期刊
CURRENT OPINION IN NEUROLOGY
卷 27, 期 3, 页码 309-314出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WCO.0000000000000086
关键词
brain structure; cortical thickness; migraine; MRI; voxel-based morphometry; white matter hyperintensities
资金
- University of Copenhagen
- Lundbeck Foundation Center for Neurovascular Signalling (LUCENS)
- Danish Council for Independent Research-Medical Sciences (FSS) [271-08-0446]
- Novo Nordisk Foundation [R172-A14333]
- Research Foundation of the Capital Region of Denmark
- Novo Nordisk Fonden [NNF11OC1014333] Funding Source: researchfish
Purpose of reviewThe aim is to provide an overview of recent studies of structural brain abnormalities in migraine and to discuss the potential clinical significance of their findings.Recent findingsBrain structure continues to be a topic of extensive research in migraine. Despite advances in neuroimaging techniques, it is not yet clear if migraine is associated with grey matter changes. Recent large population-based studies sustain the notion of increased prevalence of white matter abnormalities in migraine, and possibly of silent infarct-like lesions. The clinical relevance of this association is not clear. Structural changes are not related to cognitive decline, but a link to an increased risk of stroke, especially in patients with aura, cannot be ruled out.SummaryMigraine may be a risk factor for structural changes in the brain. It is not yet clear how factors such as migraine sub-type, attack frequency, and sex affects this association. Additional longitudinal studies are needed to address these issues. Brain structure changes in migraine could potentially serve as disease biomarkers or as a mean of identifying sub-groups of patients with specific therapeutic needs and prognoses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据