Review
Oncology
Emanuel Christ, Donato Iacovazzo, Marta Korbonits, Aurel Perren
Summary: Endogenous hyperinsulinemic hypoglycemia is a rare condition that is mostly caused by a single insulinoma. Recent evidence suggests that mutations in the MAFA gene may be associated with familial insulinomatosis.
ENDOCRINE-RELATED CANCER
(2023)
Review
Biochemistry & Molecular Biology
Elisa Stradiotto, Davide Allegrini, Giovanni Fossati, Raffaele Raimondi, Tania Sorrentino, Domenico Tripepi, Gianmaria Barone, Antonio Inforzato, Mario R. Romano
Summary: AMD is a complex disease caused by the interaction of environmental and genetic factors, with the genetic component playing a pivotal role in its development. Studies have discovered associations between genetic polymorphisms and AMD, leading to the creation of genetic tests and polygenic scores to predict risk and treatment response. Further research is needed to validate these tests and determine the impact of individual genetic structure on treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Shuji Miyagawa, Akira Maeda, Chiyoshi Toyama, Shuhei Kogata, Chizu Okamatsu, Riho Yamamoto, Kazunori Masahata, Masafumi Kamiyama, Hiroshi Eguchi, Masahito Watanabe, Hiroshi Nagashima, Masahito Ikawa, Katsuyoshi Matsunami, Hiroomi Okuyama
Summary: The origin of xeno-rejection, including the activation of antibodies and the complement system, remains controversial. The complement system is an important mechanism in xeno-rejection, and it is reasonable to use multiple complement regulatory proteins to protect xenografts. Further assessment of antigens and control of signals between macrophages and lymphocytes are necessary.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Yasmin Granot-Matok, Assaf Ezra, Srinivas Ramishetti, Preeti Sharma, Gonna Somu Naidu, Itai Benhar, Dan Peer
Summary: Cancer therapy has advanced greatly in the past decade, providing new strategies to inhibit cancer cell growth using immune modulation and gene therapy. Recent advances in mRNA delivery have shown the potential of mRNA-based vaccines and immune-modulators for cancer therapeutics. In our study, we demonstrated that local administration of LNPs entrapping a modified mRNA encoding a bacterial toxin induced significant anti-tumor effects and improved overall survival of treated mice. We propose mmRNA-loaded LNPs as a new class of anti-tumoral, toxin-based therapy.
Review
Medicine, Research & Experimental
Marzieh Sohrabi, Zahra Babaei, Vahid Haghpanah, Bagher Larijani, Ali Abbasi, Mohammad Mahdavi
Summary: This review highlights the latest advances in the use of upconversion nanoparticles as carriers for gene delivery and gene editing in cancer therapy, including monotherapy and synergistic treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biotechnology & Applied Microbiology
Cornelia Blume, Xenia Kraus, Sebastian Heene, Sebastian Loewner, Nils Stanislawski, Fabian Cholewa, Holger Blume
Summary: This review discusses the development of bioartificial vessels as a replacement for conventional synthetic vascular grafts. It emphasizes the use of biodegradable scaffolds and immune-neutral cells to reduce immune reactivity. The review also explores different sources of cells, such as autologous progenitor cells or stem cells, and describes the necessary tools and technologies for the cultivation and design of these bioartificial vessels. 3D printing is introduced as a promising method for creating complex geometries and micro-structured surfaces to enhance cell adhesion and ingrowth. Overall, this controlled biotechnological process has the potential to meet the strict approval requirements for advanced therapy medicinal products.
ENGINEERING IN LIFE SCIENCES
(2022)
Article
Hematology
Wolfgang Miesbach, Graham R. Foster, Flora Peyvandi
Summary: Adeno-associated virus-based gene therapies for hemophilia achieve long-term transgene expression and reduce annual bleeding rates. Liver-related aspects play a crucial role in various phases of gene therapy, such as assessing liver health, patient selection and follow-up, maintaining liver health after gene therapy, and managing potential adverse events. Collaboration between hemophilia treaters and hepatologists is essential to address safety concerns and ensure the success of gene therapy, especially for patients with liver conditions, history of viral infections, HIV infection, and medication usage that could impact liver function.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, Research & Experimental
Yalan Wu, Xiao Lin, Huiling Hong, Yee Lok Fung, Xiaoyun Cao, Joyce Ka Yu Tse, Tsz Ho Li, Ting Fung Chan, Xiao Yu Tian
Summary: Diabetic vasculopathy is a significant global health problem, and peripheral arterial disease (PAD) is a common and poorly treated form. Recent research reveals the important role of PPAR8 in vascular homeostasis and suggests that gene therapy targeting PPAR8 may be a promising option for treating PAD and critical limb ischemia (CLI).
