Article
Chemistry, Multidisciplinary
Maya Beena, Jimna Mohamed Ameer, Naresh Kasoju
Summary: Silk fibroin films with various properties were fabricated using different solvents and annealing processes. The results showed that the properties of silk fibroin films can be finely tuned by adjusting the fabrication and postfabrication processing conditions, while the chemical composition and optical transparency of the films remained largely unaffected.
Review
Chemistry, Multidisciplinary
Sadjad Khosravimelal, Mohammadmahdi Mobaraki, Samane Eftekhari, Mark Ahearne, Alexander Marcus Seifalian, Mazaher Gholipourmalekabadi
Summary: Hydrogel biomaterials possess favorable characteristics for corneal tissue engineering, with the potential to repair and replace damaged tissue. Research focusing on novel hydrogels for corneal injuries has shown promising outcomes in early phase clinical trials. This emerging technology is attracting significant interest from medical devices and pharmaceutical industries, indicating a potential for new products within the next five years.
Review
Anatomy & Morphology
Bijay K. Poudel, Marie-Claude Robert, Fiona C. Simpson, Kamal Malhotra, Ludovic Jacques, Paul LaBarre, May Griffith
Summary: Corneal blindness is the fourth leading cause of global blindness, with over 90% of cases occurring in low- and middle-income regions. While corneal transplantation is effective, the shortage of corneal graft tissue in many LMIRs limits access to this treatment option. Various biomaterial approaches, including in situ tissue regeneration, show promise for treating corneal injuries and diseases, potentially offering alternatives to organ transplantation and improving patient outcomes.
CELLS TISSUES ORGANS
(2022)
Article
Ophthalmology
Rebecca Guillon-Rolf, Scott Hau, Daniel F. P. Larkin
Summary: Congenital corneal anaesthesia (CCA) can lead to corneal ulceration, but significant morphological abnormalities, including decreased SBNP nerve fibre density and increased superficial corneal DCD, can be detected through confocal microscopy. Patients with CCA mainly present with corneal ulceration, but most of them still maintain good corrected visual acuity.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Review
Ophthalmology
Tu M. Tran, Joshua H. Hou
Summary: This review discusses the use of bioengineered tissue-cellular products for the treatment of corneal diseases. These products include those that have received regulatory approval, are being used off-label, or are in clinical trials.
CURRENT OPINION IN OPHTHALMOLOGY
(2023)
Review
Cell & Tissue Engineering
Mohit Parekh, Vito Romano, Kareem Hassanin, Valeria Testa, Rintra Wongvisavavit, Stefano Ferrari, Atikah Haneef, Colin Willoughby, Diego Ponzin, Vishal Jhanji, Namrata Sharma, Julie Daniels, Stephen B. Kaye, Sajjad Ahmad, Hannah J. Levis
Summary: The corneal endothelium plays a crucial role in maintaining corneal transparency, and its non-regenerative nature necessitates the need for corneal transplants. With limited availability of corneal donor tissues globally, researchers are exploring the cultivation of human corneal endothelial cells in vitro and investigating potential biomaterials for tissue engineering applications.
JOURNAL OF TISSUE ENGINEERING
(2021)
Review
Pharmacology & Pharmacy
Zeqing Wang, Zhikai Jiang, Ruijie Lu, Longfa Kou, Ying-Zheng Zhao, Qing Yao
Summary: Islet transplantation is a minimally invasive surgery that involves the transfusion of healthy islet cells into diabetic recipients to achieve insulin independence. However, poor oxygenation post-transplantation can lead to islet loss and dysfunction. This study reviews potential formulation strategies for providing oxygen-release to transplanted islets.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Review
Biotechnology & Applied Microbiology
Julie F. Jameson, Marisa O. Pacheco, Henry H. Nguyen, Edward A. Phelps, Whitney L. Stoppel
Summary: Researchers are developing engineered cellular and acellular therapeutic approaches as alternatives to corneal transplants from human cadavers due to the limited availability of healthy donors. The main goals are to optimize corneal graft properties, reduce complications, and improve outcomes in engineered tissue structures in the eye.
