Letter
Psychiatry
Alfonso Troisi
Summary: Research suggests that variation in the mu-opioid receptor gene is linked to attachment behavior in adults, with the A118G polymorphism and early maternal care interacting to influence levels of fearful attachment. Individuals carrying the minor 118G allele experience more pleasure in social situations and show lower levels of avoidant attachment compared to those with the A/A genotype.
WORLD JOURNAL OF PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Shan Liu, Wen-Jia Kang, Anna Abrimian, Jin Xu, Luca Cartegni, Susruta Majumdar, Patrick Hesketh, Alex Bekker, Ying-Xian Pan
Summary: The OPRM1 gene undergoes extensive alternative splicing to produce multiple splice variants with important pharmacological implications for the actions of opioid drugs. These variants can mediate distinct effects of various mu opioids and be targeted for the development of novel analgesics with potent efficacy against multiple types of pain while reducing side effects associated with traditional opiates.
Article
Oncology
Hao Zhang, Mengdi Qu, Aysegul Gorur, Zhirong Sun, Juan P. Cata, Wankun Chen, Changhong Miao
Summary: This study focused on the relationship between opioid use and MOR expression in patients with stage I-III PDAC. The results showed that MOR is not an independent predictor of poor survival in this stage of PDAC but is associated with perineural invasion. Patients requiring high amounts of opioids intraoperatively have worse outcomes if they express high levels of MOR.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenjian Kang, Shan Liu, Jin Xu, Anna Abrimian, Ayma F. Malik, Raymond Chien, Adejuyigbe Adaralegbe, Akwasi Amponsah, Luca Cartegni, John Pintar, Ying-Xian Pan
Summary: The mu opioid receptor gene OPRM1 undergoes extensive alternative pre-mRNA splicing to generate multiple splice variants, which have distinct pharmacological functions. Gene-targeted mouse models have been used to study the functional importance of these splice variants in the actions of mu opioids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Brandon W. Hughes, Benjamin M. Siemsen, Evgeny Tsvetkov, Stefano Berto, Jaswinder Kumar, Rebecca G. Cornbrooks, Rose Marie Akiki, Jennifer Y. Cho, Jordan S. Carter, Kirsten K. Snyder, Ahlem Assali, Michael D. Scofield, Christopher W. Cowan, Makoto Taniguchi, Kate M. Wassum
Summary: Chronic stress can lead to reward system deficits and neural circuit hypofunction in the medial prefrontal cortex. The neuronal activity-regulated transcription factor, NPAS4, is regulated by chronic social defeat stress and plays a role in sucrose preference and natural reward motivation. NPAS4 also affects excitatory synaptic transmission and is linked to genes related to glutamatergic synapses and ribosomal function.
Article
Medicine, General & Internal
Hongzhen Cheng, Xiaoyan Chu, Shenghua Yi
Summary: This study demonstrated the significant influence of OPRM1 A118G genotype on the dosage of morphine in advanced liver cancer patients, with GG genotype patients requiring higher morphine doses for pain control.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)
Article
Medicine, Research & Experimental
Amina M. Bagher, Rawan H. Hareeri
Summary: The study aimed to assess the allele frequency and genotype distribution of OPRM1 A118G SNP in Saudis. The results showed a low prevalence of the OPRM1 A118G polymorphism in the Saudi population, with a higher frequency of the 118G allele in females.
JOURNAL OF APPLIED BIOMEDICINE
(2023)
Article
Psychology, Biological
Joanna B. Thompson, Alan M. Daniel, Brenda G. Rushing, Mauricio R. Papini
Summary: In this study, animals exhibited transient rejection of reward after a reward downshift, followed by training in an operant licking task. The speed of recovery from the reward downshift was found to be associated with performance in the operant licking task, but not with genetic variations in the opioid receptor gene OPRM1.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Biochemistry & Molecular Biology
Yuta Yoshida, Misa Miyazaki, Yuhei Yajima, Atsushi Toyoda
Summary: This study utilized a mouse model to investigate the effects of psychosocial stress on peripheral taste-sensing systems, revealing that psychosocial stress can downregulate the mRNA levels of sweet and umami taste receptor subunits.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Anna Abrimian, Tamar Kraft, Ying-Xian Pan
Summary: Endogenous opioid peptides, including enkephalins, dynorphins, and beta-endorphin, act through MOR, DOR, and KOR receptors, playing important roles in analgesia and various biological processes. The OPRM1 gene undergoes extensive pre-mRNA splicing, generating multiple splice variants, with the 7TM C-terminal variants playing a key role in the pharmacological functions of endogenous opioid peptides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Taylor G. Brown, Jin Xu, Yasmin L. Hurd, Ying-Xian Pan
Summary: This study investigates the potential role of OPRM1 splice variants in heroin addiction. The results show similar expression patterns of OPRM1 splice variants in humans and rats, but dysregulated expression of certain splice variants in heroin abusers. These findings suggest that OPRM1 splice variants may play an important role in heroin addiction.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Behavioral Sciences
Elizabeth K. Wood, Zachary Baron, Melanie L. Schwandt, Stephen G. Lindell, Christina S. Barr, Stephen J. Suomi, J. Dee Higley
Summary: This study found that the OPRM1 genotype of mothers has a moderating effect on mother-infant attachment behaviors, especially for female infants.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Yimeng Wang, Yang Bai, Xi Xiao, Ling Wang, Ganjiang Wei, Mingkun Guo, Xizi Song, Yutao Tian, Dong Ming, Jiajia Yang, Chenguang Zheng
Summary: This study found that low-intensity focused ultrasound stimulation (LIFUS) can improve social avoidance behavior in defeated mice. LIFUS achieves this effect by inhibiting activation of the inflammatory response, increasing neuronal excitation, and protecting the integrity of the neuronal structure.
