Article
Pharmacology & Pharmacy
Lin Chen, Liangju Kuang, Amy E. E. Ross, Wissam Farhat, Nikolay Boychev, Sina Sharfi, Levi N. N. Kanu, Longqian Liu, Daniel S. S. Kohane, Joseph B. B. Ciolino
Summary: This study developed a contact lens device that can release miltefosine for the treatment of Acanthamoeba keratitis. The contact lens showed sustained drug release and good biocompatibility, indicating its potential as a successful treatment method.
Article
Microbiology
Marcin Padzik, Lidia Chomicz, Julita Bluszcz, Karolina Maleszewska, Jaroslaw Grobelny, David Bruce Conn, Edyta B. Hendiger
Summary: Acanthamoeba spp. can cause Acanthamoeba keratitis, particularly in contact lens wearers. It has been found that silver nanoparticles combined with tannic acid-modified contact lens solutions can enhance their anti-adhesion activity with low cytotoxicity.
Article
Medicine, General & Internal
Laura Trovato, Antonio Marino, Giovanni Pizzo, Salvatore Oliveri
Summary: Fusarium is a common filamentous fungus causing fungal keratitis, with timely diagnosis being crucial for patient treatment. The use of PCR testing can quickly confirm the pathogen and aid in selecting effective targeted antifungal therapy.
FRONTIERS IN MEDICINE
(2021)
Article
Microbiology
Yu-Jen Wang, Sung-Chou Li, Wei-Chen Lin, Fu-Chin Huang
Summary: This study reveals the abundant anaerobic Gram-positive rods present in severe keratitis isolate and characterizes the association between Acanthamoeba and ocular flora in AK progression. Further analysis shows that Blautia producta is positively correlated with the disease course, while Bacteroides ovatus is abundant in early-stage keratitis isolates.
Article
Engineering, Biomedical
Shakeel Ahmad Khan, Sammia Shahid, Tahir Mahmood, Chun-Sing Lee
Summary: Contact lenses are widely used for visual corrections, but may cause discomfort and infections. The development of multifunctional contact lenses coated with gallic acid, zinc oxide nanoparticles, and tobramycin using sonochemical technique showed significant antibacterial, antifungal, and antioxidant properties, along with good cytocompatibility and antifouling ability.
ACTA BIOMATERIALIA
(2021)
Article
Microbiology
Allison Campolo, Brian Patterson, Esther Lara, Paul Shannon, Monica Crary
Summary: Acanthamoeba keratitis is a challenging infection of the cornea, and understanding the behavior of Acanthamoebae during contact lens use and disinfection can provide insights into their colonization and the efficacy of contact lens care solutions. In this study, Acanthamoeba behavior during and after disinfection with different contact lens care solutions was examined. The results showed that all contact lens care solutions significantly impacted Acanthamoeba motility, with the solution containing PHMB showing the most effectiveness. Post-disinfection, Acanthamoebae were observed to regain motility and travel considerable distances, posing a potential risk to ocular health.
Review
Ophthalmology
Ana Gomes de Lacerda, Madalena Lira
Summary: Acanthamoeba keratitis is a widespread infection caused by a unicellular protozoan that mainly affects contact lens wearers and is linked to corneal trauma as well. It is essential to deepen the understanding of risk factors, focus on prevention strategies, and enhance the efficacy of disinfection systems to minimize the risk of infection. Additionally, there is a need for the development of effective diagnostic methods and treatments for this type of corneal infection in the near future.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2021)
Article
Microbiology
Edyta B. Hendiger, Marcin Padzik, Ines Sifaoui, Maria Reyes-Batlle, Atteneri Lopez-Arencibia, Diana Zyskowska, Marta Grodzik, Anna Pietruczuk-Padzik, Jacek Hendiger, Gabriela Oledzka, Lidia Chomicz, Jose E. Pinero, Jacob Lorenzo-Morales
Summary: Acanthamoeba keratitis is a severe corneal infection that can be effectively reduced by incorporating silver nanoparticles into contact lens solutions without increasing cytotoxicity.
Review
Ophthalmology
Maria Luiza Carneiro Buechele, Bruno Fonseca Nunes, Fabiola Branco Filippin-Monteiro, Karin Silva Caumo
Summary: Acanthamoeba spp. are pathogens that cause keratitis, and their drug resistance makes treatment difficult. This study aims to summarize literature since 2010 to reveal trends and future research directions in keratitis treatment.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Chemistry, Physical
Li Ma, Kaijun Li, Jiali Xia, Chaojian Chen, Yuqi Liu, Shiying Lang, Ling Yu, Gongyan Liu
Summary: The study introduces the use of silver nanoparticles modified contact lenses as a potential strategy for treating microbial keratitis. The modified lenses exhibit strong antimicrobial activity and have proven to be effective in inhibiting microbial biofilm growth. The treatment device has demonstrated excellent biocompatibility and the ability to prevent ocular infections and corneal damage.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Linyan Nie, Yuanfeng Li, Yong Liu, Linqi Shi, Huiyun Chen
Summary: This review examines the current applications of contact lenses for anti-corneal keratitis, discussing the development of contact lenses and the role of functionalized contact lenses.
Review
Ophthalmology
Lauren Jeang, Sonal S. Tuli
Summary: This review examines the current literature and practice patterns of antimicrobial therapy for contact lens-related microbial keratitis (CLMK). The use of topical antimicrobials is the mainstay of treatment for corneal ulcers, but bacterial, fungal, and acanthamoeba ulcers present different challenges due to resistance and the lack of effective topical medications. Novel therapies and diagnostic procedures offer hope for improved treatment outcomes. Contact lens-associated microbial keratitis is a significant health issue that can cause vision loss.
CURRENT OPINION IN OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Mathias Roth, Adriana Balasiu, Loay Daas, Christoph Holtmann, Anna Servera, Marcus Walckling, Colin R. MacKenzie, Thomas A. Fuchsluger, Gerd Geerling
Summary: The study aimed to assess the impact of Acanthamoeba PCR on the diagnosis and treatment of AK in a German tertiary referral center. The implementation of PCR significantly improved the timely diagnosis of AK, reduced the need for surgery, and improved the prognosis of patients.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Microbiology
Claudy Oliveira dos Santos, Nicolien M. Hanemaaijer, Jelina Ye, Henrich A. L. van der Lee, Paul E. Verweij, Cathrien A. Eggink
Summary: Chlorhexidine has shown in vitro fungicidal activity against Fusarium and demonstrated clinical effectiveness in the treatment of fungal keratitis patients, making it a safe and effective option for further clinical evaluation.
Article
Ophthalmology
Jerry Y. Niederkorn
Summary: Acanthamoeba keratitis is a rare protozoal infection of the cornea, primarily linked to contact lens wear. Immune studies show that exposure to Acanthamoeba is common but the disease itself is rare. Animal studies have revealed various contributing factors to the pathogenesis of AK.
EXPERIMENTAL EYE RESEARCH
(2021)
