Article
Multidisciplinary Sciences
Goichi Miyoshi, Yoshifumi Ueta, Akiyo Natsubori, Kou Hiraga, Hironobu Osaki, Yuki Yagasaki, Yusuke Kishi, Yuchio Yanagawa, Gord Fishell, Robert P. Machold, Mariko Miyata
Summary: This study reveals that FoxG1 regulates the formation of cortical GABAergic circuits affecting social behavior during a specific postnatal time window in mouse models of ASD. The second postnatal week is a critical period to prevent ASD-like social impairments. Transplantation of GABAergic precursor cells or modulation of GABAergic tone can respectively ameliorate or exacerbate circuit functionality and social behavioral defects.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Camille Mazo, Antoine Nissant, Soham Saha, Enzo Peroni, Pierre-Marie Lledo, Gabriel Lepousez
Summary: In the olfactory system, a group of GABAergic neurons in the anterior olfactory cortex projects inhibitory feedback signals to the olfactory bulb, which can enhance the separation of odor responses and affect the discrimination of similar odors in the output neurons.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Sahar Sweetat, Natania Casden, Oded Behar
Summary: Injury to the central nervous system leads to neuronal cell death and astrogliosis. The lack of Sema4B expression in glial cells improves neuronal survival by reducing toxic factors or increasing survival factors secreted by glial cells.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Xuan Li, Hexige Saiyin, Xinyu Chen, Qiong Yu, Lixiang Ma, Weimin Liang
Summary: This study revealed the mechanisms by which ketamine affects the growth cones and synapse formation of developing GABAergic neurons using human pluripotent stem cells. The results indicate that ketamine impairs growth cone formation, synaptogenesis, and dendrite maturation through the activation of GSK-3β pathway and inhibition of HDAC6.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Ashleigh Willis, Judith A. Pratt, Brian J. Morris
Summary: The study finds that enzymatic digestion of PNNs by ChABC produces an immature molecular phenotype, which is distinct from mature plasticity. Furthermore, the study highlights the involvement of TAOK signaling in BDNF regulation of plasticity and PNNs.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jeremy T. Chang, David Fitzpatrick
Summary: Using in vivo calcium imaging in ferret visual cortex, the authors demonstrated that experience-dependent emergence of orientation selectivity in inhibitory interneurons occurs in a modular fashion over the first week of visual experience. This finding provides important insights into the developmental timeline of excitatory and inhibitory neurons in the visual cortex.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Catia A. P. Silva, Annik Yalnizyan-Carson, M. Victoria Fernandez Busch, Mike van Zwieten, Matthijs Verhage, Christian Lohmann
Summary: During early development, mitochondrial motility decreases as neuronal activity frequency increases, with individual synaptic transmission events leading to local mitochondrial arrest. Pharmacological stimulation of synaptic vesicle release stops mitochondrial motility, suggesting the requirement of an unidentified factor co-released with glutamate.
Article
Multidisciplinary Sciences
Hyeji Jung, Dongsu Lee, Heejung You, Myungha Lee, Hyeonho Kim, Eunji Cheong, Ji Won Um
Summary: This study investigates the temporal sequence from microglial activation to synaptic dysfunction and cognitive behavior induced by neuroinflammation in mice. It demonstrates that neuroinflammation induces microglia activation, GABAergic synaptic deficits, and prolonged memory impairment.
SCIENTIFIC REPORTS
(2023)
Review
Cell Biology
Knut Kirmse, Chuanqiang Zhang
Summary: GABAergic signaling plays a crucial role in the inhibitory stabilization and coordination of excitatory neurons in mature cortical circuits. This review examines how GABA-releasing interneurons acquire their network functions during development, focusing on the visual neocortex and hippocampus in mice and rats. The authors propose that inhibitory stabilization is not functional at the onset of patterned activity, and that glutamatergic neurons are stable by themselves. The strengthening of inhibitory synaptic transmission toward eye opening shapes cortical network dynamics and allows the developing cortex to disengage from extra-cortical synaptic drive. The framework presented in this review has implications for our understanding of human cortical development and the treatment of neonatal seizures.
