Review
Immunology
Takumi Kawasaki, Moe Ikegawa, Taro Kawai
Summary: The lungs have an immune defense mechanism that uses various cells to eliminate harmful pathogens and activate T cell immune response. In addition to immune cells, other lung cells also participate in antigen presentation and T cell activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hejin Jiang, Rui Liu, Lu Wang, Xinyue Wang, Mengmeng Zhang, Sisi Lin, Zhenping Cao, Feng Wu, Yingbin Liu, Jinyao Liu
Summary: Chirality plays a critical role in biological systems, and this study demonstrates the potential of using supramolecular chiral polymer micelles (SCPMs) to activate the immune system for disease prevention and treatment.
ADVANCED MATERIALS
(2023)
Article
Computer Science, Information Systems
Peng Chu, Lijin Xie, Chuanjin Dai, Yarong Chen
Summary: The paper focuses on the original signal spectrum and the second-order spectrum of the pre-demodulated signal to extract modulation features, proposes a novel statistic for discrimination, and uses support vector machine (SVM) for classification.
IEEE WIRELESS COMMUNICATIONS LETTERS
(2021)
Review
Immunology
Ray A. Ohara, Kenneth M. Murphy
Summary: Cross-priming, initially recognized in cytotoxic T lymphocyte (CTL) responses, involves the presentation of minor histocompatibility antigens by antigen presenting cells (APCs) derived from immunizing cells. As understanding of T cell receptor antigen recognition progressed, cross-priming was redefined as cross-presentation and expanded to include different forms of antigens and APCs not involved in in vivo CTL priming. In vitro cell models have been utilized for studying cross-presentation, but recent studies have shown differences between these models and in vivo APCs. Current research focuses on validating in vivo pathways and gene candidates for cross-presentation, and evaluating their contributions to CTL responses across different antigens and immunologic settings.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Ryosuke Tashiro, Kuniyasu Niizuma, Jun Kasamatsu, Yuko Okuyama, Sherif Rashad, Atsuo Kikuchi, Miki Fujimura, Shigeo Kure, Naoto Ishii, Teiji Tominaga
Summary: The study found that RNF213 plays a critical role in antigen uptake, processing, and presentation, with Rnf213-KO and Rnf213-KI mice experiments showing that RNF213 deficiency leads to decreased antigen uptake and processing capabilities, resulting in the inability to effectively activate antigen-specific T cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Immunology
Jiri Brezina, Matous Voboril, Dominik Filipp
Summary: The evolution of the adaptive immune system leads to the generation of self-reactive clones, which must be eliminated to prevent autoimmunity. This process occurs in the thymic medulla, where the interaction between T cell receptor and self-peptide MHC complexes determines the fate of thymocytes. Thymic antigen presenting cells, including medullary thymic epithelial cells and dendritic cells, play a fundamental role in presenting self-antigens in the thymus for the establishment of T cell central tolerance. Recent studies have revealed the heterogeneity of these cell subsets and their roles in T cell selection processes, adding complexity to our understanding. Identification of molecular determinants controlling the presentation of self-antigens would advance our knowledge in this area.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jie Zhang, Biao Fan, Guoliang Cao, Wenping Huang, Fuhao Jia, Guangjun Nie, Hai Wang
Summary: This study developed a personalized DC-mimicking nanovaccine for stimulating TAAs-specific T cell populations. By inducing BMDCs maturation and delivering TAAs through nanostructures, the nanoDCs efficiently generated potent antigen-specific T cell responses, leading to inhibition of tumor growth and metastases formation.
