Article
Multidisciplinary Sciences
Joshua D. Rieskamp, Ileanexis Rosado-Burgos, Jacob E. Christofi, Eliza Ansar, Dalia Einstein, Ashley E. Walters, Valentina Valentini, John P. Bruno, Elizabeth D. Kirby
Summary: This study demonstrates that glutamate stimulates neural stem cells (NSCs) to self-renew and proliferate through excitatory amino acid transporter 1 (EAAT1), which also stimulates lipogenesis. Transcriptomics and pathway manipulation reveal the underlying mechanism of this process.
Article
Multidisciplinary Sciences
Katrin Gerstmann, Karine Kindbeiter, Ludovic Telley, Muriel Bozon, Florie Reynaud, Emy Theoulle, Camille Charoy, Denis Jabaudon, Frederic Moret, Valerie Castellani
Summary: During corticogenesis, diffusible signals from the cerebrospinal fluid may contribute to the dynamic regulation of apical adhesion, resulting in dual effects on cell positioning and cell progeny.
Article
Biochemistry & Molecular Biology
Wenqiang Fan, Jeronimo Jurado-Arjona, Gregorio Alanis-Lobato, Sophie Peron, Christian Berger, Miguel A. Andrade-Navarro, Sven Falk, Benedikt Berninger
Summary: Most adult hippocampal neural stem cells (NSCs) remain quiescent, but the activity of the transcriptional co-activator Yap1 is enriched in active NSCs. Genetic deletion of Yap1 reduces the proportion of active NSCs, indicating its role in regulating the transition from quiescence to activation. Overexpression of a gain-of-function Yap1 mutant leads to cell cycle entry in NSCs and astrocytes, and dysregulated Yap1 activity represses neurogenesis and induces glioblastoma stem cell-like characteristics.
Article
Developmental Biology
Maria Micaela Sartoretti, Carla A. Campetella, Guillermo M. Lanuza
Summary: This study demonstrates that a restricted pool of progenitors in the mouse spinal cord produces a subset of astrocytes with extraordinary precision. The progenitor transcriptional programs highly influence glial fate and are instrumental in creating astrocyte diversity.
Article
Neurosciences
Shirui Hou, Wan-Ling Ho, Lei Wang, Bryan Kuo, Jun Young Park, Young-Goo Han
Summary: This study demonstrates that Hedgehog signaling is necessary and sufficient to expand outer radial glia (oRGs) and intermediate progenitor cells (IPCs) in ferrets, a gyrencephalic species, through conserved cellular mechanisms. Hedgehog signaling increases oRG-producing division modes of ventricular radial glia (vRGs), oRG self-renewal, and IPC proliferation in two distinct but continuous phases during cortical development.
Article
Neurosciences
Priscilla Bluemel, Jonathan Wickel, Benedikt Gruenewald, Mihai Ceanga, Silke Keiner, Otto W. Witte, Christoph Redecker, Christian Geis, Albrecht Kunze
Summary: Sepsis associated encephalopathy (SAE) is a major complication of sepsis survivors, leading to depletion of neural stem cells and increased gliogenesis in the dentate gyrus, which may accelerate the aging process in the hippocampus.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Anneline Pinson, Lei Xing, Takashi Namba, Nereo Kalebic, Jula Peters, Christina Eugster Oegema, Sofia Traikov, Katrin Reppe, Stephan Riesenberg, Tomislav Maricic, RazVan derihaci, Pauline Wimberger, Svante Paabo, Wieland B. Huttner
Summary: This study found that the modern human variant hTKTL1, but not the Neanderthal variant, can increase the abundance of bRG without affecting bIPs, thereby affecting the generation of neocortical neurons. This indicates differences in neocortical neurogenesis between modern humans and Neanderthals.
Article
Biology
Mariah L. Hoye, Lorenzo Calviello, Abigail J. Poff, Nna-Emeka Ejimogu, Carly R. Newman, Maya D. Montgomery, Jianhong Ou, Stephen N. Floor, Debra L. Silver
Summary: Mutations in the DDX3X gene play a crucial role in cortical development and are associated with DDX3X syndrome. The study shows that DDX3X controls translational and cell cycle control of neural progenitors, influencing neurogenesis and cortical development.
Review
Biochemistry & Molecular Biology
Britt Mossink, Moritz Negwer, Dirk Schubert, Nael Nadif Kasri
Summary: This review discusses the important role of chromatin remodelers in neurodevelopment, indicating that gene mutations in NDDs are related to epigenetics, which is an important pathogenic pathway between these disorders. Over time, chromatin remodeling defects can result in impaired brain circuit establishment, especially in glutamatergic neurons, GABAergic neurons, and glia cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Zhenmeiyu Li, Guoping Liu, Lin Yang, Mengge Sun, Zhuangzhi Zhang, Zhejun Xu, Yanjing Gao, Xin Jiang, Zihao Su, Xiaosu Li, Zhengang Yang
Summary: The human cerebral cortex is responsible for our exceptional cognitive abilities. The remarkable increase in the size of the human cerebral cortex is mainly due to longer neurogenic period facilitated by increased cortical radial glial cells expressing BMP7. BMP7 promotes neurogenesis, inhibits gliogenesis, and mutually inhibits SHH signaling, which promotes cortical gliogenesis.
