuating nature of OA pain.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
K. Akin-Akinyosoye, R. J. E. James, D. F. McWilliams, B. Millar, R. das Nair, E. Ferguson, D. A. Walsh
Summary: The CAP-Knee questionnaire is a simple and valid tool for assessing a single 'Central Mechanisms' trait related to knee pain, allowing for identification and targeting of centrally-acting treatments aiming to reduce the burden of knee pain.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Rheumatology
Dong Jin Go, Dong Hyun Kim, Jie Young Kim, Ali Guermazi, Michel Daoud Crema, David J. Hunter, Hyun Ah Kim
Summary: In elderly community residents without gout, serum UA levels were not associated with knee OA progression but were negatively associated with patellofemoral cartilage loss over time. Further large-scale longitudinal studies are needed to confirm the relationship between UA and cartilage damage in different populations.
Article
Orthopedics
Maria Andersson, E. Haglund, K. Aili, A. Bremander, S. Bergman
Summary: This study found associations between metabolic factors and radiographic knee osteoarthritis (RKOA), regardless of the presence of knee pain. Particularly, the associations between metabolic factors and RKOA were more pronounced in individuals with normal body mass index (BMI). Age was the only factor associated with RKOA in obese individuals.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Medicine, General & Internal
Meike C. van Scherpenseel, Corelien J. J. Kloek, Cindy Veenhof, Martijn F. Pisters
Summary: This study found a long-term relationship between pain coping style and healthcare use in patients with knee and/or hip osteoarthritis. Patients with an active pain coping style were found to use significantly more healthcare services over a 10-year period compared to those with a passive pain coping style.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Georgina Nakafero, Matthew J. Grainge, Ana M. Valdes, Nick Townsend, Christian D. Mallen, Weiya Zhang, Michael Doherty, Mamas Mamas, Abhishek Abhishek
Summary: This study examined the association between beta-blocker prescription and first primary-care consultation for knee osteoarthritis, hip osteoarthritis, knee pain, and hip pain. The results showed that beta-blocker use was associated with a reduced risk of musculoskeletal pain-related consultations.
Article
Orthopedics
L. Baumbach, D. T. Gronne, N. C. Moller, S. T. Skou, E. M. Roos
Summary: The objective of this study was to investigate changes in physical activity in patients with knee/hip osteoarthritis following an 8-week education and exercise therapy program, with a focus on those with low physical activity levels. The study also aimed to evaluate the association between changes in pain intensity and physical activity. The data from the GLA:D registry in Denmark were used, and measures of interest included the UCLA activity scale and Visual Analog Scale for pain intensity. The results showed that a significant proportion of patients reached or maintained at least a moderate physical activity level after the program, regardless of changes in pain intensity.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Biophysics
Xiaohu Li, Xuelian Gu, Ziang Jiang, Huabing Duan, Jincheng Zhou, Yihao Chang, Ke Lu, Bo Chen
Summary: Population-based knee joint space width (JSW) assessments are important for osteoarthritis prevention and early diagnosis. This study established a statistical shape and alignment model (SSAM) of knee joints to assess anatomic variation in knee JSW in healthy Chinese males. The JSW variability within the SSAM was mainly explained by mode 1, demonstrating its significant influence. This study's findings can benefit prosthetic device design and optimization, as well as the prevention and early diagnosis of osteoarthritis.
JOURNAL OF BIOMECHANICS
(2023)
Article
Orthopedics
Chen. Huang, Ping-Keung. Chan, Kwong-Yuen. Chiu, Chun-Hoi. Yan, Shun-Shing. Yeung, Siu N. Fu
Summary: This study explored the relationship between external knee adduction moment and pain intensity in participants with knee osteoarthritis. The results showed that KAM had a negative effect on VAS pain indirectly through the mediation of KFM, with KAM and KFM being negatively related to each other. The KAM index was found to be negatively related to VAS, suggesting a potential strategy for pain avoidance related to mechanical irritation.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Endocrinology & Metabolism
Chenlin Dai, Junjing Jia, Alexander Kot, Xueping Liu, Lixian Liu, Min Jiang, Nancy E. Lane, Barton L. Wise, Wei Yao
Article
Rheumatology
Sharon L. Kolasinski, Tuhina Neogi, Marc C. Hochberg, Carol Oatis, Gordon Guyatt, Joel Block, Leigh Callahan, Cindy Copenhaver, Carole Dodge, David Felson, Kathleen Gellar, William F. Harvey, Gillian Hawker, Edward Herzig, C. Kent Kwoh, Amanda E. Nelson, Jonathan Samuels, Carla Scanzello, Daniel White, Barton Wise, Roy D. Altman, Dana DiRenzo, Joann Fontanarosa, Gina Giradi, Mariko Ishimori, Devyani Misra, Amit Aakash Shah, Anna K. Shmagel, Louise M. Thoma, Marat Turgunbaev, Amy S. Turner, James Reston
ARTHRITIS CARE & RESEARCH
(2020)
Article
Rheumatology
Sharon L. Kolasinski, Tuhina Neogi, Marc C. Hochberg, Carol Oatis, Gordon Guyatt, Joel Block, Leigh Callahan, Cindy Copenhaver, Carole Dodge, David Felson, Kathleen Gellar, William F. Harvey, Gillian Hawker, Edward Herzig, C. Kent Kwoh, Amanda E. Nelson, Jonathan Samuels, Carla Scanzello, Daniel White, Barton Wise, Roy D. Altman, Dana DiRenzo, Joann Fontanarosa, Gina Giradi, Mariko Ishimori, Devyani Misra, Amit Aakash Shah, Anna K. Shmagel, Louise M. Thoma, Marat Turgunbaev, Amy S. Turner, James Reston
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Orthopedics
Barton L. Wise, Jingbo Niu, Yuqing Zhang, Felix Liu, Joyce Pang, John A. Lynch, Nancy E. Lane
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2020)
Article
Rehabilitation
Marc J. Heronemus, Kaitlin Rabe, Irina Tolstykh, K. Douglas Gross, Barton L. Wise, Michael C. Nevitt, Cora E. Lewis, Howard J. Hillstrom, Neil A. Segal
Summary: The study found a positive correlation between parity and increased dynamic foot pronation, with greater pronation observed with higher parity levels. However, after adjusting for age and BMI, these associations were no longer statistically significant.
