Article
Anatomy & Morphology
Gianpaolo Antonio Basile, Marina Quartu, Salvatore Bertino, Maria Pina Serra, Marcello Trucas, Marianna Boi, Roberto Demontis, Alessia Bramanti, Giuseppe Pio Anastasi, Demetrio Milardi, Rosella Ciurleo, Alberto Cacciola
Summary: This study successfully reconstructed the fiber bundles of the human subthalamic area and created a large-scale normative population atlas using an optimized tractography protocol. This atlas is of great significance in both clinical anatomy and functional neurosurgery, as it improves our understanding of the complex morphology of this important brain region.
BRAIN STRUCTURE & FUNCTION
(2022)
Review
Neurosciences
James M. Shine
Summary: The human brain is a complex system, with the thalamus playing a crucial role in balancing integration and differentiation. Different thalamocortical connections may influence different information processing modes.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Hyungwoo Lee, Kijeong Lee, Young Dae Kim, Hyo Suk Nam, Hye Sun Lee, Sunghee Cho, Ji Hoe Heo
Summary: This retrospective observational study of 350 patients with basal ganglia infarction found that degeneration of the substantia nigra (SN) was associated with functional dependence or death at 3 months post-stroke. The presence of SN degeneration was significantly correlated with worse functional outcomes, indicating its potential as a predictive factor for poor stroke prognosis and a target for therapeutic interventions.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Sebastian Hormigo, Ji Zhou, Manuel A. Castro-Alamancos
Summary: The results show that unilateral excitation and inhibition of SNr neurons can generate orienting movements in opposite directions, each with distinct behavioral significance.
Article
Multidisciplinary Sciences
Patricia Gonzalez-Rodriguez, Enrico Zampese, Kristen A. Stout, Jaime N. Guzman, Ema Ilijic, Ben Yang, Tatiana Tkatch, Mihaela A. Stavarache, David L. Wokosin, Lin Gao, Michael G. Kaplitt, Jose Lopez-Barneo, Paul T. Schumacker, D. James Surmeier
Summary: Loss of functional mitochondrial complex I in dopaminergic neurons can lead to a shift in metabolism in mice, causing Parkinson's disease-like symptoms. This study challenges the traditional paradigm of Parkinson's disease by showing that dysfunction of mitochondrial complex I alone is sufficient to cause progressive parkinsonism.
Article
Neurosciences
Suthinee Attachaipanich, Takaaki Ozawa, Tom Macpherson, Takatoshi Hikidap
Summary: The nucleus accumbens (NAc) is a crucial part of the limbic basal ganglia circuit and is associated with decision-making and reward processing. This study investigated the effects of optogenetic manipulation of the NAc D1-MSN-SNr pathway on reward learning and locomotor behavior in male mice. The results showed that stimulation of this pathway induced a preference for a laser-paired location, self-stimulation, and enhanced instrumental responding for a liquid reward. Furthermore, stimulation increased locomotor behavior when delivered bilaterally and induced contralateral turning behavior when delivered unilaterally. However, inhibition of this pathway had no effect on reward-related behaviors or locomotion.
Article
Neurosciences
Mario Antonazzo, Sonia Maria Gomez-Urquijo, Luisa Ugedo, Teresa Morera-Herreras
Summary: The basal ganglia (BG) play a role in movement control, cognitive, and motivational functions, with the CB1 cannabinoid receptor and dopamine playing key roles in BG circuits. Research shows that loss of dopamine alters information processing in the circuits, potentially leading to non-motor symptoms in Parkinson's disease patients.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Cell Biology
Victoria Cheung, Philip Chung, Max Bjorni, Varvara A. Shvareva, Yesenia C. Lopez, Evan H. Feinberg
Summary: Behavioral roles and physiology of projection neurons connecting different brain areas are a major focus in modern neuroscience. A high throughput sequencing method called VECTORseq has been developed to identify multiple neuronal subtypes based on connectivity, providing a roadmap for future research in this area.
Article
Neurosciences
Wenyue Liu, Changpeng Wang, Tingting He, Minghong Su, Yuan Lu, Guanyu Zhang, Thomas F. Munte, Lirong Jin, Zheng Ye
Summary: In Parkinson's disease, damage to the substantia nigra may lead to deficits in sequential working memory, mediated by dysfunction in the basal ganglia. Patients showed poorer performance in a digitordering task and smaller SNs compared to healthy controls. The study suggests that SN integrity is crucial for sequencing performance in PD patients.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ilaria Palmieri, Tino Emanuele Poloni, Valentina Medici, Susanna Zucca, Annalisa Davin, Orietta Pansarasa, Mauro Ceroni, Livio Tronconi, Antonio Guaita, Stella Gagliardi, Cristina Cereda
Summary: The study compared two cases of different forms of dementia, highlighting similarities and differences in pathology, genetics, and transcriptomics, emphasizing the important role of transcriptome profiling in understanding the pathogenesis of AD and LBD.
