Article
Oncology
Ruth Pidsley, Dilys Lam, Wenjia Qu, Timothy J. Peters, Phuc-Loi Luu, Darren Korbie, Clare Stirzaker, Roger J. Daly, Phillip Stricker, James G. Kench, Lisa G. Horvath, Susan J. Clark
Summary: This study used methylome sequencing to investigate the DNA methylation patterns in prostate cancer patients, and identified methylation patterns associated with prostate cancer-specific mortality, as well as prognostic biomarkers. The combination of DNA methylation biomarkers and clinicopathological measures improved the prognostic models for prostate cancer mortality.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Cora Palanca-Ballester, Aitor Rodriguez-Casanova, Susana Torres, Silvia Calabuig-Farinas, Francisco Exposito, Diego Serrano, Esther Redin, Karmele Valencia, Eloisa Jantus-Lewintre, Angel Diaz-Lagares, Luis Montuenga, Juan Sandoval, Alfonso Calvo
Summary: In addition to genetic changes, cancer is also characterized by epigenetic alterations that can be used for diagnosis, prognosis, and predicting drug response. These changes can be detected in early stages of cancer and through liquid biopsies, offering valuable information for personalized treatment. Validation and standardization of epigenetic biomarkers are needed for their successful transfer from research to clinical practice.
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Oncology
Gulab Sher, Nadia Aziz Salman, Abdul Q. Khan, Kirti S. Prabhu, Afsheen Raza, Michal Kulinski, Said Dermime, Mohammad Haris, Kulsoom Junejo, Shahab Uddin
Summary: Epigenetic alterations play a crucial role in the pathogenesis of breast cancer, including drug resistance and stemness features. Understanding and utilizing these modifications for breast cancer management is challenging, but holds promise for providing novel diagnostic, prognostic markers, and therapeutic options.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria J. Pajares, Ester Alemany-Cosme, Saioa Goni, Eva Bandres, Cora Palanca-Ballester, Juan Sandoval
Summary: Cancer is a complex disease involving alterations in multiple processes, with genetic and epigenetic features as core factors. Non-coding RNAs (ncRNAs), particularly microRNAs, play a key role in cancer initiation and progression by controlling cellular processes like proliferation, differentiation, and apoptosis. The expression of microRNAs is regulated by other epigenetic factors, resulting in aberrant expression patterns in cancer, and evaluating aberrant microRNA landscape holds promise for cancer management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Stefan Harsanyi, Zuzana Varchulova Novakova, Katarina Bevizova, Lubos Danisovic, Stanislav Ziaran
Summary: Bladder cancer is the 10th most common cancer worldwide, with a variety of diagnostic methods available, including standard cystoscopy and urine cytology. Liquid biopsy as a new trend is proving to be almost equally effective in detecting bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Wenlong Du, Guojun Shi, Chun-Min Shan, Zhiming Li, Bing Zhu, Songtao Jia, Qing Li, Zhiguo Zhang
Summary: This review summarizes the recent advances in the molecular mechanisms of epigenetic inheritance, discusses the potential impacts on normal development and diseases, and outlines future research directions in this field.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Oncology
Jamaji C. Nwanaji-Enwerem, Felicia Fei-Lei Chung, Lars Van der Laan, Alexei Novoloaca, Cyrille Cuenin, Harriet Johansson, Bernardo Bonanni, Alan E. Hubbard, Martyn T. Smith, Sheri J. Hartman, Andres Cardenas, Dorothy D. Sears, Zdenko Herceg
Summary: The study conducted a 6-month trial on breast cancer survivors and found limited effect of metformin on decelerating epigenetic age. Although there was a high correlation with chronological age, no significant association was observed between intervention arms and epigenetic age. Longer duration studies are needed to further characterize these relationships.
