Article
Surgery
Matteo Di Nardo, Lorenzo Del Sorbo, Andrew Sage, Jin Ma, Mingyao Liu, Jonathan C. Yeung, Jerome Valero, Rasheed Ghany, Marcelo Cypel, Shaf Keshavjee
Summary: This study developed a mathematical model (EXPIRE model) using ex vivo lung perfusion technique to predict lung acceptance, which was successfully validated in a separate cohort. The model may help standardize lung assessment and improve transplant rates in centers using the Toronto EVLP technique.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Amaia Ojanguren, Roumen Parapanov, Anne Debonneville, Jerome Lugrin, Csaba Szabo, Arpad Hasenauer, Lorenzo Rosner, Michel Gonzalez, Jean-Yannis Perentes, Thorsten Krueger, Lucas Liaudet
Summary: Ex vivo lung perfusion (EVLP) serves as a platform for pharmacologic repair before lung transplantation (LTx). This study demonstrates that transient heat application during EVLP can effectively recondition damaged lungs and improve their outcomes after transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Medicine, Research & Experimental
Jamie E. Jeon, Lei Huang, Zhiyuan Zhu, Aaron Wong, Shaf Keshavjee, Mingyao Liu
Summary: This study investigated the effects of ischemia-reperfusion and ex vivo lung perfusion (EVLP) on gene expression in human pulmonary microvascular endothelial cells and epithelial cells. The results showed that both cell types exhibited changes in gene expressions after ischemia-reperfusion or EVLP, with the former showing upregulated pro-inflammatory genes and downregulated cell metabolism pathways, while the latter showed downregulation of cell metabolism without any inflammatory signals.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Rajarajan Ganesan, Kamal Kajal, Harkant Singh, Ashim Das, Rajinder Kaur, Naveen Saini, Goverdhan Dutt Puri
Summary: This study successfully used a locally developed EVLP system to perform ex vivo lung perfusion on discarded donor lungs and maintained the physiological condition of the lungs using a solution without red blood cells. However, challenges such as solution leakage and obstruction to drainage of RBCs containing solution were encountered.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Surgery
John K. Peel, Eleanor M. Pullenayegum, David Naimark, Meghan Aversa, Mingyao Liu, Lorenzo Del Sorbo, Kali Barrett, Beate Sander, Shaf Keshavjee
Summary: This study investigates the effect of ex vivo lung perfusion (EVLP) on organ utilization and patient outcomes in lung transplantation. The results show that EVLP has significantly increased organ transplantation, particularly through the acceptance of donation after circulatory death and extended-criteria lungs.
Article
Biology
Sebastian V. Rojas, Murat Avsar, Fabio Ius, David Schibilsky, Tim Kaufeld, Christoph Benk, Ilona Maeding, Michael Berchtold-Herz, Christoph Bara, Friedhelm Beyersdorf, Axel Haverich, Gregor Warnecke, Matthias Siepe
Summary: This study reviewed the outcomes of 119 consecutive heart transplant patients and compared the results of ex vivo organ perfusion group and conventional group. The study found that in the ex vivo organ perfusion group, there were shorter ventilation time, fewer postoperative dialysis cases, and no difference in survival rate and occurrence of graft rejection.
Article
Immunology
Michael Olausson, Deepti Antony, Galina Travnikova, Martin Johansson, Nikhil B. Nayakawde, Debashish Banerjee, John Mackay Softeland, Goditha U. Premaratne
Summary: This study demonstrates that kidneys from extended uDCD, without aCPR/EC, can be salvaged using thrombolytic treatment to remove fibrin thrombi while preserving histology. These kidneys can then be transplanted with clinically acceptable early function.
Review
Cardiac & Cardiovascular Systems
Shuji Okahara, Bronwyn Levvey, Mark McDonald, Rohit D'Costa, Helen Opdam, David Pilcher, Gregory I. Snell
Summary: This retrospective study reviewed lung donor referrals between 2014 and 2018, finding main reasons for refusal to be lung quality issues, general medical issues, and organizational issues. Despite indications, the actual number of retrievable lungs through EVLP was limited.
ANNALS OF THORACIC SURGERY
(2021)
Article
Gastroenterology & Hepatology
Wei Kelly Wu, Rei Ukita, Yatrik J. Patel, Michael Cortelli, Vincent Q. Trinh, Ioannis A. Ziogas, Sean A. Francois, Meredith Mentz, Nancy L. Cardwell, Jennifer R. Talackine, William M. Grogan, John W. Stokes, Youngmin A. A. Lee, Jinho Kim, Sophoclis P. Alexopoulos, Matthew Bacchetta
Summary: Xenogeneic cross-circulation technique has been successfully used to support and rehabilitate declined donor livers, resulting in preservation of organ structure and function, improved viability markers, and potential for further research in organ recovery and rehabilitation.
