Review
Pharmacology & Pharmacy
Oykum Kaplan-Arabaci, Alperen Acari, Pinar Ciftci, Devrim Gozuacik
Summary: Stroke is the second leading cause of death and disability globally. Ischemic stroke, caused by blood vessel blockage, has limited treatment options. Previous studies aimed at reducing glutamate in ischemic stroke and other neurodegenerative diseases have failed due to delivery obstacles. Systemic glutamate scavenging, a new therapeutic approach, offers the advantage of working in the circulating blood without interfering with brain neurophysiology.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kemeng Zhao, Pengwei Wang, Xiaoguang Tang, Na Chang, Haonan Shi, Longfei Guo, Bingyi Wang, Pengfei Yang, Tiantian Zhu, Xinghua Zhao
Summary: Stroke is caused by ruptured or blocked cerebral blood vessels and subsequent disruption of brain blood circulation, resulting in rapid neurological deficits. The majority of stroke cases are ischemic strokes. Current treatments for ischemic stroke, such as t-PA thrombolytic therapy and surgical thrombectomy, can paradoxically lead to ischemia-reperfusion injury, exacerbating brain damage. Minocycline, a semi-synthetic tetracycline antibiotic, has demonstrated a wide range of neuroprotective effects independent of its antibacterial activity. In this article, we summarize the mechanisms underlying the protective effects of minocycline against cerebral ischemia-reperfusion injury, including modulation of oxidative stress, inflammatory response, excitotoxicity, programmed cell death, and blood-brain barrier injury. We also discuss the role of minocycline in alleviating stroke-related complications, providing a theoretical basis for its clinical application in cerebral ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemical Research Methods
Adiya Rakymzhan, Yuandong Li, Peijun Tang, Ruikang K. Wang
Summary: The study used optical coherence tomography (OCT) methods to quantitatively evaluate the effect of anesthesia on cerebral vasculature and blood flow in mice, finding that anesthesia caused vasodilation. Compared to other imaging modalities, OCT provides label-free assessment of cortical tissue with a larger field of view and higher imaging speed.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Biochemistry & Molecular Biology
Chiara Di Santo, Daniele La Russa, Rosaria Greco, Alessandra Persico, Anna Maria Zanaboni, Giacinto Bagetta, Diana Amantea
Summary: The identification of novel targets to modulate the immune response triggered by cerebral ischemia is crucial for stroke therapeutics. This study revealed the involvement of tumour necrosis factor (TNF)-alpha-stimulated gene 6 (TSG-6) in regulating immune and stromal cell functions in acute neurodegeneration caused by ischemic stroke. The elevated levels of TSG-6 in the brain and peripheral blood indicate its potential detrimental role in the early reperfusion stage, while providing protection against brain infarct volume and neurological deficits when administered acutely. These findings highlight the important role of TSG-6 in ischemic stroke pathobiology and warrant further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Matteo Haupt, Stefan T. Gerner, Mathias Baehr, Thorsten R. Doeppner
Summary: Despite significant progress in stroke therapy, ischemic stroke still imposes a high socioeconomic burden on industrialized countries. Current treatment paradigms focus on thrombolysis or thrombectomy, which are only suitable for a fraction of patients. Therefore, there is an urgent need for adjuvant therapeutic approaches like neuroprotection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Yuanmei Pan, Guowen Shi
Summary: Recent efforts have focused on expanding the therapeutic window for tPA therapy in AIS patients, aiming to provide more patients with the benefits of this treatment without compromising safety. Strategies include speeding up patient recruitment, reducing door-to-needle time, and utilizing advanced technologies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Alis J. Dicpinigaitis, Steven D. Shapiro, Rolla Nuoman, Haris Kamal, Philip Overby, Gurmeen Kaur, Ji Y. Chong, Johanna T. Fifi, Neha Dangayach, Eliza C. Miller, Shadi Yaghi, Fawaz Al-Mufti