Article
Cell Biology
Ming Jiang, Tianxiang Tang, Xinyue Liang, Juchen Li, Yue Qiu, Shiwen Liu, Shan Bian, Yunli Xie, Fang Fang, Jing Cang
Summary: Maternal exposure to sevoflurane temporarily disrupts INM of RGPs without altering cell fate, potentially through the Notch signalling pathway. Offspring show no obvious cognitive impairments in MWM. Abnormalities observed in hESC-derived cerebral organoids offer new insights into general anaesthesia effects on human brain development.
CELL PROLIFERATION
(2021)
Article
Neurosciences
Tyler J. Dause, Jiyeon K. Denninger, Bryon M. Smith, Elizabeth D. Kirby
Summary: This review focuses on investigating the autocrine and paracrine functions of the endogenous NSC secretome across life. Evidence shows that the NSC secretome is critical for how endogenous NSCs regulate themselves and their niche, but there are gaps in current literature, particularly in the clinically-relevant domain of endogenous NSC paracrine function in the injured CNS.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Alba Ortega-Gasco, Antoni Parcerisas, Keiko Hino, Vicente Herranz-Perez, Fausto Ulloa, Alba Elias-Tersa, Miquel Bosch, Jose Manuel Garcia-Verdugo, Sergi Simo, Lluis Pujadas, Eduardo Soriano
Summary: NCAM2 plays a significant role in the regulation of RGPs during adult neurogenesis and corticogenesis.
Article
Cell Biology
Bhavana Gupta, Adam C. Errington, Ana Jimenez-Pascual, Vasileios Eftychidis, Simone Brabletz, Marc P. Stemmler, Thomas Brabletz, David Petrik, Florian A. Siebzehnrubl
Summary: The study reveals that the transcription factor ZEB1 plays a crucial role in the self-renewal of active RGL cells in the adult mammalian hippocampus, with its deletion leading to a shift towards symmetric cell division and an increase in newborn neurons while decreasing newly generated astrocytes. ZEB1 is identified as a positive regulator of the ets-domain transcription factor ETV5, which is essential for asymmetric division.
Article
Genetics & Heredity
Varun Suresh, Bhavana Muralidharan, Saurabh J. Pradhan, Mahima Bose, Leora D'Souza, Arpan Parichha, Puli Chandramouli Reddy, Sanjeev Galande, Shubha Tole
Summary: We investigated the differences between the hippocampal primordium (Hcp) and the neocortical primordium (Ncp) in the mouse during early neurogenesis. Our results showed that the Hcp was more accessible than the Ncp at this stage. We identified LHX2 as a candidate transcription factor that regulates gene expression in the Hcp and Ncp, controlling fundamental aspects of development.
Article
Geriatrics & Gerontology
Veronica Go, Bethany G. E. Bowley, Monica A. Pessina, Zheng Gang Zhang, Michael Chopp, Seth P. Finklestein, Douglas L. Rosene, Maria Medalla, Benjamin Buller, Tara L. Moore
Article
Biochemistry & Molecular Biology
Seiko Ikezu, Hana Yeh, Jean-Christophe Delpech, Maya E. Woodbury, Alicia A. Van Enoo, Zhi Ruan, Sudhir Sivakumaran, Yang You, Carl Holland, Teresa Guillamon-Vivancos, Asuka Yoshii-Kitahara, Mina B. Botros, Charlotte Madore, Pin-Hao Chao, Ankita Desani, Solaiappan Manimaran, Srinidhi Venkatesan Kalavai, W. Evan Johnson, Oleg Butovsky, Maria Medalla, Jennifer Luebke, Tsuneya Ikezu
Summary: The study reveals that maternal immune activation affects microglial cells and neuronal functions in the prefrontal cortex of mice, leading to behavioral abnormalities and neuronal dysfunction. Treatment with colony stimulating factor 1 receptor inhibitors corrects the microglial, synaptic, and neurobehavioral dysfunctions associated with MIA.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Chelsey Jenna LeBlang, Maria Medalla, Nicholas William Nicoletti, Emma Catherine Hays, James Zhao, Jenifer Shattuck, Anna Lourdes Cruz, Benjamin Wolozin, Jennifer Irene Luebke
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Neurosciences
Samantha M. Calderazzo, Silas E. Busch, Tara L. Moore, Douglas L. Rosene, Maria Medalla
Summary: The study revealed that connections from the entorhinal and dorsal premotor cortex are segregated in specific subregions of the ACC, while amygdalar connections are more evenly distributed. In the ventral ACC, entorhinal and amygdalar connections strongly overlap, particularly in A25. Meanwhile, in the dorsal ACC, outputs to PMC and amygdala are densely interconnected in deep layers.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Neurosciences
Veronica Go, Deniz Sarikaya, Yuxin Zhou, Bethany G. E. Bowley, Monica A. Pessina, Douglas L. Rosene, Zheng Gang Zhang, Michael Chopp, Seth P. Finklestein, Maria Medalla, Benjamin Buller, Tara L. Moore
