Article
Neurosciences
Muhammad Asim, Huajie Wang, Xi Chen, Jufang He
Summary: This study investigates the role of basolateral amygdala (BLA) neurons in mediating the behavior associated with depression. The results suggest that increased activity of excitatory BLA neurons can lead to depressive-like behavior, while inhibition of these neurons can alleviate such behavior. Additionally, inhibiting GABAergic neurons in the BLA can increase the firing frequency of excitatory neurons and mediate depressive-like phenotypes. Furthermore, activating inhibitory neurons can inhibit the activity of excitatory neurons and alleviate depressive-like behavior.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Nowrin Ahmed, Denis Pare
Summary: This study aimed to determine the neurotransmitter used by MD-projecting BLA cells in male and female rats. The results indicate that the BLA sends a mixed, glutamatergic-GABAergic projection to MD, which likely influences coordination of activity between BLA, MD, and medial prefrontal cortex.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Tsuyoshi Yamaguchi, Shukuko Minami, Shuichi Ueda
Summary: The study found that offspring of dams administered MAM intraperitoneally exhibited micrencephaly and anxiety-related behavior, with a significant decrease in PV-positive neurons in the BLA. However, there were no significant changes in the number of Nissl- and Calb-positive neurons. These results suggest that histochemical alterations in the BLA of MAM-induced model rats may be attributed to an aberrant GABAergic inhibitory system.
Article
Neurosciences
Jing Liu, Tao Hu, Meng-Qi Zhang, Chuan-Ying Xu, Mao-Yun Yuan, Rui-Xi Li
Summary: The study examined the morphology and axonal projections of GABAergic neurons in the Basolateral amygdala (BLA) and central nucleus of the amygdala (CEA), revealing distinct distributions and functions in different regions of the forebrain, midbrain, and brainstem. This sheds light on the neuroanatomical basis for exploring the role of GABAergic neurons in the BLA and CEA in fear-related behavior processing.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Vivien Miczan, Krisztina Kelemen, Judit R. Glavinics, Zsofia Laszlo, Benjamin Barti, Kata Kenesei, Mate Kisfali, Istvan Katona
Summary: The molecular repertoire of calcium-binding proteins in Ca2+ signaling pathways plays a crucial role in meeting the specific kinetic requirements of Ca2+-dependent processes in different types of neurons. By investigating CB1/CCK-positive interneurons, it was revealed that NECAB1 and NECAB2 are predominant calcium-binding proteins in this cell type, showing functional differences at the subcellular nanoscale level.
Article
Neurosciences
Ka Ng, Michael Pollock, Abraham Escobedo, Brent Bachman, Nanami Miyazaki, Edward L. L. Bartlett, Susan Sangha
Summary: Stressful events can disrupt regulation of fear and reward processing, leading to maladaptive fear responses. Post-traumatic stress disorder (PTSD) is characterized by persistent fear reactions to safety cues. In this study, the necessity of specific projections from the infralimbic cortex (IL) to the basolateral amygdala (BLA) or central amygdala (CeA) during safety recall was tested. The IL->CeA pathway was found to be necessary for suppressing fear responses in the presence of a learned safety cue, similar to the behavioral disruption seen in individuals with PTSD.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Biological
F. Z. Seno, R. F. Sgobbi, M. J. Nobre
Summary: Morphine withdrawal can disrupt neuronal pathways involved in anxiety and fear-related behaviors, particularly those related to associative learning. This study found that GABA mechanisms in the prefrontal cortex and baso-lateral nucleus can reverse contextual fear caused by morphine withdrawal.
PHYSIOLOGY & BEHAVIOR
(2022)
Review
Biochemistry & Molecular Biology
Maria F. M. Braga, Jenifer Juranek, Lee E. Eiden, Zheng Li, Taiza H. Figueiredo, Marcio de Araujo Furtado, Ann M. Marini
Summary: Traumatic brain injury (TBI) is a global epidemic and a major public health concern in the United States. Anxiety is the second most common neuropsychiatric disorder that develops in those with persistent symptoms after TBI, with abnormalities or atrophy in the temporal lobe being observed in most cases. This review compares human and animal studies to explore the relationship between post-traumatic anxiety and structural/functional changes in the amygdala, leading to both preliminary insights and potential directions for rational and more effective treatments.