ADVANCED MATERIALS
(2022)
Article
Oncology
Mirela Kremenovic, Alfred A. Chan, Bing Feng, Lukas Baeriswyl, Steve Robatel, Thomas Gruber, Li Tang, Delphine J. Lee, Mirjam Schenk
Summary: In this study, a novel BCG lysate was developed and formulated into a thermosensitive hydrogel. The BCG lysate exhibited enhanced antitumor efficacy and promoted a proinflammatory tumor microenvironment in vivo. The underlying mechanisms of BCG lysate-mediated tumor immunity relied on macrophages (M phi) and dendritic cells (DCs). The BCG hydrogel treatment induced systemic immunity, suppressed lung metastases, and improved survival in melanoma-bearing mice. Furthermore, BCG hydrogel treatment enhanced antigen processing and presentation, and increased the frequency of melanoma-reactive CD8(+) T cells. In human melanoma patients, intralesional-BCG treatment was associated with enhanced M1 M phi, mature DCs, antigen processing and presentation, and increased patient survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Christian Moebs, Martin Salheiser, Fabian Bleise, Marie Witt, Johannes U. Mayer
Summary: This review aims to highlight the role of basophils in antigen presentation and T cell priming, as well as resolving the debate on whether basophils influence antigen presentation through direct or indirect mechanisms. Tissue-specific differences in basophil phenotypes and their interactions with other antigen-presenting cells will be discussed, along with their implications on immunological and clinical outcomes of disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Janice J. Huang, Samantha B. Gaines, Mateo L. Amezcua, Tamar R. Lubell, Peter S. Dayan, Marissa Dale, Alexis D. Boneparth, Mark D. Hicar, Robert Winchester, Mark Gorelik
Summary: This study aimed to analyze the immunologic features of MIS-C patients compared to febrile controls. The results showed that elevated cytokines, activation of type 1 dendritic cells, and dysregulation of NK cells were key features in the pathophysiology of this syndrome.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Takuya Sakamoto, Terutsugu Koya, Misa Togi, Kenichi Yoshida, Tomohisa Kato, Yasuhito Ishigaki, Shigetaka Shimodaira
Summary: This study evaluated the function and preclinical validation of human dendritic cell (DC) dexosomes, small DC-secreted vesicles that contain immune signals, for cancer vaccination. The researchers characterized a potential dexosome model using immature and mature DCs derived from a cell line called MUTZ3, and found that one type of MUTZ3-derived DC dexosomes exhibited potential immunogenicity and higher antigen presentation potency, making them potential resources for cancer immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Christophe Macri, Devi Jenika, Cassandra Ouslinis, Justine D. Mintern
Summary: Dendritic cells (DCs) are specialized antigen-presenting cells that play a critical role in adaptive immunity. Targeting antigen directly to DCs is a selective vaccination strategy that takes advantage of the antigen uptake and presentation functions of DC subsets. This review focuses on DC-targeted vaccination strategies aimed at inducing effective cross-presentation for CD8+ T cell immunity. Receptors highly expressed by mouse and human cDCs, such as DEC205, Clec9A, and XCR1, are explored. The outcomes of DC-targeted vaccination in mouse models and human clinical trials are discussed, highlighting its potential for the prevention and treatment of tumors and infectious diseases.
SEMINARS IN IMMUNOLOGY
(2023)
Review
Immunology
Francois-Xavier Mauvais, Peter van Endert
Summary: The critical role of conventional dendritic cells in the immune response to tumors and pathogens is well-established. However, various other cell types, including myeloid, lymphoid, endothelial, epithelial, and stromal cells, have been shown to also possess the ability to cross-present antigens. This review analyzes the literature on this topic, discussing the antigens and readouts used, mechanistic insights, and in vivo experimentation. While many studies rely on artificial systems, there is evidence to suggest that cross-presentation by non-dendritic cells may have significant implications in anti-tumor immunity and autoimmunity.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Engineering, Mechanical
Benjamin Boll, Lennart Dorendorf, Peter Oppermann, Erik Willmann, Bodo Fiedler, Bernd-Christian Renner, Marcus Rutner, Robert Horst Meissner
Summary: The vibroacoustic modulation (VAM) is a nonlinear ultrasonic testing method that utilizes the modulation of a high-frequency/low-amplitude probe wave with a low-frequency/high-amplitude pumping vibration, resulting in high sensitivities to damages in the structure. A synthetic generation of the VAM signal using probe measurements acquired at different stress levels is proposed, reducing the sensing requirements and decoupling VAM from the need for a constant recurrent frequency and amplitude of the natural vibration. This method opens the possibility of applying VAM to assess the structural health of complex structures.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2023)
Article
Biochemistry & Molecular Biology
Payton L. Marshall, Nadine Nagy, Gernot Kaber, Graham L. Barlow, Amrit Ramesh, Bryan J. Xie, Miles H. Linde, Naomi L. Haddock, Colin A. Lester, Quynh-Lam Tran, Christiaan R. de Vries, Aviv Hargil, Andrey V. Malkovskiy, Irina Gurevich, Hunter A. Martinez, Hedwich F. Kuipers, Koshika Yadava, Xiangyue Zhang, Stephen P. Evanko, John A. Gebe, Xi Wang, Robert B. Vernon, Carol de la Motte, Thomas N. Wight, Edgar G. Engleman, Sheri M. Krams, Everett H. Meyer, Paul L. Bollyky
Summary: Treatment with 4-methylumbelliferone (4MU) reduces pericellular hyaluronan, disrupts interactions between DC and T-cells, and inhibits T-cell proliferation. 4MU can delay rejection of allogeneic pancreatic islet and cardiac transplants, as well as suppress allogeneic T-cell activation.