Article
Multidisciplinary Sciences
Mariam Al Shamsi, M. Emdadul Haque, Allen Shahin, Sami Shaban, Abdul-Kader Souid
Summary: The study investigated the effects of two inhibitors of NADH:ubiquinone oxidoreductase on cellular respiration in striatal tissue using a phosphorescence oxygen analyzer. The results showed impaired respiration in the presence of the inhibitors, suggesting that striatal cellular respiration may be a sensitive biomarker for the adverse effects of toxins.
Article
Neurosciences
Kouichi C. Nakamura, Andrew Sharott, Takuma Tanaka, Peter J. Magill
Summary: In Parkinsonism, dopamine depletion leads to dysrhythmic activity in basal ganglia-recipient zone neurons, which differs from the normal neural cell activity and may affect brain information processing.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Juha Partanen, Kaia Achim
Summary: The Substantia Nigra pars reticulata (SNpr) plays a major role in the basal ganglia network, particularly in movement regulation, behavioral state adjustment, and response to reward. It also has the potential for signal integration and action selection. This article discusses the regionalization of SNpr, specifically the division of its neurons into anterior and posterior subtypes, and how their unique developmental and molecular characteristics may correlate with region-specific connections and functional specializations of SNpr. Understanding the differentiation of SNpr neurons can provide insights into fundamental brain functions and neurological disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Kathryn L. Todd, Janusz Lipski, Peter S. Freestone
Summary: This study identified a distinct population of dopamine neurons that project to the tail region of the striatum, separate from the classic nigrostriatal pathway. The tail striatum was found to have lower basal and evoked dopamine levels, as well as diverse dopamine release kinetics compared to the dorsolateral striatum. Stimulation of the subthalamic nucleus (STN) exclusively evoked dopamine release in the tail striatum, likely mediated by the SNL. These findings suggest the existence of a novel dopamine pathway to the tail striatum, largely independent of the classic nigrostriatal pathway, and highlight the STN as an important modulator of dopamine release in this pathway.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Clinical Neurology
Koji Furukawa, Atsushi Shima, Daisuke Kambe, Akira Nishida, Ikko Wada, Haruhi Sakamaki, Kenji Yoshimura, Yuta Terada, Yusuke Sakato, Masahiro Mitsuhashi, Masanori Sawamura, Etsuro Nakanishi, Yosuke Taruno, Hodaka Yamakado, Yasutaka Fushimi, Tomohisa Okada, Yuji Nakamoto, Ryosuke Takahashi, Nobukatsu Sawamoto
Summary: This study investigates the correlation between motor impairments and striatal dopaminergic terminal degeneration and nigral neuromelanin-laden dopamine neuron loss in different stages of Parkinson's disease. The findings suggest that striatal dopaminergic terminal loss is a biomarker for early stage motor impairments, while nigral dopamine neuron loss is a biomarker for advanced stage motor impairments.
ANNALS OF NEUROLOGY
(2022)
Review
Clinical Neurology
Teresa Ravizza, Filiz Y. Onat, Amy R. Brooks-Kayal, Antoine Depaulis, Aristea S. Galanopoulou, Andrey Mazarati, Adam L. Numis, Raman Sankar, Alon Friedman
Review
Clinical Neurology
Michele Simonato, Sloka Iyengar, Amy Brooks-Kayal, Stephen Collins, Antoine Depaulis, David W. Howells, Frances Jensen, Jing Liao, Malcolm R. Macleod, Manisha Patel, Heidrun Potschka, Matthew Walker, Vicky Whittemore, Emily S. Sena
Review
Biochemistry & Molecular Biology
Silvia Sorce, Roland Stocker, Tamara Seredenina, Rikard Holmdahl, Adriano Aguzzi, Adriano Chio, Antoine Depaulis, Freddy Heitz, Peter Olofsson, Tomas Olsson, Venceslas Duveau, Despina Sanoudou, Sara Skosgater, Antonia Vlahou, Dominique Wasquel, Karl-Heinz Krause, Vincent Jaquet
FREE RADICAL BIOLOGY AND MEDICINE
(2017)
Review
Pharmacology & Pharmacy
Gilles van Luijtelaar, Mehrnoush Zobeiri, Annika Luttjohann, Antoine Depaulis
CURRENT PHARMACEUTICAL DESIGN
(2017)
Review
Neurosciences
Antoine Depaulis, Stephane Charpier
NEUROSCIENCE LETTERS
(2018)
Article
Multidisciplinary Sciences
Georgia Kalozoumi, Olga Kel-Margoulis, Elizabeth Vafiadaki, David Greenberg, Helene Bernard, Hermona Soreq, Antoine Depaulis, Despina Sanoudou
Article
Neurosciences
Florian Studer, Emel Laghouati, Guillaume Jarre, Olivier David, Benoit Pouyatos, Antoine Depaulis
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Clinical Neurology
Fanny Cavarec, Philipp Krauss, Tiffany Witkowski, Alexis Broisat, Catherine Ghezzi, Stephanie De Gois, Bruno Giros, Antoine Depaulis, Colin Deransart
Article
Clinical Neurology
Sophie Hamelin, Vasile Stupar, Lucile Maziere, Jia Guo, Wafae Labriji, Chen Liu, Ludiwine Bretagnolle, Sandrine Parrot, Emmanuel L. Barbier, Antoine Depaulis, Florence Fauvelle
Summary: Following surgery, focal seizures relapse in 20% to 50% of cases due to the difficulty of delimiting the epileptogenic zone (EZ) by current imaging or electrophysiological techniques. In this study, an unbiased metabolomics approach based on ex vivo and in vivo nuclear magnetic resonance spectroscopy (MRS) methods accurately defines the EZ in a mouse model of mesiotemporal lobe epilepsy (MTLE) by identifying gamma-aminobutyric acid (GABA) as a specific biomarker of the EZ.
