Article
Medicine, Research & Experimental
Ruochen Cong, Linlin Sun, Jushun Yang, Hengxiang Cui, Xin Ji, Jing Zhu, Jin-hua Gu, Bosheng He
Summary: Protein O-GlcNAcylation is a dynamic post-translational modification that regulates cellular functions and has protective effects on ischemia-related injuries. Pharmacological manipulation to increase O-GlcNAcylation levels enhances cell survival while reducing levels makes cells more susceptible to injury. Acute increases in O-GlcNAcylation can protect against intestinal ischemia insults, suggesting it could be a potential therapeutic target for intestinal ischemic disease.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Musadiq A. Bhat, Abolghasem Esmaeili, Elena Neumann, Karthik Balakrishnan, Dietmar Benke
Summary: GABA(B) receptors play a crucial role in controlling neuronal excitability, and their downregulation can lead to excitotoxicity. This study found that preventing the interaction between CHOP and GABA(B) receptors can restore their normal expression and reduce neuronal death.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Shin Kikuchi, Takayuki Kohno, Takashi Kojima, Haruyuki Tatsumi, Yuki Ohasaki, Takafumi Ninomiya
Summary: This study revealed that during oxygen-glucose deprivation, axonal mitochondria experience reduced motility, fragmentation of stationary mitochondria, and morphological changes, indicating their involvement in neural degeneration.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Fatemeh Forouzanfar, Elham Asadpour, Hossein Hosseinzadeh, Mohammad Taher Boroushaki, Afrouz Adab, Seyedeh Hoda Dastpeiman, Hamid R. Sadeghnia
Summary: Safranal, isolated from saffron, has been shown to possess neuroprotective effects. This study demonstrated that safranal can attenuate ischemia/reperfusion-induced PC12 cell injury by modulating oxidative and apoptotic responses, thereby protecting against neurotoxicity.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Cell Biology
Song Li, Lihua Luo, Yan He, Ruohan Li, Yangfan Xiang, Zhenjie Xing, Yejian Li, Abdullkhaleg Ali Albashari, Xiangyan Liao, Keke Zhang, Liang Gao, Qingsong Ye
Summary: This study aimed to investigate the protective effects of dental pulp stem cell-derived exosomes (DPSC-Exos) against cerebral ischaemia-reperfusion (I/R) injury and explore the underlying mechanism. DPSC-Exos were found to alleviate brain oedema, cerebral infarction, and neurological impairment in I/R mice, potentially through the inhibition of the HMGB1/TLR4/MyD88/NF-κB pathway. Additionally, DPSC-Exos also showed anti-inflammatory effects by reducing the expression of IL-6, IL-1 beta, and TNF-alpha both in vitro and in vivo.
CELL PROLIFERATION
(2021)
Article
Neurosciences
Hai-Yang Liao, Rui Ran, Chao-Ming Da, Zhi-Qiang Wang, Kai-sheng Zhou, Hai-hong Zhang
Summary: Spinal cord injury (SCI) is a common disease of the nervous system, and neuronal inflammation plays a crucial role in the pathological process of SCI. The study shows that Ski, a functional transcriptional regulator protein, is upregulated in reactive astrocytes after SCI, and its downregulation effectively inhibits glial inflammation in SCI by inhibiting the activity of the NF-kappa B pathway. This finding suggests that Ski may serve as a promising therapeutic target for inflammatory responses after SCI.