Article
Immunology
Shengbo Zhang, Hannah D. Coughlan, Mitra Ashayeripanah, Simona Seizova, Andrew J. Kueh, Daniel Brown, Wang Cao, Nicolas Jacquelot, Angela D'Amico, Andrew M. Lew, Yifan Zhan, Christopher J. Tonkin, Jose A. Villadangos, Gordon K. Smyth, Michael Chopin, Stephen L. Nutt
Summary: The transcription factor DC-SCRIPT plays a critical role in the development and function of conventional dendritic cells (cDC1), with its deficiency leading to impaired antigen capture and presentation capabilities. This study highlights the importance of DC-SCRIPT in maintaining the identity and functional attributes of cDC1s.
SCIENCE IMMUNOLOGY
(2021)
Review
Immunology
Antoine Roquilly, Justine D. Mintern, Jose A. Villadangos
Summary: Macrophages and conventional dendritic cells are crucial for maintaining tissue homeostasis, coordinating immune responses, and fighting against infections and cancer. They acquire spatiotemporal adaptations in response to different environmental challenges, but these adaptations can also lead to immunosuppression. Understanding their development and adaptation mechanisms can help harness their beneficial outcomes and minimize their adverse effects.
ANNUAL REVIEW OF IMMUNOLOGY
(2022)
Article
Oncology
Tony Yao, Patrick T. Rudak, Celine M. Laumont, Alex R. Michaud, Rasheduzzaman Rashu, Natasha N. Knier, Paula J. Foster, Hamish E. G. McWilliam, Jose A. Villadangos, Brad H. Nelson, Gabriel E. DiMattia, Trevor G. Shepherd, S. M. Mansour Haeryfar
Summary: Research on mucosa-associated invariant T (MAIT) cells in epithelial ovarian cancer (EOC) reveals their low frequency in tumors but potential immunomodulatory and cytotoxic properties. In a mouse model, MAIT cells showed IL-17A and IFN-gamma production in the peritoneal cavity but lost these functions with tumor progression. Ascitic MAIT cells in EOC patients exhibit inducible effector functions, suggesting potential modifications for future immunotherapeutic strategies.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Cell Biology
Rebecca Seneviratna, Samuel J. Redmond, Hamish E. G. McWilliam, Rangsima Reantragoon, Jose A. Villadangos, James McCluskey, Dale Godfrey, Nicholas A. Gherardin
Summary: Recent studies have shown that MR1-restricted T cells can react to a variety of antigens, including tumor cells and tumor-derived self-antigens. By using TCR gene transfer and engineered MR1-expressing antigen-presenting cells, researchers further investigated the reactivity of MR1-restricted TCRs and found differential dependence on MR1 position and competitive inhibition by ligands. However, TCR-expressing reporter cell lines failed to fully replicate the previously reported tumor specificity, suggesting the importance of accessory molecules in MR1-dependent tumor reactivity.
IMMUNOLOGY AND CELL BIOLOGY
(2022)
Article
Immunology
Shivam K. Purohit, Carolyn Samer, Hamish E. G. McWilliam, Renee Traves, Megan Steain, Brian P. McSharry, Paul R. Kinchington, David C. Tscharke, Jose A. Villadangos, Jamie Rossjohn, Allison Abendroth, Barry Slobedman
Summary: This study demonstrates that varicella zoster virus suppresses the expression of antigen presentation molecule MR1, highlighting the intricate temporal relationship between infection and ligand availability. The study also suggests that VZV likely encodes multiple viral genes targeting MR1.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Patrick Schriek, Alan C. Ching, Nagaraj S. Moily, Jessica Moffat, Lynette Beattie, Thiago M. Steiner, Laine M. Hosking, Joshua M. Thurman, V. Michael Holers, Satoshi Ishido, Mireille H. Lahoud, Irina Caminschi, William R. Heath, Justine D. Mintern, Jose A. Villadangos
Summary: Marginal zone B cells acquire dendritic cell-like properties through the trogocytic acquisition of MHC II-C3 complexes from conventional dendritic cells.
Article
Critical Care Medicine
Tanguy Chaumette, Raphael Cinotti, Alice Molle, Pierre Solomon, Louise Castain, Cynthia Fourgeux, Hamish E. G. McWilliam, Barbara Misme-Aucouturier, Alexis Broquet, Cedric Jacqueline, Mickael Vourc'h, Delphine Fradin, Celine Bossard, Laurent David, Emmanuel Montassier, Cecile Braudeau, Regis Josien, Jose A. Villadangos, Karim Asehnoune, Celine Bressollette-Bodin, Jeremie Poschmann, Antoine Roquilly
Summary: Brain injury induces immunosuppression, increasing the risk of viral reactivations and impairing neurological recovery. This study found that lung replication of herpesviridae is associated with poor recovery after brain injury, and a specific monocyte signature can predict the neurological outcome at 6 months.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Biochemical Research Methods
Vanta J. Jameson, Tina Luke, Yuting Yan, Angela Hind, Maximilien Evrard, Kevin Man, Laura K. Mackay, Axel Kallies, Jose A. Villadangos, Hamish E. G. McWilliam, Alexis Perez-Gonzalez
Summary: Understanding the impact of autofluorescence on signal resolution in cytometry is crucial for experimental design and data quality. This study provides mathematical predictions and empirical evidence to support the importance of autofluorescence extraction through full spectrum unmixing. The study also presents a novel method for isolating pure cell subset-specific autofluorescence profiles based on high dimensionality reduction algorithms.