BIOENGINEERING-BASEL
(2021)
Review
Pharmacology & Pharmacy
Samin Abbaszadeh, Vahideh Nosrati-Siahmazgi, Kiyan Musaie, Saman Rezaei, Mostafa Qahremani, Bo Xiao, Helder A. Santos, Mohammad-Ali Shahbazi
Summary: Novel transplantation techniques are being developed to preserve the function of impaired tissues or organs. However, current technologies face challenges such as graft rejection by the immune system and the need for long-term immunosuppression. Thus, the development of biomaterial-based immunoengineering strategies has gained attention as a potential solution.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Yu-Show Fu, Po-Ru Chen, Chang-Ching Yeh, Jian-Yu Pan, Wen-Chuan Kuo, Kuang-Wen Tseng
Summary: The study shows that xenografted human umbilical mesenchymal stem cells can survive in rat eye tissues for a long time and effectively support the structural integrity of injured corneal tissues, promoting repair and reducing inflammation.
Article
Biotechnology & Applied Microbiology
Alejandro Juarez, Mohamed Djallali, Marilyse Piche, Mathieu Theriault, Marc Groleau, Sharifa Beroual, Christopher D. McTiernan, Grace Lin, Pierre Helie, Michel Carrier, May Griffith, Isabelle Brunette
Summary: The study evaluated the long-term in vivo functionality of corneas regenerated using a cell-free, liquid hydrogel filler in the feline model, demonstrating successful integration of the filler and stable corneal re-epithelialization over 12 months. Compared to previous mini-pig and rabbit models, there was less inflammation and neovascularization, offering a promising alternative for human patients with ulcerated and traumatized corneas.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Letter
Oncology
Crocchiolo Roberto, Cesana Clara, Girgenti Debora, Bertani Giambattista, Barba Claudia, Liga Giuseppa, Ferri Ursula, Crucitti Lara, Grillo Giovanni, Rossini Silvano, Cairoli Roberto
Summary: The study evaluated circulating T regulatory cells in patients undergoing ECP for the prevention of chronic GvHD and found Tregs count to be a potential biomarker of ECP effectiveness. Future strategies are needed to enhance Tregs expansion and activity for effective chronic GvHD prevention.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Engineering, Biomedical
Bozica Kovacevic, Melissa Jones, Corina Ionescu, Daniel Walker, Susbin Wagle, Jacqueline Chester, Thomas Foster, Daniel Brown, Momir Mikov, Armin Mooranian, Hani Al-Salami
Summary: Endogenous bile acids serve as lipid stabilizers, aiding the uptake of lipophilic nutrients through micelle formation and saponification effects, with various applications in pharmaceutical sciences. Their unique physico-chemical profile allows them to modulate immune cell signaling pathways and provide potential clinical therapies for cardio-metabolic disorders. In addition, their antioxidant, anti-inflammatory, and immunosuppressant properties make them effective in reducing blood pressure and alleviating hypertension, while also enhancing the immunogenicity of encapsulated cells for bioartificial organ transplantations.