Article
Cell Biology
Stephan Arni, Tatsuo Maeyashiki, Necati Citak, Isabelle Opitz, Ilhan Inci
Summary: The study found that subnormothermic EVLP at 28 degrees Celsius improved lung function and inflammatory parameters, which were also observed post left lung transplantation.
Article
Surgery
Naissa Abdoul, Camille Legeai, Christelle Cantrelle, Olaf Mercier, Anne Olland, Pierre Mordant, Pascal Alexandre Thomas, Jacques Jougon, Adrien Tissot, Jean-Michel Maury, Edouard Sage, Richard Dorent
Summary: Donors whose lungs were transplanted after EVLP had similar profiles to those whose lungs were declined, but were quite different from donors with lungs transplanted without EVLP. Predictors for graft nonuse included age ≥ 50 years, smoking history, PaO2/FiO(2) ratio ≤ 300 mmHg, abnormal chest imaging, and purulent secretions. EVLP was found to increase the utilization of lungs from donors with a smoking history, PaO2/FiO(2) ratio ≤ 300 mmHg, and abnormal chest imaging.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Samantha E. Halpern, Samuel J. Kesseli, Sandra Au, Madison K. Krischak, Danae G. Olaso, Haley Smith, Greg Tipton, Ian R. Jamieson, Andrew S. Barbas, John C. Haney, Jacob A. Klapper, Matthew G. Hartwig
Summary: This study compared outcomes and index hospitalization costs between EVLP and SCS preserved lung transplant recipients, finding similar perioperative outcomes and posttransplant survival. Excluding device-specific costs, total direct variable costs were similar among EVLP, SCD, and ECD recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Oliver K. Jawitz, Vignesh Raman, David Becerra, Julie Doberne, Ashley Y. Choi, Samantha E. Halpern, Jacob A. Klapper, Matthew G. Hartwig
Summary: This study examines early lung transplant outcomes following EVLP using a large national transplant registry. The results show that EVLP recipients have comparable early outcomes to non-EVLP recipients with similar baseline characteristics. Long-term follow-up data is needed to further assess the impact of EVLP on post-lung transplant outcomes.
Article
Cardiac & Cardiovascular Systems
Lars Saemann, Sevil Korkmaz-Icoz, Fabio Hoorn, Gabor Veres, Patricia Kraft, Adrian-Iustin Georgevici, Maik Brune, Yuxing Guo, Sivakkanan Loganathan, Folker Wenzel, Matthias Karck, Gabor Szabo
Summary: The study showed that using HTK-N solution for machine perfusion can improve contractility of CD-hearts, reduce oxidative and nitrosative stress, and prevent cardiomyocyte swelling and necrosis.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Immunology
Carla Gouin, Thien-Phong Vu Manh, Luc Jouneau, Claudia Bevilacqua, Julien De Wolf, Matthieu Glorion, Laurent Hannouche, Celine Urien, Jerome Estephan, Antoine Roux, Antoine Magnan, Morgan Le Guen, Bruno Da Costa, Christophe Chevalier, Delphyne Descamps, Isabelle Schwartz-Cornil, Marc Dalod, Edouard Sage
Summary: By using single cell RNA sequencing on human lungs declined for transplantation, it was found that different lung cell types have varied responses to ex vivo lung perfusion (EVLP). Inflammatory pathways were activated in epithelial and blood endothelial cells, as well as in monocyte-derived and alveolar macrophages at different time points. Immune cells exhibited a blunted activation gene expression pattern during EVLP, suggesting a potential benefit for transplantation. The study also supports the need for therapeutic approaches targeting both the alveolar and vascular compartments to reduce inflammation during EVLP.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Luke Benvenuto, Mark E. Snyder, Meghan Aversa, Shreena Patel, Joseph Costa, Lori Shah, Hilary Robbins, Frank D'Ovidio, Joshua Sonett, Bryan P. Stanifer, Philippe Lemaitre, Selim Arcasoy, Michaela R. Anderson
Summary: During the early months of the COVID-19 pandemic, there were significant regional disparities in lung transplantation practices, with a larger decrease in transplant volume in high COVID-19 prevalence areas. Waiting list activations decreased overall, while waiting list deaths remained similar regardless of local COVID-19 prevalence.