Article
Multidisciplinary Sciences
Laura Hermans, Murat Kaynak, Jonas Braun, Victor Lobato Rios, Chin-Lin Chen, Adam Friedberg, Semih Guenel, Florian Aymanns, Mahmut Selman Sakar, Pavan Ramdya
Summary: Understanding biological networks requires minimally invasive methods to repeatedly record neural circuits in behaving animals. The authors have developed devices for long-term optical recordings in adult Drosophila ventral nerve cord, showing minimal impact on animal behavior and survival, and demonstrating the importance of tracking neural activity.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Elissa L. Newport, Anna Seydell-Greenwald, Barbara Landau, Peter E. Turkeltaub, Catherine E. Chambers, Kelly C. Martin, Rebecca Rennert, Margot Giannetti, Alexander W. Dromerick, Rebecca N. Ichord, Jessica L. Carpenter, Madison M. Berl, William D. Gaillard
Summary: The mature human brain is lateralized for language, with the left hemisphere primarily responsible for sentence processing and the right hemisphere primarily responsible for processing suprasegmental aspects of language. It has been hypothesized that there is plasticity for language in early life, allowing young children to acquire language in other cortical regions when LH areas are damaged. This reorganization is highly constrained, with sentence processing almost always occurring in the right hemisphere frontotemporal regions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Chi Ren, Kailong Peng, Ruize Yang, Weikang Liu, Chang Liu, Takaki Komiyama
Summary: This study found that different subtypes of inhibitory neurons (INs) in the cortex of mice learning a task are globally modulated throughout the cortex, with initial learning involving varying levels of activation of VIP-INs and SOM-INs. Furthermore, manipulation of the cholinergic system can affect the activity of cortical IN subtypes and subsequently impact motor learning.
Article
Multidisciplinary Sciences
Yao-Yi Wang, Bing Zhao, Meng-Meng Wu, Xiao-Li Zheng, Longnian Lin, Dong-Min Yin
Summary: Increased expression of Nrg1 in GABAergic interneurons can cause cortical disinhibition, leading to various neuropsychiatric disorders. The interaction between NRG1 and Na(v)1.1 inhibits Na-v currents critical for GABAergic interneuron excitability, and activating GABAergic interneurons or restoring NRG1 expression can rescue related symptoms.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Leechung Chang, Mayuko Masada, Masami Kojima, Nobuhiko Yamamoto
Summary: Neuronal remodeling plays a crucial role in functional recovery after brain injury. This study investigated the molecular mechanisms underlying ectopic axonal projection in the denervated midbrain after unilateral cortical lesion. The analysis revealed upregulation of axon growth-related genes, predominantly expressed by glial cells, in the denervated midbrain. Knocking out the receptors for these upregulated molecules in intact cortex reduced the ectopic projection, particularly when integrin subunit b three or neurotrophic receptor tyrosine kinase 2 (TrkB) was targeted. These findings suggest that denervated midbrain-derived glial factors contribute to lesion-induced remodeling of the cortico-mesencephalic projection via these receptors.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Joni Haikonen, Jonas Englund, Shyrley Paola Amarilla, Zoia Kharybina, Alexandra Shintyapina, Kristel Kegler, Marta Saez Garcia, Tsvetomira Atanasova, Tomi Taira, Henrike Hartung, Sari E. Lauri
Summary: Early life stress leads to long-term dysfunction in the corticolimbic circuitry, affecting emotional and social behavior. The underlying neurobiological mechanisms are still not well understood.
Review
Biochemistry & Molecular Biology
Flore Sinturel, Volodymyr Petrenko, Charna Dibner
JOURNAL OF MOLECULAR BIOLOGY
(2020)
Article
Genetics & Heredity
Tadashi Shiohama, Jacob Levman, Lana Vasung, Emi Takahashi
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2020)
Article
Neurosciences
Hyuk Jin Yun, Lana Vasung, Tomo Tarui, Caitlin K. Rollins, Cynthia M. Ortinau, P. Ellen Grant, Kiho Im
Article
Neurosciences
Evgenia Andreoli, Volodymyr Petrenko, Paul Eugene Constanthin, Alessandro Contestabile, Riccardo Bocchi, Kristof Egervari, Charles Quairiaux, Patrick Salmon, Jozsef Zoltan Kiss
Article
Developmental Biology
Paul E. Constanthin, Alessandro Contestabile, Volodymyr Petrenko, Charles Quairiaux, Patrick Salmon, Petra S. Hueppi, Jozsef Z. Kiss
Meeting Abstract
Endocrinology & Metabolism
Volodymyr Petrenko, Miri Stolovich-Rain, Bart Vandereycken, Simona Chera, Yuval Dor, Charna Dibner
Article
Clinical Neurology
Caitlin K. Rollins, Cynthia M. Ortinau, Christian Stopp, Kevin G. Friedman, Wayne Tworetzky, Borjan Gagoski, Clemente Velasco-Annis, Onur Afacan, Lana Vasung, Jeanette Beaute, Valerie Rofeberg, Judy A. Estroff, P. Ellen Grant, Janet S. Soul, Edward Yang, David Wypij, Ali Gholipour, Simon K. Warfield, Jane W. Newburger
Summary: The study found that fetuses with CHD showed a region-specific pattern of small brain volumes and impaired brain growth before 32 weeks gestation. Genetic or environmental factors related to CHD may also contribute to brain development.
