Article
Public, Environmental & Occupational Health
Albert Miller, Charles B. Black, Gregory Loewen, Curtis W. Noonan, Tracy McNew, Alan C. Whitehouse, Arthur L. Frank
Summary: Occupational and environmental exposure to Libby amphibole (LA) can lead to asbestos-related pleuropulmonary disease (ARPPD), with asbestos as the leading cause of mortality. Of the 203 deaths observed in this study, 55% were attributed to asbestos-related causes, including asbestos-related malignancy, parenchymal asbestosis, and respiratory failure.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2022)
Article
Environmental Sciences
Drew R. Van Orden
Summary: Two analytical studies have derived a discriminant function to differentiate asbestiform amphibole minerals, particularly fibers longer than 10 μm, emphasizing the importance of accurately identifying materials containing these minerals.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Matthew S. Sanchez, Monica McGrath-Koerner, Brittani D. McNamee
Summary: Elongate mineral particles, such as asbestos, have been frequently found in talc and other mineral powders. Recent concerns about talc containing asbestos have arisen due to litigation and reports from international laboratories and government bodies. This study highlights the importance of understanding mineralogy and its application through microscopy, using conflicting analyses from two independent laboratories as examples. The study discusses the need for accurate measurement and characterization of mineral-based samples using various techniques, as well as the misidentification of different mineral types. These findings emphasize the necessity for stricter analytical requirements in monitoring mineral particles in powders.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Maxime Misseri
Summary: This article proposes a model of natural asbestiform minerals growing in four stages. The study focuses on calcium amphiboles cross-fibers, which develop from altered calcium amphiboles. The observations were made on rocks from France using PLM and TEM. The stages include the development of metasomatic veins, the formation of subgrains, fracturing, and nucleation and growth. The morphology and width of the asbestos minerals are influenced by microcracks and dissolution by hydrothermal fluid.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Lucy Darnton
Summary: This study aimed to update the previous meta-analysis of mortality studies on asbestos-exposed worker populations by incorporating new data from increased follow-up and studies of worker populations exposed predominantly to single fibre types. Results showed significant differences in the risks of mesothelioma and lung cancer among different types of asbestos fibers.
ENVIRONMENTAL RESEARCH
(2023)
Article
Toxicology
Anbo Wang, Amit Gupta, Michael D. Grimm, David T. Pressburger, Barney R. Sparrow, Jamie S. Richey, John R. Shaw, Karen E. Elsass, Georgia K. Roberts, Pei-Li Yao, Matthew D. Stout, Benjamin J. Ellis, Robyn L. Ray
Summary: This research presents the development of a prototype nose-only exposure system for studying the inhalation toxicity of natural mineral fibers. The system was able to generate stable and controllable fiber aerosol, as confirmed by characterization tests using Libby Amphibole 2007. Transmission electron microscopy analysis demonstrated the consistency of the aerosol fibers with the bulk material. The results indicate that the prototype system is suitable for studying the inhalation toxicity of natural mineral fibers.
INHALATION TOXICOLOGY
(2023)
Article
Environmental Sciences
E. J. Chatfield
Summary: Respirable fractions of crushed amphibole samples were sorted and measured to address three questions: 1. Can amphiboles be classified according to the level of inhalation hazard? 2. Can prismatic amphibole be differentiated from amphibole asbestos based on particle size distributions? 3. How do different exposure indices compare when applied to these amphibole samples? The data showed that the concentration of respirable elongate mineral particles (EMPs) and their dimensions contribute to the inhalation hazard, and certain parameters can be used to discriminate prismatic amphibole from asbestiform amphibole. Additionally, exposures in terms of different metrics showed variations between asbestos and non-asbestiform amphiboles.
ENVIRONMENTAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
David M. Bernstein, Balazs Toth, Rick A. Rogers, Peter Kunzendorf, James Phillips, Dirk Schaudien
Summary: The study found that brake dust exposure caused significant differences in lung pathological responses and tumorigenicity compared to chrysotile asbestos and other amphiboles. While chrysotile showed short-term effects in the rat respiratory tract, crocidolite and amosite resulted in persistent inflammation and lung tumor response.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Toxicology
Anbo Wang, Amit Gupta, Michael D. Grimm, David T. Pressburger, Barney R. Sparrow, Jamie S. Richey, John R. Shaw, Karen E. Elsass, Georgia K. Roberts, Pei-Li Yao, Matthew D. Stout, Benjamin J. Ellis, Robyn L. Ray
Summary: This study developed a large-scale exposure system for conducting nose-only inhalation toxicity studies of Libby amphibole (LA) 2007. The system was able to deliver stable LA 2007 aerosol to individual carousels at different concentrations. The results showed that the exposure atmospheres were chemically and physically similar across carousels.