Article
Cardiac & Cardiovascular Systems
Miguel M. Leiva-Juarez, Luke Benvenuto, Joseph Costa, John W. Blackett, Meghan Aversa, Hilary Robbins, Lori Shah, Bryan P. Stanifer, Phillippe H. Lemaitre, Daniela Jodorkovsky, Selim Arcasoy, Joshua R. Sonett, Frank D'Ovidio
Summary: This study suggests that undergoing fundoplication after lung transplantation can improve posttransplant survival, especially for younger patients with restrictive diseases and those who receive single or double lung transplants. The method of diagnosing gastroesophageal reflux disease has different impacts on outcomes.
ANNALS OF THORACIC SURGERY
(2022)
Article
Gastroenterology & Hepatology
John W. Blackett, Luke Benvenuto, Miguel M. Leiva-Juarez, Frank D'Ovidio, Selim Arcasoy, Daniela Jodorkovsky
Summary: Gastroparesis is common after lung transplantation and is associated with worse outcomes, particularly the development of CLAD. Black patients are more likely to be diagnosed with gastroparesis post-transplant. While gastroparesis is linked to CLAD, it does not impact overall mortality.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
David Furfaro, Erika B. Rosenzweig, Lori Shah, Hilary Robbins, Michaela Anderson, Hanyoung Kim, Darryl Abrams, Cara L. Agerstrand, Daniel Brodie, Danielle Feldhaus, Joseph Costa, Philippe Lemaitre, Bryan P. Stanifer, Frank D'Ovidio, Joshua R. Sonett, Selim Arcasoy, Luke Benvenuto
Summary: In patients bridging to transplant on ECMO, those with PAH had a lower transplantation rate compared to patients with other conditions like OLD, CF, and ILD.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Andreacarola Urso, Miguel M. Leiva-Juarez, Domenica F. Briganti, Beatrice Aramini, Luke Benvenuto, Joseph Costa, Renu Nandakumar, Estela Area Gomez, Hilary Y. Robbins, Lori Shah, Meghan Aversa, Joshua R. Sonnet, Selim Arcasoy, Serge Cremers, Frank D'Ovidio
Summary: The study found that high levels of bile acids and predominance of conjugated bile acids are independent predictors of chronic lung allograft dysfunction, mortality, and bacterial infections. Primary conjugated bile acids are associated with changes in airway lipidome and bacterial infections.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Rheumatology
Miguel M. Leiva-Juarez, Andreacarola Urso, Joseph Costa, Bryan P. Stanifer, Joshua R. Sonett, Luke Benvenuto, Megan Aversa, Hilary Robbins, Lori Shah, Selim Arcasoy, Frank D'Ovidio
Summary: In systemic sclerosis lung transplant recipients, fundoplication is associated with an increased freedom from chronic lung allograft dysfunction and overall survival, while also reducing the risk of mortality. There is no difference in post-transplant survival between double and single lung transplant recipients.
JOURNAL OF SCLERODERMA AND RELATED DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Ilhan Inci, Jonas Peter Ehrsam, Dirk Van Raemdonck, Laurens Joseph Ceulemans, Thorsten Krueger, Angela Koutsokera, Marco Schiavon, Eleonora Faccioli, Mario Nosotti, Lorenzo Rosso, Frank D'Ovidio, Miguel Leiva-Juarez, Clemens Aigner, Alexis Slama, Waleed Saleh, Khaled Manaa Alkattan, Pascal Alexandre Thomas, Geoffrey Brioude, Alberto Benazzo, Konrad Hoetzenecker
Summary: This study investigated the outcomes of recipients bridged to a first-time retransplantation (ReTx) by extracorporeal life support (ECLS). The results showed that the overall survival of the ECLS-ReTx group was significantly worse compared to the regular-ReTx and index-Tx groups. Risk factors such as recipient age, intertransplant interval, primary graft dysfunction as transplant indication, and type of ECLS were identified as significant factors affecting mortality in ECLS-ReTx recipients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Immunology
Harpreet Singh Grewal, Renu K. Virk, Maggie E. Carroll, Luke J. Benvenuto, Hilary Robbins, Lori Shah, Frank D'Ovidio, Selim M. Arcasoy
Summary: Lung nodules or masses can occur after lung transplant and can be caused by various malignant or benign conditions, including opportunistic infections. In this study, we report the clinical course and management of a lung transplant recipient with pulmonary malakoplakia and provide a literature review. This is the first reported case of pulmonary malakoplakia in a lung allograft caused by Escherichia coli infection.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Immunology
Phoebe Kahn, Markus Siegelin, Maggie Carroll, Frank D'ovidio, Selim Arcasoy
Summary: Pulmonary alveolar proteinosis is a rare disorder that occurs in lung transplant recipients, with few reported cases. This article reports a case of pulmonary alveolar proteinosis diagnosed in a lung transplant recipient approximately one year after transplantation, and describes its treatment approach.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Transplantation
Kemarut Laothamatas, Jamie Hum, Luke Benvenuto, Lori Shah, Harpreet Singh Grewal, Marcus Pereira, Jenna Scheffert, Maggie Carroll, Margaret Nolan, Genevieve Reilly, Philippe Lemaitre, Bryan P. Stanifer, Joshua R. Sonett, Frank D'Ovidio, Hilary Robbins, Selim M. Arcasoy
Summary: This study analyzed the clinical presentation, management, and outcomes of lung transplant recipients during the first and second surge of the COVID-19 pandemic. The results showed that the second surge cohort had a higher proportion of patients with mild disease, fewer patients with a history of obesity, and a decreased mortality rate compared to the first cohort.