Summary: Population-level data from the United States over a twenty-year period show that intravenous thrombolysis treatment for pediatric AIS patients is associated with high rates of favorable outcomes without an increased risk of hemorrhagic transformation.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Multidisciplinary Sciences
Adriana Knezic, Brad R. S. Broughton, Robert E. Widdop, Claudia A. McCarthy
Summary: This study examined the effect of different lengths of light exposure on photothrombotic stroke in two strains of mice. The results showed that increasing light exposure systematically increases infarct volume but does not worsen functional outcomes. Additionally, there were subtle differences in functional outcomes between the FVB/N and C57Bl/6 mice.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Amanda S. Zakeri, Debra G. Wheeler, Allyson Huttinger, Arianna Carfora, Aarushi Kini, Taggart Stork, Simon Yacoub, Cole Anderson, Matthew Joseph, Mohammed T. Shujaat, Shahid M. Nimjee
Summary: In this study, a canine model of large vessel occlusion stroke was established using an autologous clot, resulting in a stable and prolonged occlusion. The efficacy of the model was confirmed by various assessments, including digital subtraction angiography (DSA), magnetic resonance imaging (MRI), Thrombolysis in Cerebral Infarction scale (TICI), and histological examination. The model successfully replicated the lack of collateral flow and consistent infarct volumes observed in human thromboembolic stroke. This model is important for studying the treatment of large vessel occlusion in acute ischemic stroke, especially outside the established therapeutic window.
Article
Biochemistry & Molecular Biology
Jeong Yeon Kim, Dipankar Manna, Michael Etscheid, Trygve B. Leergaard, Sandip M. Kanse
Summary: This article investigates the therapeutic effect of FSAP in the treatment of ischemic stroke. The study found that FSAP can enhance thrombolysis, improve cerebral perfusion and neurological function, and reduce infarct size in stroke. Moreover, FSAP has other effects on stroke progression, representing a promising novel therapeutic strategy.
Article
Clinical Neurology
Konstantinos M. Themistoklis, Themistoklis I. Papasilekas, Konstantinos S. Melanis, Konstantinos A. Boviatsis, Stefanos I. Korfias, Konstaninos Vekrellis, Damianos E. Sakas
Summary: The tifMCAO stroke model in rats is widely used and has been proven to reliably mimic human stroke. The surgical technique has been detailed with stepwise instructions and visual aids provided.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Mehdi Bouslama, Diogo C. Haussen, Jonathan A. Grossberg, Clara M. Barreira, Imramsjah Martijn J. van der Bom, Fred van Nijnatten, Thijs Gruenhagen, Larry Moyer, Michael R. Frankel, Raul G. Nogueira
Summary: The study aimed to investigate whether the use of flat-panel detector multiphase computed tomography angiography protocol is associated with reduced treatment times for stroke patients while maintaining safety. The results showed that this method can significantly shorten treatment times and has a similar safety profile compared to the standard imaging protocol.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Biochemistry & Molecular Biology
Yujiao Lu, Jing Wang, Fulei Tang, Uday P. Pratap, Gangadhara R. Sareddy, Krishnan M. Dhandapani, Ana Capuano, Zoe Arvanitakis, Ratna K. Vadlamudi, Darrell W. Brann
Summary: Hemoglobin plays an important role in regulating neuronal oxygenation and neuroprotection. The levels of neuronal hemoglobin decrease with age in mice, leading to increased hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Iris Muehlen, Maximilian Sprugel, Philip Hoelter, Stefan Hock, Michael Knott, Hagen B. Huttner, Stefan Schwab, Bernd Kallmunzer, Arnd Doerfler
Summary: This study evaluated two commonly used automated computed tomography perfusion software applications and found that by adjusting the relative cerebral blood flow thresholds, comparable results with reliable information on the follow-up infarct volume after complete recanalization can be obtained. Keeping the software specific default settings means being more inclusive in patient selection but sacrificing the highest possible accuracy in the estimation of the infarct volume.