Article
Biochemistry & Molecular Biology
Yu Feng, Luodan Yang, Xiaohui Ma, Zhihai Huang, Xuemei Zong, Cristiane Teresinha Citadin, Hung Wen Lin, Quanguang Zhang
Summary: The study investigated the effects of photobiomodulation (PBM) on synaptic proteins and astrocyte polarization after stroke. PBM treatment increased synaptic proteins and neuroprotective astrocytic marker, while inhibiting neurotoxic astrocytic marker in stroke-induced rats. In vitro studies also showed that PBM treatment could protect neurons and preserve synaptic proteins during oxygen-glucose deprivation (OGD) exposure. Overall, PBM was effective in inhibiting neurotoxic astrocytic polarization and protecting neurons against stroke injury.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Neurosciences
Vito Antonio Baldassarro, Maura Cescatti, Maria Luisa Rocco, Luigi Aloe, Luca Lorenzini, Luciana Giardino, Laura Calza
Summary: This study revealed the impact of nerve growth factor (NGF) on the survival, differentiation, and maturation of astrocytes and the cells responsible for myelin formation, turnover, and repair in the central nervous system (CNS), as well as its protective role in OPCs under pathological conditions.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Cell Biology
Dandan Xu, Tingting Kong, Shengnan Zhang, Baohua Cheng, Jing Chen, Chunmei Wang
Summary: The study found that Orexin A can exert neuroprotective effects by inhibiting over-activated autophagy pathway in cerebral ischemia-reperfusion injury. The results elucidate the roles of autophagy in injury and the molecular mechanisms underlying the neuroprotective action of Orexin A.
CELLULAR SIGNALLING
(2021)
Article
Cardiac & Cardiovascular Systems
Li Wang, Chuanhe Wang, Zhaoqing Sun, Aolin Du, Fei Shan, Zhijun Sun
Summary: Knockdown of circ-0001380 alleviates myocardial injury in MI/R mice. In vitro, silence of circ-0001380 enhances cell viability, inhibits apoptosis and oxidative stress in HL-1 cells under OGD/R. The miR-106b-5p/Phlpp2 axis mediates the effect of circ-0001380 on OGD/R-induced apoptosis.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Zhanyang Yu, Wenlu Li, Jing Lan, Kazuhide Hayakawa, Xunming Ji, Eng H. Lo, Xiaoying Wang
Summary: The study suggests that ephrin-B2-EphB2 signaling may serve as a promising therapeutic target for protecting both neuronal soma and dendrites against ischemic injury.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Justyna Gargas, Justyna Janowska, Karolina Ziabska, Malgorzata Ziemka-Nalecz, Joanna Sypecka
Summary: This study aimed at developing a protocol for efficient culture of rat neonatal glial cells in oxygen concentrations relevant to the nervous tissue. The protocol allows for obtaining three major cell populations and can be used to model selected neuropathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Min Zhang, Wei Lin, Xiaoyue Tao, Wei Zhou, Zhiming Liu, Zhe Zhang, Shuqing Jin, Haojie Zhang, Cheng Teng, Jianghu Zhu, Xiaoling Guo, Zhenlang Lin
Summary: Hypoxic ischemic encephalopathy (HIE) is a major cause of neonatal mortality and currently lacks effective treatment. Ginsenoside Rb1 (GsRb1), a component of ginseng, has shown protective effects against oxidative stress, inflammation, and hypoxic injury. However, the role and mechanism of GsRb1 in HIE remain unclear.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Jinying Xu, Tong Ji, Guichen Li, Haiying Zhang, Yangyang Zheng, Meiying Li, Jie Ma, Yulin Li, Guangfan Chi
Summary: The study reveals that under conditions of ischemia or oxygen-glucose deprivation (OGD), lactate stabilizes NDRG2 in astrocytes by inhibiting its ubiquitination, which plays an important anti-inflammatory role and inhibits TNF alpha expression and secretion. This finding suggests that NDRG2 may be a potential therapeutic target for cerebral ischemia.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Daniel Bormann, Tamara Stojanovic, Ana Cicvaric, Gabor J. Schuld, Maureen Cabatic, Hendrik Jan Ankersmit, Francisco J. Monje
Summary: The deletion of miRNA-132/212 genes worsened the detrimental effects of ischemia on synaptic transmission in the dentate gyrus while altering the expression of cholinergic signaling elements, suggesting the presence of a miRNA-132/212-dependent adaptive mechanism protecting synaptic function in the acute phase of cerebral ischemia.