Review
Rheumatology
Barton L. Wise, Matthias F. Seidel, Nancy E. Lane
Summary: NGF is an important neurotrophin involved in pain signal transmission, and inhibitors have shown efficacy in reducing joint pain in osteoarthritis patients, but higher doses may increase the risk of rapidly progressive osteoarthritis. Ongoing studies aim to better understand the mechanisms involved in this adverse event.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Article
Rheumatology
Bo Hu, DongBai Han, Michael C. Nevitt, Barton L. Wise, Neil A. Segal
Summary: This study aimed to determine if the amount of physical activity is a determinant of joint space narrowing (JSN) worsening in knee osteoarthritis patients over 48 months. The results showed that compared to moderate physical activity, both higher and lower amounts of physical activity are associated with an increased risk of JSN worsening in men and participants with K/L grade 2 knees.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Orthopedics
Qiang Liu, Zhikun Li, Manuela Ferreira, Barton Wise, David J. Hunter, Ke Tao, Jianhao Lin, Yuqing Zhang
Summary: Recent knee injury, more severe radiographic osteoarthritis, and lower quadriceps strength were associated with an increased risk of knee pain exacerbation during walking.
JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
(2021)
Article
Oncology
Muhammad Umar Jawad, Brad H. Pollock, Barton L. Wise, Lauren N. Zeitlinger, Edmond F. O' Donnell, Janai R. Carr-Ascher, Amy Cizik, Betty Ferrell, Steven W. Thorpe, R. Lor Randall
Summary: The study analyzed disparities in the incidence of metastatic bone disease (MBD) based on sex, race/ethnicity, and socioeconomic status, finding higher rates among lower socioeconomic groups and specific racial/ethnic populations. This suggests delays in diagnosis and limited access to screening modalities for these populations.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Manmeet Kaur, Daniel Black, Jeffrey Fine, Barton L. Wise
Summary: This study found a significant reduction in PT referrals for OA in 2020 during the COVID-19 pandemic, especially in the months following state-mandated actions and closures. Factors contributing to this outcome may include increased difficulty in accessing primary care providers, decreased awareness of PT availability among healthcare providers, reduced mobility limiting access to clinic and PT appointments, and patients' willingness to engage in PT during the pandemic.
Article
Oncology
Muhammad Umar Jawad, Brad H. Pollock, Barton L. Wise, Lauren N. Zeitlinger, Edmond F. O' Donnell, Janai R. Carr-Ascher, Amy Cizik, Betty Ferrell, Steven W. Thorpe, R. Lor Randall
Summary: This study explores the impact of socioeconomic status and insurance status on survival disparities among patients with metastatic bone disease. The results demonstrate that lower socioeconomic status and lack of insurance are associated with worse disease-specific survival in patients with primary tumors in the lung, prostate, breast, and colon.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Mary Claire B. Manske, Machelle D. Wilson, Barton L. Wise, Joy Melnikow, Herman L. Hedriana, Michelle A. James, Daniel J. Tancredi
Summary: The study aimed to evaluate the incidence of brachial plexus birth injury (BPBI) and its associations with maternal demographic factors. The incidence of BPBI between 1991 and 2012 was 1.28 per 1,000 live births, with variations in different demographic groups. Infants of Black, Hispanic, and advanced-age mothers had higher risks of BPBI compared to other groups.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Multidisciplinary Sciences
Micaela White, Lauren Hisatomi, Alex Villegas, Dagoberto Pina, Alec Garfinkel, Garima Agrawal, Nisha Punatar, Barton L. Wise, Polly Teng, Hai Le
Summary: This study aimed to determine whether the initiation of pharmacologic treatment for newly diagnosed osteoporosis patients was delayed during the COVID-19 pandemic. The study found that only 40.5% of newly diagnosed patients started pharmacologic therapy within six months of diagnosis, and the pandemic did not significantly affect treatment rates.
Meeting Abstract
Orthopedics
A. Mathur, J. B. Driban, T. E. McAlindon, F. Guillemin, T. Neogi, C. Kwoh, A. Mobasheri, M. C. Nevitt, P. G. Conaghan, B. L. Wise, Y. Zhang, D. J. Hunter, L. Huxham, C. Scotti
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Rheumatology
Lixian Liu, Junjing Jia, Min Jiang, Xueping Liu, Chenling Dai, Barton L. Wise, Nancy E. Lane, Wei Yao
ARTHRITIS RESEARCH & THERAPY
(2020)