Article
Ophthalmology
Damien Guindolet, Anna Gemahling, Antoine Rousseau, Pauline Nguyen Kim, Georges Azar, Gilles C. Martin, Isabelle Cochereau, Marc Labetoulle, Eric E. Gabison
Summary: Purpose Archipelago keratitis (ApK) is a subtype of Herpesviridae stromal keratitis that typically presents unilaterally and has a high risk of recurrence. Combined treatment with antiviral and anti-inflammatory drugs, including topical ciclosporin, is usually required for long-term management.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Endocrinology & Metabolism
Fritz Cayabyab, Lina R. Nih, Eiji Yoshihara
Summary: Diabetes is a complex global disease affecting over 400 million people, with pancreatic islet transplantation showing promise in treating type 1 diabetes but facing challenges such as immune rejection. Current research focuses on finding optimal transplantation sites and methods to improve islet graft survival, with the aim of translating these studies into successful clinical therapies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Engineering, Biomedical
Jaganmohan R. Jangamreddy, Michel K. C. Haagdorens, M. Mirazul Islam, Philip Lewis, Ayan Samanta, Per Fagerholm, Aneta Liszka, Monika K. Ljunggren, Oleksiy Buznyk, Emilio I. Alarcon, Nadia Zakaria, Keith M. Meek, May Griffith
ACTA BIOMATERIALIA
(2018)
Article
Polymer Science
Mattias Tengdelius, Kwan Yee Cheung, May Griffith, Peter Pahlsson, Peter Konradsson
EUROPEAN POLYMER JOURNAL
(2018)
Article
Ophthalmology
Jennifer Walshe, Neil A. Richardson, Najla Khaled Al Abdulsalam, Sally-Anne Stephenson, Damien G. Harkin
EXPERIMENTAL EYE RESEARCH
(2018)
Review
Ophthalmology
Samantha Bobba, Nick Di Girolamo, Megan Munsie, Fred Chen, Alice Pebay, Damien Harkin, Alex W. Hewitt, Michael O'Connor, Samuel McLenachan, Audra M. A. Shadforth, Stephanie L. Watson
EXPERIMENTAL EYE RESEARCH
(2018)
Article
Ophthalmology
Najla Khaled Al Abdulsalam, Nigel L. Barnett, Damien G. Harkin, Jennifer Walshe
EXPERIMENTAL EYE RESEARCH
(2018)
Article
Ophthalmology
Peter J. Gillies, Neil A. Richardson, Jennifer Walshe, Sally-Anne Stephenson, Rebecca A. Dawson, Damien G. Harkin
EXPERIMENTAL EYE RESEARCH
(2018)
Article
Ophthalmology
Chih-Huang Yang, Julie Albietz, Damien G. Harkin, Michael G. Kimlin, Katrina L. Schmid
CONTACT LENS & ANTERIOR EYE
(2018)
Article
Cell & Tissue Engineering
Elham Nili, Fiona J. Li, Rebecca A. Dawson, Cora Lau, Blair McEwan, Nigel L. Barnett, Steven Weier, Jennifer Walshe, Neil A. Richardson, Damien G. Harkin
CELL TRANSPLANTATION
(2019)
Review
Multidisciplinary Sciences
Irene Guzman-Soto, Christopher McTiernan, Mayte Gonzalez-Gomez, Alex Ross, Keshav Gupta, Erik J. Suuronen, Thien-Fah Mah, May Griffith, Emilio Alarcon
Summary: Biofilm formation is linked to infections and antibiotic resistance, making it crucial for the development of antibiofilm treatments. While decades of research have contributed to in vitro and in vivo biofilm models, there is still no universally applicable model available.
Letter
Ophthalmology
Luisa H. Colorado, Samantha J. Dando, Damien G. Harkin, Katie Edwards
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Cell & Tissue Engineering
Olivia J. McGifford, Damien G. Harkin, Leila Cuttle
Summary: ROCK inhibitors can impact cell behavior and have potential for optimizing tissue engineering applications. However, the current understanding of their effects on epidermal keratinocytes is unclear, highlighting the need for further research.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Article
Chemistry, Physical
Christopher D. McTiernan, Matias Zuniga-Bustos, Roberto Rosales-Rojas, Pablo Barrias, May Griffith, Horacio Poblete, Peter S. Sherin, Ismael Lopez-Duarte, Marina K. Kuimova, Emilio Alarcon
Summary: Our study suggests that incorporating a positive charge on the hydrophobic tail of the BODIPY molecular rotor enhances its specificity as a reporter for viscosity of collagen-like peptide solutions.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Zohra Khatoon, Irene Guzman-Soto, Christopher D. McTiernan, Caitlin Lazurko, Fiona Simpson, Li Zhang, David Cortes, Thien-Fah Mah, May Griffith, Emilio Alarcon
Correction
Engineering, Biomedical
W. C. Mak, K. Olesen, P. Sivler, C. J. Lee, I. Moreno-Jimenez, J. Edin, D. Courtman, M. Skog, M. Griffith
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2018)
Article
Engineering, Biomedical
Vijayalakshmi Rajendran, Magdalena Netukova, May Griffith, John V. Forrester, Lucia Kuffova
ACTA BIOMATERIALIA
(2017)