期刊
CURRENT OPINION IN PHARMACOLOGY
卷 11, 期 5, 页码 453-456出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2011.07.009
关键词
-
资金
- Achaogen
- AstraZeneca
- Merck
The widespread emergence of resistance to antimicrobial agents has taken mammoth dimension and warrants immediate steps to minimize it. Pharmacokinetics/pharmacodynamics of antimicrobial agents, differences among bacterial species, and time-dependent changes in the bacterial population are important factors involved in the development of drug resistance. The key to minimizing resistance lies in understanding how these factors affect resistance emergence and incorporating them in dosing regimen design. In vitro models have proven to be a valuable tool to study these factors and their contribution in resistance emergence. This review summarizes the key factors implicated in resistance development and the lessons learnt from in vitro studies optimizing antimicrobial dosing to prevent resistance emergence.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据