Article
Neurosciences
Jennifer M. Bossert, Carlos A. Mejias-Aponte, Thomas Saunders, Lindsay Altidor, Michael Emery, Ida Fredriksson, Ashley Batista, Sarah M. Claypool, Kiera E. Caldwell, David J. Reiner, Jonathan J. Chow, Matthew Foltz, Vivek Kumar, Audrey Seasholtz, Elizabeth Hughes, Wanda Filipiak, Brandon K. Harvey, Christopher T. Richie, Francois Vautier, Juan L. Gomez, Michael Michaelides, Brigitte L. Kieffer, Stanley J. Watson, Huda Akil, Yavin Shaham
Summary: By introducing the Oprm1-Cre knock-in transgenic rat, this study investigated the role of the mu-opioid receptor (MOR) in heroin self-administration. The study found that heroin self-administration showed different patterns in male and female Oprm1-Cre rats. This research provides new strategies for understanding the involvement of MOR-expressing cells in opioid addiction, pain-related behaviors, and other opioid-mediated functions.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Aysegul Gorur, Miguel Patino, Ted Shi, German Corrales, Hideaki Takahashi, Roberto Rangel, Frederico O. Gleber-Netto, Curtis Pickering, Jeffrey N. Myers, Juan P. Cata
Summary: The study suggests that the expression and activity of Mu-opioid receptor (MOR) play a key role in the proliferation, invasion, and migration of head and neck squamous cell carcinoma (HNSCC) cells, and the antagonist methylnaltrexone (MNTX) shows inhibitory effects on HNSCC cell lines.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Neurosciences
Megan M. Wickens, Andre U. Deutschmann, Anna G. McGrath, Vinay Parikh, Lisa A. Briand
Review
Behavioral Sciences
Anna G. McGrath, Lisa A. Briand
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2019)
Article
Cell & Tissue Engineering
Xuyu Qian, Yijing Su, Christopher D. Adam, Andre U. Deutschmann, Sarshan R. Pather, Ethan M. Goldberg, Kenong Su, Shiying Li, Lu Lu, Fadi Jacob, Phuong T T Nguyen, Sooyoung Huh, Ahmet Hoke, Sarah E. Swinford-Jackson, Zhexing Wen, Xiaosong Gu, R. Christopher Pierce, Hao Wu, Lisa A. Briand, H. Isaac Chen, John A. Wolf, Hongjun Song, Guo-Ii Ming
Article
Multidisciplinary Sciences
Evelyn Ordones Sanchez, Charlotte C. Bavley, Andre U. Deutschmann, Rachel Carpenter, Drew R. Peterson, Reza Karbalaei, James Flowers, Charleanne M. Rogers, Miranda G. Langrehr, Cory S. Ardekani, Sydney T. Famularo, Angela R. Bongiovanni, Melissa C. Knouse, Stan B. Floresco, Lisa A. Briand, Mathieu E. Wimmer, Debra A. Bangasser
Summary: This study investigated the stress inoculation effect of early adversity using the LBN model, focusing on addiction-related phenotypes in adulthood. Results showed that LBN reduced impulsive choice, morphine self-administration, and AMPA/NMDA ratio in males, indicating a male-specific stress inoculation effect against addiction-related behaviors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Megan M. Wickens, Julia M. Kirkland, Melissa C. Knouse, Anna G. McGrath, Lisa A. Briand
Summary: Disruption of prefrontal glutamate receptor interacting protein (GRIP) enhances cue-induced cocaine seeking in both males and females, while protein interacting with C kinase 1 (PICK1) plays an opposing role. Deletion of PICK1 in the prefrontal cortex reduces cue-induced cocaine seeking in male mice but increases it in females, with androgens potentially influencing the compensatory effects of PICK1 knockdown.
