期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 24, 期 -, 页码 47-54出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2013.08.011
关键词
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资金
- Neurocure, Bernstein Center for Computational, Neuroscience (BMBF)
- Humboldt University
- Neuro-behavior ERC grant
- DFG
Spatial discharge patterns in medial entorhinal cortex consist of grid, head direction, border and spatial-band cells. These firing patterns differ from the single-peaked fields of hippocampal place cells, in that they have well-defined geometries and extend throughout the available space. Such discharge properties could contribute to a metric representation of space. Both functional and anatomical evidence point to principal cell diversity, modularity and columnar organization, but linking entorhinal anatomy and physiology remains challenging. Layer 2 microcircuits consist of pyramidal neurons and a stellate cell network, which lacks recurrent excitation and is coupled by disynaptic inhibition. Intracellular recordings showed that periodic, grid-like firing emerges from depolarization ramps, whereas theta-oscillations determine spike timing. Interference with various inputs to entorhinal cortex abolishes grid activity, often without concomitant loss of hippocampal place activity.
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