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Anna-Sophie Mursch-Edlmayr, Matthias Bolz, Clemens Strohmaier
Summary: Glaucomatous optic neuropathies have long been considered diseases caused by high intraocular pressure, but recent research has shown that vascular factors also play an important role in glaucoma. Advances in the study of ocular vasculature, ciliary circulation, retinal circulation, etc., may bring new breakthroughs in the treatment of glaucoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Maohua Huang, Yuning Lin, Chenran Wang, Lijuan Deng, Minfeng Chen, Yehuda G. Assaraf, Zhe-Sheng Chen, Wencai Ye, Dongmei Zhang
Summary: Angiogenesis is essential for tumor growth, but resistance to antiangiogenic therapy is a major challenge. This review describes the cellular and molecular mechanisms behind tumor resistance to antiangiogenic therapy and potential biomarkers for predicting treatment response. It also discusses recent advances in combination strategies to enhance therapeutic efficacy.
DRUG RESISTANCE UPDATES
(2022)
Review
Cell Biology
Xuejiao Yang, Junwei Yan
Summary: This article summarizes the progress in neuroprotection for glaucoma in the past five years, including modulation of neuroinflammation, gene and cell therapy, dietary supplementation, and sustained-release system.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Dingkun Lu, Han Jiang, Ting Zou, Yuanwang Jia, Yunyun Zhao, Zhongqun Wang
Summary: With the continuous progress of atherosclerosis research, vascular calcification has gained increasing attention as a significant pathological change. Numerous studies have shown that it is an independent predictor of death risk of cardiovascular disease and has a strong correlation with poor clinical prognosis. As the world's population continues to age, the occurrence of vascular calcification is expected to reach its highest point in the near future. Therefore, it is essential to investigate ways to prevent or even reverse this process for clinical purposes.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Dabbu Kumar Jaijyan, Anca Selariu, Ruth Cruz-Cosme, Mingming Tong, Shaomin Yang, Alketa Stefa, David Kekich, Junichi Sadoshima, Utz Herbig, Qiyi Tang, George Church, Elizabeth L. Parrish, Hua Zhu
Summary: As the global elderly population grows, it is crucial to provide diverse and effective means of mitigating the impact of aging on human health. In this study, we found that using a high-capacity cytomegalovirus vector can effectively extend the lifespan of mice and improve age-related physiological decline. This research has significant implications for human longevity and health.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Pawel Drag, Marlena Drag
Summary: This study explores the feasibility of personalized therapy design and proposes solution feasibility levels for optimization-based therapy design tasks. Through computer simulations and mathematical modeling, the efficiency of treatment is improved. The research findings are valuable for clinical research.
APPLIED SCIENCES-BASEL
(2022)
Review
Environmental Sciences
Nasim Ebrahimi, Mahdokht Sadat Manavi, Ahmad Nazari, Amirali Momayezi, Ferdos Faghihkhorasani, Al-Hasnawi Rasool Riyadh Abdulwahid, Fatemeh Rezaei-Tazangi, Mohammed Kavei, Roya Rezaei, Halimeh Mobarak, Amir Reza Aref, Wei Fang
Summary: RNA interference (RNAi) is a treatment approach used to decrease excessive gene expression in diseases, including cancer. However, challenges such as poor cellular uptake, off-target effects, and susceptibility to destruction restrict the therapeutic potential of small interfering RNAs (siRNAs). This research focuses on sophisticated nanocarriers that aid in the transport of siRNA payloads, their combination with anticancer medications, and their use in cancer treatment. It examines molecular manifestations, transport difficulties, delivery method design and development, and the advantages and disadvantages of various nanocarriers. Challenges such as siRNA trapping in endosomes and techniques for siRNA release are also discussed. The study also provides an evaluation of the current state of siRNA treatments in clinical trials for efficient cancer therapy.