Article
Cardiac & Cardiovascular Systems
Dana Raub, Katharina Platzbecker, Stephanie D. Grabitz, Xinling Xu, Karuna Wongtangman, Stephanie B. Pham, Kadhiresan R. Murugappan, Khalid A. Hanafy, Ala Nozari, Timothy T. Houle, Samir M. Kendale, Matthias Eikermann
Summary: This retrospective cohort study of surgical patients undergoing general anesthesia at two tertiary care centers in Boston found that higher doses of volatile anesthetics had a protective effect on postoperative ischemic stroke incidence and severity. The protective effect was observed for 17 postoperative days.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemical Research Methods
Aline Silva da Cruz, Maria Margarida Drehmer, Wagner Baetas-da-Cruz, Joao Carlos Machado
Summary: This study quantified microcirculation cerebral blood flow in a rat model of ischemic stroke using ultrasound biomicroscopy and ultrasound contrast agents. The results showed high sensitivity and specificity of this method, making it a valuable tool for preclinical studies.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Christina Dalla, Ivana Jaric, Pavlina Pavlidi, Georgia E. Hodes, Nikolaos Kokras, Anton Bespalov, Martien J. Kas, Thomas Steckler, Mohamed Kabbaj, Hanno Wuerbel, Jordan Marrocco, Jessica Tollkuhn, Rebecca Shansky, Debra Bangasser, Jill B. Becker, Margaret McCarthy, Chantelle Ferland-Beckham
Summary: Many funding agencies have emphasized the importance of considering sex as a biological variable in experimental design to improve the reproducibility and translational relevance of preclinical research. Omitting the female sex from experimental designs in neuroscience and pharmacology can result in biased or limited understanding of disease mechanisms. This article provides methodological considerations for incorporating sex as a biological variable in in vitro and in vivo experiments, including the influence of age and hormone levels, and proposes strategies to enhance methodological rigor and translational relevance in preclinical research.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Wenyu Gu, Dongxu Li, Jia-Hong Gao
Summary: We developed a precise and rapid method for positioning and labelling triaxial OPMs on a wearable magnetoencephalography (MEG) system, improving the efficiency of OPM positioning and labelling.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Kai Lin, Linhang Zhang, Jing Cai, Jiaqi Sun, Wenjie Cui, Guangda Liu
Summary: The article introduces an EEG feature map processing model for emotion recognition, which achieves significantly improved accuracy by fusing EEG information at different spatial scales and introducing a channel attention mechanism.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
John E. Parker, Asier Aristieta, Aryn H. Gittis, Jonathan E. Rubin
Summary: This work presents a toolbox that implements a methodology for automated classification of neural responses based on spike train recordings. The toolbox provides a user-friendly and efficient approach to detect various types of neuronal responses that may not be identified by traditional methods.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Yun Liang, Ke Bo, Sreenivasan Meyyappan, Mingzhou Ding
Summary: This study compared the performance of SVM and CNN on the same datasets and found that CNN achieved consistently higher classification accuracies. The classification accuracies of SVM and CNN were generally not correlated, and the heatmaps derived from them did not overlap significantly.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Antonino Visalli, Maria Montefinese, Giada Viviani, Livio Finos, Antonino Vallesi, Ettore Ambrosini
Summary: This study introduces an analytical strategy that allows the use of mixed-effects models (LMM) in mass univariate analyses of EEG data. The proposed method overcomes the computational costs and shows excellent performance properties, making it increasingly important in the field of neuroscience.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Xavier Cano-Ferrer, Alexandra Tran -Van -Minh, Ede Rancz
Summary: This study developed a novel rotation platform for studying neural processes and spatial navigation. The platform is modular, affordable, and easy to build, and can be driven by the experimenter or animal movement. The research demonstrated the utility of the platform, which combines the benefits of head fixation and intact vestibular activity.
JOURNAL OF NEUROSCIENCE METHODS
(2024)