Review
Critical Care Medicine
Eric Lang, Hossam Abdou, Joseph Edwards, Neerav Patel, Jonathan J. Morrison
Summary: Trauma-hemorrhage is a major cause of death both before and early in hospitalization, and it also contributes to the development of organ dysfunction/failure and sepsis. Sex hormone therapy, including estradiol and its derivatives, has shown beneficial effects in animal models. Gender-based differences in mortality following trauma-hemorrhage have been observed, suggesting a role for estrogens.
Article
Cell Biology
Tina B. McKay, Shrestha Priyadarsini, Dimitrios Karamichos
Summary: This review focuses on the effects of systemic hormones, including androgens, estrogens, human growth hormone, and insulin growth factor-1, on ocular surface homeostasis, wound healing, and corneal thickness. The findings suggest that age-related changes in hormone levels should be considered as an important factor in the study of corneal health and disease.
Review
Neurosciences
Erin L. L. Beech, Nina Riddell, Melanie J. J. Murphy, Sheila G. G. Crewther
Summary: Migraine, occurring predominantly in females, is associated with hypothalamic sex and stress hormonal function, as well as autonomic nervous system activation. This study aimed to analyze the literature on sex hormones, cortisol responses, and heart rate variability in male and female migraineurs. The results showed reduced estrogen concentrations in female migraineurs during the luteal phase, elevated cortisol concentrations in both male and female migraineurs, and no differences in heart rate variability between migraineurs and controls. These findings highlight the dysregulation of estrogen and cortisol in migraineurs and the importance of further investigation into hypothalamic neuroendocrine functions.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Review
Clinical Neurology
Jennifer A. Hranilovich, Eric A. Kaiser, Anna Pace, Mark Barber, Jason Ziplow
Summary: This review discusses the unique aspects of managing headache in gender minorities and current research, including the potential relationship between gender-affirming hormone therapy (GAHT) and headache. Despite being medically underserved, the population of transgender and gender-diverse individuals has seen limited research on headache. Understanding the effects of hormonal therapy on headache in transgender patients is essential for providing quality care in this population.
Article
Medicine, Research & Experimental
Bo Tang, Xiaojun Yu, Wei Jiang, Chuang Zhang, Tao Zhan, Yuqin He
Summary: This study found a close correlation between sex hormones and vestibular migraine in postmenopausal women, particularly estradiol levels. Higher estradiol levels may be associated with the progression and disease-free survival time of vestibular migraine.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Environmental Sciences
Xin Wang, Ning Ding, Sioban D. Harlow, John F. Randolph Jr, Ellen B. Gold, Carol Derby, Howard M. Kravitz, Gail Greendale, Xiangmei Wu, Keita Ebisu, Joel Schwartz, Sung Kyun Park
Summary: This study investigated the association between air pollution and levels of estradiol (E2) and follicle-stimulating hormone (FSH) in women during menopause. The findings showed that increased levels of PM2.5 and NO2 were associated with significant decreases in E2 levels, while increased levels of NO2 were associated with decreases in FSH levels. This suggests that air pollutants have a detrimental impact on women's reproductive hormones.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Endocrinology & Metabolism
Peik M. A. Brundin, Britt-Marie Landgren, Peter Fjallstrom, Mohamed M. M. Shamekh, Jan-Ake Gustafsson, Anders F. F. Johansson, Ivan Nalvarte
Summary: The study reveals the expression patterns of sex hormone receptors in different immune cells and the lack of significant correlation between sex hormone levels and expression of SHR or immune response genes. However, there is a positive correlation between sex hormone-binding globulin and the expression of certain genes. Additionally, immune response genes show significant differences in expression between different phases of the menstrual cycle, suggesting a potential role for sex hormones in immune response.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Bin Ke, Chunyu Li, Huifang Shang
Summary: The study found a link between higher levels of estradiol and a reduced risk of epilepsy, particularly in males. No association was found between testosterone or progesterone and the risk of epilepsy. These findings highlight the importance of estradiol in the development of preventive or therapeutic interventions in clinical trials.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Christiana K. Miller, John Meitzen
Summary: This study investigates the modulation of anxiety-related and locomotor behaviors in female rodents by the sex steroid hormone 17 beta-estradiol (estradiol) and its Estrogen Receptors (ERs). The results suggest that estradiol mitigates anxiety-related behaviors through activating Estrogen Receptor (ER) beta and increases locomotor behaviors through ER alpha. However, the influence of ERs on these behaviors cannot always be detected.
HORMONES AND BEHAVIOR
(2023)
Review
Pharmacology & Pharmacy
D. -H. Lu, S. -Y. Zhou, L. -Z. Xu
Summary: The aim of this study was to systematically review and meta-analyze the changes in hormonal profile of postmenopausal women treated with hormone replacement therapy (HRT). The results showed that oral and transdermal HRT increased estradiol (E2) serum levels and decreased follicle stimulating hormone (FSH) levels, while vaginal HRT had no effect. There was no significant difference in the effects of different HRT regimens on E2 and FSH levels.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Review
Pharmacology & Pharmacy
D. -H. Lu, S. -Y. Zhou, L. -Z. Xu
Summary: This study systematically reviewed and meta-analyzed the effects of hormone replacement therapy (HRT) on the hormonal profile of postmenopausal women. The analysis showed that oral and transdermal HRT increased estradiol (E2) levels and decreased follicle stimulating hormone (FSH) levels, while vaginal HRT did not have a significant effect. There were no significant changes in E2 and FSH levels between different treatment durations or regimes. However, oral estrogen combined with synthetic progestin led to a reduction in sex hormone-binding globulin (SHGB) levels.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Katie M. Linstra, Khatera Ibrahimi, Daphne S. van Casteren, Marieke J. H. Wermer, Gisela M. Terwindt, Antoinette MaassenVandenBrink
Summary: This study investigated pain perception in women with menstrually-related migraine throughout different phases of the menstrual cycle. Results showed that women with migraine had lower levels of trigeminal pain compared to healthy controls throughout the cycle, indicating that pain perception varies during the menstrual cycle.
Article
Clinical Neurology
Seonghoon Kim, Si Baek Lee, Yun Jeong Hong, Yongbang Kim, Kyungdo Han, Jeong Wook Park
Summary: This study found that in spontaneous postmenopausal women, there is a higher risk of migraines in the group with shorter lifetime number of years of menstruation, as well as in all hormone replacement therapy (HRT) groups compared to the non-HRT group. Migraine risk also tends to increase with greater postmenopausal years.
Review
Oncology
Carolyn A. Bernstein
Summary: This review article provides a comprehensive overview of headache evaluation and treatment in cancer patients, including the diagnostic process, common types of headaches, pharmacological treatment, and complementary and integrative therapies.
Review
Clinical Neurology
Jason Charles Ray, Mahima Kapoor, Richard J. Stark, Shuu-Jiun Wang, Lars Bendtsen, Manjit Matharu, Elspeth Jane Hutton
Summary: Migraine is the second largest cause of years lost to disability globally, with limited therapeutics specifically developed for its treatment. After 30 years of research, CGRP inhibitors have emerged as a promising tool for migraine prevention. However, with limited real-world experience, the systemic actions of CGRP need to be considered for potential side effects.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)