Article
Clinical Neurology
Fabien Boux, Florence Forbes, Nora Collomb, Emma Zub, Lucile Maziere, Frederic de Bock, Marine Blaquiere, Vasile Stupar, Antoine Depaulis, Nicola Marchi, Emmanuel L. Barbier
Summary: The study aims to improve the identification of the epileptogenic zone and associated seizure-spreading regions using multi-parametric MRI analysis. The results show that combining multiple cellular and cerebrovascular MRI read-outs can effectively differentiate epileptogenic from seizure-spreading areas in an experimental model of mesial temporal lobe epilepsy. The potential clinical value of these findings is discussed.
Article
Clinical Neurology
Florian Studer, Guillaume Jarre, Benoit Pouyatos, Christian Nemoz, Elke Brauer-Krisch, Clemence Muzelle, Raphael Serduc, Christophe Heinrich, Antoine Depaulis
Summary: In this study, the researchers used a genetic model of absence epilepsy in rats to investigate the role of structural connectivity of cortical neurons in the generation of absence seizures. The results showed that increased structural connectivity contributes to the increased neuronal synchronization associated with absence seizures. This study provides strong evidence that aberrant structural connectivity patterns of cortical neurons are critical pathological substrates for increased neuronal synchronization and the generation of absence seizures.
Article
Cell & Tissue Engineering
Celia Lentini, Marie D'Orange, Nicolas Marichal, Marie-Madeleine Trottmann, Rory Vignoles, Louis Foucault, Charlotte Verrier, Celine Massera, Olivier Raineteau, Karl-Klaus Conzelmann, Sylvie Rival-Gervier, Antoine Depaulis, Benedikt Berninger, Christophe Heinrich
Summary: Reprogramming brain-resident glial cells into induced neurons (iNs) has shown potential as a disease-modifying strategy to reduce seizures in therapy-resistant epilepsy, as demonstrated in a mouse model of mesial temporal lobe epilepsy (MTLE).
Article
Clinical Neurology
Emel Laghouati, Florian Studer, Antoine Depaulis, Isabelle Guillemain
Summary: Our study found that the epileptic circuit in GAERS changes during the epileptogenesis period, involving different cortical layers of wS1. Neuronal activities evoked by whisker stimulation were reduced in the wS1 cortex in GAERS at P15 and P30, while increased in the thalamic nuclei compared to control rats. We also observed lower performance in whisker-mediated behavioral tasks in GAERS at both P15 and P30.
Article
Multidisciplinary Sciences
Cian McCafferty, Benjamin F. Gruenbaum, Renee Tung, Jing-Jing Li, Xinyuan Zheng, Peter Salvino, Peter Vincent, Zachary Kratochvil, Jun Hwan Ryu, Aya Khalaf, Kohl Swift, Rashid Akbari, Wasif Islam, Prince Antwi, Emily A. Johnson, Petr Vitkovskiy, James Sampognaro, Isaac G. Freedman, Adam Kundishora, Antoine Depaulis, Francois David, Vincenzo Crunelli, Basavaraju G. Sanganahalli, Peter Herman, Fahmeed Hyder, Hal Blumenfeld
Summary: A rat absence seizure model replicates the characteristics of human absence seizures, with changes in behavior, electroencephalography, and cortical functional magnetic resonance imaging. The study reveals prolonged brain state changes before consciousness-impairing seizures and identifies four distinct patterns of neuronal activity during seizures in the cortex and thalamus.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Anesthesiology
Benjamin F. Gruenbaum, Cian P. McCafferty, Peter S. Salvino, Renee Tung, Peter Vincent, Zachary B. Kratochvil, Jacob Prince, Kohl Swift, Jun Hwan Ryu, Isaac G. Freedman, Rashid Akbari, Peter Herman, Basavaraju Sanganahalli, Fahmeed Hyder, Antoine Depaulis, Hal Blumenfeld
ANESTHESIA AND ANALGESIA
(2020)