Article
Biochemistry & Molecular Biology
Mariia P. Smirnova, Tatiana M. Medvedeva, Irina Pavlova, Lyudmila V. Vinogradova
Summary: The study demonstrates that the amygdala has different susceptibilities to SD, with the basolateral (BLA) region more prone to SD compared to the centromedial (CMA) region. The spatiotemporal features of SD triggered in the amygdala show diverse propagation patterns to the cortex.
Article
Psychiatry
Jonas Englund, Joni Haikonen, Vasilii Shteinikov, Shyrley Paola Amarilla, Tsvetomira Atanasova, Alexandra Shintyapina, Maria Ryazantseva, Juha Partanen, Vootele Voikar, Sari E. Lauri
Summary: Early life stress can alter the function of kainate receptors in the amygdala, leading to changes in GABAergic microcircuits and potentially contributing to anxio-genesis. These changes showed gender specificity and affected behavioral phenotypes in male rodents.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Wei Gao, Bharat Biswal, ShengDong Chen, XinRan Wu, JiaJin Yuan
Summary: Functional couplings between the orbitofrontal cortex (OFC) and the basolateral amygdala (BLA) are associated with both dispositional and actual uses of cognitive reappraisal, while coupling between the dorsolateral prefrontal cortex (dlPFC) and the centromedial amygdala (CMA) are associated with suppression. The coupling of the right OFC-BLA partially mediates the association between reappraisal and emotional response.
Review
Biochemistry & Molecular Biology
Alexander K. Zinsmaier, Yan Dong, Yanhua H. Huang
Summary: Cocaine craving, seeking, and relapse are partially mediated by adaptive changes in the brain reward circuits induced by cocaine. The nucleus accumbens integrates emotional and motivational inputs and prioritizes them for the reward system. Medium spiny neurons in the NAc show complex adaptations following cocaine experience, influenced by various factors such as cocaine regimen, withdrawal time, cell type, location, and input/output projections.
MOLECULAR PSYCHIATRY
(2022)
Article
Immunology
Xiao Zhuang, Bing Zhan, Yufeng Jia, Chaoze Li, Nan Wu, Ming Zhao, Nuo Chen, Yaxin Guo, Yingxin Du, Yi Zhang, Baihui Cao, Yan Li, Faliang Zhu, Chun Guo, Qun Wang, Yuan Li, Lining Zhang
Summary: Hyper-inflammatory reaction can activate anxiety circuits by suppressing BDNF and GABAergic neurons transmission.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Tomohiro Tokutake, Takashi Asano, Hajime Miyanishi, Shigetoshi Nakaya, Naotaka Izuo, Atsumi Nitta
Summary: The number of cannabis users is increasing globally, but the mechanisms behind the psychiatric effects and addiction formation are still unclear. This study found that the main active substance in cannabis, THC, affects CB1 receptors in the brain, specifically in the BLA region, which is involved in anxiety and reward behavior. The results suggest that CB1 receptors in the BLA contribute to the behavior disorders caused by acute or chronic cannabis use.
NEUROCHEMICAL RESEARCH
(2022)
Article
Neurosciences
Maxine K. Loh, J. Amiel Rosenkranz
Summary: Nucleus accumbens (NAc) neurons integrate excitatory inputs from cortical and limbic structures, contributing to critical cognitive functions, including decision-making. These inputs may summate differently in NAc between different age groups. Decision-making involves both reward and risk assessment, indicating an interplay between reward- and risk-related circuits. Medial orbitofrontal cortex (MO)-NAc circuits are responsible for risk assessment behaviors and likely play a role in risk information incorporation. However, adolescents tend to make reward-centric choices regardless of risk, suggesting that MO activity may alter reward-related NAc circuits differently based on age. Using single-unit electrophysiology, MO train stimulation was found to change the strength but not the timing of interactions between the basolateral amygdala (BLA) and NAc in an age-dependent manner. In adults, MO train stimulation had a frequency-dependent, bidirectional effect on BLA-evoked NAc action potential probability. On the other hand, MO train stimulation uniformly attenuated BLA-NAc interactions in adolescents. The findings suggest that while the mature MO can modulate reward-related circuits in response to decision outcomes, the adolescent MO may have a limited ability to bidirectionally impact these circuits, resulting in biased decision-making.