INHALATION TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Reagan Badger, Kyewon Park, Ralph A. Pietrofesa, Melpo Christofidou-Solomidou, Kinta M. Serve
Summary: The study found that LGM2605 can alleviate late inflammation post-exposure to LA, inhibiting immune cell influx, oxidative stress, and immunoglobulin changes, indicating its potential efficacy in prolonged treatment of LA-related diseases and other inflammatory conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Alessandro F. Gualtieri, Alessandro Zoboli, Monica Filaferro, Monia Benassi, Sonia Scarfi, Serena Mirata, Rossella Avallone, Giovanni Vitale, Mark Bailey, Martin Harper, Dario Di Giuseppe
Summary: The study investigated the toxicity effects of fibrous glaucophane on lung cells, revealing that it may lead to a decrease in cell viability, an increase in extracellular lactate dehydrogenase release, and induction of oxidative stress. Although fibrous glaucophane exhibits lower toxic effects compared to crocidolite, exposure to this fiber could still potentially cause lung diseases in exposed unprotected workers and the population.
Article
Materials Science, Multidisciplinary
Andrea Bloise
Summary: This study systematically investigates the thermal behavior of twelve tremolite samples and finds that the breakdown temperature of tremolite is around 200°C. Thermal analysis could be a new method for effectively distinguishing between asbestos and non-asbestos tremolite samples.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Justine Gallet, Francois Laurent, Christophe Paris, Benedicte Clin, Antoine Gislard, Isabelle Thaon, Soizick Chammings, Celine Gramond, Guy Ogier, Gilbert Ferretti, Pascal Andujar, Patrick Brochard, Fleur Delva, Jean-Claude Pairon, Aude Lacourt
Summary: This study aimed to evaluate the association between occupational asbestos exposure and lung cancer with pleural plaques (PP). The results showed a significant association between PP and lung cancer incidence and mortality, particularly in non-smokers.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Eerika Keskitalo, Johanna Salonen, Hannu Vahanikkila, Riitta Kaarteenaho
Summary: The study investigated the pulmonary function test results of patients with asbestosis and found that baseline DLCO% predicted, age, and GAP stage were important predictors of survival. Restrictive lung function was the most common impairment, and the median estimated survival time for patients was 124 months.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Andrew J. Ghio, Matthew Stewart, Rahul G. Sangani, Elizabeth N. Pavlisko, Victor L. Roggli
Summary: Theories on disease pathogenesis following asbestos exposure have emphasized the role of iron. The competition for iron between the host and asbestos leads to functional metal deficiency. The disruption of iron homeostasis activates kinases and transcription factors, resulting in inflammatory and fibrotic responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Public, Environmental & Occupational Health
Alfred Franzblau, Vinicius C. Antao, Germania Pinheiro, Theodore Larson
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2018)
Article
Environmental Sciences
Vinicius C. Antao, L. Laszlo Pallos, Shannon L. Graham, Youn K. Shim, James H. Sapp, Brian Lewis, Steven Bullard, Howard E. Alper, James E. Cone, Mark R. Farfel, Robert M. Brackbill
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Editorial Material
Public, Environmental & Occupational Health
Kristin J. Cummings, Michael J. Becich, David J. Blackley, Dennis Deapen, Robert Harrison, Raffit Hassan, Sarah Jane Henley, Mary Hesdorffer, David Kevin Horton, Jacek M. Mazurek, Harvey I. Pass, Emanuela Taioli, Xiao-Cheng Wu, Marjorie G. Zauderer, David N. Weissman
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2020)
Article
Orthopedics
Susan M. Goodman, Bella Y. Mehta, Lisa A. Mandl, Jackie D. Szymonifka, Jackie Finik, Mark P. Figgie, Iris Y. Navarro-Millan, Mathias P. Bostrom, Michael L. Parks, Douglas E. Padgett, Alexander S. McLawhorn, Vinicius C. Antao, Adolph J. Yates, Bryan D. Springer, Stephen L. Lyman, Jasvinder A. Singh
JOURNAL OF ARTHROPLASTY