TRANSPLANTATION DIRECT
(2022)
Article
Cardiac & Cardiovascular Systems
Luke J. Benvenuto, Michaela R. Anderson, Meghan Aversa, Mark E. Snyder, Hilary Robbins, Lori Shah, Harpreet Singh Grewal, David Anderson, Joseph Costa, Brian P. Stanifer, Philippe Lemaitre, Joshua R. Sonett, Frank D'Ovidio, Selim M. Arcasoy
Summary: The expansion of the primary lung allocation unit improved disparities in waitlist outcomes, but significant differences remain due to geographic factors.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Transplantation
Luke Benvenuto, Seema Qayum, Hanyoung Kim, Hilary Robbins, Lori Shah, Angela Dimango, Gabriela Magda, Harpreet Grewal, Philippe Lemaitre, Bryan P. Stanifer, Joshua Sonett, Frank D'Ovidio, Selim M. Arcasoy
Summary: This study describes the characteristics, management, and outcomes of lung transplantation in 11 candidates with HPS-related pulmonary fibrosis. The results suggest that HPS should not be considered a contraindication for lung transplantation, although patients with HPS have an increased risk of bleeding.
TRANSPLANTATION DIRECT
(2022)
Letter
Respiratory System
Jamie Hum, Kemarut Laothamatas, Jenna Scheffert, Margaret Nolan, Genevieve Reilly, Frank D'Ovidio, Luke Benvenuto, Selim M. Arcasoy
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Surgery
Mario Nosotti, Miguel Leiva-Juarez, Frank D'Ovidio, Dirk Van Raemdonck, Laurens Ceulemans, Shaf Keshavjee, Mindaugas Rackauskas, Piero Paladini, Luca Luzzi, Paula Moreno Casado, Antonio Alvarez, Ilhan Inci, Jonas Ehrsam, Thorsten Krueger, Andrey Roth, Federico Rea, Marco Schiavon, Lorenzo Rosso
Summary: Repeated exposure to antigens through inhalation is the main cause of hypersensitivity pneumonitis, a type of interstitial pneumonia. This study examined the outcomes of lung transplantation in patients with hypersensitivity pneumonitis, revealing a high survival rate and suggesting that these patients are good candidates for lung transplantation.
TRANSPLANT INTERNATIONAL
(2022)
Article
Respiratory System
Darryl Abrams, Purnema Madahar, Christina M. Eckhardt, Briana Short, Natalie H. Yip, Madhavi Parekh, Alexis Serra, Richard L. Dubois, Danial Saleem, Cara Agerstrand, Peter Scala, Luke Benvenuto, Selim M. Arcasoy, Joshua R. Sonett, Koji Takeda, Anne Meier, James Beck, Patrick Ryan, Eddy Fan, Carol L. Hodgson, Matthew Bacchetta, Daniel Brodie
Summary: This study aimed to identify factors associated with achieving out-of-bed physical therapy in ECMO-supported patients and assess the safety and feasibility of early mobilization with femoral cannulation. The results showed that pre-transplantation, venovenous ECMO, later cannulation year, and higher Charlson comorbidity index were associated with increased odds of achieving out-of-bed physical therapy, while invasive mechanical ventilation and femoral cannulation were associated with decreased odds. Physical therapy with femoral cannulation was safe, feasible, and had low complication rates.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