Review
Neurosciences
Marco Bocchio, Stephen B. McHugh, David M. Bannerman, Trevor Sharp, Marco Capogna
FRONTIERS IN NEURAL CIRCUITS
(2016)
Article
Neurosciences
Boglarka Barsy, Gergely G. Szabo, Tibor Andrasi, Attila Vikor, Norbert Hajos
EUROPEAN JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Ayesha Sengupta, Marco Bocchio, David M. Bannerman, Trevor Sharp, Marco Capogna
JOURNAL OF NEUROSCIENCE
(2017)
Review
Neurosciences
Marco Bocchio, Sadegh Nabavi, Marco Capogna
Review
Clinical Neurology
Vincenzo Di Lazzaro, John Rothwell, Marco Capogna
Editorial Material
Neurosciences
Wen-Hsien Hou, Marco Capogna
Article
Neurosciences
Marco Bocchio, Istvan P. Lukacs, Richard Stacey, Puneet Plaha, Vasileios Apostolopoulos, Laurent Livermore, Arjune Sen, Olaf Ansorge, Martin J. Gillies, Peter Somogyi, Marco Capogna
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Neurosciences
Nathalie Krauth, Valentina Khalil, Meet Jariwala, Noemie Mermet-Joret, Anne-Katrine Vestergaard, Marco Capogna, Sadegh Nabavi
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Review
Neurosciences
Marco Capogna, Pablo E. Castillo, Arianna Maffei
Summary: GABAergic interneurons are highly diverse and play a crucial role in regulating neural circuits for learning and memory. Inhibitory synaptic plasticity in the hippocampus and neocortex is essential for circuit dynamics, with different interneuron types supporting unique roles.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Rafael Yuste, Michael Hawrylycz, Nadia Aalling, Argel Aguilar-Valles, Detlev Arendt, Ruben Armananzas Arnedillo, Giorgio A. Ascoli, Concha Bielza, Vahid Bokharaie, Tobias Borgtoft Bergmann, Irina Bystron, Marco Capogna, Yoonjeung Chang, Ann Clemens, Christiaan P. J. de Kock, Javier DeFelipe, Sandra Esmeralda Dos Santos, Keagan Dunville, Dirk Feldmeyer, Richard Fiath, Gordon James Fishell, Angelica Foggetti, Xuefan Gao, Parviz Ghaderi, Natalia A. Goriounova, Onur Guentuerkuen, Kenta Hagihara, Vanessa Jane Hall, Moritz Helmstaedter, Suzana Herculano, Markus M. Hilscher, Hajime Hirase, Jens Hjerling-Leffler, Rebecca Hodge, Josh Huang, Rafiq Huda, Konstantin Khodosevich, Ole Kiehn, Henner Koch, Eric S. Kuebler, Malte Kuhnemund, Pedro Larranaga, Boudewijn Lelieveldt, Emma Louise Louth, Jan H. Lui, Huibert D. Mansvelder, Oscar Marin, Julio Martinez-Trujillo, Homeira Moradi Chameh, Alok Nath, Maiken Nedergaard, Pavel Nemec, Netanel Ofer, Ulrich Gottfried Pfisterer, Samuel Pontes, William Redmond, Jean Rossier, Joshua R. Sanes, Richard Scheuermann, Esther Serrano-Saiz, Jochen F. Steiger, Peter Somogyi, Gabor Tamas, Andreas Savas Tolias, Maria Antonietta Tosches, Miguel Turrero Garcia, Hermany Munguba Vieira, Christian Wozny, Thomas V. Wuttke, Liu Yong, Juan Yuan, Hongkui Zeng, Ed Lein
NATURE NEUROSCIENCE
(2020)
Editorial Material
Neurosciences
Noemie Mermet-Joret, Marco Capogna, Sadegh Nabavi
Summary: This study revealed that extinguished fear memories may relapse due to converging sensory and contextual cues from the auditory cortex and ventral hippocampus to the lateral amygdala.
