Review
Cell Biology
Alejandro Ordaz-Ramos, Olivia Tellez-Jimenez, Karla Vazquez-Santillan
Summary: Breast cancer stem cells (BCSCs) are a specific subpopulation of cells capable of self-renewal and differentiation into diverse tumor cells. The involvement of cancer stem cells in treatment resistance and cancer recurrence is well established. Specific signaling pathways, such as Wnt/beta-catenin, NF-kappa B, Notch, Hedgehog, TGF-beta, and Hippo, play crucial roles in regulating the self-renewal ability of cancer stem cells. Targeting these signaling pathways holds promise as a therapeutic strategy for combating breast cancer aggressiveness. This review discusses the main signaling pathways involved in maintaining the self-renewal ability of BCSCs and highlights current strategies to disrupt stemness-related signaling molecules.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell & Tissue Engineering
Kai Song, Maryam Farzaneh
Summary: Breast cancer stem cells play a critical role in the metastasis and aggressiveness of breast cancer, making them a suitable target for treatment. Signaling pathways such as Wnt, NF kappa B, and miRNAs are key players in regulating BCSC self-renewal and metastasis. Targeting these pathways may offer a novel therapeutic approach for breast cancer diagnosis and therapy.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Oncology
Lei Wang, Zeng Jin, Rohan P. Master, Chandra K. Maharjan, Madison E. Carelock, Tiffany B. A. Reccoppa, Myung-Chul Kim, Ryan Kolb, Weizhou Zhang
Summary: This article summarizes the important features of breast cancer stem cells, major signaling pathways, and cellular interactions within the tumor microenvironment, highlighting the significance of BCSCs in breast cancer and potential therapeutic strategies.
Article
Cell & Tissue Engineering
Sidse Ehnnsen, Henrik J. Ditzel
Summary: Breast cancer stem cells play a crucial role in cancer initiation, therapy resistance, and progression, with recent research focusing on cellular signaling pathways such as the WNT pathway, NF-κB pathway, and cholesterol biosynthesis pathway. Targeting these pathways in combination with standard treatments may improve the prognosis of breast cancer patients.
Article
Cell Biology
Ava Nasrolahi, Shirin Azizidoost, Klaudia Radoszkiewicz, Sajad Najafi, Farhoodeh Ghaedrahmati, Omid Anbiyaee, Seyed Esmaeil Khoshnam, Maryam Farzaneh, Shahab Uddin
Summary: Glioma is a common malignant brain tumor that arises from glial tissue. Glioma cancer stem cells (GCSCs) have been identified as playing important roles in tumor initiation and metastasis. Targeting GCSCs and their associated signaling pathways, as well as non-coding RNAs, could be a novel strategy for glioma treatment. In this review, critical signaling pathways involved in GCSC tumorigenesis and invasiveness are summarized.
CELLULAR SIGNALLING
(2023)
Review
Biochemistry & Molecular Biology
Andrea Angius, Antonio Mario Scanu, Caterina Arru, Maria Rosaria Muroni, Vincenzo Rallo, Giulia Deiana, Maria Chiara Ninniri, Ciriaco Carru, Alberto Porcu, Giovanna Pira, Paolo Uva, Paolo Cossu-Rocca, Maria Rosaria De Miglio
Summary: Colorectal cancer stem cells (CCSCs) with stemness behaviors play a crucial role in tumor progression and therapy resistance, associated with genetic changes in signaling pathways. Dysregulated CCSC-related miRNAs modulate stemness features and functions, involving cell cycle gene expression, epithelial-mesenchymal transition, and drug-resistance mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Emilio M. Serrano-Lopez, Teresa Coronado-Parra, Consuelo Marin-Vicente, Zoltan Szallasi, Victoria Gomez-Abellan, Maria Jose Lopez-Andreo, Marcos Gragera, Juan C. Gomez-Fernandez, Ruben Lopez-Nicolas, Senena Corbalan-Garcia