Summary: Cortical injury can trigger neurotoxic reactions, especially damaging axons and myelin, which impacts neuronal function recovery. Interventions targeting oligodendrocytes show potential in enhancing myelin maintenance and improving functional recovery in the aged brain after injury.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Peter E. A. Ash, Shuwen Lei, Jenifer Shattuck, Samantha Boudeau, Yari Carlomagno, Maria Medalla, Bryce L. Mashimo, Guillermo Socorro, Louloua F. A. Al-Mohanna, Lulu Jiang, Muhammet M. Ozturk, Mark Knobel, Pavel Ivanov, Leonard Petrucelli, Susanne Wegmann, Nicholas M. Kanaan, Benjamin Wolozin
Summary: Tau protein interacts with RNA and RNA binding protein TIA1 to drive phase separation at physiological concentrations, generating toxic tau oligomers. This pathway may be a crucial source for toxic tau oligomers in tau-related neurodegenerative diseases. The selective mixing of proteins like tau and TIA1 in phase-separated droplets provides a basis for coassortment of functionally relevant proteins, potentially promoting specific biological activities.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Geriatrics & Gerontology
W. Chang, C. M. Weaver, M. Medalla, T. L. Moore, J. Luebke
Summary: A study found that layer 3 pyramidal neurons in the lateral prefrontal cortex of aged rhesus monkeys exhibit increased excitability and reduced spine density, while middle-aged monkeys given curcumin showed better working memory performance and less neuronal excitability.
NEUROBIOLOGY OF AGING
(2022)
Review
Neurosciences
Francisco J. Martini, Teresa Guillamon-Vivancos, Veronica Moreno-Juan, Miguel Valdeolmillos, Guillermina Lopez-Bendito
Summary: Spontaneous activity in developing sensory circuits plays a crucial role in the construction and refinement of functional networks. Originating from various sensory structures, such as the thalamus and cortex, this activity is fundamental for sensory map formation and circuit plasticity. Current data suggest similarities between the developmental trajectory of brain activity in experimental models and humans, offering potential for early diagnosis of developmental disorders.
Article
Cell Biology
Jean-Christophe Delpech, Dhruba Pathak, Merina Varghese, Srinidhi Venkatesan Kalavai, Emma C. Hays, Patrick R. Hof, W. Evan Johnson, Seiko Ikezu, Maria Medalla, Jennifer Luebke, Tsuneya Ikezu
Summary: The study shows that in early stages of Alzheimer's disease, Wfs1(+) neurons in the ECII region are associated with abnormally phosphorylated tau, leading to the spread of tau and potential functional abnormalities in CA1 pyramidal neurons.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Neurosciences
Samantha M. Shelton, Alexandra R. Soucy, Ronni Kurzion, Ella Zeldich, John H. Connor, Tarik F. Haydar
Summary: The study using a novel murine model of fetal ZIKV infection identified the time course of virus infection and the identity of cells that are initially infected or spared during neocortical neurogenesis. Results showed that ZIKV primarily infects apical radial glial cells early on, while basal intermediate progenitor cells reach peak infection rates after three days of exposure to the virus.
Article
Neurosciences
Maria Medalla, Wayne Chang, Sara Ibanez, Teresa Guillamon-Vivancos, Mathias Nittmann, Anastasia Kapitonava, Silas E. Busch, Tara L. Moore, Douglas L. Rosene, Jennifer Luebke
Summary: The study revealed that the anterior cingulate cortex in rhesus monkeys exhibits specialized motor and affective network dynamics through layer-specific biophysical and structural properties of pyramidal neurons. Neurons targeting the amygdala were found to be more excitable and tuned to slow oscillations, while neurons targeting the dorsal premotor cortex showed strong beta/gamma synchrony implicated in rapid sensorimotor processing. These findings highlight the role of layer-specific cellular and circuit properties in driving diverse laminar activity related to flexible behavior.
Article
Endocrinology & Metabolism
Karen R. Bottenfield, Bethany G. E. Bowley, Monica A. Pessina, Maria Medalla, Douglas L. Rosene, Tara L. Moore
Summary: The study found that female rhesus monkeys recovered to their pre-operative latency and grasp patterns significantly faster than males, suggesting the need for further research on the role of estrogen and other sex hormones in recovery outcomes in the primate brain.
BIOLOGY OF SEX DIFFERENCES
(2021)
Article
Multidisciplinary Sciences
Teresa Guillamon-Vivancos, Mar Anibal-Martinez, Lorenzo Puche-Aroca, Juan Antonio Moreno-Bravo, Miguel Valdeolmillos, Francisco J. Martini, Guillermina Lopez-Bendito
Summary: This study found that the segregation of sensory pathways is closely related to early retinal activity. During the embryonic period, somatosensory and visual circuits are intermingled, but they gradually separate into distinct pathways after birth. Blocking early retinal activity prolongs the existence of multimodal configuration and leads to spatial organization defects in the visual system.