Article
Multidisciplinary Sciences
Haiyin Liu, Kayla R. Wilson, Ashley M. Firth, Christophe Macri, Patrick Schriek, Annabelle B. Blum, Javiera Villar, Samuel Wormald, Mitch Shambrook, Bangyan Xu, Hui Jing Lim, Hamish E. G. McWilliam, Andrew F. Hill, Laura E. Edgington-Mitchell, Irina Caminschi, Mireille H. Lahoud, Elodie Segura, Marco J. Herold, Jose A. Villadangos, Justine D. Mintern
Summary: This study reveals the critical role of ubiquitin-like protein 3 (UBL3) in the trafficking process controlled by MARCH1. UBL3 has wide-ranging immunological consequences and is essential for immune responses.
NATURE COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Mickael Vourc'h, Antoine Roquilly, Adrien Foucher, Christelle Retiere, Fanny Feuillet, Sapna Devi, Hamish E. G. McWilliam, Cecile Braudeau, Geraldine Bourreille, Abderrahman Hachani, Dermot O'Kane, Scott N. Mueller, Joseph Ischia, Jean-Christian Roussel, Jean-Christophe Rigal, Regis Josien, Bertrand Rozec, Jose A. Villadangos, Karim Asehnoune
Summary: This study found that transfusion of packed red blood cells with high levels of MRP_14 may increase the incidence of AKI after cardiac surgery. Higher concentrations of MRP_14 were found in packed red blood cells from female donors or prepared by whole blood filtration.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Cell Biology
Marine Gros, Elodie Segura, Derek C. Rookhuizen, Blandine Baudon, Sandrine Heurtebise-Chretien, Nina Burgdorf, Mathieu Maurin, Eugene A. Kapp, Richard J. Simpson, Patrycja Kozik, Jose A. Villadangos, Mathieu J. M. Bertrand, Marianne Burbage, Sebastian Amigorena
Summary: Despite its importance in immune responses, the molecular pathways underlying antigen cross-presentation are not fully understood. This study reveals that membrane repair plays a crucial role in containing antigen export to the cytosol and cross-presentation in conventional dendritic cells (cDCs).
Article
Cell Biology
Hui Jing Lim, Jacinta M. Wubben, Cristian Pinero Garcia, Sebastian Cruz-Gomez, Jieru Deng, Jeffrey Y. W. Mak, Abderrahman Hachani, Regan J. Anderson, Gavin F. Painter, Jesse Goyette, Shanika L. Amarasinghe, Matthew E. Ritchie, Antoine Roquilly, David P. Fairlie, Katharina Gaus, Jamie Rossjohn, Jose A. Villadangos, Hamish E. G. McWilliam
Summary: MR1 is a conserved microbial immune-detection system in mammals that presents antigens to specific lymphocytes, contributing to host defense and tissue repair. This study reveals that human MR1 interacts with the endocytic adaptor protein 2 (AP2) complex to regulate its internalization from the cell surface, thus controlling antigen presentation and microbial metabolic detection.
JOURNAL OF CELL BIOLOGY
(2022)
Editorial Material
Immunology
Antoine Roquilly, Jose A. Villadangos
Summary: The BCG vaccine provides homotypic protection against tuberculosis and surprising heterotypic protection against other pathogens. New research reveals that BCG vaccination leads to leakage of gut microbial metabolites into circulation, triggering protective changes in alveolar macrophages against pneumonia.
Article
Immunology
Caroline L. Ashley, Brian P. McSharry, Hamish E. G. McWilliam, Richard J. Stanton, Ceri A. Fielding, Rommel A. Mathias, David P. Fairlie, James McCluskey, Jose A. Villadangos, Jamie Rossjohn, Allison Abendroth, Barry Slobedman
Summary: This study reveals that human cytomegalovirus (HCMV) inhibits the MR1 pathway and disrupts the MR1:MAIT cell axis through the viral protein gpUS9. The interaction between this virus and MAIT cells in the context of viral infection is not well characterized.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Patrick Schriek, Jose A. Villadangos
Summary: Antigen-presenting cells capture or synthesize antigens and present them on their plasma membrane through major histocompatibility complex (MHC) molecules. Trogocytosis is a mechanism where cells acquire fragments from other cells and incorporate them into their own plasma membrane, including intact antigens and MHC molecules. Trogocytosis expands cellular immunological functions with both beneficial and deleterious consequences.
CURRENT OPINION IN IMMUNOLOGY
(2023)