(2020)
Article
Orthopedics
Susan M. Goodman, Bella Y. Mehta, Cynthia A. Kahlenberg, Ethan C. Krell, Joseph Nguyen, Jackie Finik, Mark P. Figgie, Michael L. Parks, Douglas E. Padgett, Vinicius C. Antao, Adolph J. Yates, Bryan D. Springer, Steven L. Lyman, Jasvinder A. Singh
JOURNAL OF ARTHROPLASTY
(2020)
Article
Public, Environmental & Occupational Health
Theodore C. Larson, Laura Williamson, Vinicius C. Antao
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2020)
Letter
Public, Environmental & Occupational Health
Theodore C. Larson, Laura Williamson, Vinicius C. Antao
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2020)
Letter
Orthopedics
Susan M. Goodman, Bella Y. Mehta, Cynthia A. Kahlenberg, Ethan C. Krell, Joseph Nguyen, Jackie Finik, Mark P. Figgie, Michael L. Parks, Douglas E. Padgett, Vinicius C. Antao, Adolph J. Yates, Bryan D. Springer, Steven L. Lyman, Jasvinder A. Singh
JOURNAL OF ARTHROPLASTY
(2020)
Article
Clinical Neurology
Jaime Raymond, Paul Mehta, Ted Larson, Pam Factor-Litvak, Bryn Davis, Kevin Horton
Summary: The study suggests that there is an association between vigorous physical activity and early onset ALS, particularly during adolescence and early adulthood. Further research is needed to explore this relationship in more detail.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2021)
Article
Clinical Neurology
Todd M. Bear, Angela M. Malek, Abigail Foulds, Judith Rager, Sarah E. Deperrior, John E. Vena, Theodore C. Larson, Paul Mehta, D. Kevin Horton, Evelyn O. Talbott
Summary: The study team successfully recruited eligible controls for a case-control study using targeted landline phone samples from commercial/consumer databases. Despite some unmatched characteristics, the recruitment of controls was relatively successful and cost-effective, with estimated costs per complete participation within a reasonable range.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2021)
Article
Cell Biology
Marianna J. Bledsoe, Lindsay Rechtman, Laurie Wagner, Paul Mehta, D. Kevin Horton, Wendy E. Kaye
Summary: ALS is a rare neurological condition that affects motor neurons. The National ALS Biorepository collects biospecimens for future research and analyzes demand and utilization to ensure effectiveness.
BIOPRESERVATION AND BIOBANKING
(2021)
Article
Clinical Neurology
Hiroshi Mitsumoto, Diana C. Garofalo, Madison Gilmore, Leslie Andrews, Regina M. Santella, Howard Andrews, Martin McElhiney, Jennifer Murphy, Jeri W. Nieves, Judith Rabkin, Jonathan Hupf, D. Kevin Horton, Paul Mehta, Pam Factor-Litvak
Summary: The study identified an increased risk of ALS diagnosis among those with occupational exposure to lead and agricultural chemicals, as well as increased oxidative stress biomarkers among ALS cases compared to controls. These findings suggest that oxidative stress may be an important pathogenic mechanism in ALS.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2022)
Article
Health Care Sciences & Services
Paul Mehta, Jaime Raymond, Moon Kwon Han, Theodore Larson, James D. Berry, Sabrina Paganoni, Hiroshi Mitsumoto, Richard Stanley Bedlack, D. Kevin Horton
Summary: The study describes how the National ALS Registry's Research Notification Mechanism (RNM) connects ALS patients with researchers. From 2013 to 2019, over 600,000 emails were sent to over 2000 patients recruited for clinical trials and studies. The highest participation was among patients aged 60-69, with more male participants (59.32%) than female participants (40.68%).
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Orthopedics
Cynthia A. Kahlenberg, J. Alex B. Gibbons, Bella Y. Mehta, Vinicius C. Antao, Emily Y. Lai, Huong T. Do, Linda A. Russell, Peter K. Sculco, Mark P. Figgie, Susan M. Goodman
Summary: There is a weak correlation between early postoperative satisfaction with the process of care and 2-year satisfaction with the outcome of care after arthroplasty.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Rheumatology
Bella Mehta, Deanna Jannat-Khah, Mark Alan Fontana, Carine J. Moezinia, Carol A. Mancuso, Anne R. Bass, Vinicius C. Antao, Allan Gibofsky, Susan M. Goodman, Said Ibrahim