Summary: PKC comprises a family of serine/threonine protein kinases involved in multiple signaling pathways controlling cell proliferation, survival, and differentiation. Inhibition of PKC alpha gene expression in breast cancer cells identified a set of down-regulated proteins and oncogenic kinases, suggesting an oncogenic role for PKC alpha in this specific cancer model. The study also provides insights into the signaling mode of PKC alpha and suggests potential targeted cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Nasim Ebrahimi, Maral Afshinpour, Siavash Seifollahy Fakhr, Paniz Ghasempour Kalkhoran, Vida Shadman-Manesh, Samaneh Adelian, Sheida Beiranvand, Fatemeh Rezaei-Tazangi, Roya Khorram, Michael R. Hamblin, Amir Reza Aref
Summary: Colorectal cancer (CRC) is a major cause of cancer death worldwide. The presence of cancer stem cells (CSCs) contributes to therapy resistance and recurrence. This review examines the role of signaling pathways in colorectal CSCs and discusses potential drugs for treatment of resistant CRC.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Oncology
Gulab Sher, Tariq Masoodi, Kalyani Patil, Sabah Akhtar, Shilpa Kuttikrishnan, Aamir Ahmad, Shahab Uddin
Summary: Since the introduction of the cancer stem cell paradigm, significant progress has been made in understanding the role of cancer stem cells (CSCs) in tumor biology, including metastasis and drug resistance. The transcription factor FOXM1 has emerged as a key regulator of CSCs, involved in their formation, maintenance, and functionality. This review summarizes the evidence for the mechanisms by which FOXM1 promotes stemness in different types of cancers and highlights its prognostic importance.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Martha Robles-Flores, Angela P. Moreno-Londono, M. Cristina Castaneda-Patlan
Summary: Cancer cells exhibit high proliferation rates and must adapt their metabolism to cope with environmental stressors. Cancer stem cells can switch between glycolysis and oxidative phosphorylation based on environmental factors, displaying high metabolic plasticity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Oncology
Jing Jin, Florina Grigore, Clark C. Chen, Ming Li
Summary: Glioblastoma multiforme (GBM) is a primary brain tumor with a high mortality rate, and the treatment is mainly palliative. GBM contains subsets of GBM stem cells (GSCs) which are potentially associated with tumor initiation and exhibit resistance to radiotherapy and chemotherapy. Targeting self-renewal signaling pathways in cancer stem cells may help reduce tumor recurrence.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Sabya Sachi Das, Sandeep Kumar Singh, P. R. P. Verma, Rekha Gahtori, Belay Zeleke Sibuh, Kavindra Kumar Kesari, Niraj Kumar Jha, Sugapriya Dhanasekaran, Vijay Kumar Thakur, Ling Shing Wong, Sinouvassane Djearamane, Piyush Kumar Gupta
Summary: Inflammations play a crucial role in the growth and treatment of cancer cells. Conventional chemotherapeutics have limitations, while nanotechnology offers potential benefits. Polyester-based nanoparticulate delivery systems have been extensively studied for targeting inflammation-mediated cancers.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Josiane W. Tessmann, Murilo R. Rocha, Jose A. Morgado-Diaz
Summary: Radiotherapy is commonly used for tumor treatment, but cancer cells often develop resistance to it, leading to therapeutic failure. This review discusses recent studies on the relationship between radioresistance and alterations in cellular mechanisms and signaling pathways in colorectal cancer. Understanding these mechanisms can improve radiotherapy sensitivity and patient outcomes.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Review
Oncology
Giuliana Catara, Daniela Spano
Summary: Cancer is a global public health issue with increasing cases expected by 2040, and cancer stem cells (CSCs) play a crucial role in treatment due to their resistance to conventional therapies. It is crucial to research and design alternative combinatorial therapeutic strategies to combat this resistance.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Tong Niu, Weiwei Zhang, Wei Xiao