ENVIRONMENTAL RESEARCH
(2023)
Article
Peripheral Vascular Disease
Johanna P. Laakkonen, Jari P. Lappalainen, Thomas L. Theelen, Pyry I. Toivanen, Tiina Nieminen, Suvi Jauhiainen, Minna U. Kaikkonen, Judith C. Sluimer, Seppo Yla-Herttuala
Article
Hematology
Jarkko Hytonen, Olli Leppanen, Jan Hinrich Braesen, Wolf-Hagen Schunck, Dominik Mueller, Friedrich Jung, Christoph Mrowietz, Martin Jastroch, Michael von Bergwelt-Baildon, Kai Kappert, Arnd Heuser, Joerg-Detlef Drenckhahn, Burkert Pieske, Ludwig Thierfelder, Seppo Yla-Herttuala, Florian Blaschke
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Sanna Hellberg, Johanna M. U. Silvola, Max Kiugel, Heidi Liljenback, Olli Metsala, Tapio Viljanen, Jari Metso, Matti Jauhiainen, Pekka Saukko, Pirjo Nuutila, Seppo Yla-Herttuala, Juhani Knuuti, Anne Roivainen, Antti Saraste
CARDIOVASCULAR DIABETOLOGY
(2016)
Article
Cell Biology
Lars Muhl, Christine Moessinger, Milena Z. Adzemovic, Marike H. Dijkstra, Ingrid Nilsson, Manuel Zeitelhofer, Carolina E. Hagberg, Jenni Huusko, Annelie Falkevall, Seppo Yla-Herttuala, Ulf Eriksson
CELL AND TISSUE RESEARCH
(2016)
Article
Cardiac & Cardiovascular Systems
Jussi Nurro, Paavo J. Halonen, Antti Kuivanen, Miikka Tarkia, Antti Saraste, Krista Honkonen, Johanna Lahteenvuo, Tuomas T. Rissanen, Juhani Knuuti, Seppo Yla-Herttuala
Article
Biotechnology & Applied Microbiology
Iiro Hassinen, Antti Kivela, Antti Hedman, Antti Saraste, Juhani Knuuti, Juha Hartikainen, Seppo Yla-Herttuala
HUMAN GENE THERAPY
(2016)
Article
Medicine, Research & Experimental
Emilia A. Korhonen, Anita Lampinen, Hemant Giri, Andrey Anisimov, Minah Kim, Breanna Allen, Shentong Fang, Gabriela D'Amico, Tuomas J. Sipila, Marja Lohela, Tomas Strandin, Antti Vaheri, Seppo Yla-Herttuala, Gou Young Koh, Donald M. McDonald, Kari Alitalo, Pipsa Saharinen
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Clinical Neurology
Eliisa Ollikainen, Riikka Tulamo, Satu Lehti, Miriam Lee-Rueckert, Juha Hernesniemi, Mika Niemela, Seppo Yla-Herttuala, Petri T. Kovanen, Juhana Frosen
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Sanna Hellberg, Johanna M. U. Silvola, Max Kiugel, Heidi Liljenback, Nina Savisto, Xiang-Guo Li, Andrea Thiele, Lutz Lehmann, Tobias Heinrich, Sonja Vollmer, Harri Hakovirta, V. Jukka O. Laine, Seppo Yla-Herttuala, Juhani Knuuti, Anne Roivainen, Antti Saraste
JOURNAL OF NUCLEAR CARDIOLOGY
(2017)
Editorial Material
Biotechnology & Applied Microbiology
Robert M. Frederickson, Seppo Yla-Herttuala
Review
Cardiac & Cardiovascular Systems
Seppo Yla-Herttuala, Charles Bridges, Michael G. Katz, Petra Korpisalo
EUROPEAN HEART JOURNAL
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Auni Lindgren, Maarit Anttila, Suvi Rautiainen, Otso Arponen, Annukka Kivela, Petri Makinen, Kirsi Harma, Kirsi Hamalainen, Veli-Matti Kosma, Seppo Yla-Herttuala, Ritva Vanninen, Hanna Sallinen
EUROPEAN RADIOLOGY
(2017)
Review
Biotechnology & Applied Microbiology
Seppo Yla-Herttuala, Andrew H. Baker
Article
Multidisciplinary Sciences
Johanna M. U. Silvola, Helena Virtanen, Riikka Siitonen, Sanna Hellberg, Heidi Liljenback, Olli Metsala, Mia Stahle, Tiina Saanijoki, Meeri Kakela, Harri Hakovirta, Seppo Yla-Herttuala, Pekka Saukko, Matti Jauhiainen, Tibor Z. Veres, Sirpa Jalkanen, Juhani Knuuti, Antti Saraste, Anne Roivainen
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
A. M. Kivela, J. Huusko, E. Gurzeler, A. Laine, M. H. Dijkstra, G. Dragneva, C. B. F. Andersen, S. K. Moestrup, S. Yla-Herttuala
SCIENTIFIC REPORTS
(2017)
