期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 27, 期 -, 页码 158-164出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2014.03.001
关键词
-
资金
- Taiwan Merit Scholarships Program - National Science Council [NSC-095-SAF-I-564-015-TMS]
- NIH [1RC4GM096355-01]
Signaling pathways and cellular processes that regulate neural development are used post-developmentally for proper function and maintenance of the nervous system. Genes that have been studied in the context of the development of Drosophila peripheral nervous system (PNS) and neuromuscular junction (NMJ) have been identified as players in the pathogenesis of human neurodegenerative diseases, including spinocerebellar ataxia, amyotrophic lateral sclerosis, and spinal muscular atrophy. Hence, by unraveling the molecular mechanisms that underlie proneural induction, cell fate determination, axonal targeting, dendritic branching, and synapse formation in Drosophila, novel features related to these disorders have been revealed. In this review, we summarize and discuss how studies of Drosophila PNS and NMJ development have provided guidance in experimental approaches for these diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据