CLINICAL EPIGENETICS
(2021)
Review
Biochemistry & Molecular Biology
Eshaan Patnaik, Chikezie Madu, Yi Lu
Summary: Epigenetics plays a crucial role in gene regulation and tumor development. DNA methylation inhibitors and histone deacetylase inhibitors can restore normal gene expression and be effective against cancer. Understanding epigenetic modifications and utilizing inhibitors offer new possibilities for cancer research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Joana Dias Apolonio, Joao S. Dias, Monica Teotonio Fernandes, Martin Komosa, Tatiana Lipman, Cindy H. Zhang, Ricardo Leao, Donghyun Lee, Nuno Miguel Nunes, Ana-Teresa Maia, Jose L. Morera, Luis Vicioso, Uri Tabori, Pedro Castelo-Branco
Summary: THOR hypermethylation plays an important role in breast tumorigenesis and is associated with hTERT upregulation, making it a potential biomarker and therapeutic target for breast cancer.
CLINICAL EPIGENETICS
(2022)
Review
Biochemistry & Molecular Biology
Sarah S. Wang, Jihao Xu, Keely Y. Ji, Chang-Il Hwang
Summary: Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDA), is a significant cause of cancer-related deaths in the United States. While genetic mutations driving PDA initiation and progression have been identified, the mechanisms underlying PDA metastasis remain elusive. It is suggested that epigenetic fluctuations may play a critical role in driving PDA metastasis.
Review
Cell Biology
Daniela Mauceri
Summary: Pain is an unpleasant sensation resulting from tissue damage, and when it persists after the injury has resolved, it becomes pathological. The transition from acute to chronic pain involves plasticity events along the neural pathways and alterations in gene expression. Epigenetic mechanisms play a crucial role in these adaptive processes in the nervous system.
Review
Oncology
Yuhao Zhao, Mao Yang, Shijia Wang, Sk Jahir Abbas, Junzhe Zhang, Yongsheng Li, Rong Shao, Yingbin Liu
Summary: This review focuses on the mechanistic insights of DNA, histone, and RNA methylation in regulating the progression of pancreatic cancer. The roles of methylation regulators in modulating gene expression associated with cell proliferation, invasion, and apoptosis are discussed. Recent clinical trials on methylation drug targeting are also explored. Understanding the novel regulatory mechanisms of methylation modification may offer alternative opportunities to improve therapeutic efficacy in combating this devastating disease.
FRONTIERS IN ONCOLOGY
(2022)
Article
Geriatrics & Gerontology
Giovanni Fiorito, Sara Pedron, Carolina Ochoa-Rosales, Cathal McCrory, Silvia Polidoro, Yan Zhang, Pierre-Antoine Dugue, Scott Ratliff, Wei N. Zhao, Gareth J. McKay, Giuseppe Costa, Maria Giuliana Solinas, Kathleen Mullan Harris, Rosario Tumino, Sara Grioni, Fulvio Ricceri, Salvatore Panico, Hermann Brenner, Lars Schwettmann, Melanie Waldenberger, Pamela R. Matias-Garcia, Annette Peters, Allison Hodge, Graham G. Giles, Lauren L. Schmitz, Morgan Levine, Jennifer A. Smith, Yongmei Liu, Frank Kee, Ian S. Young, Bernadette McGuinness, Amy Jayne McKnight, Joyce van Meurs, Trudy Voortman, Rose A. Kenny, Paolo Vineis, Cristian Carmeli
Summary: Educational inequalities have long been associated with all-cause mortality, but the biological mechanisms behind this association are not well understood. This study examines the role of DNA methylation changes in explaining these inequalities and finds that they play a larger role in male mortality rates compared to females. The study also suggests that unhealthy lifestyles and World Health Organization risk factors contribute to the mediation of this association.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Lirui Wang, Chunlei Zhang, Yuping Hong, Xinhong Li, Tangan Li, Ang Gao, Shaojun Pan, Bin Liu, Han Jin, Daxiang Cui
Summary: The study developed a method of combinatorial delivery of epigenetic modulatory drugs through self-assembly, effectively regulating DNA methylation and histone deacetylation, ultimately inhibiting tumor cell proliferation and promoting cell apoptosis.