Summary: Breast cancer stem cells (BCSCs) play critical roles in modulating breast tumor behaviors and drug resistance, while miRNAs in breast cancer exhibit multifaceted roles as suppressors or oncogenes in regulating cancer progression. The review highlights the importance of miRNAs in regulating key signaling pathways that are essential for BCSC maintenance.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell & Tissue Engineering
Masamitsu Konno, Hideshi Ishii, Jun Koseki, Nobuhiro Tanuma, Naohiro Nishida, Koichi Kawamoto, Tatsunori Nishimura, Asuka Nakata, Hidetoshi Matsui, Kozou Noguchi, Miyuki Ozaki, Yuko Noguchi, Hiroshi Shima, Noriko Gotoh, Hiroaki Nagano, Yuichiro Doki, Masaki Mori
REGENERATIVE THERAPY
(2015)
Article
Oncology
Soichiro Sasaki, Tomohisa Baba, Tatsunori Nishimura, Yoshihiro Hayakawa, Shin-ichi Hashimoto, Noriko Gotoh, Naofumi Mukaida
Article
Oncology
Takahiko Murayama, Takashi Nakaoku, Masato Enari, Tatsunori Nishimura, Kana Tominaga, Asuka Nakata, Arinobu Tojo, Sumio Sugano, Takashi Kohno, Noriko Gotoh
Article
Gastroenterology & Hepatology
Shuji Hibiya, Kiichiro Tsuchiya, Ryohei Hayashi, Keita Fukushima, Nobukatsu Horita, Sho Watanabe, Tomoaki Shirasaki, Ryu Nishimura, Natsuko Kimura, Tatsunori Nishimura, Noriko Gotoh, Shigeru Oshima, Ryuichi Okamoto, Tetsuya Nakamura, Mamoru Watanabe
JOURNAL OF CROHNS & COLITIS
(2017)
Article
Biochemistry & Molecular Biology
K. Tominaga, T. Shimamura, N. Kimura, T. Murayama, D. Matsubara, H. Kanauchi, A. Niida, S. Shimizu, K. Nishioka, E-I Tsuji, M. Yano, S. Sugano, Y. Shimono, H. Ishii, H. Saya, M. Mori, K. Akashi, K-I Tada, T. Ogawa, A. Tojo, S. Miyano, N. Gotoh
Article
Multidisciplinary Sciences
Atsunobu Sagara, Katsuhide Igarashi, Maky Otsuka, Takeshi Karasawa, Noriko Gotoh, Michiko Narita, Naoko Kuzumaki, Minoru Narita, Yoshinori Kato
Article
Biochemistry & Molecular Biology
S. Kitajima, A. Yoshida, S. Kohno, F. Li, S. Suzuki, N. Nagatani, Y. Nishimoto, N. Sasaki, H. Muranaka, Y. Wan, T. C. Thai, N. Okahashi, F. Matsuda, H. Shimizu, T. Nishiuchi, Y. Suzuki, K. Tominaga, N. Gotoh, M. Suzuki, M. E. Ewen, D. A. Barbie, O. Hirose, T. Tanaka, C. Takahashi
Article
Genetics & Heredity
Ankur Garg, Mukesh Bansal, Noriko Gotoh, Gen-Sheng Feng, Jian Zhong, Fen Wang, Ariana Kariminejad, Steven Brooks, Xin Zhang
Article
Cell Biology
Hongge Li, Chenqi Tao, Zhigang Cai, Kristina Hertzler-Schaefer, Tamica N. Collins, Fen Wang, Gen-Sheng Feng, Noriko Gotoh, Xin Zhang
JOURNAL OF CELL SCIENCE
(2014)
Article
Oncology
Shinji Kohsaka, Kunihiko Hinohara, Lei Wang, Tatsunori Nishimura, Masana Urushido, Kazuhiro Yachi, Masumi Tsuda, Mishie Tanino, Taichi Kimura, Hiroshi Nishihara, Noriko Gotoh, Shinya Tanaka
Article
Multidisciplinary Sciences
Hisataka Ogawa, Xin Wu, Koichi Kawamoto, Naohiro Nishida, Masamitsu Konno, Jun Koseki, Hidetoshi Matsui, Kozou Noguchi, Noriko Gotoh, Tsuyoshi Yamamoto, Kanjiro Miyata, Nobuhiro Nishiyama, Hiroaki Nagano, Hirofumi Yamamoto, Satoshi Obika, Kazunori Kataoka, Yuichiro Doki, Masaki Mori, Hideshi Ishii
Article
Multidisciplinary Sciences
Masamitsu Konno, Jun Koseki, Koichi Kawamoto, Naohiro Nishida, Hidetoshi Matsui, Dyah Laksmi Dewi, Miyuki Ozaki, Yuko Noguchi, Koshi Mimori, Noriko Gotoh, Nobuhiro Tanuma, Hiroshi Shima, Yuichiro Doki, Masaki Mori, Hideshi Ishii
Article
Multidisciplinary Sciences
Atsushi Hamabe, Masamitsu Konno, Nobuhiro Tanuma, Hiroshi Shima, Kenta Tsunekuni, Koichi Kawamoto, Naohiro Nishida, Jun Koseki, Koshi Mimori, Noriko Gotoh, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori, Hideshi Ishii
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Review
Cell Biology
Takahiko Murayama, Noriko Gotoh
Article
Oncology
Mizuki Yamamoto, Kota Sakane, Kana Tominaga, Noriko Gotoh, Takayoshi Niwa, Yasuko Kikuchi, Keiichiro Tada, Naoki Goshima, Kentaro Semba, Jun-ichiro Inoue