TRENDS IN NEUROSCIENCES
(2021)
Correction
Neurosciences
Rafael Yuste, Michael Hawrylycz, Nadia Aalling, Argel Aguilar-Valles, Detlev Arendt, Ruben Armananzas, Giorgio A. Ascoli, Concha Bielza, Vahid Bokharaie, Tobias Borgtoft Bergmann, Irina Bystron, Marco Capogna, YoonJeung Chang, Ann Clemens, Christiaan P. J. De Kock, Javier DeFelipe, Sandra Esmeralda Dos Santos, Keagan Dunville, Dirk Feldmeyer, Richard Fiath, Gordon James Fishell, Angelica Foggetti, Xuefan Gao, Parviz Ghaderi, Natalia A. Goriounova, Onur Gunturkun, Kenta Hagihara, Vanessa Jane Hall, Moritz Helmstaedter, Suzana Herculano-Houzel, Markus M. Hilscher, Hajime Hirase, Jens Hjerling-Leffler, Rebecca Hodge, Josh Huang, Rafiq Huda, Konstantin Khodosevich, Ole Kiehn, Henner Koch, Eric S. Kuebler, Malte Kuhnemund, Pedro Larranaga, Boudewijn Lelieveldt, Emma Louise Louth, Jan H. Lui, Huibert D. Mansvelder, Oscar Marin, Julio Martinez-Trujillo, Homeira Moradi Chameh, Alok Nath Mohapatra, Hermany Munguba, Maiken Nedergaard, Pavel Nemec, Netanel Ofer, Ulrich Gottfried Pfisterer, Samuel Pontes, William Redmond, Jean Rossier, Joshua R. Sanes, Richard H. Scheuermann, Esther Serrano-Saiz, Jochen F. Staiger, Peter Somogyi, Gabor Tamas, Andreas Savas Tolias, Maria Antonietta Tosches, Miguel Turrero Garcia, Christian Wozny, Thomas V. Wuttke, Yong Liu, Juan Yuan, Hongkui Zeng, Ed Lein
NATURE NEUROSCIENCE
(2021)
Article
Neurosciences
Emma Louise Louth, Rasmus Langelund Jorgensen, Anders Rosendal Korshoej, Jens Christian Hedemann Sorensen, Marco Capogna
Summary: The study found that dopamine exerts different modulatory effects on excitatory synaptic plasticity in mouse and human cortical neurons. These results emphasize the importance of dopamine in regulating cognition and may provide insights for therapeutic interventions to recover brain function.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Gergely G. Szabo, Jordan S. Farrell, Barna Dudok, Wen-Hsien Hou, Anna L. Ortiz, Csaba Varga, Prannath Moolchand, Cafer Ikbal Gulsever, Tilo Gschwind, Jordane Dimidschstein, Marco Capogna, Ivan Soltesz
Summary: This study identifies a specific group of GABAergic cells in the mouse hippocampus that exhibit high-frequency firing during ripples, a type of high-frequency electrographic event. These cells remain largely silent during other states, showing a unique property in coordinating ripple-related neuronal activity. The controlled inputs from septal GABAergic, cholinergic, and CA3 glutamatergic neurons allow these cells to innervate local interneurons and target extra-hippocampal regions.
Article
Neurosciences
Marco Bocchio, Simon P. Fisher, Gunes Unal, Tommas J. Ellender, Vladyslav V. Vyazovskiy, Marco Capogna