Article
Biochemistry & Molecular Biology
Andre U. Deutschmann, Julia M. Kirkland, Lisa A. Briand
Summary: Exposure to adversity during early childhood and adolescence increases vulnerability to substance use disorder, with excitatory afferents to the nucleus accumbens mediating responses to stress and reward. Social isolation rearing alters presynaptic glutamatergic transmission in the NAc, with projections from the ventral hippocampus potentially being a target for reversing stress-induced plasticity.
Article
Behavioral Sciences
Melissa C. Knouse, Lisa A. Briand
Summary: Females exhibit stronger behavioral responses than males to drugs like cocaine and opioids, possibly driven by ovarian hormones. While there are overlapping neural mechanisms underlying cocaine and opioid abuse, they have divergent effects on synaptic plasticity. This suggests that behavioral sex differences in substance use disorder may be driven by different mechanisms depending on the drug class.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Anna G. McGrath, Lisa A. Briand
Summary: Post-weaning social isolation stress affects addiction-like behavior in adulthood. Long-term changes in behavior may be due to lasting structural changes in reward-related brain regions. Previous studies have shown that stress alters dendritic spine density in these regions, but many studies only focus on short-term effects and mainly involve male subjects. There is growing evidence of sex differences in stress responses and plasticity. This study examines the long-lasting, sex-specific alterations in spine density following post-weaning social isolation in mice.
Article
Endocrinology & Metabolism
Melissa C. Knouse, Anna G. McGrath, Andre U. Deutschmann, Matthew T. Rich, Lia J. Zallar, Anjali M. Rajadhyaksha, Lisa A. Briand
Summary: This article investigates the sex differences in glutamatergic transmission within the medial prefrontal cortex, finding higher levels of glutamatergic transmission in females. This provides important evidence for the development of sex-specific pharmacotherapies for psychiatric diseases.
BIOLOGY OF SEX DIFFERENCES
(2022)
Article
Endocrinology & Metabolism
Melissa C. Knouse, Andre U. Deutschmann, Miroslav N. Nenov, Mathieu E. Wimmer, Lisa A. Briand
Summary: In this study, potential sex differences in synaptic plasticity and excitatory transmission within the nucleus accumbens core were examined. The results showed that female mice and rats have higher AMPA/NMDA ratios, a larger readily releasable pool of glutamate, and lower release probability compared to males. These sex differences should be considered in the development of pharmacotherapies for treating depression and substance use disorder.
BIOLOGY OF SEX DIFFERENCES
(2023)
Correction
Multidisciplinary Sciences
Evelyn Ordones Sanchez, Charlotte C. Bavley, Andre U. Deutschmann, Rachel Carpenter, Drew R. Peterson, Reza Karbalaei, James Flowers, Charleanne M. Rogers, Miranda G. Langrehr, Cory S. Ardekani, Sydney T. Famularo, Angela R. Bongiovanni, Melissa C. Knouse, Stan B. Floresco, Lisa A. Briand, Mathieu E. Wimmer, Debra A. Bangasser
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Meeting Abstract
Neurosciences
Debra Bangasser, Evelyn Ordones Sanchez, Charlotte Bavley, Andre Deutschmann, Drew Peterson, Rachel Carpenter, Reza Karbalaei, James Flowers, Charleanne Rogers, Miranda Langrehr, Cory Ardekani, Sydney Famularo, Angela Bongiovanni, Melissa Knouse, Stan Floresco, Benjamin Garcia, Lisa Briand, Mathieu Wimmer
BIOLOGICAL PSYCHIATRY
(2021)
Meeting Abstract
Neurosciences
Evelyn Ordones Sanchez, Charlotte Bavley, Rachel Carpenter, Drew Peterson, Reza Karbalaei, James Flowers, Charleanne Rogers, Miranda Langrehr, Cory Ardekani, Sydney Famularo, Angela Bongiovanni, Stan Floresco, Benjamin Garcia, Lisa Briand, Mathieu Wimmer, Debra Bangasser
NEUROPSYCHOPHARMACOLOGY
(2020)
Meeting Abstract
Neurosciences
Debra Bangasser, Evelyn Ordones Sanchez, Rachel Carpenter, Drew Peterson, James Flowers, Charleanne Rogers, Cory Ardekani, Reza Karbalaei, Stan Floresco, Benjamin Garcia, Lisa Briand, Mathieu Wimmer
NEUROPSYCHOPHARMACOLOGY
(2019)
Meeting Abstract
Neurosciences
Lisa Briand, Andre Deutschmann
NEUROPSYCHOPHARMACOLOGY
(2019)