Physiological and therapeutic complement regulators in kidney transplantation

Purpose of reviewThis review will summarize the key contribution of complement regulators in the immune response to an allograft.Recent findingsOver the past 10 years, compelling evidences have been accumulated in support of a critical role of complement in the pathological phenomena related to organ transplantation. In addition to recurrence of complement-mediated disease after graft, complement is involved in situations as diverse as brain death induced tissue damages, ischaemia-reperfusion and antibody-mediated rejections. This complement activation is counterbalanced by various regulatory mechanisms.SummaryWe discuss the role of physiological and therapeutic complement regulators that are designed to overcome the impact of complement overactivation with the aim of improving long-term transplant outcomes. We will focus primarily on renal allograft, but the discussed mechanisms take place to a different degree in any kind of organ transplantation.