ANNALS OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Phillip Alexander Keller Andersen, Volodymyr Petrenko, Peter Horskjaer Rose, Melissa Koomen, Nico Fischer, Seyed Mojtaba Ghiasi, Tina Dahlby, Charna Dibner, Thomas Mandrup-Poulsen
Summary: The combination of proinflammatory cytokines IL-1 beta and interferon-gamma disrupted the intrinsic clocks in mouse and human pancreatic islets, leading to uncoordinated clock gene expression in INS-1 cells. This effect was associated with nitric oxide (NO), lysine deacetylase HDAC3, and immunoproteasome activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Flore Sinturel, Pascal Gos, Volodymyr Petrenko, Claudia Hagedorn, Florian Kreppel, Kai-Florian Storch, Darko Knutti, Andre Liani, Charles Weitz, Yann Emmenegger, Paul Franken, Luigi Bonacina, Charna Dibner, Ueli Schibler
Summary: The study suggests that the suprachiasmatic nucleus is necessary for synchronizing organs, but even in the absence of the suprachiasmatic nucleus or other cellular oscillators, the livers of mice still exhibit circadian rhythms.
GENES & DEVELOPMENT
(2021)
Article
Neurosciences
Lana Vasung, Chenying Zhao, Matthew Barkovich, Caitlin K. Rollins, Jennings Zhang, Claude Lepage, Teddy Corcoran, Clemente Velasco-Annis, Hyuk Jin Yun, Kiho Im, Simon Keith Warfield, Alan Charles Evans, Hao Huang, Ali Gholipour, Patricia Ellen Grant
Summary: This study reveals an association between structural changes in the cerebral cortex and gene expression levels, particularly highlighting the relationship between the FLNA gene and cortical evolving organization. The findings suggest the need for further research to identify early MRI biomarkers of gene expression in abnormal cortical development.
Article
Computer Science, Artificial Intelligence
Davood Karimi, Lana Vasung, Camilo Jaimes, Fedel Machado-Rivas, Shadab Khan, Simon K. Warfield, Ali Gholipour
Summary: A machine learning-based technique is proposed for accurately estimating the number and orientations of fascicles in a voxel, outperforming classical and machine learning methods in predicting crossing fascicles and leading to more accurate tractography. This method also shows better robustness to measurement down sampling and expert quality assessment of tractography results compared to other methods.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Neurosciences
Lana Vasung, Caitlin K. Rollins, Jennings Zhang, Clemente Velasco-Annis, Edward Yang, Ivy Lin, Jason Sutin, Simon Keith Warfield, Janet Soul, Judy Estroff, Susan Connolly, Carol Barnewolt, Ali Gholipour, Henry A. Feldman, Patricia Ellen Grant
Summary: This study aimed to explore the neurobiological substrate and influencing factors of isolated fetal ventriculomegaly (iFVM). Through magnetic resonance imaging of 89 fetuses, it was found that the development of transient fetal zones/compartments was abnormal in iFVM fetuses, suggesting a link between the enlarged lateral ventricles and the development of transient fetal zones.
Article
Biochemistry & Molecular Biology
Volodymyr Petrenko, Flore Sinturel, Ursula Loizides-Mangold, Jonathan Paz Montoya, Simona Chera, Howard Riezman, Charna Dibner
Summary: Recent evidence suggests that circadian clocks play a role in regulating lipid metabolism in human pancreatic islets and perturbation of temporal regulation of lipid metabolism in islets upon type 2 diabetes leads to altered insulin secretion and membrane fluidity. These findings provide important insights into the pathophysiology of metabolic diseases and the role of circadian rhythms in pancreatic function.
Article
Developmental Biology
Lana Vasung, Junshen Xu, Esra Abaci-Turk, Cindy Zhou, Elizabeth Holland, William H. H. Barth, Carol Barnewolt, Susan Connolly, Judy Estroff, Polina Golland, Henry A. A. Feldman, Elfar Adalsteinsson, P. Ellen Grant
Summary: This prospective study used machine learning to quantitatively analyze fetal limb movement based on in-utero MRI images. The study found that maternal factors, such as increased oxygen levels, and fetal factors, such as gestational age, influenced the duration of fetal limb movements. The results showed longer movement time during maternal hyperoxia and a decrease in upper limb movement time with increasing gestational age while the lower limb movement time increased.
DEVELOPMENTAL NEUROSCIENCE
(2023)
Article
Cell Biology
Volodymyr Petrenko, Miri Stolovich-Rain, Bart Vandereycken, Laurianne Giovannoni, Kai-Florian Storch, Yuval Dor, Simona Chera, Charna Dibner
GENES & DEVELOPMENT
(2020)